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WO1996012190B1 - Presentation d'antigenes hydrophobes a des lymphocytes t par des molecules cd1 - Google Patents

Presentation d'antigenes hydrophobes a des lymphocytes t par des molecules cd1

Info

Publication number
WO1996012190B1
WO1996012190B1 PCT/US1995/013274 US9513274W WO9612190B1 WO 1996012190 B1 WO1996012190 B1 WO 1996012190B1 US 9513274 W US9513274 W US 9513274W WO 9612190 B1 WO9612190 B1 WO 9612190B1
Authority
WO
WIPO (PCT)
Prior art keywords
cdl
presented
antigen
lipoarabinomannan
lipoarabinomannan antigen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1995/013274
Other languages
English (en)
Other versions
WO1996012190A9 (fr
WO1996012190A3 (fr
WO1996012190A2 (fr
Filing date
Publication date
Priority claimed from US08/322,980 external-priority patent/US5679347A/en
Priority claimed from US08/322,979 external-priority patent/US5853737A/en
Priority claimed from US08/501,600 external-priority patent/US6238676B1/en
Priority to EP95941326A priority Critical patent/EP0786088B1/fr
Priority to AU42779/96A priority patent/AU694299B2/en
Priority to DE69525058T priority patent/DE69525058D1/de
Priority to JP8513411A priority patent/JPH10510142A/ja
Priority to AT95941326T priority patent/ATE212129T1/de
Application filed filed Critical
Publication of WO1996012190A2 publication Critical patent/WO1996012190A2/fr
Publication of WO1996012190A3 publication Critical patent/WO1996012190A3/fr
Publication of WO1996012190A9 publication Critical patent/WO1996012190A9/fr
Publication of WO1996012190B1 publication Critical patent/WO1996012190B1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Abstract

L'invention concerne des antigènes présentés par CD1, des compositions, des cellules, des inhibiteurs et des procédés relatifs à l'utilisation de la présentation de l'antigène lipoarabinomannane (LAM) par des molécules CD1, y compris des procédés de détection de la présence d'un antigène LAM présenté par CD1 dans un échantillon; des procédés d'isolement desdits antigènes LAM présentés par CD1 ainsi que les antigènes isolés; des vaccins contenant des antigènes LAM présentés par CD1 ainsi que des méthodes de vaccination, des procédés de blocage de la présentation de l'antigène LAM par CD1, des procédés d'identification et/ou d'isolement d'agents bloquant la CD1 ainsi que les agents bloquant la CD1 isolée, des procédés d'induction de l'expression de CD1 ainsi que les lymphocytes T destinés à être utilisés dans les procédés énoncés.
PCT/US1995/013274 1994-10-13 1995-10-13 Presentation d'antigenes hydrophobes a des lymphocytes t par des molecules cd1 Ceased WO1996012190A2 (fr)

Priority Applications (5)

Application Number Priority Date Filing Date Title
EP95941326A EP0786088B1 (fr) 1994-10-13 1995-10-13 Presentation d'antigenes de lipoarabinomannane a des lymphocytes t par des molecules cd1
AU42779/96A AU694299B2 (en) 1994-10-13 1995-10-13 Presentation of hydrophobic antigens to T-cells by CD1 molecules
DE69525058T DE69525058D1 (de) 1994-10-13 1995-10-13 Präsentation von aus lipoarabinomannan bestehenden antigenen an t-zellen durch cd1 moleküle
JP8513411A JPH10510142A (ja) 1994-10-13 1995-10-13 Ｃｄ１分子によるｔ細胞に対する疎水性抗原の提示
AT95941326T ATE212129T1 (de) 1994-10-13 1995-10-13 Präsentation von aus lipoarabinomannan bestehenden antigenen an t-zellen durch cd1 moleküle

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US08/322,979 1994-10-13
US08/322,980 US5679347A (en) 1992-12-10 1994-10-13 Methods of isolating CD1-presented antigens, vaccines comprising CD1-presented antigens, and cell lines for use in said methods
US08/322,980 1994-10-13
US08/322,979 US5853737A (en) 1992-12-10 1994-10-13 Method for inducing a CD1-restricted immune response
US50149195A 1995-07-12 1995-07-12
US08/501,600 1995-07-12
US08/501,600 US6238676B1 (en) 1992-12-10 1995-07-12 Presentation of hydrophobic antigens to T-cells by CD1 molecules
US08/501,491 1995-07-12

Publications (4)

Publication Number Publication Date
WO1996012190A2 WO1996012190A2 (fr) 1996-04-25
WO1996012190A3 WO1996012190A3 (fr) 1996-06-27
WO1996012190A9 WO1996012190A9 (fr) 1996-08-01
WO1996012190B1 true WO1996012190B1 (fr) 1996-09-06

Family

ID=27502254

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1995/013274 Ceased WO1996012190A2 (fr) 1994-10-13 1995-10-13 Presentation d'antigenes hydrophobes a des lymphocytes t par des molecules cd1

Country Status (7)

Country Link
EP (2) EP0786088B1 (fr)
JP (1) JPH10510142A (fr)
AT (1) ATE212129T1 (fr)
AU (1) AU694299B2 (fr)
CA (1) CA2202680A1 (fr)
DE (1) DE69525058D1 (fr)
WO (1) WO1996012190A2 (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7063844B2 (en) 1992-12-10 2006-06-20 The Brigham And Women's Hospital, Inc. Presentation of hydrophobic antigens to T-cells by CD1 molecules
US6238676B1 (en) 1992-12-10 2001-05-29 Brigham And Women's Hospital Presentation of hydrophobic antigens to T-cells by CD1 molecules
WO1995028642A1 (fr) 1994-04-14 1995-10-26 Brown, Keith, Edwin, Frank Methode de detection de la presence d'une espece mycobacterium, kit et anticorps utilises dans cette methode
JP2001515868A (ja) * 1997-09-12 2001-09-25 ブライハム アンド ウイメンズ ホスピタル Ｃｄ１制限免疫応答のための合成抗原
JP2002511421A (ja) * 1998-04-13 2002-04-16 ザ ブライハム アンド ウイミンズ ホスピタル， インコーポレイテッド Ｃｄ−１抗原およびｔ細胞刺激化合物を含むワクチン組成物およびその使用方法
WO2001094949A2 (fr) * 2000-06-05 2001-12-13 The Brigham And Women's Hospital, Inc. Compositions solubles a base de cd1 et leurs utilisations
FR2819724B1 (fr) * 2001-01-22 2005-05-13 Inst Necker Moyens pour induire une reponse immune aux antigenes bacteriens polysccharidiques et aux structures proteiques des capsides de virus
WO2004093903A2 (fr) 2003-04-18 2004-11-04 The Brigham And Women's Hospital, Inc. Procedes et compositions d'immunomodulation mettant en oeuvre des antigenes cd1
GB0708874D0 (en) * 2007-05-08 2007-06-13 Univ The Of Birmingham Assay for detecting mycrobacterial infection
CN112805369A (zh) 2018-08-08 2021-05-14 南特生物公司 重组cd1限制性t细胞及方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU1423892A (en) * 1991-02-12 1992-09-07 Colorado State University Research Foundation Monoclonal antibodies directed towards mycobacterial antigens
AU1564592A (en) * 1991-02-12 1992-09-07 Dynagen, Inc. Agglutination test for mycobacterial antigens in biological samples
CA2165786A1 (fr) * 1993-06-21 1995-01-05 Steven A. Porcelli Methodes pour isoler des antigenes presentes en cd1; vaccins renfermant des antigenes presentes en cd1; lignees de cellules utilisables dans la methode

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