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WO1993006874A1 - Systeme dialyseur - Google Patents

Systeme dialyseur Download PDF

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Publication number
WO1993006874A1
WO1993006874A1 PCT/JP1992/001266 JP9201266W WO9306874A1 WO 1993006874 A1 WO1993006874 A1 WO 1993006874A1 JP 9201266 W JP9201266 W JP 9201266W WO 9306874 A1 WO9306874 A1 WO 9306874A1
Authority
WO
WIPO (PCT)
Prior art keywords
dialysate
dialysis
blood
ultrafiltration
flow rate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP1992/001266
Other languages
English (en)
Japanese (ja)
Inventor
Fumio Watanabe
Hideo Yonejima
Koichi Tanaka
Seiji Yamazaki
Osamu Kusano
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
KUSANO SCIENTIFIC INSTRUMENT Manufacturing Co Ltd
Original Assignee
KUSANO SCIENTIFIC INSTRUMENT Manufacturing Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by KUSANO SCIENTIFIC INSTRUMENT Manufacturing Co Ltd filed Critical KUSANO SCIENTIFIC INSTRUMENT Manufacturing Co Ltd
Publication of WO1993006874A1 publication Critical patent/WO1993006874A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
    • A61M1/1601—Control or regulation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
    • A61M1/1621—Constructional aspects thereof
    • A61M1/1647—Constructional aspects thereof with flow rate measurement of the dialysis fluid, upstream and downstream of the dialyser
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A61M1/3403—Regulation parameters
    • A61M1/341—Regulation parameters by measuring the filtrate rate or volume
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/33—Controlling, regulating or measuring
    • A61M2205/3317—Electromagnetic, inductive or dielectric measuring means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/33—Controlling, regulating or measuring
    • A61M2205/3324—PH measuring means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/33—Controlling, regulating or measuring
    • A61M2205/3331—Pressure; Flow
    • A61M2205/3334—Measuring or controlling the flow rate

Definitions

  • the present invention relates to an artificial analyzer used for the purpose of removing waste products in blood, which is used as a treatment for patients with renal failure and the like.
  • an artificial dialysis machine by continuously measuring the amount of liquid containing waste products that is continuously dialyzed from the blood during dialysis, that is, the amount of ultrafiltration,
  • the present invention relates to an artificial dialysis device provided with an ultrafiltration amount measuring device for the purpose of knowing the degree of dialysis progress and the total ultrafiltration amount and performing appropriate artificial dialysis.
  • Blood is continuously introduced into a dialyzer (artificial dialysis membrane) at a medical facility to treat patients with renal failure, etc., to remove waste products from the blood, and then re-enter the body.
  • a dialyzer artificial dialysis membrane
  • the purpose of dialysis is to remove waste products from the blood of patients with renal failure, etc.
  • the flow rate at the dialysate inlet was kept constant for a sufficient period of time. For example, the goal was achieved by conducting the analysis for 5 hours.
  • FIG. 3 shows an apparatus having a configuration shown in FIG. 3 .
  • Figure 4 shows the dialer diagram. It is a schematic diagram which shows the structure of.
  • Blood guided from the blood vessel of patient 1 is sent to dialyser 13 by pump 2.
  • the dialysate is also sent from the dialysate tank 4 to the dialyzer 13 by the permeate pump 5.
  • the flow rate of the dialysate is adjusted to a predetermined fixed amount by the control flow meter 6.
  • the blood 8 entered from the blood inlet 7 is separated from the dialysate 10 entered from the dialysate inlet 9 and the blood outlet 12 via the dialysis membrane 11. And flows into the dialysate outlet 13.
  • the waste matter in the blood 8 is dialyzed into the dialysate 10 contained in the ultrafiltrate 14 and discharged, and is discarded as the waste 15 through the dialysate outlet 13. It is possible.
  • the folding is continued for a certain period of time, for example, 5 hours, until the wastes in the blood 8 are sufficiently removed.
  • Figure 5 shows an example of the relationship between the dialysis time and the blood concentration of urea nitrogen, which is known as one of the waste products in the patient's blood.
  • the dialysate inlet flow and the blood inlet flow to the dialyzer are adjusted to a predetermined fixed amount at the start of dialysis. While this is possible, it has the drawback that the ultrafiltration rate, which is controlled from the patient's blood, is not monitored at all.
  • the total amount of ultrafiltration drained from the patient during the dialysis treatment is very important for the dialysis treatment, and if it is too small, too much or too burdensome for the patient . That is, too little As a result, blood waste is not sufficiently removed, and the concentration of blood waste increases before the next dialysis treatment, resulting in uremic pathology. Also, if too much, the concentration of low-molecular-weight substances in the blood, such as electrolytes and blood sugar, decreases, and side effects such as fever and chills during dialysis may occur.
  • the dialysis time is set based on the experience of the doctor, and during the dialysis, the ultrafiltration amount cannot be monitored at all.
  • the present invention has been made to solve such a problem, and therefore, it is possible to continuously monitor the ultrafiltration amount during dialysis, and it is possible for the patient to appropriately monitor the ultrafiltration amount. It is an object of the present invention to provide an artificial immunoassay device equipped with an ultrafiltration amount measuring device, which is excellent in that it can perform various dialysis treatments.
  • the artificial dialysis apparatus equipped with the ultrafiltration amount measuring device of the present invention is provided with a blood flow path and a dialysis device for removing waste products in blood.
  • a dialyzer in which a liquid flow path is separated by a dialysis membrane, a dialysate inlet side to the dialyzer and the dialyzer
  • a flow detector for measuring the dialysate flow rate is provided at each of the dialysate outlet sides from one of the dialysers, and the blood flow is calculated by calculating the output of each flow detector. It is characterized in that it is equipped with an ultrafiltration amount measuring device that continuously measures the ultrafiltration amount, which is the gradual water amount dialyzed from the inside.
  • the flow rate detector provided on each of the liquid outlet sides may be provided with an ultrafiltration amount measuring device formed in an integrated structure.
  • the integrated flow rate detector includes an ultrafiltration amount measuring device constituted by an electromagnetic flow meter arranged in the same magnetic field. You can be
  • FIG. 1 is a block diagram showing an artificial filtration apparatus provided with an ultrafiltration amount measuring apparatus according to an embodiment of the present invention.
  • FIG. 2 is a configuration diagram of the ultrafiltration amount measuring device in the embodiment.
  • Figure 3 is a block diagram showing a conventional dialysis machine.
  • Figure 4 is an explanatory diagram of a dializer.
  • Figure 5 is an explanatory diagram showing the relationship between the dialysis time and the concentration of waste products in blood in dialysis.
  • FIG. 1 is a block diagram showing a human dialysis device incorporating the ultrafiltration amount measuring device 16 of the present invention
  • FIG. 2 is a configuration diagram showing an internal structure of the ultrafiltration amount measuring device 16.
  • the blood of the patient 1 is introduced into the dialyser 13 by the pump 2.
  • the dialysate in the dialysate tank 4 was ultrafiltrated by the dialysate pump 5. It is introduced into the dializer 13 through the inlet 18 of the flow detector 17 of the measuring device 16.
  • the dialyzer 13 has a blood flow path and a dialysate flow path separated by the dialysis membrane 11 as described in FIG. Is dialyzed into the dialysate together with the ultrafiltrate by a dialysis membrane.
  • the dialysate containing waste matter that has exited the dialyser 13 flows through the other inlet 19 of the flow detector 17 of the ultrafiltration amount measuring device 16 and the waste liquid 1 Drained as 5.
  • the flow signal passing through the inlet 18 of the flow detector 17 and the flow signal passing through the inlet 19 are sent to the amplifier 20, and the calculator 21 sends the inlet 19.
  • the flow rate at the inlet 18 is subtracted from the flow rate at this point, and the resulting calculated output signal, that is, the ultrafiltration amount, is output continuously as a display and signal output 22. .
  • the flow rate detector 17 has an integrated structure of two flow paths, and is arranged in the same magnetic field of the electromagnet 23. A current is supplied to the excitation coil 26 from the excitation power supply 25 connected to the power supply 24 and the electromagnet 23 is excited.
  • a flow detector having two integrated flow paths in the same magnetic field, and an amplifier for amplifying a flow signal from each flow detector are provided. And a calculator for calculating the difference between the amplifier output signals of the two flow paths, and a display and a signal output for displaying and increasing the result of the calculation.
  • a calculator for calculating the difference between the amplifier output signals of the two flow paths, and a display and a signal output for displaying and increasing the result of the calculation.
  • the functions and the like of the human dialysis device provided with the ultrafiltration amount measuring device in the present embodiment are merely examples, and the dialysis is performed by using the flow rate signal of the eluate inlet as the control output signal. By controlling the liquid pump, it is easy to obtain a constant dialysate flow rate during dialysis.
  • the artificial dialysis device provided with the ultrafiltration amount measuring device of the present invention
  • dialysis from the dialysate inlet side of the dialyzer and the dialyzer can be performed.
  • a flow rate detector that measures the dialysate flow rate is placed at each of the fluid outlet sides, and the output of each flow rate detector is calculated to determine the amount of reduced water that can be analyzed from the blood. Since the ultrafiltration volume is continuously measured, it is possible to monitor the total ultrafiltration volume that is gradually reduced by the patient during dialysis to an appropriate range. It is possible to perform appropriate dialysis treatment without burdening the patient.
  • the flow rate-output voltage characteristics of the flow detectors can be easily equalized, and the Since each flow detector is similarly affected by fluctuations in its magnetic field, the ultrafiltration obtained as the difference between the outputs of each flow detector is affected. Do not give. Therefore, it is possible to continuously output a stable ultrafiltration volume during dialysis (about 4 to 5 hours).
  • the flow rate detector has an integrated structure and is arranged in the same magnetic field, so that a stable and highly accurate ultrafiltration amount can be obtained. Can output continuously

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  • Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Vascular Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Emergency Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Fluid Mechanics (AREA)
  • External Artificial Organs (AREA)

Abstract

Est décrit un système dialyseur équipé d'un dispositif de mesure de quantité d'ultrafiltration permettant le contrôle en continu d'une quantité d'ultrafiltration lors de la dialyse pour donner au patient un traitement de dialyse adapté. Ce système dialyseur permettant d'éliminer des déchets contenus dans le sang comporte un dialyseur (3) constitué de passages destinés au sang et de pasages destinés au dialysat, séparés les uns des autres par des membranes de dialyse. Ledit système comprend également des détecteurs de débit permettant de mesurer les débits du dialysat et situés respectivement côté entrée pour le dialysat s'écoulant vers le dialyseur (3) et côté sortie pour le dialysat s'écoulant en provenance de ce dernier. Le système dialyseur est aussi pourvu d'un dispositif de mesure de quantité d'ultrafiltration (16) permettant de mesurer en continu une quantité d'ultrafiltration, sous forme d'une quantité de fluide dialysée, par dialyse du sang, par évaluation des signaux de sortie des détecteurs de débit respectifs.
PCT/JP1992/001266 1991-10-01 1992-10-01 Systeme dialyseur Ceased WO1993006874A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP3253929A JPH05329205A (ja) 1991-10-01 1991-10-01 人工透析装置
JP3/253929 1991-10-01

Publications (1)

Publication Number Publication Date
WO1993006874A1 true WO1993006874A1 (fr) 1993-04-15

Family

ID=17257989

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP1992/001266 Ceased WO1993006874A1 (fr) 1991-10-01 1992-10-01 Systeme dialyseur

Country Status (2)

Country Link
JP (1) JPH05329205A (fr)
WO (1) WO1993006874A1 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102010003642A1 (de) * 2010-03-15 2011-09-15 Fresenius Medical Care Deutschland Gmbh Kassette mit einem Sensor zur Bestimmung der Differenz eines ersten und eines zweiten Flüssigkeitsstroms
KR102176978B1 (ko) * 2018-05-23 2020-11-10 연세대학교 원주산학협력단 투석기 제어 장치 및 그의 구동 방법

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58171140U (ja) * 1982-05-10 1983-11-15 牛山　喜久 人工透析除水量監視装置
JPS58221954A (ja) * 1982-06-19 1983-12-23 牛山　喜久 透析除水量監視装置
JPS5979810A (ja) * 1982-09-28 1984-05-09 ガンブロ・ルンデイア・アクチ−ボラグ ２本の別々なダクト内の２つの流れの間の差の測定装置
JPS61272058A (ja) * 1985-05-24 1986-12-02 株式会社　三陽電機製作所 限外濾過量制御測定装置
JPS6214862A (ja) * 1985-07-12 1987-01-23 株式会社　三陽電機製作所 限外ろ過量測定装置

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58171140U (ja) * 1982-05-10 1983-11-15 牛山　喜久 人工透析除水量監視装置
JPS58221954A (ja) * 1982-06-19 1983-12-23 牛山　喜久 透析除水量監視装置
JPS5979810A (ja) * 1982-09-28 1984-05-09 ガンブロ・ルンデイア・アクチ−ボラグ ２本の別々なダクト内の２つの流れの間の差の測定装置
JPS61272058A (ja) * 1985-05-24 1986-12-02 株式会社　三陽電機製作所 限外濾過量制御測定装置
JPS6214862A (ja) * 1985-07-12 1987-01-23 株式会社　三陽電機製作所 限外ろ過量測定装置

Also Published As

Publication number Publication date
JPH05329205A (ja) 1993-12-14

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