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WO1993003374A3 - Verfahren und anordnung zur analyse von agglutinationsreaktionen - Google Patents

Verfahren und anordnung zur analyse von agglutinationsreaktionen Download PDF

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Publication number
WO1993003374A3
WO1993003374A3 PCT/DE1992/000601 DE9200601W WO9303374A3 WO 1993003374 A3 WO1993003374 A3 WO 1993003374A3 DE 9200601 W DE9200601 W DE 9200601W WO 9303374 A3 WO9303374 A3 WO 9303374A3
Authority
WO
WIPO (PCT)
Prior art keywords
column
analysis
agglutinated
agglutination reactions
reactants
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/DE1992/000601
Other languages
English (en)
French (fr)
Other versions
WO1993003374A2 (de
Inventor
Anton Horn
Barbara Horn
Heindrun Rhode
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Friedrich Schiller Universtaet Jena FSU
Original Assignee
Friedrich Schiller Universtaet Jena FSU
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Friedrich Schiller Universtaet Jena FSU filed Critical Friedrich Schiller Universtaet Jena FSU
Publication of WO1993003374A2 publication Critical patent/WO1993003374A2/de
Publication of WO1993003374A3 publication Critical patent/WO1993003374A3/de
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5025—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures for parallel transport of multiple samples
    • B01L3/50255—Multi-well filtration
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G01N33/537—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with separation of immune complex from unbound antigen or antibody
    • G01N33/538—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with separation of immune complex from unbound antigen or antibody by sorbent column, particles or resin strip, i.e. sorbent materials
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/38—Flow patterns
    • G01N2030/381—Flow patterns centrifugal chromatography
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
    • G01N2030/8809—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample
    • G01N2030/8813—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/38—Flow patterns
    • G01N30/46—Flow patterns using more than one column
    • G01N30/466—Flow patterns using more than one column with separation columns in parallel
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/50—Conditioning of the sorbent material or stationary liquid
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/60—Construction of the column
    • G01N30/6052—Construction of the column body

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)

Abstract

Die Erfindung betrifft ein Verfahren und eine Anordnung zur Analyse von Agglutinationsreaktionen, wobei die Reaktionspartner in eine Mikrosäule gegeben werden. Die Agglutinationsreaktion erfolgt in der Mikrosäule, vorzugsweise vor Durchlauf der Reaktionspartner durch die Gelmatrix. Agglutinierte und nichtagglutinierte Partikel werden vorzugsweise mittels durch Krafteinwirkung beschleunigter Filtration getrennt. Das nichtagglutinierte Partikel enthaltende Eluat wird nach Verlassen der Mikrosäule einer quantitativen Analyse unterzogen.
PCT/DE1992/000601 1991-07-26 1992-07-25 Verfahren und anordnung zur analyse von agglutinationsreaktionen Ceased WO1993003374A2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DEP4124778.7 1991-07-26
DE19914124778 DE4124778A1 (de) 1991-07-26 1991-07-26 Verfahren und anordnung zur analyse von agglutinationsreaktionen

Publications (2)

Publication Number Publication Date
WO1993003374A2 WO1993003374A2 (de) 1993-02-18
WO1993003374A3 true WO1993003374A3 (de) 1993-05-27

Family

ID=6437055

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DE1992/000601 Ceased WO1993003374A2 (de) 1991-07-26 1992-07-25 Verfahren und anordnung zur analyse von agglutinationsreaktionen

Country Status (3)

Country Link
AU (1) AU2374592A (de)
DE (1) DE4124778A1 (de)
WO (1) WO1993003374A2 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2702050B1 (fr) * 1993-02-26 1995-05-24 Boy Inst Jacques Procédé de groupage sanguin faisant appel à des réactions immunoenzymatiques.
FR2719122B1 (fr) * 1994-04-22 1996-07-12 Scibiex Sarl Dispositif et procédé d'analyse immunologique.
DE19601346A1 (de) * 1996-01-16 1997-07-17 Bernd Dr Pevec Analyseverfahren auf Basis von Immunreaktion
NL1006680C2 (nl) * 1997-03-04 1998-09-07 Alexander Adrianus Moen Werkwijze voor het detecteren van de aanwezigheid van een immunologisch reactief molecuul in een monster.
DE19734135A1 (de) 1997-08-07 1999-02-11 Boehringer Mannheim Gmbh System zum Zurverfügungstellen biologischer Materialien
EP0941766B1 (de) * 1998-03-12 2006-12-20 Miltenyi Biotec GmbH Mikrokolonnen-System für Magnettrennung
JP2003521689A (ja) * 2000-01-31 2003-07-15 エモリー・ユニバーシティ 免疫学的なアッセイシステム及び方法
WO2003047756A2 (de) * 2001-12-04 2003-06-12 Omx Gmbh Einrichtungen und verfahren zur verarbeitung biologischer oder chemischer substanzen oder deren substanzgemische
DE102004033811A1 (de) * 2004-07-12 2006-02-02 Salama, Abdulgabar, Prof. Dr. Verfahren zum einfachen und schnellen Nachweis von Zellen und Biomolekülen mit Hilfe paramagnetischer Partikel
DE102006002258B4 (de) 2006-01-17 2008-08-21 Siemens Ag Modul zur Aufbereitung einer biologischen Probe, Biochip-Satz und Verwendung des Moduls
DE102006055358A1 (de) * 2006-11-23 2008-05-29 Omx Gmbh Verfahren zum quantitativen Vergleich von zwei oder mehr Proteinen
US10241120B2 (en) 2011-12-06 2019-03-26 Universite Libre De Bruxelles Method and device for assaying an antigen present on erythrocytes or an antibody binding to an antigen present on erythrocytes
CN105652014A (zh) * 2015-12-31 2016-06-08 合肥天生物技术研究所 一种直接抗人球蛋白检测卡的制备方法

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU578154A (en) * 1954-12-24 1955-06-30 International Business Machines Corporation Record conversion system
EP0060700A1 (de) * 1981-03-13 1982-09-22 Immuno-Mycologics, Inc. Untersuchungsverfahren und -vorrichtung
EP0088636A2 (de) * 1982-03-09 1983-09-14 Bio-Metrics Systems, Inc. Verfahren und Vorrichtung zur quantitativen Analyse
WO1986007463A1 (en) * 1985-06-03 1986-12-18 American National Red Cross Microtiter - surface - flocculation assay for antigen or antibody screening
WO1988009201A1 (fr) * 1987-05-22 1988-12-01 Diagen Procede et dispositif pour separer et nettoyer des molecules
WO1989000290A1 (en) * 1987-07-02 1989-01-12 In Vitro Technologies, Inc. Capillary device for immunoassay of multiple analytes
EP0305337A1 (de) * 1987-08-24 1989-03-01 Stiftung Für Diagnostische Forschung Verfahren zum Nachweis von Antigenen und/oder Antikörpern sowie Testausrüstung zur Durchführung des Verfahrens
EP0485228A1 (de) * 1990-11-09 1992-05-13 Ortho Diagnostic Systems Inc. Säulenagglutinationsassay und Vorrichtung

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU578154A (en) * 1954-12-24 1955-06-30 International Business Machines Corporation Record conversion system
EP0060700A1 (de) * 1981-03-13 1982-09-22 Immuno-Mycologics, Inc. Untersuchungsverfahren und -vorrichtung
EP0088636A2 (de) * 1982-03-09 1983-09-14 Bio-Metrics Systems, Inc. Verfahren und Vorrichtung zur quantitativen Analyse
WO1986007463A1 (en) * 1985-06-03 1986-12-18 American National Red Cross Microtiter - surface - flocculation assay for antigen or antibody screening
WO1988009201A1 (fr) * 1987-05-22 1988-12-01 Diagen Procede et dispositif pour separer et nettoyer des molecules
WO1989000290A1 (en) * 1987-07-02 1989-01-12 In Vitro Technologies, Inc. Capillary device for immunoassay of multiple analytes
EP0305337A1 (de) * 1987-08-24 1989-03-01 Stiftung Für Diagnostische Forschung Verfahren zum Nachweis von Antigenen und/oder Antikörpern sowie Testausrüstung zur Durchführung des Verfahrens
EP0485228A1 (de) * 1990-11-09 1992-05-13 Ortho Diagnostic Systems Inc. Säulenagglutinationsassay und Vorrichtung

Also Published As

Publication number Publication date
DE4124778A1 (de) 1993-01-28
WO1993003374A2 (de) 1993-02-18
AU2374592A (en) 1993-03-02

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