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WO1988001605A1 - Bouchon a l'epreuve de contaminations, en particulier bouchon filete, pour flacons contenant des cultures de cellules - Google Patents

Bouchon a l'epreuve de contaminations, en particulier bouchon filete, pour flacons contenant des cultures de cellules Download PDF

Info

Publication number
WO1988001605A1
WO1988001605A1 PCT/EP1987/000468 EP8700468W WO8801605A1 WO 1988001605 A1 WO1988001605 A1 WO 1988001605A1 EP 8700468 W EP8700468 W EP 8700468W WO 8801605 A1 WO8801605 A1 WO 8801605A1
Authority
WO
WIPO (PCT)
Prior art keywords
closure
bottle
opening
contamination
outside
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP1987/000468
Other languages
German (de)
English (en)
Inventor
Johann Hinrich Peters
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ca Greiner und Sohne & Co KG GmbH
Original Assignee
Ca Greiner und Sohne & Co KG GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ca Greiner und Sohne & Co KG GmbH filed Critical Ca Greiner und Sohne & Co KG GmbH
Publication of WO1988001605A1 publication Critical patent/WO1988001605A1/fr
Priority to GB8903273A priority Critical patent/GB2214498A/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/02—Form or structure of the vessel
    • C12M23/08—Flask, bottle or test tube
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5082—Test tubes per se
    • B01L3/50825—Closing or opening means, corks, bungs
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D51/00—Closures not otherwise provided for
    • B65D51/16—Closures not otherwise provided for with means for venting air or gas
    • B65D51/1605—Closures not otherwise provided for with means for venting air or gas whereby the interior of the container is maintained in permanent gaseous communication with the exterior
    • B65D51/1616—Closures not otherwise provided for with means for venting air or gas whereby the interior of the container is maintained in permanent gaseous communication with the exterior by means of a filter
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/38—Caps; Covers; Plugs; Pouring means
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M37/00—Means for sterilizing, maintaining sterile conditions or avoiding chemical or biological contamination
    • C12M37/02—Filters

Definitions

  • Contamination-safe closure in particular screw closure for cell culture bottles
  • the invention relates to a contamination-proof closure, in particular screw closure for sterilized cell culture bottles, which are used for the cultivation and maintenance of tissue cultures for biological, virological, immunological and cytological analysis and diagnostics.
  • Such bottles are offered by a wide variety of manufacturers as sterilized, disposable plastic bottles, mostly polystyrene or polycarbonate, PP.
  • the bottles have either a cuboid shape and can be used both horizontally and vertically and are made of crystal-clear plastic for microscopic examinations.
  • such bottles are offered in cylindrical form with a narrow or wide neck or in the form of Erlenmeyer flasks.
  • To close the bottle necks, which are usually equipped with an external thread they are equipped with a screw cap made of plastic, with which the bottles can be hermetically sealed.
  • the bottles are used, for example, for the cultivation and maintenance of cell cultures from cells of freshly trypsinized tissue, permanent and permanent cell cultures of human and animal and vegetable origin, for the biochemical, immunological, cell biological research and diagnostics used.
  • the invention is therefore based on the object with simple means to improve a closure, in particular screw cap or a cell culture bottle of the type mentioned in such a way that sterile ventilation of the bottles is ensured under poor environmental conditions and generally the ventilation of the contamination-proof closure state of the Bottles can be maintained and is guaranteed without deteriorating the handling.
  • This object is achieved according to the invention by the means specified in the main claim or in claim 12.
  • Advantageous Wei developments are specified in the subclaims.
  • the advantages can be seen in the fact that with the cell and microbiological contamination-proof permanent closure of the bottle, a permanent, uniform gas exchange with the surrounding atmosphere is guaranteed, the filter element ensuring that only sterile gas can get into the bottle even in an impure ambient atmosphere. Handling has also become safer, and the filter element also preferably has a place within the closure body that is safe to touch and thus contamination-proof for the user.
  • Bottles used horizontally can also be filled up higher using a shaking mechanism, so that a higher breeding yield can be achieved.
  • FIG. 1 shows a cross section through the closure body with a rectangular bottle
  • Figure 2 shows an enlarged detail cross section of the
  • FIG. 3 shows a perspective view of another commercially available bottle
  • FIG. 4 shows a perspective view of a bottle in the form of an Erlenmeyer flask with a screw cap
  • FIG. 5 shows a modified closure
  • Figure 7 is a bottom view of the innermost part of the
  • Figure 8 is a plan view of the screw closure of Figure
  • Figure 9 shows a detail cross section through another
  • Figure 10 is a plan view of the screw cap of Figure 9 as a cutout.
  • the bottle F is partially filled with a liquid cell culture Z and is closed in a contamination-proof manner by the screw cap 1.
  • the screw cap 1 after Figures 1 and 2 usually have an internal thread 7, which corresponds to the Quss thread of the bottle neck F 'and with its inner shoulder 6 presses tightly onto or against the upper edge of the bottle neck F'.
  • the part 2 of the closure body 1 made of plastic covering the bottle opening F 1 is equipped with at least one or more openings 3.
  • a draining filter support 5 for example in the form of conical support bodies, is integrated on the inside of the closure body 1.
  • a hydrophobic, microporous flat filter cut 4 is attached with its edge in a leak-tight manner, preferably by welding or ultrasound 1 welding.
  • the openings 3 can be covered by a self-adhesive protective film 8, so that the Fi 1 terelemer.t 4 additionally mechanically protected before use or, if necessary, the gas exchange can be allowed or prevented.
  • contamination by touching the flat filter blank 4 and also undesired mechanical damage to the flat filter blank by the user is prevented despite the continuous openings 3.
  • Figures 9 and 10 show an embodiment in which also Damage to the flat filter blank 4 by the user through the openings 3 is practically impossible, since the opening 3 each has an axial and radial offset 3 'within the wall thickness of the plastic body.
  • a silicone stopper 9 is arranged in the screw cap, which is outside the limited filter area, but within the area of the bottle neck opening F ', the Si 1 i konstopfe ⁇ 9 is dimensioned in diameter and thickness so that it is again hermetically automatic seals when the pierced hollow needle is removed again after sampling.
  • the filter element consists of a cartridge-shaped filter body, approximately in the shape of the silicone plug 9.
  • the cover of the screw closure itself is designed in the form of a porous sintered plastic section, which enables gas exchange and prevents liquid leakage .
  • the filter material is also made of a plastic that is inert with respect to the cell cultures, e.g. Polypropylene, PTFE, silicone, hydrophobic cell ul osederivat formed and has a pore size or a cut off, which allows a gas exchange under sterile conditions, is non-toxic or cytotoxic for the liquid and cell cultures and otherwise prevents cell and microorganisms from growing through .
  • a plastic that is inert with respect to the cell cultures, e.g. Polypropylene, PTFE, silicone, hydrophobic cell ul osederivat formed and has a pore size or a cut off, which allows a gas exchange under sterile conditions, is non-toxic or cytotoxic for the liquid and cell cultures and otherwise prevents cell and microorganisms from growing through .

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Clinical Laboratory Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Sustainable Development (AREA)
  • Mechanical Engineering (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Devices For Use In Laboratory Experiments (AREA)

Abstract

Un bouchon à l'épreuve de contaminations, en particulier un bouchon fileté en plastique, sert à fermer des flacons stérilisés (F) de culture de cellules utilisés pour cultiver et conserver des cultures de tissus utiles pour des procédés d'analyse et de diagnostic biologiques, virologiques, immunologiques et cytologiques. A la partie (Z) du bouchon en plastique (1) qui couvre l'ouverture (F') du flacon est incorporé un élément hydrophobe de filtrage (4) formé d'un matériau de filtrage inerte vis à vis de la culture de cellules (Z) et ayant une grosseur de pores ou cut-off qui permet un échange gazeux stérile entre le contenu du flacon et l'atmosphère ambiante et empêche une contamination cellulaire ou microbiologique de se produire, aussi bien de l'intérieur vers l'extérieur que de l'extérieur vers l'intérieur.
PCT/EP1987/000468 1986-08-26 1987-08-20 Bouchon a l'epreuve de contaminations, en particulier bouchon filete, pour flacons contenant des cultures de cellules Ceased WO1988001605A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB8903273A GB2214498A (en) 1986-08-26 1989-02-14 Contamination-proof stopper,in particular screw cap,for cell culture bottles

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DEP3628930.2 1986-08-26
DE19863628930 DE3628930A1 (de) 1986-08-26 1986-08-26 Kontaminationssicherer verschluss, insbesondere schraubverschluss fuer zellkulturflaschen

Publications (1)

Publication Number Publication Date
WO1988001605A1 true WO1988001605A1 (fr) 1988-03-10

Family

ID=6308170

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1987/000468 Ceased WO1988001605A1 (fr) 1986-08-26 1987-08-20 Bouchon a l'epreuve de contaminations, en particulier bouchon filete, pour flacons contenant des cultures de cellules

Country Status (5)

Country Link
JP (1) JPH01503595A (fr)
DE (1) DE3628930A1 (fr)
FR (1) FR2603258B3 (fr)
GB (1) GB2214498A (fr)
WO (1) WO1988001605A1 (fr)

Cited By (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989006272A3 (fr) * 1987-12-30 1989-08-24 American Sterilizer Co Recipient sterilisable permeable au gaz utilise pour la culture de cellules vivantes
EP0337677A3 (fr) * 1988-04-11 1990-04-04 Costar Corporation Bouchon de ventilation
EP0593840A1 (fr) * 1992-10-23 1994-04-27 The Procter & Gamble Company Procédé de fabrication de matériaux comprenant un réseau de microcanaux
FR2698375A1 (fr) * 1992-11-20 1994-05-27 Biopredic Sarl Dispositif pour le transport et le stockage de liquides utilisable, notamment, pour réaliser des kits pour test in vitro.
FR2699894A1 (fr) * 1992-12-29 1994-07-01 De Buyer Herve Conteneur isotherme.
WO1996006018A1 (fr) * 1994-08-19 1996-02-29 W. L. Gore & Associates, Inc. Flacon a event pour lyophilisation et procede permettant de minimiser la contamination de produits lyophilises
EP0734769A1 (fr) * 1995-03-31 1996-10-02 Roche Diagnostics GmbH Couvercle pour la fermeture de récipients
EP0641856A3 (fr) * 1993-09-01 1998-01-07 Becton, Dickinson and Company Ensemble récipient fermeture
EP0791649A3 (fr) * 1996-02-26 1998-05-20 Arbor Technologies, Inc. Bouchon de bouteille avec valve d'évent
US5801054A (en) * 1996-09-19 1998-09-01 The United States Of America As Represented By The Secretary Of The Air Force Cell culture vessel with self-maintained atmosphere
GB2327372A (en) * 1997-07-19 1999-01-27 Gore & Ass Sterilisable vent
US6095356A (en) * 1999-03-10 2000-08-01 Children's Medical Center Corp. Vented flask cap for absorbing radioactive gases
US6193088B1 (en) * 1996-02-26 2001-02-27 Monty E. Vincent Flask vent and method of making same
EP2085464A1 (fr) 2008-02-01 2009-08-05 Eppendorf AG Récipient de laboratoire doté d'une fermeture pouvant être déplacée
FR2948646A1 (fr) * 2009-07-29 2011-02-04 Pascal Boudjema Dispositif de stockage d'unites biologiques
WO2009128892A3 (fr) * 2008-04-18 2011-12-29 Corning Incorporated Soupape à membrane souple pour récipient de culture cellulaire
WO2012156682A1 (fr) * 2011-05-16 2012-11-22 Parker Hannifin Manufacturing Limited Chambre de bioréacteur
WO2012156683A1 (fr) * 2011-05-16 2012-11-22 Parker Hannifin Manufacturing Limited Chambre de bioréacteur
CN105691878A (zh) * 2016-04-14 2016-06-22 李悦晨 一种饮料容器及其封盖
EP3034616A1 (fr) * 2014-12-17 2016-06-22 Mohammad Salehi Dispositif de fabrication et/ou de nettoyage de biomateriaux couples a des nanoparticules et son procede d'utilisation
US20210087508A1 (en) * 2019-09-20 2021-03-25 Scientific Industries, Inc. Cell culture flasks, sensor inserts, and systems and methods comprising the same

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE68923750T2 (de) * 1988-09-06 1996-01-18 Dainippon Printing Co Ltd Streckblasformverfahren zur Herstellung einer expandierten Flasche, Deformiervorrichtung zum Deformieren oder Biegen eines Streckvorformlings und streckblasgeformte Flasche.
US5173225A (en) * 1990-05-07 1992-12-22 Bowolfe, Inc. Method for making ultra-thin dense skin membrane
JPH04330397A (ja) * 1991-04-30 1992-11-18 Fujitsu Ltd ターボ分子ポンプ
US5958778A (en) * 1995-09-22 1999-09-28 The United States Of America As Represented By The Department Of Health And Human Services Container for drying biological samples, method of making such container, and method of using same
US6312648B1 (en) 1998-01-12 2001-11-06 The United States Of America As Represented By The Department Of Health And Human Services Applicator system
DE19953772A1 (de) * 1999-11-09 2001-05-17 Coripharm Medizinprodukte Gmbh Verschluss für Behälter zur Aufnahme von pulverförmigen festen Stoffen, insbesondere Knochenzementen und Verfahren zur Sterilisierung von in derartigen Behältern abgefüllten Stoffen
DE60135750D1 (de) * 2000-06-30 2008-10-23 Lesaffre & Cie Verpackung für flüssige Hefe
DE102005013153A1 (de) * 2005-03-22 2006-09-28 Kynast, Jürgen Starres Behältnis mit Deckel zur sterilen Aufzucht von Pilzsubstraten
EP3770247A1 (fr) * 2006-12-07 2021-01-27 Wilson Wolf Manufacturing Corporation Dispositifs perméables au gaz particulièrement efficaces et procédés de culture de cellules
DE102018131184A1 (de) * 2018-12-06 2020-06-10 Adolf Kühner Ag Begasungsvorrichtung

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE574647C (de) * 1932-01-22 1933-04-19 Otto Hummer Dr Verschluss fuer Gefaesse mit Bakterien- und Hefekulturen
US2240101A (en) * 1938-05-10 1941-04-29 Smith Fred Closure for test tubes or the like
DE2038543A1 (de) * 1970-04-09 1971-02-25 Shinetsu Chemical Co Luftdurchlaessige sterilisierbare Stopfen fuer Kulturgefaesse und Verfahren zur Herstellung derselben
GB1312447A (en) * 1969-05-14 1973-04-04 Nat Res Dev Method of continuous addition of a component to a chemical or biological system and apparatus therefor
WO1980001825A1 (fr) * 1979-02-22 1980-09-04 D Deutsch Dispositif permeable asymetrique
US4410630A (en) * 1981-12-11 1983-10-18 The United States Of America As Represented By The Department Of Health And Human Services Lysis filtration culture chamber
US4416984A (en) * 1981-05-22 1983-11-22 Concord Laboratories, Inc. Sterilization indicator

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3326401A (en) * 1965-10-11 1967-06-20 Bellco Glass Inc Closure

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE574647C (de) * 1932-01-22 1933-04-19 Otto Hummer Dr Verschluss fuer Gefaesse mit Bakterien- und Hefekulturen
US2240101A (en) * 1938-05-10 1941-04-29 Smith Fred Closure for test tubes or the like
GB1312447A (en) * 1969-05-14 1973-04-04 Nat Res Dev Method of continuous addition of a component to a chemical or biological system and apparatus therefor
DE2038543A1 (de) * 1970-04-09 1971-02-25 Shinetsu Chemical Co Luftdurchlaessige sterilisierbare Stopfen fuer Kulturgefaesse und Verfahren zur Herstellung derselben
WO1980001825A1 (fr) * 1979-02-22 1980-09-04 D Deutsch Dispositif permeable asymetrique
US4416984A (en) * 1981-05-22 1983-11-22 Concord Laboratories, Inc. Sterilization indicator
US4410630A (en) * 1981-12-11 1983-10-18 The United States Of America As Represented By The Department Of Health And Human Services Lysis filtration culture chamber

Cited By (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4935371A (en) * 1986-12-31 1990-06-19 American Sterilizer Company Sterilizable gas permeable container for use in culturing living cells
WO1989006272A3 (fr) * 1987-12-30 1989-08-24 American Sterilizer Co Recipient sterilisable permeable au gaz utilise pour la culture de cellules vivantes
EP0337677A3 (fr) * 1988-04-11 1990-04-04 Costar Corporation Bouchon de ventilation
EP0593840A1 (fr) * 1992-10-23 1994-04-27 The Procter & Gamble Company Procédé de fabrication de matériaux comprenant un réseau de microcanaux
FR2698375A1 (fr) * 1992-11-20 1994-05-27 Biopredic Sarl Dispositif pour le transport et le stockage de liquides utilisable, notamment, pour réaliser des kits pour test in vitro.
FR2699894A1 (fr) * 1992-12-29 1994-07-01 De Buyer Herve Conteneur isotherme.
EP0641856A3 (fr) * 1993-09-01 1998-01-07 Becton, Dickinson and Company Ensemble récipient fermeture
US5522155A (en) * 1994-08-19 1996-06-04 W. L. Gore & Associates, Inc. Vented vial method of minimizing contamination of freeze-dried products
US5732837A (en) * 1994-08-19 1998-03-31 W. L. Gore & Associates, Inc. Vented vial closure member for freeze-drying which minimizes contamination of freeze-dried products
WO1996006018A1 (fr) * 1994-08-19 1996-02-29 W. L. Gore & Associates, Inc. Flacon a event pour lyophilisation et procede permettant de minimiser la contamination de produits lyophilises
EP0734769A1 (fr) * 1995-03-31 1996-10-02 Roche Diagnostics GmbH Couvercle pour la fermeture de récipients
US6170684B1 (en) 1996-02-26 2001-01-09 Monty E. Vincent Flask vent and method of making same
EP0791649A3 (fr) * 1996-02-26 1998-05-20 Arbor Technologies, Inc. Bouchon de bouteille avec valve d'évent
US6193088B1 (en) * 1996-02-26 2001-02-27 Monty E. Vincent Flask vent and method of making same
US5801054A (en) * 1996-09-19 1998-09-01 The United States Of America As Represented By The Secretary Of The Air Force Cell culture vessel with self-maintained atmosphere
GB2327372A (en) * 1997-07-19 1999-01-27 Gore & Ass Sterilisable vent
US6095356A (en) * 1999-03-10 2000-08-01 Children's Medical Center Corp. Vented flask cap for absorbing radioactive gases
EP2085464A1 (fr) 2008-02-01 2009-08-05 Eppendorf AG Récipient de laboratoire doté d'une fermeture pouvant être déplacée
WO2009128892A3 (fr) * 2008-04-18 2011-12-29 Corning Incorporated Soupape à membrane souple pour récipient de culture cellulaire
US8177082B2 (en) 2008-04-18 2012-05-15 Corning Incorporated Flexible membrane valve for cell culture vessel
FR2948646A1 (fr) * 2009-07-29 2011-02-04 Pascal Boudjema Dispositif de stockage d'unites biologiques
WO2012156682A1 (fr) * 2011-05-16 2012-11-22 Parker Hannifin Manufacturing Limited Chambre de bioréacteur
WO2012156683A1 (fr) * 2011-05-16 2012-11-22 Parker Hannifin Manufacturing Limited Chambre de bioréacteur
US9422516B2 (en) 2011-05-16 2016-08-23 Parker-Hannifin Manufacturing Limited Bioreactor chamber
EP3034616A1 (fr) * 2014-12-17 2016-06-22 Mohammad Salehi Dispositif de fabrication et/ou de nettoyage de biomateriaux couples a des nanoparticules et son procede d'utilisation
CN105691878A (zh) * 2016-04-14 2016-06-22 李悦晨 一种饮料容器及其封盖
US20210087508A1 (en) * 2019-09-20 2021-03-25 Scientific Industries, Inc. Cell culture flasks, sensor inserts, and systems and methods comprising the same

Also Published As

Publication number Publication date
FR2603258A1 (fr) 1988-03-04
GB2214498A (en) 1989-09-06
JPH01503595A (ja) 1989-12-07
FR2603258B3 (fr) 1988-11-25
GB8903273D0 (en) 1989-05-17
DE3628930A1 (de) 1988-05-05

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