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WO1991008298A3 - Proteines de fusion comprenant une proteine de fixation de ligand et une proteine plasmatique stable - Google Patents

Proteines de fusion comprenant une proteine de fixation de ligand et une proteine plasmatique stable Download PDF

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Publication number
WO1991008298A3
WO1991008298A3 PCT/US1990/006849 US9006849W WO9108298A3 WO 1991008298 A3 WO1991008298 A3 WO 1991008298A3 US 9006849 W US9006849 W US 9006849W WO 9108298 A3 WO9108298 A3 WO 9108298A3
Authority
WO
WIPO (PCT)
Prior art keywords
fusion proteins
protein
ligand binding
stable plasma
proteins consisting
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1990/006849
Other languages
English (en)
Other versions
WO1991008298A2 (fr
Inventor
Daniel J Capon
Laurence A Lasky
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genentech Inc
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23749509&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO1991008298(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority to EP91901202A priority Critical patent/EP0526452B2/fr
Priority to DK91901202T priority patent/DK0526452T4/da
Priority to HK98114595.3A priority patent/HK1013298B/en
Priority to CA002072642A priority patent/CA2072642C/fr
Priority to DK99123412T priority patent/DK1029870T3/da
Application filed by Genentech Inc filed Critical Genentech Inc
Priority to AT91901202T priority patent/ATE199261T1/de
Priority to DE69033705T priority patent/DE69033705T3/de
Publication of WO1991008298A2 publication Critical patent/WO1991008298A2/fr
Publication of WO1991008298A3 publication Critical patent/WO1991008298A3/fr
Anticipated expiration legal-status Critical
Priority to GR20010400708T priority patent/GR3035856T3/el
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70514—CD4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/04—Fusion polypeptide containing a localisation/targetting motif containing an ER retention signal such as a C-terminal HDEL motif
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/32—Fusion polypeptide fusions with soluble part of a cell surface receptor, "decoy receptors"
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/705—Fusion polypeptide containing domain for protein-protein interaction containing a protein-A fusion

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Psychiatry (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Hospice & Palliative Care (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)

Abstract

Nouveaux polypeptides, leurs procédés de fabrication et d'utilisation, et acides nucléiques les codant. Ces polypeptides sont utiles en tant que molécules et ligands d'adhérence à des surfaces cellulaires, et sont utiles dans des compositions et des procédés thérapeutiques ou diagnostiques.
PCT/US1990/006849 1989-11-22 1990-11-21 Proteines de fusion comprenant une proteine de fixation de ligand et une proteine plasmatique stable Ceased WO1991008298A2 (fr)

Priority Applications (8)

Application Number Priority Date Filing Date Title
DE69033705T DE69033705T3 (de) 1989-11-22 1990-11-21 Hybride immunglobuline
DK91901202T DK0526452T4 (da) 1989-11-22 1990-11-21 Hybridimmunoglobuliner
HK98114595.3A HK1013298B (en) 1989-11-22 1990-11-21 Hybrid immunoglobulins
CA002072642A CA2072642C (fr) 1989-11-22 1990-11-21 Proteines de fusion formee d'une proteine liant un ligand et d'une proteine plasmatique stable
DK99123412T DK1029870T3 (da) 1989-11-22 1990-11-21 Hybride immunglobuliner til anvendelse i terapeutiske fremgangsmåder
EP91901202A EP0526452B2 (fr) 1989-11-22 1990-11-21 Immunoglobulines hybrides
AT91901202T ATE199261T1 (de) 1989-11-22 1990-11-21 Hybride immunglobuline
GR20010400708T GR3035856T3 (en) 1989-11-22 2001-05-11 Hybrid immunoglobulins.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/440,625 US5116964A (en) 1989-02-23 1989-11-22 Hybrid immunoglobulins
US440,625 1989-11-22

Publications (2)

Publication Number Publication Date
WO1991008298A2 WO1991008298A2 (fr) 1991-06-13
WO1991008298A3 true WO1991008298A3 (fr) 1991-10-17

Family

ID=23749509

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1990/006849 Ceased WO1991008298A2 (fr) 1989-11-22 1990-11-21 Proteines de fusion comprenant une proteine de fixation de ligand et une proteine plasmatique stable

Country Status (12)

Country Link
US (1) US5116964A (fr)
EP (3) EP1029870B1 (fr)
JP (2) JPH05503009A (fr)
AT (2) ATE396735T1 (fr)
CA (1) CA2072642C (fr)
DE (3) DE69033705T3 (fr)
DK (2) DK0526452T4 (fr)
ES (2) ES2155819T5 (fr)
GR (1) GR3035856T3 (fr)
LU (1) LU91498I2 (fr)
NL (1) NL300372I1 (fr)
WO (1) WO1991008298A2 (fr)

Cited By (12)

* Cited by examiner, † Cited by third party
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US6838260B2 (en) 1997-12-08 2005-01-04 Emd Lexigen Research Center Corp. Heterodimeric fusion proteins useful for targeted immune therapy and general immune stimulation
US6969517B2 (en) 2001-05-03 2005-11-29 Emd Lexigen Research Center Corp. Recombinant tumor specific antibody and use thereof
US7141651B2 (en) 1999-08-09 2006-11-28 Emd Lexigen Research Center Corp. Multiple cytokine protein complexes
US7148321B2 (en) 2001-03-07 2006-12-12 Emd Lexigen Research Center Corp. Expression technology for proteins containing a hybrid isotype antibody moiety
US7211253B1 (en) 1999-11-12 2007-05-01 Merck Patentgesellschaft Mit Beschrankter Haftung Erythropoietin forms with improved properties
US7323549B2 (en) 2003-12-30 2008-01-29 Emd Lexigen Research Center Corp. IL-7 fusion proteins
US7462350B2 (en) 2001-12-04 2008-12-09 Emd Serono Research Center, Inc. Cancer treatments including administering IL-2 fusion proteins with modulated selectivity
US7465447B2 (en) 2003-12-31 2008-12-16 Merck Patent Gmbh Fc-erythropoietin fusion protein with improved pharmacokinetics
US7517526B2 (en) 2000-06-29 2009-04-14 Merck Patent Gmbh Enhancement of antibody-cytokine fusion protein mediated immune responses by combined treatment with immunocytokine uptake enhancing agents
US7589179B2 (en) 2004-12-09 2009-09-15 Merck Patent Gmbh IL-7 variants with reduced immunogenicity
US8691952B2 (en) 2005-12-30 2014-04-08 Merck Patent Gmbh Anti-CD19 antibodies with reduced immunogenicity
US9114175B2 (en) 2005-08-12 2015-08-25 Amgen Inc. Modified Fc molecules

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* Cited by examiner, † Cited by third party
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US5750375A (en) * 1988-01-22 1998-05-12 Zymogenetics, Inc. Methods of producing secreted receptor analogs and biologically active dimerized polypeptide fusions
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US6685941B1 (en) 1988-11-23 2004-02-03 The Regents Of The University Of Michigan Methods of treating autoimmune disease via CTLA-4Ig
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US5242687A (en) * 1989-03-15 1993-09-07 Tkb Associates Limited Partnership Method of reducing cellular immune response involving T-cells using CD8-bearing antigen presenting cells
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WO1991008298A2 (fr) 1991-06-13
DE69033705T2 (de) 2001-08-02
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JP2002325589A (ja) 2002-11-12
EP1970386A8 (fr) 2009-07-08
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ATE199261T1 (de) 2001-03-15
EP1970386A2 (fr) 2008-09-17
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DK1029870T3 (da) 2008-09-29
DE69033705D1 (de) 2001-03-29
GR3035856T3 (en) 2001-08-31
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DE122008000063I2 (de) 2011-06-16
DE69033705T3 (de) 2007-07-12
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US5116964A (en) 1992-05-26
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EP1029870A2 (fr) 2000-08-23
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LU91498I2 (fr) 2009-01-19
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