[go: up one dir, main page]

WO1979001137A1 - Procede de conservation de proteines immobilisees - Google Patents

Procede de conservation de proteines immobilisees Download PDF

Info

Publication number
WO1979001137A1
WO1979001137A1 PCT/SU1979/000017 SU7900017W WO7901137A1 WO 1979001137 A1 WO1979001137 A1 WO 1979001137A1 SU 7900017 W SU7900017 W SU 7900017W WO 7901137 A1 WO7901137 A1 WO 7901137A1
Authority
WO
WIPO (PCT)
Prior art keywords
filler
distinguished
fact
different
drying
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/SU1979/000017
Other languages
English (en)
Russian (ru)
Inventor
L Kozlov
L Kudryavtseva
J Krylova
V Surovtsev
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
INST BIOORG KHIMII AN SSSR
INST BIOORG KHIM AN SSSR
Original Assignee
INST BIOORG KHIMII AN SSSR
INST BIOORG KHIM AN SSSR
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by INST BIOORG KHIMII AN SSSR, INST BIOORG KHIM AN SSSR filed Critical INST BIOORG KHIMII AN SSSR
Publication of WO1979001137A1 publication Critical patent/WO1979001137A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Definitions

  • immobilized runaways an important issue is their storage and transportation without substantial change of business.
  • pepsin - an enzyme that is dry and freeze-drying, is 100% active; Volume 2, ⁇ 2, published in 1976 / Yazdatelstvo Sauka, Russia /: Yu.I. ⁇ rylova, ⁇ . ⁇ . “Acidic Acidase”, see page. 273-278 /.
  • volume 2 ⁇ 2
  • Yazdatelstvo Sauka Russia
  • Yu.I. ⁇ rylova ⁇ . ⁇ . “Acidic Acidase”
  • P ⁇ s ⁇ avlennaya problem was ⁇ eshena s ⁇ s ⁇ b ⁇ m ⁇ nse ⁇ va- tion imm ⁇ bizhz ⁇ vanny ⁇ bezh ⁇ v ⁇ u ⁇ em zh ⁇ iln ⁇ g ⁇ Drying out Nia i ⁇ sus ⁇ enzy in IL v ⁇ de in bu ⁇ e ⁇ n ⁇ m ⁇ as ⁇ v ⁇ e, ⁇ - ⁇ y, s ⁇ glasn ⁇ iz ⁇ b ⁇ e ⁇ eniyu, ⁇ a ⁇ a ⁇ e ⁇ izue ⁇ sya ⁇ em, ch ⁇ zh ⁇ - ⁇ iln ⁇ e drying ⁇ v ⁇ dya ⁇ in ⁇ isu ⁇ s ⁇ vii ine ⁇ n ⁇ g ⁇ ⁇ as ⁇ v ⁇ im ⁇ g ⁇ in v ⁇ de ⁇ ve ⁇ d ⁇ g ⁇ na ⁇ lni ⁇ elya.
  • a foreign product in the drive of a foreign owner may be used by an unorganized soot, for example, an irregular one; agglomerates, for example, glycine; carbohydrates, for example, glucose-synthetic, for example, blasted, and also any other kind of food, suitable for food
  • the dried product is suspended in 0.01 ⁇ réelle of the acetate buffer, ⁇ 4.5, removes the filler by means of the washing process with the separation of the separators. It removes the wet moisture of the product and makes it more active to hydrate the dehumidifier. It also accepts the activity of the original drug and the active ingredient of the drug, the core is active. dried without the addition of a filler / empty pan /.
  • ⁇ ivn ⁇ s ⁇ is ⁇ dn ⁇ g ⁇ ⁇ e ⁇ a ⁇ a ⁇ a ⁇ inimayu ⁇ 100% ⁇ gda a ⁇ ivn ⁇ s ⁇ zh ⁇ iln ⁇ vysushenn ⁇ g ⁇ ⁇ e ⁇ a ⁇ a without na ⁇ lni ⁇ elya s ⁇ s ⁇ avlyae ⁇ 9% and a ⁇ ivn ⁇ s ⁇ ⁇ e ⁇ a ⁇ a ⁇ a, sh- sushenn ⁇ g ⁇ zh ⁇ iln ⁇ in ⁇ isu ⁇ s ⁇ vii ⁇ zhe ⁇ ilengli ⁇ lya, s ⁇ s ⁇ avlyae ⁇ 78%.
  • ⁇ due to e ⁇ im e ⁇ i n ⁇ si ⁇ ezh not is ⁇ lzu- yu ⁇ sya for ⁇ lucheniya ⁇ e ⁇ a ⁇ a ⁇ v, ⁇ dlezhaschi ⁇ ⁇ aneniyu and ⁇ e ⁇ a ⁇ a ⁇ y bezh ⁇ v, imm ⁇ bizhz ⁇ vanny ⁇ on ni ⁇ not ⁇ izv ⁇ - dya ⁇ sya in ⁇ myshlenn ⁇ m massh ⁇ abe on ⁇ dazhu and ts ⁇ ig ⁇ v- lyayu ⁇ sya ne ⁇ s ⁇ eds ⁇ venn ⁇ ⁇ e ⁇ ed is ⁇ lz ⁇ vaniem.
  • the invention will allow the manufacture of industrial devices for the treatment of poor people who are immobilized in a dry place; For the best understanding of the invention, the following are applicable.
  • Example I only in the quality of the filler add 20 mg of sugar. Factor 44. 15 Example 8.
  • EXAMPLE 9 20 conserveing, as in example I, only in the case of a dietary supplement, add 20 mg of potassium pervolentum with a mass of 25,000.
  • Example 9 It is sold, as in Example 9, only in the 25th part of the filler add 200 mg of zhvinilpiruzhda. The efficiency of 75%.
  • Example II Comparative Example II.
  • Example 15 It is sold, as in Example 13, only in the size of the filler add 200 mg of steroid. The efficiency of 31%.
  • Example 15 It is sold, as in Example 13, only in the size of the filler add 200 mg of steroid. The efficiency of 31%.
  • Example 16 20 mg of chicken powder, which is diet-friendly, conserves an analogous example I. As a rule, 20 mg of glycine is used as a filling medium. The efficiency of the preparation after hematoglobin after a quick drying with a filler of 60%. The potency of a vegan dried product without a filler is 50%.
  • Example 18 Conservatively, as in Example 16, only 200 milligrams of glycine is added as a filler. Effectiveness 67. Example 18.
  • Example 22 It is sold, as in Example 20, only in the case of a heater add 20 mg of anti-ethylene glycol / with a molecular weight of 3000 /. Activity 93.
  • Example 22 It is sold, as in Example 20, only in the case of a heater add 20 mg of anti-ethylene glycol / with a molecular weight of 3000 /. Activity 93.
  • Example 22 It is sold, as in Example 20, only in the case of a heater add 20 mg of anti-ethylene glycol / with a molecular weight of 3000 /. Activity 93.
  • Example 22 It is sold, as in Example 20, only in the case of a heater add 20 mg of anti-ethylene glycol / with a molecular weight of 3000 /. Activity 93.
  • Example 22 It is sold, as in Example 20, only in the case of a heater add 20 mg of anti-ethylene glycol / with a molecular weight of 3000 /. Activity 93.
  • Example 22 It is sold, as in Example 20, only in the case

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)

Abstract

Procede de conservation de proteines immobilisees pour leur stockage prolonge et leur transport, utilise dans les industries alimentaire, microbiologique et medicale. Le procede consiste en la lyophilisation des proteines immobilisees en presence d'une substance de remplissage inerte soluble dans l'eau telle que des sels mineraux, des acides amines, des hydrates de carbone, des polysaccharides, des polymeres solubles dans l'eau, des polyalcools.
PCT/SU1979/000017 1978-05-29 1979-04-13 Procede de conservation de proteines immobilisees Ceased WO1979001137A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SU782620877A SU943280A1 (ru) 1978-05-29 1978-05-29 Способ консервации иммобилизованных ферментов
SU2620877 1978-05-29

Publications (1)

Publication Number Publication Date
WO1979001137A1 true WO1979001137A1 (fr) 1979-12-27

Family

ID=20766846

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/SU1979/000017 Ceased WO1979001137A1 (fr) 1978-05-29 1979-04-13 Procede de conservation de proteines immobilisees

Country Status (7)

Country Link
CH (1) CH633560A5 (fr)
CS (1) CS222968B1 (fr)
DE (1) DE2952815C1 (fr)
GB (1) GB2049700B (fr)
SE (1) SE8000648L (fr)
SU (1) SU943280A1 (fr)
WO (1) WO1979001137A1 (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60258125A (ja) * 1984-06-06 1985-12-20 Hayashibara Biochem Lab Inc 蛋白性生理活性物質を含有する水溶性乾燥物
GB8500698D0 (en) * 1985-01-11 1985-02-13 Unilever Plc Preparation of reagents
US4931385A (en) * 1985-06-24 1990-06-05 Hygeia Sciences, Incorporated Enzyme immunoassays and immunologic reagents
US5102788A (en) * 1988-11-21 1992-04-07 Hygeia Sciences, Inc. Immunoassay including lyophilized reactant mixture
RU2172170C2 (ru) * 1999-10-07 2001-08-20 Московская медицинская академия им. И.М. Сеченова Лекарственное средство для улучшения пищеварения
CA2466896A1 (fr) 2001-09-06 2003-03-20 Adnagen Ag Procede et kit de diagnostic destines a la selection et/ou detection qualitative et/ou quantitative de cellules
DE10323901A1 (de) * 2003-05-26 2005-01-05 Institut Virion/Serion Gmbh Verfahren und Testmittel zur Untersuchung und/oder zum Nachweis von Biomolekülen und/oder Wirkstoffen in Flüssigkeitsproben

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3133001A (en) * 1959-11-26 1964-05-12 Muset Pedro Puig Stabilization of enzymes

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3133001A (en) * 1959-11-26 1964-05-12 Muset Pedro Puig Stabilization of enzymes

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
"Bioorganicheskaya Khimiya", volume 2, No. 2 published in February 1976 "Nauka" publishing house (Moscow), J.L. Krylova, V.L. Kozlov, V.K. Antonov, B.S. Chaina, E.N. Datunashvili, N.M. Pavlenko "Immobilizatsiya Kislych proteinaz", pages 273-278 *

Also Published As

Publication number Publication date
GB2049700A (en) 1980-12-31
SE8000648L (sv) 1980-01-28
GB2049700B (en) 1982-08-25
DE2952815C1 (de) 1985-05-30
CH633560A5 (de) 1982-12-15
CS222968B1 (en) 1983-08-26
SU943280A1 (ru) 1982-07-15

Similar Documents

Publication Publication Date Title
Gibbons et al. Synthesis of extracellular dextran by cariogenic bacteria and its presence in human dental plaque
Liu Exotoxins of Pseudomonas aeruginosa. I. Factors that influence the production of exotoxin A
Winkelstein et al. Heat labile opsonins to pneumococcus: III. The participation of immunoglobulin and of the alternate pathway of C3 activation
Borsos et al. Antigenic relationship between Mycobacterium bovis (BCG) and a guinea pig hepatoma
US4029762A (en) Lipid A-preparation
US4464165A (en) Material and method for removing immunoglobulins from whole blood
Nakanishi et al. Activation of rainbow trout complement by C-reactive protein
WO1979001137A1 (fr) Procede de conservation de proteines immobilisees
Moore et al. Specific inhibition of Escherichia coli ferrienterochelin uptake by a normal human serum immunoglobulin
Kearney et al. Meat fermentations with immobilized lactic acid bacteria
Bellstedt et al. Acid-treated, naked bacteria as immune carriers for protein antigens
AU3420689A (en) Method and means for immuno-stimulating blood treatment with a mitogen
US4001080A (en) Production of immunological materials
De Boer et al. Formation of polynucleate avian erythrocytes by polylysine and phospholipase C
Buckmire et al. Penetrability of a marine pseudomonad by inulin, sucrose, and glycerol and its relation to the mechanism of lysis
Smulson et al. O-methylthreonine inhibition of growth and of threonine deaminase in Escherichia coli
Coles et al. Cardiovascular disease: an infectious aetiology?
Mond et al. Thymus-derived cell (T cell) activation by heterologous antigens as a replacement of specific immune T cells in the transfer of the secondary response to sheep erythrocytes
Tamauchi et al. Enhancement of immunogenicity by incorporation of lipid A into liposomal model membranes and its application to membrane-associated antigens
Stein et al. A quick method for the preparation of stable DNP red cell conjugates
Maruyama et al. The influence of growth phase on enzymatic adaptation of bacteria
Mathison Kinetics of death induced by penicillin and chloramphenicol in synchronous cultures of Escherichia coli
Kanai et al. Further studies on the antimycobacterial principle of mouse lysosomal components
Knop et al. Effect of Vibrio cholerae neuraminidase on the phagocytosis of E. coli by macrophages in vivo and in vitro
Thorling et al. INHIBITORY EFFECT OF DEAE‐DEXTRAN ON TUMOUR GROWTH: 3. Effect of Charge Density and Molecular Size

Legal Events

Date Code Title Description
AK Designated states

Designated state(s): CH DE GB SE US

RET De translation (de og part 6b)

Ref country code: DE

Ref document number: 2952815

Date of ref document: 19801211

Format of ref document f/p: P