UY30984A1 - Proteinas de fusion de formula m-a para degradar péptidos beta amiloides, composiciones en base a ella, preparacion y aplicaciones. - Google Patents
Proteinas de fusion de formula m-a para degradar péptidos beta amiloides, composiciones en base a ella, preparacion y aplicaciones.Info
- Publication number
- UY30984A1 UY30984A1 UY30984A UY30984A UY30984A1 UY 30984 A1 UY30984 A1 UY 30984A1 UY 30984 A UY30984 A UY 30984A UY 30984 A UY30984 A UY 30984A UY 30984 A1 UY30984 A1 UY 30984A1
- Authority
- UY
- Uruguay
- Prior art keywords
- fusion proteins
- amiloid
- peptides
- applications
- preparation
- Prior art date
Links
- 102000037865 fusion proteins Human genes 0.000 title abstract 4
- 108020001507 fusion proteins Proteins 0.000 title abstract 4
- 230000000593 degrading effect Effects 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title 1
- 102000004196 processed proteins & peptides Human genes 0.000 title 1
- 108090000765 processed proteins & peptides Proteins 0.000 title 1
- DZHSAHHDTRWUTF-SIQRNXPUSA-N amyloid-beta polypeptide 42 Chemical compound C([C@@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(O)=O)[C@@H](C)CC)C(C)C)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC(O)=O)C(C)C)C(C)C)C1=CC=CC=C1 DZHSAHHDTRWUTF-SIQRNXPUSA-N 0.000 abstract 2
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 150000001413 amino acids Chemical group 0.000 abstract 1
- 238000003776 cleavage reaction Methods 0.000 abstract 1
- 230000002255 enzymatic effect Effects 0.000 abstract 1
- 235000004252 protein component Nutrition 0.000 abstract 1
- 235000018102 proteins Nutrition 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 230000007017 scission Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/36—Blood coagulation or fibrinolysis factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Genetics & Genomics (AREA)
- Neurosurgery (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Wood Science & Technology (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- Biophysics (AREA)
- Toxicology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Psychiatry (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
Abstract
La presente invencion se refiere a proteínas de fusion y su uso en el tratamiento enzimático de pacientes con enfermedad de Alzheimer. Dicha proteína de fusion tiene la formula M-A, capaz de degradar el péptido beta amiloide en uno o más sitios de escision en su secuencia de aminoácido, donde M es un componente proteico que prolonga la vida media de la proteína de fusion y A es un componente proteico que escinde al péptido beta amiloide.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US90847107P | 2007-03-28 | 2007-03-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UY30984A1 true UY30984A1 (es) | 2008-10-31 |
Family
ID=39788753
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UY30984A UY30984A1 (es) | 2007-03-28 | 2008-03-27 | Proteinas de fusion de formula m-a para degradar péptidos beta amiloides, composiciones en base a ella, preparacion y aplicaciones. |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20080242590A1 (es) |
| EP (1) | EP2139525A4 (es) |
| JP (1) | JP2010522559A (es) |
| CN (1) | CN101668545A (es) |
| AR (1) | AR066199A1 (es) |
| AU (1) | AU2008230177B2 (es) |
| CA (1) | CA2681404A1 (es) |
| CL (1) | CL2008000910A1 (es) |
| PE (1) | PE20090225A1 (es) |
| TW (1) | TW200907056A (es) |
| UY (1) | UY30984A1 (es) |
| WO (1) | WO2008118093A1 (es) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102647998A (zh) * | 2009-06-19 | 2012-08-22 | 医学免疫有限责任公司 | 蛋白酶变体 |
| WO2011160732A1 (en) | 2010-06-21 | 2011-12-29 | Medimmune, Llc. | Protease variants of human neprilysin |
| WO2011161127A1 (en) | 2010-06-21 | 2011-12-29 | Medimmune, Llc | Protease variants of human neprilysin |
| WO2012145428A2 (en) * | 2011-04-21 | 2012-10-26 | Washington University | Altering protein concentrations in cerebrospinal fluid and/or brain interstitial fluid |
| CN103529182B (zh) * | 2012-07-06 | 2016-03-16 | 中国科学院上海生命科学研究院 | rbo/Efr3a/Efr3b基因或其蛋白在诊断和治疗阿尔茨海默病中的应用 |
| PE20160720A1 (es) * | 2013-08-02 | 2016-07-28 | Hoffmann La Roche | Proteina de fusion terapeutica |
| EP2832854A1 (en) * | 2013-08-02 | 2015-02-04 | F. Hoffmann-La Roche AG | Method for improving the recombinant expression of a polypeptide by C-terminal fusion to human neprilysin |
| EP3540441A1 (en) * | 2014-05-22 | 2019-09-18 | Shimadzu Corporation | Surrogate biomarker for evaluating intracerebral amyloid ss peptide accumulation and method for analysis thereof |
| US20190145962A1 (en) * | 2016-04-14 | 2019-05-16 | Tao Health Life Pharma Co., Ltd. | Peptide for inhibiting binding of amylospheroids (aspd), and evaluation and screening method |
| WO2018138709A1 (en) * | 2017-01-30 | 2018-08-02 | National Research Council Of Canada | Blood-brain barrier transmigrating compounds and uses thereof |
| TWI798209B (zh) | 2017-03-23 | 2023-04-11 | 南韓商韓美藥品股份有限公司 | 對胰島素受體有降低親和性之胰島素類似物之接合物及其用途 |
| CN110241128B (zh) * | 2018-03-07 | 2020-10-02 | 上海大学 | 一种含有cbd的融合基因、细胞系、液态ecm与应用 |
| AU2019310040A1 (en) | 2018-07-23 | 2021-02-11 | Enclear Therapies, Inc. | Methods of treating neurological disorders |
| AU2019310039A1 (en) | 2018-07-23 | 2021-02-18 | Enclear Therapies, Inc. | Methods of treating neurological disorders |
| CN114007665B (zh) | 2019-04-11 | 2024-11-12 | 因柯利尔疗法公司 | 改善脑脊液的方法及其装置和系统 |
| US12329930B2 (en) | 2020-09-29 | 2025-06-17 | Enclear Therapies, Inc. | Subarachnoid fluid management method and system |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5541087A (en) * | 1994-09-14 | 1996-07-30 | Fuji Immunopharmaceuticals Corporation | Expression and export technology of proteins as immunofusins |
| CZ20003099A3 (cs) * | 1998-02-25 | 2002-04-17 | Lexigen Pharmaceuticals Corporation | Zvýąení doby poloviční ľivotnosti cirkulujících fúzních proteinů odvozených od protilátek |
| US20020086405A1 (en) * | 2000-09-25 | 2002-07-04 | Inmaculada Silos-Santiago | 56638, a novel human neprilysin protease and uses thereof |
| CA2260376A1 (en) * | 1999-02-11 | 2000-08-11 | Universite De Montreal | New metalloproteases of the neprilysin family |
| US20030083277A1 (en) * | 2000-02-24 | 2003-05-01 | Hersh Louis B. | Use of insulin degrading enzyme (IDE) for the treatment of alzheimer's disease in patients |
| WO2002096460A1 (en) * | 2001-05-30 | 2002-12-05 | Cornell Research Foundation, Inc. | Endopeptidase/anti-psma antibody fusion proteins for treatment of cancer |
| US20050118632A1 (en) * | 2003-11-06 | 2005-06-02 | Jian Chen | Polynucleotides and polypeptides encoding a novel metalloprotease, Protease-40b |
| US20080274096A1 (en) * | 2005-10-03 | 2008-11-06 | Astrazeneca Ab | Fusion Proteins Having a Modulated Half-Life in Plasma |
-
2008
- 2008-03-26 TW TW097110852A patent/TW200907056A/zh unknown
- 2008-03-27 CN CN200880010294A patent/CN101668545A/zh active Pending
- 2008-03-27 AR ARP080101265A patent/AR066199A1/es not_active Application Discontinuation
- 2008-03-27 CA CA002681404A patent/CA2681404A1/en not_active Abandoned
- 2008-03-27 EP EP08741880A patent/EP2139525A4/en not_active Withdrawn
- 2008-03-27 PE PE2008000557A patent/PE20090225A1/es not_active Application Discontinuation
- 2008-03-27 JP JP2010500877A patent/JP2010522559A/ja not_active Withdrawn
- 2008-03-27 WO PCT/SE2008/050346 patent/WO2008118093A1/en not_active Ceased
- 2008-03-27 AU AU2008230177A patent/AU2008230177B2/en not_active Ceased
- 2008-03-27 UY UY30984A patent/UY30984A1/es not_active Application Discontinuation
- 2008-03-28 CL CL2008000910A patent/CL2008000910A1/es unknown
- 2008-03-28 US US12/057,464 patent/US20080242590A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| TW200907056A (en) | 2009-02-16 |
| CL2008000910A1 (es) | 2008-11-21 |
| WO2008118093A1 (en) | 2008-10-02 |
| EP2139525A4 (en) | 2010-08-18 |
| AR066199A1 (es) | 2009-08-05 |
| US20080242590A1 (en) | 2008-10-02 |
| CN101668545A (zh) | 2010-03-10 |
| PE20090225A1 (es) | 2009-04-19 |
| JP2010522559A (ja) | 2010-07-08 |
| AU2008230177A1 (en) | 2008-10-02 |
| AU2008230177B2 (en) | 2012-05-10 |
| CA2681404A1 (en) | 2008-10-02 |
| EP2139525A1 (en) | 2010-01-06 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| UY30984A1 (es) | Proteinas de fusion de formula m-a para degradar péptidos beta amiloides, composiciones en base a ella, preparacion y aplicaciones. | |
| ES2563646T3 (es) | Composiciones y métodos relacionados con variantes de la proteína A (SpA) | |
| ES2512141T3 (es) | Análogo peptídico de oxintomodulina | |
| ES2534744T3 (es) | Plasmina modificada de forma recombinante | |
| ES2558330T3 (es) | Péptido WT1 restringido por HLA-A*3303 y composición farmacéutica que comprende el mismo | |
| PE20120358A1 (es) | Mutantes fgf21 y usos de los mismos | |
| AR072009A1 (es) | Mutantes del factor de crecimiento de los fibroblastos fgf21 y usos de los mismos | |
| AR081454A1 (es) | Proteinas de dominio de armazon basadas en fibronectina que se unen a pcsk9 (proproteina convertasa subtilisina kexina 9) | |
| AR069362A1 (es) | Variantes de enzimas asparraginasas y sus usos | |
| BRPI0809366B8 (pt) | polipeptídeo substancialmente alfa-helicoidal, método para fabricação do mesmo, aminoácido e composição farmacêutica | |
| BRPI0816784A8 (pt) | Fatores neuro-endócrinos para o tratamento de doenças degenerativas | |
| BRPI0614761A2 (pt) | proteìnas de fusão de albumina | |
| CO2022016595A2 (es) | Nuevas proteinas de unión a repeticiones de anquirina y sus usos | |
| CL2011003121A1 (es) | Proteína de fusión que comprende una secuencia de hormona de crecimiento (gh), ligada a un polipéptido recombinante extendido (xten) que comprende al menos 200 aminoácidos, carece de epítopes de células t y los residuos g, a, s, t, e y p suman más del 90%; ácido nucleico, vector y célula; método de producción; composición farmacéutica y uso. | |
| AR080229A1 (es) | Proteinas de dominio de armazon de fibronectina que se unen a il -23 (interleucina 23) | |
| BR112013029409A8 (pt) | produtos farmacêuticos de peptídeo melhorados para resistência à insulina | |
| ECSP088758A (es) | Métodos para reducir la aglomeración de proteína | |
| PE20141727A1 (es) | Composiciones, usos y metodos para tratamiento de trastornos y enfermedades metabolicas | |
| MX2013015323A (es) | Polipeptidos de fusion de serpina y metodos de uso de los mismos. | |
| EA201100070A1 (ru) | Туберкулезный белок rv2386c, композиции и их применения | |
| BR112017008304A2 (pt) | tripeptidil peptidases tolerantes à prolina e seus usos | |
| BR112012013330A2 (pt) | composições e métodos para aumentar meia vida do soro de proteínas de fusão fc | |
| BRPI0406800B8 (pt) | "dímero de peptídeo, composição farmacêutica contendo o mesmo e seu uso | |
| MY150226A (en) | Novel h5 proteins, nucleic acid molecules and vectors encoding for those, and medicinal use | |
| AR076977A1 (es) | Proteinas precursoras repetitivas autoensambladas |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 109 | Application deemed to be withdrawn |
Effective date: 20170919 |