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ECSP10010599A - Derivados de tienopiridonas como activadores de proteina quinasa activados por amp (ampk) - Google Patents

Derivados de tienopiridonas como activadores de proteina quinasa activados por amp (ampk)

Info

Publication number
ECSP10010599A
ECSP10010599A EC2010010599A ECSP10010599A ECSP10010599A EC SP10010599 A ECSP10010599 A EC SP10010599A EC 2010010599 A EC2010010599 A EC 2010010599A EC SP10010599 A ECSP10010599 A EC SP10010599A EC SP10010599 A ECSP10010599 A EC SP10010599A
Authority
EC
Ecuador
Prior art keywords
tienopiridon
ampk
derivatives
protein kinase
activated protein
Prior art date
Application number
EC2010010599A
Other languages
English (en)
Inventor
Christine Charon
Daniel Cravo
Sophie Hallakou-Bozec
Franck Lepifre
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40671017&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ECSP10010599(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of ECSP10010599A publication Critical patent/ECSP10010599A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La presente invencion se refiere a compuestos de la formula (I) en donde R1, R2 y R3 son como se definen en la reivindicacion 1, incluyendo sus composiciones farmaceuticas y su uso en el tratamiento y/o la prevencion de enfermedades y trastornos modulados por agonistas de AMP. La invencion tambien se refiere a intermediarios y a un metodo de preparacion de compuestos de la formula (I).
EC2010010599A 2008-04-11 2010-11-09 Derivados de tienopiridonas como activadores de proteina quinasa activados por amp (ampk) ECSP10010599A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP08290364 2008-04-11

Publications (1)

Publication Number Publication Date
ECSP10010599A true ECSP10010599A (es) 2010-12-30

Family

ID=40671017

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2010010599A ECSP10010599A (es) 2008-04-11 2010-11-09 Derivados de tienopiridonas como activadores de proteina quinasa activados por amp (ampk)

Country Status (25)

Country Link
US (1) US8563729B2 (es)
EP (1) EP2262500B1 (es)
JP (1) JP5592348B2 (es)
KR (1) KR101630466B1 (es)
CN (1) CN101998853B (es)
AU (1) AU2009235784B2 (es)
BR (1) BRPI0910439B8 (es)
CA (1) CA2721025C (es)
CO (1) CO6300954A2 (es)
DK (1) DK2262500T3 (es)
EA (1) EA017756B1 (es)
EC (1) ECSP10010599A (es)
ES (1) ES2584278T3 (es)
HR (1) HRP20160907T1 (es)
HU (1) HUE027857T2 (es)
IL (1) IL208067A (es)
MX (1) MX2010011047A (es)
MY (1) MY155836A (es)
NZ (1) NZ589136A (es)
PL (1) PL2262500T3 (es)
PT (1) PT2262500T (es)
SI (1) SI2262500T1 (es)
UA (1) UA103321C2 (es)
WO (1) WO2009124636A1 (es)
ZA (1) ZA201008050B (es)

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WO2011107494A1 (de) 2010-03-03 2011-09-09 Sanofi Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung
EP2552435A1 (en) 2010-04-02 2013-02-06 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and compositions comprising ampk activator (metformin/troglitazone) for the treatment of myotonic dystrophy type 1 (dm1)
US8530413B2 (en) 2010-06-21 2013-09-10 Sanofi Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
TW201215388A (en) 2010-07-05 2012-04-16 Sanofi Sa (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments
TW201215387A (en) 2010-07-05 2012-04-16 Sanofi Aventis Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament
TW201221505A (en) 2010-07-05 2012-06-01 Sanofi Sa Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament
CN103189376B (zh) 2010-09-01 2016-02-24 拜耳知识产权有限责任公司 具有除草活性的酮基磺内酰胺和二酮基吡啶
EP2683690A1 (en) * 2011-03-07 2014-01-15 GlaxoSmithKline LLC Quinolinone derivatives
WO2013037390A1 (en) 2011-09-12 2013-03-21 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
EP2760862B1 (en) 2011-09-27 2015-10-21 Sanofi 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
US8889730B2 (en) 2012-04-10 2014-11-18 Pfizer Inc. Indole and indazole compounds that activate AMPK
EP2679591A1 (en) 2012-06-29 2014-01-01 Poxel Thienopyridone derivatives useful as activators of AMPK
JP6064062B2 (ja) 2013-03-15 2017-01-18 ファイザー・インク Ａｍｐｋを活性化させるインダゾール化合物
US9827222B2 (en) * 2013-07-01 2017-11-28 Emory University Treating or preventing nephrogenic diabetes insipidus
WO2015103480A1 (en) 2014-01-02 2015-07-09 Massachusetts Eye & Ear Infirmary Treating ocular neovascularization
CN104945369A (zh) * 2015-06-23 2015-09-30 佛山市赛维斯医药科技有限公司 一种含六甲基苯环和硝基苯结构的黄原酸酯类化合物、其制备方法及用途
CN105037321A (zh) * 2015-06-23 2015-11-11 佛山市赛维斯医药科技有限公司 含六甲基苯环的黄原酸酯类的ampk激活剂、制备方法及用途
CN104945370A (zh) * 2015-06-23 2015-09-30 佛山市赛维斯医药科技有限公司 含卤代噻吩和硝苯六甲苯结构的黄原酸酯类化合物、制备方法及用途
CN104892569A (zh) * 2015-06-23 2015-09-09 佛山市赛维斯医药科技有限公司 末端取代的硝苯六甲苯黄原酸酯类的化合物、制备方法及用途
CN104892568A (zh) * 2015-06-23 2015-09-09 佛山市赛维斯医药科技有限公司 一种含六甲基苯环和腈基苯结构的黄原酸酯类化合物、其制备方法及用途
CN105037322A (zh) * 2015-06-23 2015-11-11 佛山市赛维斯医药科技有限公司 含六甲基苯环和烷氧苯结构的黄原酸酯类化合物、其制备方法及用途
CN104945371A (zh) * 2015-06-24 2015-09-30 佛山市赛维斯医药科技有限公司 一种含腈基噻吩以及六甲苯结构的黄原酸酯类化合物、制备方法及用途
CN104926757A (zh) * 2015-06-24 2015-09-23 佛山市赛维斯医药科技有限公司 含烷氧苯基的双酰基苄胺类ampk激活剂、其制备方法及用途
CN105001181A (zh) * 2015-06-24 2015-10-28 佛山市赛维斯医药科技有限公司 一类双酰基苄胺类的ampk激活剂、其制备方法及用途
CN104926756A (zh) * 2015-06-24 2015-09-23 佛山市赛维斯医药科技有限公司 一类含腈基苯的双酰基苄胺类化合物、其制备方法及用途
CN105001194A (zh) * 2015-06-24 2015-10-28 佛山市赛维斯医药科技有限公司 一种含氨基噻吩以及六甲苯结构的黄原酸酯类化合物、制备方法及用途
CN105037296A (zh) * 2015-06-24 2015-11-11 佛山市赛维斯医药科技有限公司 一类卤代苯双酰基苄胺类的ampk激活剂、其制备方法及用途
CN104926755A (zh) * 2015-06-24 2015-09-23 佛山市赛维斯医药科技有限公司 硝苯双酰基苄胺类ampk激活剂、其制备方法及用途
CN104945372A (zh) * 2015-06-24 2015-09-30 佛山市赛维斯医药科技有限公司 一种含二硝基以及六甲苯结构的黄原酸酯类化合物、制备方法及用途
BR112017027241B1 (pt) 2015-06-25 2023-09-26 University Health Network Inibidores de hpk1 e composição farmacêutica
US20190054096A1 (en) 2015-09-30 2019-02-21 Instituto De Medicina Molecular Methods for attenuating parasite virulence
US20190350955A1 (en) 2016-06-30 2019-11-21 Inserm (Institut National De La Sante Et De La Recherche Medicale Methods and pharmaceutical compositions for the treatment of cardiomyopathies
CN113166168A (zh) * 2018-11-16 2021-07-23 博希尔公司 噻吩并吡啶酮衍生物的一水合钾盐及其制备方法
WO2020201263A1 (en) 2019-04-01 2020-10-08 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for the treatment and prevention of cardiac remodeling
CN115335048B (zh) 2020-03-26 2025-04-04 博希尔公司 噻吩并吡啶酮衍生物在治疗肾上腺脑白质营养不良或肾上腺脊髓神经病中的用途
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Also Published As

Publication number Publication date
MX2010011047A (es) 2010-10-26
WO2009124636A1 (en) 2009-10-15
NZ589136A (en) 2012-06-29
JP5592348B2 (ja) 2014-09-17
HRP20160907T1 (hr) 2016-09-23
UA103321C2 (ru) 2013-10-10
CA2721025C (en) 2016-07-26
BRPI0910439A2 (pt) 2015-09-29
ZA201008050B (en) 2011-07-27
HUE027857T2 (en) 2016-11-28
AU2009235784B2 (en) 2013-09-19
BRPI0910439B8 (pt) 2021-05-25
EA017756B1 (ru) 2013-02-28
CA2721025A1 (en) 2009-10-15
IL208067A0 (en) 2010-12-30
IL208067A (en) 2015-05-31
US8563729B2 (en) 2013-10-22
EP2262500B1 (en) 2016-04-27
ES2584278T3 (es) 2016-09-26
KR20100137563A (ko) 2010-12-30
CN101998853A (zh) 2011-03-30
DK2262500T3 (en) 2016-08-15
PL2262500T3 (pl) 2016-09-30
BRPI0910439B1 (pt) 2020-10-20
CO6300954A2 (es) 2011-07-21
PT2262500T (pt) 2016-08-16
CN101998853B (zh) 2015-02-11
KR101630466B1 (ko) 2016-06-14
SI2262500T1 (sl) 2016-09-30
JP2011516510A (ja) 2011-05-26
EP2262500A1 (en) 2010-12-22
US20110034505A1 (en) 2011-02-10
MY155836A (en) 2015-12-15
EA201001585A1 (ru) 2011-06-30
HK1155955A1 (en) 2012-06-01
AU2009235784A1 (en) 2009-10-15

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