WO1996006601B1 - Use of 5-ht ligands as anti-pruritic agents - Google Patents
Use of 5-ht ligands as anti-pruritic agentsInfo
- Publication number
- WO1996006601B1 WO1996006601B1 PCT/US1995/010838 US9510838W WO9606601B1 WO 1996006601 B1 WO1996006601 B1 WO 1996006601B1 US 9510838 W US9510838 W US 9510838W WO 9606601 B1 WO9606601 B1 WO 9606601B1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- ligand
- antagonist
- agonist
- agonists
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Abstract
The present invention is based on the finding that 5-HT receptor ligands are useful in treating experimental models of clinically encountered pruritus (itch). A 5-HT ligand as used in this specification is a compound capable of binding with some selectivity to one or more of 5-HT receptor sites. Systemic administration of 5-HT agonists and antagonists causes a reduction in the number of itch-scratch responses to an ocular challenge by allergenic antigens. Therefore, the present invention relates to a method for treating pruritus by administering systemically a therapeutically effective amount of a 5-HT agonist or antagonist to a mammal afflicted with pruritus. The 5-HT ligands may, for example, be selected from the group consisting of 5-HT1, 5-HT2, 5-HT3, and 5-HT4 agonists, partial agonists and antagonists.
Claims
AMENDED CLAIMS
[received by the International Bureau on 20 February 1996 (20.02.96); original claims 3, 6, 7, 13, 16 and 17 cancelled; new claims 1, 9, 11, 12, 14, 15 and 18-20 added;
remaining claims unchanged; all claims renumbered 1-20 (2 pages)]
HT1 and 2 antagonists and all subtypes thereof, and a pharmaceutically acceptable salt or ester thereof.
12. The method of claim 11, wherein said 5-HT ligand is a 5-HT agonist.
14. The method of claim 11, wherein said 5-HT ligand is a 5- HT1A, 1B, or 1D antagonist. 15. The method of claim. 11, wherein said 5-HT ligand is a 5-
HT2, or 5-HT2C antagonist
15. The method of claim 11, wherein said 5-HT ligand is a 5- HT4 agonist.
19. The method of claim 11m wherein said 5-HT iigand is selected from the group consisting of a-methylserotonin, spirotraxine, ketanserin, quipazine. 2-methylserotononin, 8-OH-DPAT and CGS 12066B.
20. The method of claim 11, wherein said 5-HT ligand or salt or ester is administered orally.
1. A method for treating pruritis which comprises
administering a therapeutically effective amount of a 5-HT ligand selected from the group consisting of 5-HT1, 2, 3 and 4 agonists and all subtypes thereof, 5-HT1 and 2 antagonist and all subtypes thereof, and a pharmaceutically acceptable salt or ester thereof, to a mammal afflicted with pruritis.
2. The method of claim 1, wherein said 5-HT ligand is a 5-HT agonist. 4. The method of claim 1, wherein said 5-HT ligand is a 5-HT-
1A, 1B, or 1D antagonist.
5. The method of claim 1, wherein said 5-HT is a 5-HT2, or 5- HT2C antagonist.
8. The method of claim 1, wherein said 5-HT ligand is a 5-HT4 agonist.
9. The method of claim 1, wherein said 5-HT ligand is selected from the group consisting of α-methylserotonin, spirotraxine, ketanserin, quipazine, 2-methylserotonin, 8-OH-DPAT and CGS 12066B.
10. The method of claim 1 wherein said 5-HT ligand or salt or ester is administered orally.
11. A method of treating pruritus in a mammal afflicted with allergic conjunctivitis which comprises administering systemically a therapeutically effective amount of a 5-HT ligand selected from the group consisting of 5-HT1, 2, 3 arid 4 agonists and all subtypes thereof, 5-
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/298,245 US5521183A (en) | 1994-08-30 | 1994-08-30 | Use of 5-HT ligands as anti-pruritic agents |
| US08/298,245 | 1994-08-30 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO1996006601A1 WO1996006601A1 (en) | 1996-03-07 |
| WO1996006601B1 true WO1996006601B1 (en) | 1996-03-21 |
Family
ID=23149684
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/US1995/010838 Ceased WO1996006601A1 (en) | 1994-08-30 | 1995-08-25 | Use of 5-ht ligands as anti-pruritic agents |
Country Status (2)
| Country | Link |
|---|---|
| US (1) | US5521183A (en) |
| WO (1) | WO1996006601A1 (en) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR9708146A (en) * | 1996-03-15 | 1999-07-27 | Lilly Co Eli | Treatment process for common cold or allergic rhinitis |
| US5869497A (en) * | 1996-03-15 | 1999-02-09 | Eli Lilly And Company | Method of treating or ameliorating the symptoms of common cold or allergic rhinitis |
| US5886003A (en) * | 1996-03-25 | 1999-03-23 | Eli Lilly And Company | Methods of treating or ameliorating the symptoms of venomous bites and stings |
| FR2758263B1 (en) * | 1997-01-16 | 1999-12-17 | Oreal | USE OF AN ANTAGONIST OR AN AGONIST OF SEROTONIN RESPECTIVELY OF THE RECEPTOR 5HT2 AND 5HT1D IN A COSMETIC OR DERMATOLOGICAL COMPOSITION FOR SENSITIVE SKINS AND COMPOSITION OBTAINED |
| KR100715344B1 (en) * | 1999-11-23 | 2007-05-08 | 얀센 파마슈티카 엔.브이. | Use of 5HT3 agonists for basal relaxation |
| AU2001238552A1 (en) * | 2000-03-17 | 2001-10-03 | Alcon, Inc. | Compounds with 5-HT2 and 5-HT1A agonist activity for treating glaucoma |
| US20080213252A1 (en) * | 2007-01-03 | 2008-09-04 | Ethan Lerner | Methods of treating itch |
| US9044510B2 (en) | 2007-11-01 | 2015-06-02 | Washington University | Compositions and methods for treating pruritus |
| US20100048607A1 (en) * | 2008-08-25 | 2010-02-25 | Chandrashekhar Kocherlakota | Formulations comprising palonosetron |
| US8957024B2 (en) | 2011-07-27 | 2015-02-17 | Washington University | Composition and methods for reducing opioid-induced pruritus |
| WO2013154513A1 (en) | 2012-04-04 | 2013-10-17 | Mi̇lli̇ Savunma Bakanliği | The use of 5-ht7 receptor antagonists including some atypical antipsychotics as antipruritic agents |
| US9198898B2 (en) | 2013-06-24 | 2015-12-01 | Tigercat Pharma, Inc. | Use of NK-1 receptor antagonists in pruritus |
| US8906951B1 (en) | 2013-06-24 | 2014-12-09 | Tigercat Pharma, Inc. | Use of NK-1 receptor antagonists in pruritus |
| WO2016118632A1 (en) | 2015-01-20 | 2016-07-28 | The General Hospital Corporation | Prevention and treatment of itch with an mrgpr antagonist |
| SG11201901449XA (en) * | 2016-08-23 | 2019-03-28 | Neurim Pharmaceuticals 1991 Ltd | Method for treating pruritus and/or itch |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4839374A (en) * | 1984-01-09 | 1989-06-13 | Janssen Pharmaceutica, N.V. | 4-((Bicyclic heterocyclyl)-methyl and -hetero)-piperidines |
| PH23995A (en) * | 1984-01-09 | 1990-02-09 | Janssen Pharmaceutica Nv | 4((bicycle heterocyclyl)-methyl and hetero)piperidines |
| GB8515934D0 (en) * | 1985-06-24 | 1985-07-24 | Janssen Pharmaceutica Nv | (4-piperidinomethyl and-hetero)purines |
| FR2605008B1 (en) * | 1986-10-08 | 1988-12-02 | Synthelabo | IMIDAZO (4,5-B) PYRIDINONE-2 DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION |
| US5071846A (en) * | 1987-07-01 | 1991-12-10 | Janssen Pharmaceutica N.V. | Anti-hystaminic [(bicyclic heterocyclyl) methyl and --hetero] substituted hexahydro-1H-azepines and pyrrolidines |
| US5151424A (en) * | 1987-07-01 | 1992-09-29 | Janssen Pharmaceutica N.V. | Pharmacologically active (Bicyclic heterocyclyl)methyl and -hetero) substituted hexahydro-1H-azepines and pyrrolidines |
| GB8900380D0 (en) * | 1989-01-09 | 1989-03-08 | Janssen Pharmaceutica Nv | 2-aminopyrimidinone derivatives |
| PH30434A (en) * | 1989-04-07 | 1997-05-09 | Janssen Pharmaceutica Nv | Hydroxyalkylfuranyl derivatives |
| DE69432749T2 (en) * | 1993-03-26 | 2004-04-08 | The Beth Israel Hospital Association, Boston | TOPICAL AND SYSTEMIC APPLICATION OF BUSPIRON AND ITS DERIVATIVES FOR THE TREATMENT OF PATHOLOGICAL CONDITIONS RELATED TO IMMUNE RESPONSES |
| AU7707994A (en) * | 1993-09-30 | 1995-04-18 | Tokyo Tanabe Company Limited | Indoline derivative and 5-ht3 receptor antagonist containing the same as active ingredient |
-
1994
- 1994-08-30 US US08/298,245 patent/US5521183A/en not_active Expired - Fee Related
-
1995
- 1995-08-25 WO PCT/US1995/010838 patent/WO1996006601A1/en not_active Ceased
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| WO1996006601B1 (en) | Use of 5-ht ligands as anti-pruritic agents | |
| Canton et al. | Binding of typical and atypical antipsychotics to 5-HT1C and 5-HT2 sites: clozapine potently interacts with 5-HT1C sites | |
| EP1112106B1 (en) | Serotonergic 5ht2 agonists for treating glaucoma | |
| Jaiswal et al. | Pharmacological characterization of the vascular muscarinic receptors mediating relaxation and contraction in rabbit aorta. | |
| JP3617055B2 (en) | Stable pharmaceutical composition containing 4,5-epoxymorphinan derivative | |
| AU2001294117B2 (en) | Combination use of acetylcholinesterase inhibitors and GABAA inverse agonists for the treatment of cognitive disorders | |
| Cohen et al. | Evidence that blood pressure reduction by serotonin antagonists is related to alpha receptor blockade in spontaneously hypertensive rats. | |
| Clapp et al. | Evidence that Ca2+-activated K+ channels play a major role in mediating the vascular effects of iloprost and cicaprost | |
| AR042463A1 (en) | PAIN TREATMENT WITH NALBUFINE COMBINATIONS AND KAPPA OPIOID RECEIVER AGONISTS AND OPIOID RECEIVER ANTAGOSNIST | |
| CA2331053A1 (en) | Compositions and methods for treating conditions responsive to estrogen | |
| US5281591A (en) | Combinations of selective alpha-adrenergic agonists and antagonists useful in lowering intraocular pressure | |
| US5180721A (en) | Combinations of selective alpha-adrenergic agonists and antagonists useful in lowering intraocular pressure | |
| EP0399791A1 (en) | Combinations of selective alpha-adrenergic agonists and antagonists useful in lowering intraocular pressure | |
| CA2059526A1 (en) | Partial agonists of the strychnine insensitive glycine modulatory site of the n-methyl-d-asparate receptor complex as neuropsychopharmacological agents | |
| Desager et al. | Pharmacokinetic-pharmacodynamic relationships of H1-antihistamines | |
| US5330982A (en) | Pharmaceutical composition containing a 5-HT receptor antagonist and an H+ K+ Atpase inhibitor and a method of treating gastrointestingal disorders therewith | |
| Fuller et al. | The effect of quipazine, a serotonin receptor agonist, on serum corticosterone concentration in rats | |
| Krantic et al. | Evidence for a new subtype of serotonin receptor in oocytes of the surf clam Spisula solidissima | |
| DE69317418D1 (en) | PHARMACEUTICAL COMPOSITIONS OF 5HT1 AGONISTIC ALKYL SULPHONAMIDES FOR RECTAL ADMINISTRATIONS | |
| Hustveit | Binding of fentanyl and pethidine to muscarinic receptors in rat brain | |
| JP2010508306A5 (en) | ||
| US7622476B2 (en) | Methods of using 1-allyl ergot alkaloid derivatives to treat migraines | |
| Michelucci et al. | Reduced plasma nisoldipine concentrations in phenytoin‐treated patients with epilepsy | |
| EP0738513A1 (en) | Method for using ergoline compounds to effect physiological and pathological functions at the 5-HT7 receptor | |
| EP2140864A3 (en) | Use of GAL3 receptor antagonists for the treatment of depression and / or anxiety and compounds useful in such methods |