WO1996019205B1 - Transdermal delivery system with adhesive overlay and peel seal disc - Google Patents
Transdermal delivery system with adhesive overlay and peel seal discInfo
- Publication number
- WO1996019205B1 WO1996019205B1 PCT/US1995/016498 US9516498W WO9619205B1 WO 1996019205 B1 WO1996019205 B1 WO 1996019205B1 US 9516498 W US9516498 W US 9516498W WO 9619205 B1 WO9619205 B1 WO 9619205B1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- peel seal
- backing layer
- active agent
- seal disc
- adhesive
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Abstract
A device (10) for administering an active agent to the skin or mucosa of an individual comprising a laminated composite of an adhesive overlay (26), a backing layer (14) underlying the central portion of the adhesive overlay, an active agent-permeable membrane (16), the backing layer and membrane defining a reservoir (12) that contains a formulation of the active agent, a peel seal disc (20) underlying the active agent-permeable membrane, a heat seal (22) about the periphery of the peel seal disc, the active agent-permeable membrane and the backing layer and a removable release liner (24) underlying the exposed overlay and peel seal disc. The adhesive layer is above and peripheral to the path of the active agent to the skin or mucosa and is protected from degradation by the components of the reservoir by a multiplicity of heat seals. The peel seal disc protects against release of the active agent-containing reservoir and the release liner protects the adhesive from exposure to the environment prior to use.
Claims
1. A device for administering an active agent to the skin or mucosa of an individual comprising a laminated composite of:
(a) a backing layer defining an upper portion of a reservoir and extending to the periphery of a peel seal disk;
(b) an active agent-permeable membrane extending to the periphery of the peel seal disk and the backing layer, and underlying the backing layer, the backing layer and membrane defining
(c) the reservoir therebetween that contains a formulation of the active agent; (d) the peel seal disc underlying an active agent-permeable membrane;
(e) a heat seal about the periphery of the peel seal disc, the active agent- permeable membrane and the backing layer;
(f) an adhesive overlay having a central portion overlying the backing layer and a peripheral portion that extends beyond the periphery of the peel seal disc; and (g) a removable release liner underlying the peripheral portion of the adhesive overlay and the peel seal disc.
2. The device of claim 1 wherein the adhesive is made of a material selected from the group consisting of polyisobutenes. natural rubbers, acrylates. methacrylates and silicone.
3. The device of claim 1 wherein the backing layer comprises at least one impermeable film layer.
4. The device of claim 1 wherein the membrane is selected from the group consisting of microporous membranes and dense membranes.
5. The device of claim 1 wherein the peel seal disc is composed of at least one layer.
6. The device of claim 1 further comprising a percutaneous absorption enhancer.
7. The device of claim 1 wherein the formulation further comprises a material selected from the group consisting of a solvent, a gelling agent, stabilizer and an anti-irritant.
8. The device of claim 1 including an adhesive layer that underlies the peripheral portion of the adhesive overlay and the peel seal disc and overlies the release liner.
9. The device of claim 1 wherein the adhesive overlay is nonocclusive and the backing layer is occlusive.
10. A device for administering an active agent to the skin or mucosa of an individual comprising a laminated composite of: (a) a backing layer defining an upper portion of a reservoir and extending to the periphery of a peel seal disk;
(b) an active agent-permeable membrane extending to the periphery of the peel seal disk and the backing layer, and underlying the backing layer and membrane defining (c) the reservoir therebetween that contains a formulation of an active agent;
(d) the peel seal disc underlying an active agent-permeable membrane:
(e) a heat seal about the periphery of the peel seal disc, the active agent- permeable membrane and the backing layer; (f) an adhesive overlay having a central portion overlying the backing layer and a peripheral portion that extends beyond the periphery of the peel seal disc: -29-
(g) a removable release liner underlying the peripheral portion of the adhesive overlay and the peel seal disc; and
(h) a tab on said peel seal disc to aid in removal of said disc.
1 1. The device of claim 10 including an adhesive layer that underlies the peripheral portion of the adhesive overlay and the peel seal disc and overlies the release liner.
12. The device of claim 10 wherein the adhesive overlay is nonocclusive and the backing layer is occlusive.
13. A device for administering an active agent to the skin or mucosa of an individual comprising a laminated composite of:
(a) a backing layer defining an upper portion of a reservoir and extending to the periphery of a peel seal disc;
(b) an active agent-permeable membrane extending to the periphery of the peel seal disc and the backing layer, and underlying the backing layer, the backing layer and the membrane defining
(c) the reservoir therebetween that contains a formulation of an active agent; (d) the peel seal disc underlying the active agent-permeable membrane:
(e) a heat seal about the periphery of the peel seal disc, active agent- permeable membrane and backing layer;
(f) an adhesive overlay having a central portion overlying the backing layer and a peripheral portion that extends beyond the peripheral of the peel seal disc; (g) a removable release liner underlying the peripheral portion of the adhesive overlay and the peel seal disc and extending beyond the peripheral portion: and
(h) a second adhesive layer underlying the peelable disk and peripheral region of the adhesive overlay, the second adhesive layer extending beyond the periphery of the backing film, the reservoir, and the membrane. -30-
14. The device of claim 13 wherein the adhesive is made of a material selected from the group consisting of polyisobutenes, natural rubbers, acrylates, methacrylates and silicone.
15. The device of claim 13 wherein the backing layer comprises at least one impermeable film layer.
16. The device of claim 13 wherein the membrane is selected from the group consisting of microporous membranes and dense membranes.
17. The device of claim 13 wherein the peel seal disc is composed of at least one layer.
18. The device of claim 13 further comprising a percutaneous absorption enhancer.
19. The device of claim 13 wherein the formulation further comprises a material selected from the group consisting of a solvent, a gelling agent, stabilizer and an anti-irritant.
20. The device of claim 13 wherein the adhesive overlay is nonocclusive and the backing layer is occlusive.
Priority Applications (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU45233/96A AU695170B2 (en) | 1994-12-21 | 1995-12-08 | Transdermal delivery system with adhesive overlay and peel seal disc |
| EP95943869A EP0799029A1 (en) | 1994-12-21 | 1995-12-08 | Transdermal delivery system with adhesive overlay and peel seal disc |
| JP8519931A JPH10511353A (en) | 1994-12-21 | 1995-12-08 | Transdermal delivery system using adhesive overlay and peelable seal disk |
| MXPA/A/1997/004291A MXPA97004291A (en) | 1994-12-21 | 1997-06-10 | System of release transdermica conrecubrimiento adhesivo and disco de selladodesprendi |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36180094A | 1994-12-21 | 1994-12-21 | |
| US08/361,800 | 1994-12-21 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO1996019205A1 WO1996019205A1 (en) | 1996-06-27 |
| WO1996019205B1 true WO1996019205B1 (en) | 1996-08-08 |
Family
ID=23423499
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/US1995/016498 Ceased WO1996019205A1 (en) | 1994-12-21 | 1995-12-08 | Transdermal delivery system with adhesive overlay and peel seal disc |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US5662925A (en) |
| EP (1) | EP0799029A1 (en) |
| JP (1) | JPH10511353A (en) |
| CN (1) | CN1170360A (en) |
| AU (1) | AU695170B2 (en) |
| CA (1) | CA2208132A1 (en) |
| TW (1) | TW438607B (en) |
| WO (1) | WO1996019205A1 (en) |
| ZA (1) | ZA9510786B (en) |
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-
1995
- 1995-12-08 WO PCT/US1995/016498 patent/WO1996019205A1/en not_active Ceased
- 1995-12-08 CN CN95196946A patent/CN1170360A/en active Pending
- 1995-12-08 JP JP8519931A patent/JPH10511353A/en not_active Withdrawn
- 1995-12-08 AU AU45233/96A patent/AU695170B2/en not_active Ceased
- 1995-12-08 CA CA002208132A patent/CA2208132A1/en not_active Abandoned
- 1995-12-08 EP EP95943869A patent/EP0799029A1/en not_active Withdrawn
- 1995-12-11 TW TW084113258A patent/TW438607B/en not_active IP Right Cessation
- 1995-12-19 ZA ZA9510786A patent/ZA9510786B/en unknown
-
1996
- 1996-04-26 US US08/638,440 patent/US5662925A/en not_active Expired - Lifetime
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