WO1993006874A1 - Dialyzer system - Google Patents
Dialyzer system Download PDFInfo
- Publication number
- WO1993006874A1 WO1993006874A1 PCT/JP1992/001266 JP9201266W WO9306874A1 WO 1993006874 A1 WO1993006874 A1 WO 1993006874A1 JP 9201266 W JP9201266 W JP 9201266W WO 9306874 A1 WO9306874 A1 WO 9306874A1
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- WIPO (PCT)
- Prior art keywords
- dialysate
- dialysis
- blood
- ultrafiltration
- flow rate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
- A61M1/1601—Control or regulation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
- A61M1/1621—Constructional aspects thereof
- A61M1/1647—Constructional aspects thereof with flow rate measurement of the dialysis fluid, upstream and downstream of the dialyser
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
- A61M1/3403—Regulation parameters
- A61M1/341—Regulation parameters by measuring the filtrate rate or volume
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/33—Controlling, regulating or measuring
- A61M2205/3317—Electromagnetic, inductive or dielectric measuring means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/33—Controlling, regulating or measuring
- A61M2205/3324—PH measuring means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/33—Controlling, regulating or measuring
- A61M2205/3331—Pressure; Flow
- A61M2205/3334—Measuring or controlling the flow rate
Definitions
- the present invention relates to an artificial analyzer used for the purpose of removing waste products in blood, which is used as a treatment for patients with renal failure and the like.
- an artificial dialysis machine by continuously measuring the amount of liquid containing waste products that is continuously dialyzed from the blood during dialysis, that is, the amount of ultrafiltration,
- the present invention relates to an artificial dialysis device provided with an ultrafiltration amount measuring device for the purpose of knowing the degree of dialysis progress and the total ultrafiltration amount and performing appropriate artificial dialysis.
- Blood is continuously introduced into a dialyzer (artificial dialysis membrane) at a medical facility to treat patients with renal failure, etc., to remove waste products from the blood, and then re-enter the body.
- a dialyzer artificial dialysis membrane
- the purpose of dialysis is to remove waste products from the blood of patients with renal failure, etc.
- the flow rate at the dialysate inlet was kept constant for a sufficient period of time. For example, the goal was achieved by conducting the analysis for 5 hours.
- FIG. 3 shows an apparatus having a configuration shown in FIG. 3 .
- Figure 4 shows the dialer diagram. It is a schematic diagram which shows the structure of.
- Blood guided from the blood vessel of patient 1 is sent to dialyser 13 by pump 2.
- the dialysate is also sent from the dialysate tank 4 to the dialyzer 13 by the permeate pump 5.
- the flow rate of the dialysate is adjusted to a predetermined fixed amount by the control flow meter 6.
- the blood 8 entered from the blood inlet 7 is separated from the dialysate 10 entered from the dialysate inlet 9 and the blood outlet 12 via the dialysis membrane 11. And flows into the dialysate outlet 13.
- the waste matter in the blood 8 is dialyzed into the dialysate 10 contained in the ultrafiltrate 14 and discharged, and is discarded as the waste 15 through the dialysate outlet 13. It is possible.
- the folding is continued for a certain period of time, for example, 5 hours, until the wastes in the blood 8 are sufficiently removed.
- Figure 5 shows an example of the relationship between the dialysis time and the blood concentration of urea nitrogen, which is known as one of the waste products in the patient's blood.
- the dialysate inlet flow and the blood inlet flow to the dialyzer are adjusted to a predetermined fixed amount at the start of dialysis. While this is possible, it has the drawback that the ultrafiltration rate, which is controlled from the patient's blood, is not monitored at all.
- the total amount of ultrafiltration drained from the patient during the dialysis treatment is very important for the dialysis treatment, and if it is too small, too much or too burdensome for the patient . That is, too little As a result, blood waste is not sufficiently removed, and the concentration of blood waste increases before the next dialysis treatment, resulting in uremic pathology. Also, if too much, the concentration of low-molecular-weight substances in the blood, such as electrolytes and blood sugar, decreases, and side effects such as fever and chills during dialysis may occur.
- the dialysis time is set based on the experience of the doctor, and during the dialysis, the ultrafiltration amount cannot be monitored at all.
- the present invention has been made to solve such a problem, and therefore, it is possible to continuously monitor the ultrafiltration amount during dialysis, and it is possible for the patient to appropriately monitor the ultrafiltration amount. It is an object of the present invention to provide an artificial immunoassay device equipped with an ultrafiltration amount measuring device, which is excellent in that it can perform various dialysis treatments.
- the artificial dialysis apparatus equipped with the ultrafiltration amount measuring device of the present invention is provided with a blood flow path and a dialysis device for removing waste products in blood.
- a dialyzer in which a liquid flow path is separated by a dialysis membrane, a dialysate inlet side to the dialyzer and the dialyzer
- a flow detector for measuring the dialysate flow rate is provided at each of the dialysate outlet sides from one of the dialysers, and the blood flow is calculated by calculating the output of each flow detector. It is characterized in that it is equipped with an ultrafiltration amount measuring device that continuously measures the ultrafiltration amount, which is the gradual water amount dialyzed from the inside.
- the flow rate detector provided on each of the liquid outlet sides may be provided with an ultrafiltration amount measuring device formed in an integrated structure.
- the integrated flow rate detector includes an ultrafiltration amount measuring device constituted by an electromagnetic flow meter arranged in the same magnetic field. You can be
- FIG. 1 is a block diagram showing an artificial filtration apparatus provided with an ultrafiltration amount measuring apparatus according to an embodiment of the present invention.
- FIG. 2 is a configuration diagram of the ultrafiltration amount measuring device in the embodiment.
- Figure 3 is a block diagram showing a conventional dialysis machine.
- Figure 4 is an explanatory diagram of a dializer.
- Figure 5 is an explanatory diagram showing the relationship between the dialysis time and the concentration of waste products in blood in dialysis.
- FIG. 1 is a block diagram showing a human dialysis device incorporating the ultrafiltration amount measuring device 16 of the present invention
- FIG. 2 is a configuration diagram showing an internal structure of the ultrafiltration amount measuring device 16.
- the blood of the patient 1 is introduced into the dialyser 13 by the pump 2.
- the dialysate in the dialysate tank 4 was ultrafiltrated by the dialysate pump 5. It is introduced into the dializer 13 through the inlet 18 of the flow detector 17 of the measuring device 16.
- the dialyzer 13 has a blood flow path and a dialysate flow path separated by the dialysis membrane 11 as described in FIG. Is dialyzed into the dialysate together with the ultrafiltrate by a dialysis membrane.
- the dialysate containing waste matter that has exited the dialyser 13 flows through the other inlet 19 of the flow detector 17 of the ultrafiltration amount measuring device 16 and the waste liquid 1 Drained as 5.
- the flow signal passing through the inlet 18 of the flow detector 17 and the flow signal passing through the inlet 19 are sent to the amplifier 20, and the calculator 21 sends the inlet 19.
- the flow rate at the inlet 18 is subtracted from the flow rate at this point, and the resulting calculated output signal, that is, the ultrafiltration amount, is output continuously as a display and signal output 22. .
- the flow rate detector 17 has an integrated structure of two flow paths, and is arranged in the same magnetic field of the electromagnet 23. A current is supplied to the excitation coil 26 from the excitation power supply 25 connected to the power supply 24 and the electromagnet 23 is excited.
- a flow detector having two integrated flow paths in the same magnetic field, and an amplifier for amplifying a flow signal from each flow detector are provided. And a calculator for calculating the difference between the amplifier output signals of the two flow paths, and a display and a signal output for displaying and increasing the result of the calculation.
- a calculator for calculating the difference between the amplifier output signals of the two flow paths, and a display and a signal output for displaying and increasing the result of the calculation.
- the functions and the like of the human dialysis device provided with the ultrafiltration amount measuring device in the present embodiment are merely examples, and the dialysis is performed by using the flow rate signal of the eluate inlet as the control output signal. By controlling the liquid pump, it is easy to obtain a constant dialysate flow rate during dialysis.
- the artificial dialysis device provided with the ultrafiltration amount measuring device of the present invention
- dialysis from the dialysate inlet side of the dialyzer and the dialyzer can be performed.
- a flow rate detector that measures the dialysate flow rate is placed at each of the fluid outlet sides, and the output of each flow rate detector is calculated to determine the amount of reduced water that can be analyzed from the blood. Since the ultrafiltration volume is continuously measured, it is possible to monitor the total ultrafiltration volume that is gradually reduced by the patient during dialysis to an appropriate range. It is possible to perform appropriate dialysis treatment without burdening the patient.
- the flow rate-output voltage characteristics of the flow detectors can be easily equalized, and the Since each flow detector is similarly affected by fluctuations in its magnetic field, the ultrafiltration obtained as the difference between the outputs of each flow detector is affected. Do not give. Therefore, it is possible to continuously output a stable ultrafiltration volume during dialysis (about 4 to 5 hours).
- the flow rate detector has an integrated structure and is arranged in the same magnetic field, so that a stable and highly accurate ultrafiltration amount can be obtained. Can output continuously
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Abstract
Description
明 細 書 人 工 透 析 装 置 Spectroscopy
〔技術分野〕 〔Technical field〕
本発明 は腎不全等の患者に対 し て治療 と し て行われて い る血液中の老廃物を除去す る 目 的で使用 さ れ る 人工透 析装置 に関 し 、 詳 し く は、 人工透析装置に お い て、 透析 中 に連続的 に血液中か ら透析 さ れ る 老廃物を含ん だ液量 すな わ ち 限外濾過量を連続的 に測定す る こ と に よ っ て、 透析の進行度合お よ び総限外濾過量を知 り 、 適切な人工 透析を行 う こ と を 目 的 と す る 限外濾過量測定装置を備え てな る人工透析装置に関す る 。 The present invention relates to an artificial analyzer used for the purpose of removing waste products in blood, which is used as a treatment for patients with renal failure and the like. In an artificial dialysis machine, by continuously measuring the amount of liquid containing waste products that is continuously dialyzed from the blood during dialysis, that is, the amount of ultrafiltration, Also, the present invention relates to an artificial dialysis device provided with an ultrafiltration amount measuring device for the purpose of knowing the degree of dialysis progress and the total ultrafiltration amount and performing appropriate artificial dialysis.
〔背景技術〕 (Background technology)
腎不全等の患者の治療の た め に 医療施設に おい て血液 を連続的 に ダイ ヤ ラ イ ザ一 （人工透析膜） に導入 し 、 血 液中の老廃物を除去 し た後、 再び体内 に戻す、 すな わ ち 人工透析が知 ら れてい る 。 Blood is continuously introduced into a dialyzer (artificial dialysis membrane) at a medical facility to treat patients with renal failure, etc., to remove waste products from the blood, and then re-enter the body. In other words, artificial dialysis is known.
人工透析の 目 的 は腎不全患者等の血液か ら 老廃物を除 去す る こ と であ る が、 従来は医師の経験か ら透析液入 口 の流量を一定に し て十分な一定時間、 例え ば 5 時間の透 析を実施す る こ と によ っ て 目 的を達成 し て い た。 The purpose of dialysis is to remove waste products from the blood of patients with renal failure, etc.Conventionally, based on the experience of a physician, the flow rate at the dialysate inlet was kept constant for a sufficient period of time. For example, the goal was achieved by conducting the analysis for 5 hours.
従来法に よ る 人工透析装置の一例 と し て図 3 に示す構 成の装置が知 ら れてい る 。 ま た 、 図 4 は ダイ ヤ ラ イ ザ一 の構造を示す模式図であ る。 As an example of a conventional artificial dialysis apparatus, an apparatus having a configuration shown in FIG. 3 is known. Figure 4 shows the dialer diagram. It is a schematic diagram which shows the structure of.
患者 1 の血管か ら導かれた血液はポ ン プ 2 に よ っ てダ ィ ャラ イ ザ一 3 に送 られる。 こ の と き 同時に透析液タ ン ク 4 か ら透折液ポ ン プ 5 によ っ て透析液 も ダイ ヤラ イ ザ 一 3 に送 られる 。 こ の と き の透析液の流量は調節流量計 6 に よ つ て所定の一定量に調節 される。 Blood guided from the blood vessel of patient 1 is sent to dialyser 13 by pump 2. At the same time, the dialysate is also sent from the dialysate tank 4 to the dialyzer 13 by the permeate pump 5. At this time, the flow rate of the dialysate is adjusted to a predetermined fixed amount by the control flow meter 6.
ダイ ヤ ラ イ ザ一 3 内では、 血液入口 7 か ら入 っ た血液 8 が透析液入口 9 か ら入 っ た透析液 1 0 と透析膜 1 1 を 隔ててそれぞれの血液出 口 1 2 およ び透析液出 口 1 3 に 流れる 。 こ の と き血液 8 中の老廃物は限外濾過液 1 4 に 含ま れてい る透析液 1 0 中に透析されて排出 され、 透析 液出 口 1 3 を通っ て廃液 1 5 と して捨て られ る。 血液 8 中の老廃物が十分に除去される ま で一定時間、 例え ば 5 時間の間透折は继続される。 In the dialyzer 13, the blood 8 entered from the blood inlet 7 is separated from the dialysate 10 entered from the dialysate inlet 9 and the blood outlet 12 via the dialysis membrane 11. And flows into the dialysate outlet 13. At this time, the waste matter in the blood 8 is dialyzed into the dialysate 10 contained in the ultrafiltrate 14 and discharged, and is discarded as the waste 15 through the dialysate outlet 13. It is possible. The folding is continued for a certain period of time, for example, 5 hours, until the wastes in the blood 8 are sufficiently removed.
図 5 に透析時間 と 患者の血液中の老廃物の一つ と し て 知 られてい る 尿素窒素の血中濃度の関係の一例を示す。 Figure 5 shows an example of the relationship between the dialysis time and the blood concentration of urea nitrogen, which is known as one of the waste products in the patient's blood.
と こ ろで こ の よ う な従来の人工透析装置にお い ては、 ダイ ヤ ラ イ ザ一への透析液入口側流量およ び血液入口側 流量を透析開始時に所定の一定量に調節す る こ と は可能 であ るが、 患者の血液か ら徐水 される 限外濾過量に関 し ては全 く 監視されてい な い と い う 欠点があ る。 In such a conventional artificial dialysis machine, the dialysate inlet flow and the blood inlet flow to the dialyzer are adjusted to a predetermined fixed amount at the start of dialysis. While this is possible, it has the drawback that the ultrafiltration rate, which is controlled from the patient's blood, is not monitored at all.
透析治療中に患者か ら徐水 される総限外濾過量は透析 治療に と っ て非常に重要であ り 、 少なすぎて も 、 多す ぎ て も患者に と っ て も負担と な る 。 すなわ ち 、 少なすぎ る と血中老廃物の除去が不十分 と な り 、 次回の透析治療 ま での間に血中老廃物の濃度が上昇 し 、 尿毒症の病状を呈 す る よ う に な る 。 ま た、 多す ぎ る と血中低分子物質、 例 え ば電解質や血糖な どの濃度が低下 し 、 透析中 に発熱や 悪寒な どの副作用病状を呈す る こ と に な る 。 従来法では 透析時間を医師の経験に よ っ て設定 し てお り 、 透析中 は 限外濾過量を全 く 監視で き な い状態に あ る。 The total amount of ultrafiltration drained from the patient during the dialysis treatment is very important for the dialysis treatment, and if it is too small, too much or too burdensome for the patient . That is, too little As a result, blood waste is not sufficiently removed, and the concentration of blood waste increases before the next dialysis treatment, resulting in uremic pathology. Also, if too much, the concentration of low-molecular-weight substances in the blood, such as electrolytes and blood sugar, decreases, and side effects such as fever and chills during dialysis may occur. In the conventional method, the dialysis time is set based on the experience of the doctor, and during the dialysis, the ultrafiltration amount cannot be monitored at all.
本発明 は、 こ の よ う な 問題を解決す る た め に な さ れた も ので、 透析中 に連続 し て限外濾過量を監視す る こ と が 可能で、 患者に と っ て適正な透析治療を行 う こ と がで き る点で優れた、 限外濾過量測定装置を備え て な る 人工透 析装置を提供す る こ と を 目 的 と す る 。 The present invention has been made to solve such a problem, and therefore, it is possible to continuously monitor the ultrafiltration amount during dialysis, and it is possible for the patient to appropriately monitor the ultrafiltration amount. It is an object of the present invention to provide an artificial immunoassay device equipped with an ultrafiltration amount measuring device, which is excellent in that it can perform various dialysis treatments.
〔発明の開示〕 [Disclosure of the Invention]
上記 目 的を達成す る た め に本発明の 限外濾過量測定装 置を備え てな る 人工透析装置 は、 血液中の老廃物を赊去 す る た めの、 血液の流路 と 透析液の流路が透析膜に よ つ て隔て られてな る ダイ ヤ ラ イ ザ一を備え た人工透析装置 に お い て、 前記ダイ ヤ ラ イ ザ一 への透析液入 口側 と 前記 ダイ ヤ ラ イ ザ一 か ら の透析液出 口側の そ れぞれに透析液 流量を測定す る 流量検出器を設け、 それぞれの流量検出 器の 出力を演算す る こ と に よ っ て血液中か ら 透析 さ れ る 徐水量であ る 限外濾過量を連続的に測定す る 限外濾過量 測定装置を備え てな る こ と を特徵 と す る 。 In order to achieve the above-mentioned object, the artificial dialysis apparatus equipped with the ultrafiltration amount measuring device of the present invention is provided with a blood flow path and a dialysis device for removing waste products in blood. In an artificial dialysis machine having a dialyzer in which a liquid flow path is separated by a dialysis membrane, a dialysate inlet side to the dialyzer and the dialyzer A flow detector for measuring the dialysate flow rate is provided at each of the dialysate outlet sides from one of the dialysers, and the blood flow is calculated by calculating the output of each flow detector. It is characterized in that it is equipped with an ultrafiltration amount measuring device that continuously measures the ultrafiltration amount, which is the gradual water amount dialyzed from the inside.
本発明の好ま し い態様に おい て、 透析液入 口側 と 透析 液出 口側の それぞれに設け られる 前記流量検出器が一体 型の構造に形成 さ れた限外濾過量測定装置を備え てな る も の とする こ と がで き る 。 In a preferred embodiment of the present invention, the dialysate inlet side and the dialysis The flow rate detector provided on each of the liquid outlet sides may be provided with an ultrafiltration amount measuring device formed in an integrated structure.
本発明の好ま し い他の態様におい て、 前記一体型構造 の流量検出器が同一磁場の中に配置された電磁流量計に よ り 構成される 限外濾過量測定装置を備えてな る も の と する こ とができ る 。 In another preferred aspect of the present invention, the integrated flow rate detector includes an ultrafiltration amount measuring device constituted by an electromagnetic flow meter arranged in the same magnetic field. You can be
〔図面の簡単な説明〕 [Brief description of drawings]
図 1 は本発明の実施例の限外濾過量測定装置を備えて な る人工透折装置を示すプロ ッ ク 図。 FIG. 1 is a block diagram showing an artificial filtration apparatus provided with an ultrafiltration amount measuring apparatus according to an embodiment of the present invention.
図 2 は実施例 におけ る 限外濾過量測定装置の構成図。 図 3 は従来例の人工透析装置を示すプロ ッ ク 図。 FIG. 2 is a configuration diagram of the ultrafiltration amount measuring device in the embodiment. Figure 3 is a block diagram showing a conventional dialysis machine.
図 4 はダイ ヤ ラ イ ザ一 の説明図。 Figure 4 is an explanatory diagram of a dializer.
図 5 は人工透析におけ る透析時間 と血液中老廃物濃度 の関係を示す説明図。 Figure 5 is an explanatory diagram showing the relationship between the dialysis time and the concentration of waste products in blood in dialysis.
〔発明を実施する ための最良の形態〕 以下、 本発明の実施例を図面に基づい て説明する 。 本 発明 は こ れ ら の実施例 に よ り そ の範囲が限定 される も の ではな い。 BEST MODE FOR CARRYING OUT THE INVENTION Hereinafter, embodiments of the present invention will be described with reference to the drawings. The scope of the present invention is not limited by these examples.
図 1 は本発明の 限外濾過量測定装置 1 6 を組込んだ人 ェ透析装置を示すブロ ッ ク 図、 図 2 は限外濾過量測定装 置 1 6 の内部構造を示す構成図で、 ポ ン プ 2 に よ っ て患 者 1 の血液をダイ ヤ ラ イ ザ一 3 に導入する 。 一方透析液 ポ ン プ 5 に よ っ て透析液タ ン ク 4 の透析液を限外濾過量 測定装置 1 6 の流量検出器 1 7 の入口 1 8 を通 し て ダイ ャ ラ イ ザ一 3 に導入す る 。 ダイ ヤ ラ イ ザ一 3 は図 4 に お い て説明 し た よ う に血液の流路 と 透析液の流路が透析膜 1 1 に よ っ て隔て られてお り 、 血液中の老廃物は透析膜 に よ っ て限外濾過液 と と も に透析液中 に透析 さ れる 。 ダ ィ ャ ラ イ ザ一 3 を出 た老廃物を含んだ透析液 は、 限外濾 過量測定装置 1 6 の 流量検 出 器 1 7 の他の一方の入 口 1 9 を通 し て廃液 1 5 と し て排水 さ れ る 。 こ の と き 、 流 量検出器 1 7 の入口 1 8 を通 っ た流量信号 と 、 入 口 1 9 を通 っ た流量信号を増幅器 2 0 に送 り 、 演算器 2 1 で入 口 1 9 の流量か ら入口 1 8 の流量を差 し 引 き 、 得 ら れた 演算出力信号、 すな わ ち 限外濾過量を連続的 に表示器お よ び信号出力 2 2 と し て出力す る 。 FIG. 1 is a block diagram showing a human dialysis device incorporating the ultrafiltration amount measuring device 16 of the present invention, and FIG. 2 is a configuration diagram showing an internal structure of the ultrafiltration amount measuring device 16. The blood of the patient 1 is introduced into the dialyser 13 by the pump 2. On the other hand, the dialysate in the dialysate tank 4 was ultrafiltrated by the dialysate pump 5. It is introduced into the dializer 13 through the inlet 18 of the flow detector 17 of the measuring device 16. The dialyzer 13 has a blood flow path and a dialysate flow path separated by the dialysis membrane 11 as described in FIG. Is dialyzed into the dialysate together with the ultrafiltrate by a dialysis membrane. The dialysate containing waste matter that has exited the dialyser 13 flows through the other inlet 19 of the flow detector 17 of the ultrafiltration amount measuring device 16 and the waste liquid 1 Drained as 5. At this time, the flow signal passing through the inlet 18 of the flow detector 17 and the flow signal passing through the inlet 19 are sent to the amplifier 20, and the calculator 21 sends the inlet 19. The flow rate at the inlet 18 is subtracted from the flow rate at this point, and the resulting calculated output signal, that is, the ultrafiltration amount, is output continuously as a display and signal output 22. .
流量検出器 1 7 は 2 個の流路が一体化構造 と な っ てお り 、 電磁石 2 3 の 同一磁場 中 に 配置 さ れて い る 。 電源 2 4 に接続す る 励磁電源 2 5 力、 ら励磁 コ イ ル 2 6 に電流 が供給 さ れて電磁石 2 3 が励磁 さ れて い る 。 The flow rate detector 17 has an integrated structure of two flow paths, and is arranged in the same magnetic field of the electromagnet 23. A current is supplied to the excitation coil 26 from the excitation power supply 25 connected to the power supply 24 and the electromagnet 23 is excited.
こ のよ う な本発明の実施例 に よ れば、 同一磁場中 に一 体型の 2 個の流路を持つ流量検出器 と 、 それぞれの流量 検出器か ら の流量信号を増幅す る 増幅器 と 、 2 個の流路 の増幅器出力信号の差を演算す る 演算器 と 、 そ の演算結 果を表示お よ び岀カす る表示器お よ び信号出力を備え る こ と に よ っ て、 人工透析に お け る 限外濾過量を安定に し か も精度よ く 、 連続的に測定す る こ と が可能 と な る 。 本実施例におけ る 限外濾過量測定装置を備えてな る人 ェ透析装置の機能等は、 一例を図示 し た も のであ り 、 透 析液入口流量信号を制御出力信号と し て透析液ポ ン プを 制御する こ と に よ り 、 透析中一定量の透析液流量を得る と お容易 の 《3 ο According to such an embodiment of the present invention, a flow detector having two integrated flow paths in the same magnetic field, and an amplifier for amplifying a flow signal from each flow detector are provided. And a calculator for calculating the difference between the amplifier output signals of the two flow paths, and a display and a signal output for displaying and increasing the result of the calculation. In addition, it is possible to stably measure the ultrafiltration amount in the artificial dialysis, and to perform continuous measurement with high accuracy. The functions and the like of the human dialysis device provided with the ultrafiltration amount measuring device in the present embodiment are merely examples, and the dialysis is performed by using the flow rate signal of the eluate inlet as the control output signal. By controlling the liquid pump, it is easy to obtain a constant dialysate flow rate during dialysis.
こ の よ う に、 本発明の限外濾過量測定装置を備えてな る人工透析装置に よれば、 ダイ ヤ ラ イ ザ ^の透析液入 口側とダイ ヤ ラ イ ザ一か ら の透析液出 口側の それぞれに 透析液流量を測定す る 流量検出器を配置 し、 それぞれの 流量検出器の 出力を演算す る こ と によ っ て血液中か ら透 析される徐水量であ る 限外濾過量を連続的に測定する よ う に し たので、 透析中 に患者か ら徐水される総限外濾過 量を適切な範囲に監視す る こ と が可能と な り 、 患者に と つ て負担の な い適正な透析治療を行う こ と ができ る。 As described above, according to the artificial dialysis device provided with the ultrafiltration amount measuring device of the present invention, dialysis from the dialysate inlet side of the dialyzer and the dialyzer can be performed. A flow rate detector that measures the dialysate flow rate is placed at each of the fluid outlet sides, and the output of each flow rate detector is calculated to determine the amount of reduced water that can be analyzed from the blood. Since the ultrafiltration volume is continuously measured, it is possible to monitor the total ultrafiltration volume that is gradually reduced by the patient during dialysis to an appropriate range. It is possible to perform appropriate dialysis treatment without burdening the patient.
ま た、 流量検出器を一体型の構造と して同一磁場中 に 配置する こ と に よ っ て、 流量検出器の流量一 出力電圧特 性が容易に同一化 し やす く 、 しか も磁場の変動に対 し て はそれぞれの流量検出器が全 く 同様に そ の磁場の変動の 影響を受け る ため に、 それぞれの流量検出器の 出力の差 と して得 られる 限外濾過量に は影響を与えな い。 従 っ て、 透析中 （約 4 〜 5 時間） 連統的に安定な 限外濾過量を出 力する こ と ができ る 。 In addition, by arranging the flow detectors in an integrated structure in the same magnetic field, the flow rate-output voltage characteristics of the flow detectors can be easily equalized, and the Since each flow detector is similarly affected by fluctuations in its magnetic field, the ultrafiltration obtained as the difference between the outputs of each flow detector is affected. Do not give. Therefore, it is possible to continuously output a stable ultrafiltration volume during dialysis (about 4 to 5 hours).
即ち、 流量検出器を一体型の構造と し て同一磁場中 に 配置す る こ と によ っ て、 安定で精度の高い限外濾過量を 連続的に 出力す る こ と がで き る In other words, the flow rate detector has an integrated structure and is arranged in the same magnetic field, so that a stable and highly accurate ultrafiltration amount can be obtained. Can output continuously
Claims
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP3/253929 | 1991-10-01 | ||
| JP3253929A JPH05329205A (en) | 1991-10-01 | 1991-10-01 | Artificial dialysis machine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| WO1993006874A1 true WO1993006874A1 (en) | 1993-04-15 |
Family
ID=17257989
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/JP1992/001266 Ceased WO1993006874A1 (en) | 1991-10-01 | 1992-10-01 | Dialyzer system |
Country Status (2)
| Country | Link |
|---|---|
| JP (1) | JPH05329205A (en) |
| WO (1) | WO1993006874A1 (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102010003642A1 (en) * | 2010-03-15 | 2011-09-15 | Fresenius Medical Care Deutschland Gmbh | Cassette with a sensor for determining the difference between a first and a second liquid flow |
| KR102176978B1 (en) * | 2018-05-23 | 2020-11-10 | 연세대학교 원주산학협력단 | Dialyzer control apparatus and method for controlling the same |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS58171140U (en) * | 1982-05-10 | 1983-11-15 | 牛山 喜久 | Artificial dialysis water removal amount monitoring device |
| JPS58221954A (en) * | 1982-06-19 | 1983-12-23 | 牛山 喜久 | Apparatus for monitoring dialytically removed water amount |
| JPS5979810A (en) * | 1982-09-28 | 1984-05-09 | ガンブロ・ルンデイア・アクチ−ボラグ | Measuring device for difference between two flow in two separate duct |
| JPS61272058A (en) * | 1985-05-24 | 1986-12-02 | 株式会社 三陽電機製作所 | Ultrafiltration amount control measuring apparatus |
| JPS6214862A (en) * | 1985-07-12 | 1987-01-23 | 株式会社 三陽電機製作所 | Apparatus for measuring ultrafiltration amount |
-
1991
- 1991-10-01 JP JP3253929A patent/JPH05329205A/en active Pending
-
1992
- 1992-10-01 WO PCT/JP1992/001266 patent/WO1993006874A1/en not_active Ceased
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS58171140U (en) * | 1982-05-10 | 1983-11-15 | 牛山 喜久 | Artificial dialysis water removal amount monitoring device |
| JPS58221954A (en) * | 1982-06-19 | 1983-12-23 | 牛山 喜久 | Apparatus for monitoring dialytically removed water amount |
| JPS5979810A (en) * | 1982-09-28 | 1984-05-09 | ガンブロ・ルンデイア・アクチ−ボラグ | Measuring device for difference between two flow in two separate duct |
| JPS61272058A (en) * | 1985-05-24 | 1986-12-02 | 株式会社 三陽電機製作所 | Ultrafiltration amount control measuring apparatus |
| JPS6214862A (en) * | 1985-07-12 | 1987-01-23 | 株式会社 三陽電機製作所 | Apparatus for measuring ultrafiltration amount |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH05329205A (en) | 1993-12-14 |
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