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WO1993003374A3 - Method and apparatus for the analysis of agglutination reactions - Google Patents

Method and apparatus for the analysis of agglutination reactions Download PDF

Info

Publication number
WO1993003374A3
WO1993003374A3 PCT/DE1992/000601 DE9200601W WO9303374A3 WO 1993003374 A3 WO1993003374 A3 WO 1993003374A3 DE 9200601 W DE9200601 W DE 9200601W WO 9303374 A3 WO9303374 A3 WO 9303374A3
Authority
WO
WIPO (PCT)
Prior art keywords
column
analysis
agglutinated
agglutination reactions
reactants
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/DE1992/000601
Other languages
German (de)
French (fr)
Other versions
WO1993003374A2 (en
Inventor
Anton Horn
Barbara Horn
Heindrun Rhode
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Friedrich Schiller Universtaet Jena FSU
Original Assignee
Friedrich Schiller Universtaet Jena FSU
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Friedrich Schiller Universtaet Jena FSU filed Critical Friedrich Schiller Universtaet Jena FSU
Publication of WO1993003374A2 publication Critical patent/WO1993003374A2/en
Publication of WO1993003374A3 publication Critical patent/WO1993003374A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5025—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures for parallel transport of multiple samples
    • B01L3/50255—Multi-well filtration
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G01N33/537—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with separation of immune complex from unbound antigen or antibody
    • G01N33/538—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with separation of immune complex from unbound antigen or antibody by sorbent column, particles or resin strip, i.e. sorbent materials
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/38—Flow patterns
    • G01N2030/381—Flow patterns centrifugal chromatography
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
    • G01N2030/8809—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample
    • G01N2030/8813—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/38—Flow patterns
    • G01N30/46—Flow patterns using more than one column
    • G01N30/466—Flow patterns using more than one column with separation columns in parallel
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/50—Conditioning of the sorbent material or stationary liquid
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/60—Construction of the column
    • G01N30/6052—Construction of the column body

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)

Abstract

The invention concerns a method and apparatus for analysing agglutination reactions, the reactants being placed on a micro-column. The agglutination reaction takes place on the micro-column, preferably before the reactants have passed through the gel matrix. Agglutinated and non-agglutinated particles are preferably separated from each other by filtration accelerated by force application. The eluate containing the non-agglutinated particles is subjected to quantitative analysis after it has left the column.
PCT/DE1992/000601 1991-07-26 1992-07-25 Method and apparatus for the analysis of agglutination reactions Ceased WO1993003374A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DEP4124778.7 1991-07-26
DE19914124778 DE4124778A1 (en) 1991-07-26 1991-07-26 METHOD AND ARRANGEMENT FOR ANALYZING AGGLUTINATION REACTIONS

Publications (2)

Publication Number Publication Date
WO1993003374A2 WO1993003374A2 (en) 1993-02-18
WO1993003374A3 true WO1993003374A3 (en) 1993-05-27

Family

ID=6437055

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DE1992/000601 Ceased WO1993003374A2 (en) 1991-07-26 1992-07-25 Method and apparatus for the analysis of agglutination reactions

Country Status (3)

Country Link
AU (1) AU2374592A (en)
DE (1) DE4124778A1 (en)
WO (1) WO1993003374A2 (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2702050B1 (en) * 1993-02-26 1995-05-24 Boy Inst Jacques A method of blood grouping using immunoenzymatic reactions.
FR2719122B1 (en) * 1994-04-22 1996-07-12 Scibiex Sarl Device and method for immunological analysis.
DE19601346A1 (en) * 1996-01-16 1997-07-17 Bernd Dr Pevec Analysis method based on immune response
NL1006680C2 (en) * 1997-03-04 1998-09-07 Alexander Adrianus Moen Method for detecting the presence of an immunologically reactive molecule in a sample.
DE19734135A1 (en) 1997-08-07 1999-02-11 Boehringer Mannheim Gmbh Biological materials supply system
EP0941766B1 (en) * 1998-03-12 2006-12-20 Miltenyi Biotec GmbH Micro column system for magnetic separation
JP2003521689A (en) * 2000-01-31 2003-07-15 エモリー・ユニバーシティ Immunological assay systems and methods
WO2003047756A2 (en) * 2001-12-04 2003-06-12 Omx Gmbh Device and method for processing biological or chemical substances or substance mixtures thereof
DE102004033811A1 (en) * 2004-07-12 2006-02-02 Salama, Abdulgabar, Prof. Dr. Method for the simple and rapid detection of cells and biomolecules with the aid of paramagnetic particles
DE102006002258B4 (en) 2006-01-17 2008-08-21 Siemens Ag Module for the preparation of a biological sample, biochip set and use of the module
DE102006055358A1 (en) * 2006-11-23 2008-05-29 Omx Gmbh Quantitative comparison process for two or more proteins involves reductive alkylizing with keton in presence of hydrating reagent
US10241120B2 (en) 2011-12-06 2019-03-26 Universite Libre De Bruxelles Method and device for assaying an antigen present on erythrocytes or an antibody binding to an antigen present on erythrocytes
CN105652014A (en) * 2015-12-31 2016-06-08 合肥天生物技术研究所 Preparation method of detection card for direct antiglobulin test

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU578154A (en) * 1954-12-24 1955-06-30 International Business Machines Corporation Record conversion system
EP0060700A1 (en) * 1981-03-13 1982-09-22 Immuno-Mycologics, Inc. Assay method and device
EP0088636A2 (en) * 1982-03-09 1983-09-14 Bio-Metrics Systems, Inc. Quantitative analysis apparatus and method
WO1986007463A1 (en) * 1985-06-03 1986-12-18 American National Red Cross Microtiter - surface - flocculation assay for antigen or antibody screening
WO1988009201A1 (en) * 1987-05-22 1988-12-01 Diagen Process and device for separating and cleaning molecules
WO1989000290A1 (en) * 1987-07-02 1989-01-12 In Vitro Technologies, Inc. Capillary device for immunoassay of multiple analytes
EP0305337A1 (en) * 1987-08-24 1989-03-01 Stiftung Für Diagnostische Forschung Method for the detection of antigens and/or antibodies, and a kit for carrying out the method
EP0485228A1 (en) * 1990-11-09 1992-05-13 Ortho Diagnostic Systems Inc. Column agglutination assay and device

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU578154A (en) * 1954-12-24 1955-06-30 International Business Machines Corporation Record conversion system
EP0060700A1 (en) * 1981-03-13 1982-09-22 Immuno-Mycologics, Inc. Assay method and device
EP0088636A2 (en) * 1982-03-09 1983-09-14 Bio-Metrics Systems, Inc. Quantitative analysis apparatus and method
WO1986007463A1 (en) * 1985-06-03 1986-12-18 American National Red Cross Microtiter - surface - flocculation assay for antigen or antibody screening
WO1988009201A1 (en) * 1987-05-22 1988-12-01 Diagen Process and device for separating and cleaning molecules
WO1989000290A1 (en) * 1987-07-02 1989-01-12 In Vitro Technologies, Inc. Capillary device for immunoassay of multiple analytes
EP0305337A1 (en) * 1987-08-24 1989-03-01 Stiftung Für Diagnostische Forschung Method for the detection of antigens and/or antibodies, and a kit for carrying out the method
EP0485228A1 (en) * 1990-11-09 1992-05-13 Ortho Diagnostic Systems Inc. Column agglutination assay and device

Also Published As

Publication number Publication date
DE4124778A1 (en) 1993-01-28
WO1993003374A2 (en) 1993-02-18
AU2374592A (en) 1993-03-02

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