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WO1991011453A3 - 2,4,6-triaminopyrimidines oxygenees en position 5 - Google Patents

2,4,6-triaminopyrimidines oxygenees en position 5 Download PDF

Info

Publication number
WO1991011453A3
WO1991011453A3 PCT/US1991/000017 US9100017W WO9111453A3 WO 1991011453 A3 WO1991011453 A3 WO 1991011453A3 US 9100017 W US9100017 W US 9100017W WO 9111453 A3 WO9111453 A3 WO 9111453A3
Authority
WO
WIPO (PCT)
Prior art keywords
oxygenated
pyrimidines
disclosed
substituent
trolox
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1991/000017
Other languages
English (en)
Other versions
WO1991011453A2 (fr
Inventor
John Michael Mccall
Eric Jon Jacobsen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Priority to KR1019920701769A priority Critical patent/KR927003579A/ko
Publication of WO1991011453A2 publication Critical patent/WO1991011453A2/fr
Publication of WO1991011453A3 publication Critical patent/WO1991011453A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/50—Three nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Pyrimidines de la formule (X) à substitution amino oxygénées en position 5, dans laquelle R1 représente (1) un substituant de stéroïde de la formule (Stéroïde), (2) un substituant de trolox de la formule (trolox), (3) un substituant d'alkyle choisi dans le groupe composé de (A)Q2-CH2n2. L'invention concerne également des pyrimidines (XIII) N,N-disubstituées oxygénées, toutes utiles dans le traitement d'un certain nombre d'états pathologiques parmi lesquels le traumatisme crânien, des lésions de la moelle épinière etc.. De plus, l'invention concerne des intermédiaires utiles parmi lesquelles les pyrimidines (VII) oxygénées en position 5 et les pyrimidines (VIII) oxygénées en position 5. En outre, l'invention concerne des pyrimidines (XI) à substitution 5-hydroxy amino.
PCT/US1991/000017 1990-01-26 1991-01-08 2,4,6-triaminopyrimidines oxygenees en position 5 Ceased WO1991011453A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1019920701769A KR927003579A (ko) 1990-01-26 1991-01-08 5-산소화된-2,4,6-트리아미노피리미딘

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US47122890A 1990-01-26 1990-01-26
US471,228 1990-01-26

Publications (2)

Publication Number Publication Date
WO1991011453A2 WO1991011453A2 (fr) 1991-08-08
WO1991011453A3 true WO1991011453A3 (fr) 1991-11-14

Family

ID=23870783

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1991/000017 Ceased WO1991011453A2 (fr) 1990-01-26 1991-01-08 2,4,6-triaminopyrimidines oxygenees en position 5

Country Status (7)

Country Link
EP (1) EP0513177A1 (fr)
JP (1) JPH05503705A (fr)
KR (1) KR927003579A (fr)
AU (1) AU642711B2 (fr)
CA (1) CA2071000A1 (fr)
NZ (1) NZ236801A (fr)
WO (1) WO1991011453A2 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU209678B (en) 1992-06-09 1994-10-28 Richter Gedeon Vegyeszet Process for producing biologically active eburnamenin-14-carbonyl-amino derivatives and pharmaceutical compositions containing them
HUT64323A (en) * 1992-06-09 1993-12-28 Richter Gedeon Vegyeszet Process for production new piperazinyl-bis(alkyl-amino)-pyrimidine derivatives
HU212308B (en) * 1992-06-09 1996-05-28 Richter Gedeon Vegyeszet Process for producing novel pregnane steroids and pharmaceutical compositions containing the same
DE4330727C2 (de) * 1993-09-10 1998-02-19 Jenapharm Gmbh Steroidzwischenprodukte und Verfahren zu ihrer Herstellung
DE4338314C1 (de) 1993-11-10 1995-03-30 Jenapharm Gmbh Pharmazeutische Präparate zur Prophylaxe und Therapie radikalvermittelter Zellschädigungen
DE4338316A1 (de) * 1993-11-10 1995-05-11 Jenapharm Gmbh Neue Steroide mit radikophilen Substituenten, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1987001706A2 (fr) * 1985-09-12 1987-03-26 The Upjohn Company Amino-steroides c20 a c26
WO1987007895A1 (fr) * 1986-06-23 1987-12-30 The Upjohn Company Aminoesters corticaux et du type androstane
WO1988008424A1 (fr) * 1987-04-27 1988-11-03 The Upjohn Company Amines pharmaceutiquement actives
EP0389370A1 (fr) * 1989-03-22 1990-09-26 Roussel-Uclaf Nouveaux stéroides 19-Nor 3-céto comportant une chaîne en 17 aminosubstituée, leur procédé de préparation et les intermédiaires de ce procédé,leur application comme médicaments et les compositions pharmaceutiques les contenant
EP0389368A1 (fr) * 1989-03-22 1990-09-26 Roussel Uclaf Nouveaux dérivés de la 6-(1-pipérazinyl) 2,5-pyridine diamine N,N,N',N'-substituée, leur procédé de préparation et les intermédiaires de ce procédé, leur application comme médicaments et les compositions pharmaceutiques les renfermant

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1987001706A2 (fr) * 1985-09-12 1987-03-26 The Upjohn Company Amino-steroides c20 a c26
WO1987007895A1 (fr) * 1986-06-23 1987-12-30 The Upjohn Company Aminoesters corticaux et du type androstane
WO1988008424A1 (fr) * 1987-04-27 1988-11-03 The Upjohn Company Amines pharmaceutiquement actives
EP0389370A1 (fr) * 1989-03-22 1990-09-26 Roussel-Uclaf Nouveaux stéroides 19-Nor 3-céto comportant une chaîne en 17 aminosubstituée, leur procédé de préparation et les intermédiaires de ce procédé,leur application comme médicaments et les compositions pharmaceutiques les contenant
EP0389368A1 (fr) * 1989-03-22 1990-09-26 Roussel Uclaf Nouveaux dérivés de la 6-(1-pipérazinyl) 2,5-pyridine diamine N,N,N',N'-substituée, leur procédé de préparation et les intermédiaires de ce procédé, leur application comme médicaments et les compositions pharmaceutiques les renfermant

Also Published As

Publication number Publication date
JPH05503705A (ja) 1993-06-17
AU642711B2 (en) 1993-10-28
WO1991011453A2 (fr) 1991-08-08
CA2071000A1 (fr) 1991-07-27
NZ236801A (en) 1992-11-25
KR927003579A (ko) 1992-12-18
AU7243891A (en) 1991-08-21
EP0513177A1 (fr) 1992-11-19

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