UY30352A1 - Nuevas prolinamidas sustituidas, composiciones conteniéndolas, procesos de preparacion y aplicaciones - Google Patents
Nuevas prolinamidas sustituidas, composiciones conteniéndolas, procesos de preparacion y aplicacionesInfo
- Publication number
- UY30352A1 UY30352A1 UY30352A UY30352A UY30352A1 UY 30352 A1 UY30352 A1 UY 30352A1 UY 30352 A UY30352 A UY 30352A UY 30352 A UY30352 A UY 30352A UY 30352 A1 UY30352 A1 UY 30352A1
- Authority
- UY
- Uruguay
- Prior art keywords
- new
- prolined
- substitutes
- applications
- compositions containing
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title 1
- 150000003839 salts Chemical class 0.000 abstract 2
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
- 150000007522 mineralic acids Chemical class 0.000 abstract 1
- 150000007524 organic acids Chemical class 0.000 abstract 1
- 235000005985 organic acids Nutrition 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
Son objeto de la presente invencion nuevas prolinamidas sustituidas de la formula general (I) en donde D, L, E, G, J, M, R3, R4, R5 y R13 se definen como en la descripcion, sus tautomeros, sus enantiomeros, sus diastereomeros, sus mezclas y sus sales, en especial sus sales fisiologicamente tolerables con ácidos o bases inorgánicos u orgánicos, que presentan valiosas propiedades.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06113977 | 2006-05-16 | ||
| EP07102566 | 2007-02-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UY30352A1 true UY30352A1 (es) | 2008-01-02 |
Family
ID=38646563
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UY30352A UY30352A1 (es) | 2006-05-16 | 2007-05-15 | Nuevas prolinamidas sustituidas, composiciones conteniéndolas, procesos de preparacion y aplicaciones |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US7807693B2 (es) |
| EP (1) | EP2051975B1 (es) |
| JP (1) | JP5263686B2 (es) |
| KR (1) | KR101422456B1 (es) |
| AR (1) | AR060945A1 (es) |
| AU (1) | AU2007251614B2 (es) |
| BR (1) | BRPI0711648A2 (es) |
| CA (1) | CA2653753C (es) |
| CL (1) | CL2007001391A1 (es) |
| DK (1) | DK2051975T3 (es) |
| EA (1) | EA200802210A1 (es) |
| EC (1) | ECSP088824A (es) |
| ES (1) | ES2395538T3 (es) |
| IL (1) | IL195245A (es) |
| MX (1) | MX2008014499A (es) |
| MY (1) | MY146623A (es) |
| NO (1) | NO20084530L (es) |
| NZ (1) | NZ573573A (es) |
| PE (1) | PE20080702A1 (es) |
| PL (1) | PL2051975T3 (es) |
| TW (1) | TW200813047A (es) |
| UY (1) | UY30352A1 (es) |
| WO (1) | WO2007131982A2 (es) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1975165A1 (de) | 2007-03-27 | 2008-10-01 | Boehringer Ingelheim Pharma GmbH & Co. KG | Substituierte Pyrrolidinamide, deren Herstellung und deren Verwendung als Arzneimittel |
| JP5524852B2 (ja) | 2007-11-15 | 2014-06-18 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 置換アミド、それらの製造及び医薬品としての使用 |
| EP2268638A1 (en) * | 2008-03-31 | 2011-01-05 | Evotec AG | Tetrahydronaphthyridines and aza derivatives thereof as histamine h3 receptor antagonists |
| GB201209138D0 (en) * | 2012-05-24 | 2012-07-04 | Ono Pharmaceutical Co | Compounds |
| JP6052527B2 (ja) | 2013-02-21 | 2016-12-27 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ジヒドロプテリジノンｉ |
| JP6337750B2 (ja) * | 2013-11-22 | 2018-06-06 | 小野薬品工業株式会社 | 化合物 |
| SG11201606080SA (en) | 2014-02-03 | 2016-08-30 | Vitae Pharmaceuticals Inc | Dihydropyrrolopyridine inhibitors of ror-gamma |
| MY199131A (en) * | 2014-03-07 | 2023-10-17 | Biocryst Pharm Inc | Human plasma kallikrein inhibitors |
| CN107074852B (zh) | 2014-10-14 | 2019-08-16 | 生命医药有限责任公司 | ROR-γ的二氢吡咯并吡啶抑制剂 |
| US9845308B2 (en) | 2014-11-05 | 2017-12-19 | Vitae Pharmaceuticals, Inc. | Isoindoline inhibitors of ROR-gamma |
| US9663515B2 (en) | 2014-11-05 | 2017-05-30 | Vitae Pharmaceuticals, Inc. | Dihydropyrrolopyridine inhibitors of ROR-gamma |
| EP3078378B1 (en) | 2015-04-08 | 2020-06-24 | Vaiomer | Use of factor xa inhibitors for regulating glycemia |
| US10301261B2 (en) | 2015-08-05 | 2019-05-28 | Vitae Pharmaceuticals, Llc | Substituted indoles as modulators of ROR-gamma |
| EP3377482B1 (en) | 2015-11-20 | 2021-05-12 | Vitae Pharmaceuticals, LLC | Modulators of ror-gamma |
| TWI757266B (zh) | 2016-01-29 | 2022-03-11 | 美商維它藥物有限責任公司 | ＲＯＲ－γ調節劑 |
| US9481674B1 (en) | 2016-06-10 | 2016-11-01 | Vitae Pharmaceuticals, Inc. | Dihydropyrrolopyridine inhibitors of ROR-gamma |
| WO2019018975A1 (en) | 2017-07-24 | 2019-01-31 | Vitae Pharmaceuticals, Inc. | INHIBITORS OF ROR GAMMA |
| MA49685A (fr) | 2017-07-24 | 2021-04-14 | Vitae Pharmaceuticals Llc | INHIBITEURS DE ROR gamma |
| CN114646701B (zh) * | 2022-03-01 | 2023-09-29 | 浙江国邦药业有限公司 | 一种l-脯氨酰胺中有关物质的hplc测试方法 |
| CN121311466A (zh) * | 2023-04-14 | 2026-01-09 | 辉瑞大药厂 | 葡萄糖依赖性促胰岛素多肽受体拮抗剂及其用途 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7030141B2 (en) * | 2001-11-29 | 2006-04-18 | Christopher Franklin Bigge | Inhibitors of factor Xa and other serine proteases involved in the coagulation cascade |
| JP3975254B2 (ja) * | 2002-07-25 | 2007-09-12 | 日野自動車株式会社 | チャイルドシート用アンカの取付構造 |
| DE10329457A1 (de) | 2003-04-03 | 2005-01-20 | Merck Patent Gmbh | Ethinylprolinderivate |
| DE502004009440D1 (de) | 2003-04-03 | 2009-06-10 | Merck Patent Gmbh | Pyrrolidin-1,2-dicarbonsäure-1-(phenylamid)-2-(4-(3-oxo-morpholin-4-yl)-phenylamid) derivate und verwandte verbindungen als inhibitoren des koagulationsfaktors xa zur behandlung von thromboembolischen erkrankungen |
| US7557222B2 (en) * | 2003-06-18 | 2009-07-07 | Merck Patent Gmbh | 1-[(4-Ethynylphenyl)]-2-[(phenyl)]-pyrrolidine-1,2-dicarboxamide derivatives as inhibitors of coagulation factors Xa and VIIa for the treatment of thrombosis |
| ES2223277B1 (es) | 2003-06-19 | 2006-03-01 | Fernando Bouffard Fita | Composicion anestesica para administracion topica. |
| DE10358814A1 (de) | 2003-12-16 | 2005-07-21 | Merck Patent Gmbh | Prolinylarylacetamide |
| DE102004014945A1 (de) | 2004-03-26 | 2005-10-13 | Merck Patent Gmbh | Prolinylderivate |
| US7453002B2 (en) * | 2004-06-15 | 2008-11-18 | Bristol-Myers Squibb Company | Five-membered heterocycles useful as serine protease inhibitors |
| DE102004045796A1 (de) | 2004-09-22 | 2006-03-23 | Merck Patent Gmbh | Arzneimittel enthaltend Carbonylverbindungen sowie deren Verwendung |
| JP2008535887A (ja) | 2005-04-11 | 2008-09-04 | グラクソ グループ リミテッド | 第Ｘａ因子阻害剤としての３−スルホニルアミノ−ピロリジン−２−オン誘導体 |
| BRPI0613045A2 (pt) | 2005-07-15 | 2010-12-14 | Hoffmann La Roche | aminas cÍclicas fundidas a heteroarila |
-
2007
- 2007-05-14 AU AU2007251614A patent/AU2007251614B2/en not_active Ceased
- 2007-05-14 MY MYPI20084581A patent/MY146623A/en unknown
- 2007-05-14 CA CA2653753A patent/CA2653753C/en not_active Expired - Fee Related
- 2007-05-14 WO PCT/EP2007/054631 patent/WO2007131982A2/de not_active Ceased
- 2007-05-14 DK DK07729083.1T patent/DK2051975T3/da active
- 2007-05-14 JP JP2009510435A patent/JP5263686B2/ja not_active Expired - Fee Related
- 2007-05-14 PE PE2007000580A patent/PE20080702A1/es not_active Application Discontinuation
- 2007-05-14 MX MX2008014499A patent/MX2008014499A/es active IP Right Grant
- 2007-05-14 KR KR1020087027907A patent/KR101422456B1/ko not_active Expired - Fee Related
- 2007-05-14 EA EA200802210A patent/EA200802210A1/ru unknown
- 2007-05-14 BR BRPI0711648-9A patent/BRPI0711648A2/pt not_active IP Right Cessation
- 2007-05-14 PL PL07729083T patent/PL2051975T3/pl unknown
- 2007-05-14 ES ES07729083T patent/ES2395538T3/es active Active
- 2007-05-14 NZ NZ573573A patent/NZ573573A/en not_active IP Right Cessation
- 2007-05-14 EP EP07729083A patent/EP2051975B1/de active Active
- 2007-05-15 UY UY30352A patent/UY30352A1/es not_active Application Discontinuation
- 2007-05-15 CL CL2007001391A patent/CL2007001391A1/es unknown
- 2007-05-15 TW TW096117145A patent/TW200813047A/zh unknown
- 2007-05-16 US US11/749,204 patent/US7807693B2/en active Active
- 2007-05-16 AR ARP070102101A patent/AR060945A1/es unknown
-
2008
- 2008-10-15 EC EC2008008824A patent/ECSP088824A/es unknown
- 2008-10-28 NO NO20084530A patent/NO20084530L/no not_active Application Discontinuation
- 2008-11-12 IL IL195245A patent/IL195245A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| ES2395538T3 (es) | 2013-02-13 |
| BRPI0711648A2 (pt) | 2011-11-29 |
| KR20090017523A (ko) | 2009-02-18 |
| CA2653753A1 (en) | 2007-11-22 |
| AU2007251614B2 (en) | 2013-01-17 |
| IL195245A0 (en) | 2009-09-22 |
| DK2051975T3 (da) | 2012-10-15 |
| AU2007251614A1 (en) | 2007-11-22 |
| US20080139605A1 (en) | 2008-06-12 |
| EP2051975B1 (de) | 2012-09-12 |
| WO2007131982A3 (de) | 2008-01-10 |
| JP2009537483A (ja) | 2009-10-29 |
| PE20080702A1 (es) | 2008-07-10 |
| MX2008014499A (es) | 2008-11-27 |
| HK1131140A1 (en) | 2010-01-15 |
| ECSP088824A (es) | 2008-11-27 |
| EP2051975A2 (de) | 2009-04-29 |
| MY146623A (en) | 2012-09-14 |
| PL2051975T3 (pl) | 2013-01-31 |
| AR060945A1 (es) | 2008-07-23 |
| US7807693B2 (en) | 2010-10-05 |
| JP5263686B2 (ja) | 2013-08-14 |
| WO2007131982A2 (de) | 2007-11-22 |
| NZ573573A (en) | 2011-10-28 |
| CL2007001391A1 (es) | 2008-01-18 |
| TW200813047A (en) | 2008-03-16 |
| NO20084530L (no) | 2008-12-12 |
| IL195245A (en) | 2012-09-24 |
| EA200802210A1 (ru) | 2009-06-30 |
| CA2653753C (en) | 2013-09-24 |
| KR101422456B1 (ko) | 2014-07-23 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| UY30352A1 (es) | Nuevas prolinamidas sustituidas, composiciones conteniéndolas, procesos de preparacion y aplicaciones | |
| UY30979A1 (es) | Pirrolidinamidas sustituidas, su preparacion y su uso como medicamentos | |
| ECSP078058A (es) | Nuevas glicinamidas sustituidas, su preparación y su uso como medicamentos | |
| ECSP12012161A (es) | Compuestos en calidad de antagonistas de Bradiquinina-b1 | |
| ATE548374T1 (de) | 2'-fluor-2'-desoxytetrahydrouridine als cytidindeaminaseinhibitoren | |
| UY28773A1 (es) | Nuevas amidas de ácidos carboxílicos, su preparación y su uso como medicamentos. | |
| ECSP10010599A (es) | Derivados de tienopiridonas como activadores de proteina quinasa activados por amp (ampk) | |
| CR11370A (es) | Inhibidores de quinasas simil polo | |
| GT200800170A (es) | Compuestos de n-formil-hidroxilamina | |
| CO6280399A2 (es) | Peptidil nitrilos y uso de los mismos como inhibidores de peptidil peptidasa i | |
| ATE522518T1 (de) | Indazol- und isoindolderivate als glucokinaseaktivierende stoffe | |
| ECSP10010722A (es) | Compuestos orgánicos | |
| ECSP109978A (es) | Nuevos compuestos | |
| ECSP10010654A (es) | Derivados de tienopiridonas como activadores de proteína quinasa activados por amp (ampk) | |
| ECSP066898A (es) | Antagonistas de cgrp seleccionados, procedimiento para su preparación así como su uso como medicamento | |
| UY32098A (es) | Heteroarilos sustituidos | |
| PA8855001A1 (es) | Monocarbamas | |
| GT200600174A (es) | Pirrolopiridinas sustituidas, composiciones que las contienen, proceso de fabricacion y utilizacion | |
| CR11273A (es) | Derivados-2-ona disustituidos en 3, su preparacion y su aplicacion en terapeutica | |
| DE602007013077D1 (de) | Organische verbindungen | |
| UY28848A1 (es) | Antagonistas de cgrp seleccionados, procedimientos para su preparación, y su empleo como medicamentos | |
| GT200500292A (es) | Derivados de 2-amido-4-feniltiazol, su preparacion y su aplicacion en terapeutica | |
| DE602007008691D1 (de) | Cyclische sulfone, die zur verwendung als bace-inhibitoren geeignet sind | |
| UY31286A1 (es) | Antagonistas de receptores de bradiquinina b1. proceso de preparación y aplicaciones. | |
| UY30957A1 (es) | Nuevos compuestos, procedimientos de preparacion, compuestos intermedios utiles en la preparacion, composiciones farmacéuticas conteniéndolos y aplicaciones |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 109 | Application deemed to be withdrawn |
Effective date: 20170609 |