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WO1991011453A3 - 5-oxygenated-2,4,6-triaminopyrimidines - Google Patents

5-oxygenated-2,4,6-triaminopyrimidines Download PDF

Info

Publication number
WO1991011453A3
WO1991011453A3 PCT/US1991/000017 US9100017W WO9111453A3 WO 1991011453 A3 WO1991011453 A3 WO 1991011453A3 US 9100017 W US9100017 W US 9100017W WO 9111453 A3 WO9111453 A3 WO 9111453A3
Authority
WO
WIPO (PCT)
Prior art keywords
oxygenated
pyrimidines
disclosed
substituent
trolox
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1991/000017
Other languages
French (fr)
Other versions
WO1991011453A2 (en
Inventor
John Michael Mccall
Eric Jon Jacobsen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Priority to KR1019920701769A priority Critical patent/KR927003579A/en
Publication of WO1991011453A2 publication Critical patent/WO1991011453A2/en
Publication of WO1991011453A3 publication Critical patent/WO1991011453A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/50—Three nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

The present invention discloses 5-oxygenated amino substituted pyrimidines (X), where R1 is (1) steroid substituent of formula (Steroid), (2) trolox substituent of formula (trolox), (3) an alkyl substituent selected from the group consisting of (A)Q2-(CH2)n2. Also disclosed are the oxygenated N,N-disubstituted pyrimidines (XIII) all of which are useful for treating a number of conditions including head injury, stroke, spinal cord injury, etc. Useful intermediates including the protected 5-oxygenated pyrimidines (VII) and the 5-oxygenated pyrimidines (VIII) are also disclosed. Further disclosed are 5-hydroxy amino substituted pyrimidines (XI).
PCT/US1991/000017 1990-01-26 1991-01-08 5-oxygenated-2,4,6-triaminopyrimidines Ceased WO1991011453A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1019920701769A KR927003579A (en) 1990-01-26 1991-01-08 5-oxygenated-2,4,6-triaminopyrimidine

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US47122890A 1990-01-26 1990-01-26
US471,228 1990-01-26

Publications (2)

Publication Number Publication Date
WO1991011453A2 WO1991011453A2 (en) 1991-08-08
WO1991011453A3 true WO1991011453A3 (en) 1991-11-14

Family

ID=23870783

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1991/000017 Ceased WO1991011453A2 (en) 1990-01-26 1991-01-08 5-oxygenated-2,4,6-triaminopyrimidines

Country Status (7)

Country Link
EP (1) EP0513177A1 (en)
JP (1) JPH05503705A (en)
KR (1) KR927003579A (en)
AU (1) AU642711B2 (en)
CA (1) CA2071000A1 (en)
NZ (1) NZ236801A (en)
WO (1) WO1991011453A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU209678B (en) 1992-06-09 1994-10-28 Richter Gedeon Vegyeszet Process for producing biologically active eburnamenin-14-carbonyl-amino derivatives and pharmaceutical compositions containing them
HUT64323A (en) * 1992-06-09 1993-12-28 Richter Gedeon Vegyeszet Process for production new piperazinyl-bis(alkyl-amino)-pyrimidine derivatives
HU212308B (en) * 1992-06-09 1996-05-28 Richter Gedeon Vegyeszet Process for producing novel pregnane steroids and pharmaceutical compositions containing the same
DE4330727C2 (en) * 1993-09-10 1998-02-19 Jenapharm Gmbh Steroid intermediates and processes for their manufacture
DE4338314C1 (en) 1993-11-10 1995-03-30 Jenapharm Gmbh Pharmaceutical preparations for the prophylaxis and therapy of radical-mediated cell damage
DE4338316A1 (en) * 1993-11-10 1995-05-11 Jenapharm Gmbh New steroids with radicallyophilic substituents, process for their preparation and medicaments containing these compounds

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1987001706A2 (en) * 1985-09-12 1987-03-26 The Upjohn Company C20 through c26 amino steroids
WO1987007895A1 (en) * 1986-06-23 1987-12-30 The Upjohn Company Androstane-type and cortical aminoesters
WO1988008424A1 (en) * 1987-04-27 1988-11-03 The Upjohn Company Pharmaceutically active amines
EP0389370A1 (en) * 1989-03-22 1990-09-26 Roussel-Uclaf 19-Nor 3-keto steroids with an amine substituted 17-chain, method for their production and intermediates thereof. Their use as medicines and pharmaceutical composition containing them
EP0389368A1 (en) * 1989-03-22 1990-09-26 Roussel Uclaf New derivatives of 6-(1-piperazinyl) 2,5-pyridine diamine N,N,N',N'-substituted, procedure for their production and intermediates, their use as medicines and pharmaceutical preparations containing them

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1987001706A2 (en) * 1985-09-12 1987-03-26 The Upjohn Company C20 through c26 amino steroids
WO1987007895A1 (en) * 1986-06-23 1987-12-30 The Upjohn Company Androstane-type and cortical aminoesters
WO1988008424A1 (en) * 1987-04-27 1988-11-03 The Upjohn Company Pharmaceutically active amines
EP0389370A1 (en) * 1989-03-22 1990-09-26 Roussel-Uclaf 19-Nor 3-keto steroids with an amine substituted 17-chain, method for their production and intermediates thereof. Their use as medicines and pharmaceutical composition containing them
EP0389368A1 (en) * 1989-03-22 1990-09-26 Roussel Uclaf New derivatives of 6-(1-piperazinyl) 2,5-pyridine diamine N,N,N',N'-substituted, procedure for their production and intermediates, their use as medicines and pharmaceutical preparations containing them

Also Published As

Publication number Publication date
JPH05503705A (en) 1993-06-17
AU642711B2 (en) 1993-10-28
WO1991011453A2 (en) 1991-08-08
CA2071000A1 (en) 1991-07-27
NZ236801A (en) 1992-11-25
KR927003579A (en) 1992-12-18
AU7243891A (en) 1991-08-21
EP0513177A1 (en) 1992-11-19

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