PE20090225A1 - Proteinas de fusion que degradan el peptido beta amiloide - Google Patents
Proteinas de fusion que degradan el peptido beta amiloideInfo
- Publication number
- PE20090225A1 PE20090225A1 PE2008000557A PE2008000557A PE20090225A1 PE 20090225 A1 PE20090225 A1 PE 20090225A1 PE 2008000557 A PE2008000557 A PE 2008000557A PE 2008000557 A PE2008000557 A PE 2008000557A PE 20090225 A1 PE20090225 A1 PE 20090225A1
- Authority
- PE
- Peru
- Prior art keywords
- fusion proteins
- amyloid peptide
- beta amyloid
- fusion protein
- peptide
- Prior art date
Links
- 108020001507 fusion proteins Proteins 0.000 title abstract 4
- DZHSAHHDTRWUTF-SIQRNXPUSA-N amyloid-beta polypeptide 42 Chemical compound C([C@@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(O)=O)[C@@H](C)CC)C(C)C)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC(O)=O)C(C)C)C(C)C)C1=CC=CC=C1 DZHSAHHDTRWUTF-SIQRNXPUSA-N 0.000 title 1
- 230000000593 degrading effect Effects 0.000 title 1
- 102000037865 fusion proteins Human genes 0.000 title 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 3
- 235000004252 protein component Nutrition 0.000 abstract 2
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 150000001413 amino acids Chemical group 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/36—Blood coagulation or fibrinolysis factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Genetics & Genomics (AREA)
- Neurosurgery (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Wood Science & Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biophysics (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Toxicology (AREA)
- General Engineering & Computer Science (AREA)
- Hematology (AREA)
- Psychology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
Abstract
REFERIDA A UNA PROTEINA DE FUSION DE FORMULA M-A, DONDE M ES UN COMPONENTE PROTEICO QUE PROLONGA LA VIDA MEDIA DE LA PROTEINA DE FUSION TAL COMO UNA PARTE Fc DE UN ANTICUERPO IgG2 Y A ES UN COMPONENTE PROTEICO QUE CORTA EL PEPTIDO BETA AMILOIDE TAL COMO NEPRILISINA EXTRACELULAR QUE TIENE UNA SECUENCIA DE AMINOACIDOS DE SEQ ID N 1,2,3 O 4 Y DONDE DICHOS M Y A ESTAN UNIDOS POR UN CONECTOR L TAL COMO UN PEPTIDO O UN CONECTOR QUIMICO. DICHA PROTEINA DE FUSION CORTA EL PEPTIDO BETA AMILOIDE Y ES UTIL EN EL TRATAMIENTO DE LA ENFERMEDAD DE ALZHEIMER
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US90847107P | 2007-03-28 | 2007-03-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20090225A1 true PE20090225A1 (es) | 2009-04-19 |
Family
ID=39788753
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2008000557A PE20090225A1 (es) | 2007-03-28 | 2008-03-27 | Proteinas de fusion que degradan el peptido beta amiloide |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20080242590A1 (es) |
| EP (1) | EP2139525A4 (es) |
| JP (1) | JP2010522559A (es) |
| CN (1) | CN101668545A (es) |
| AR (1) | AR066199A1 (es) |
| AU (1) | AU2008230177B2 (es) |
| CA (1) | CA2681404A1 (es) |
| CL (1) | CL2008000910A1 (es) |
| PE (1) | PE20090225A1 (es) |
| TW (1) | TW200907056A (es) |
| UY (1) | UY30984A1 (es) |
| WO (1) | WO2008118093A1 (es) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102647998A (zh) * | 2009-06-19 | 2012-08-22 | 医学免疫有限责任公司 | 蛋白酶变体 |
| WO2011161127A1 (en) | 2010-06-21 | 2011-12-29 | Medimmune, Llc | Protease variants of human neprilysin |
| WO2011160732A1 (en) | 2010-06-21 | 2011-12-29 | Medimmune, Llc. | Protease variants of human neprilysin |
| US20140377319A1 (en) * | 2011-04-21 | 2014-12-25 | Washington University | Altering protein concentrations in cerebrospinal fluid and/or brain interstitial fluid |
| CN103529182B (zh) * | 2012-07-06 | 2016-03-16 | 中国科学院上海生命科学研究院 | rbo/Efr3a/Efr3b基因或其蛋白在诊断和治疗阿尔茨海默病中的应用 |
| BR112016001782A2 (pt) * | 2013-08-02 | 2017-08-29 | Hoffmann La Roche | Proteína de fusão terapêutica |
| EP2832854A1 (en) * | 2013-08-02 | 2015-02-04 | F. Hoffmann-La Roche AG | Method for improving the recombinant expression of a polypeptide by C-terminal fusion to human neprilysin |
| CN106574930B (zh) * | 2014-05-22 | 2019-09-03 | 株式会社岛津制作所 | 评价脑内的淀粉样蛋白β肽蓄积状态的替代性生物标记物和其分析方法 |
| CN109071600A (zh) * | 2016-04-14 | 2018-12-21 | 道健康生活医药株式会社 | 淀粉样蛋白球体（aspd）结合抑制肽以及评价和筛选方法 |
| CA3052058A1 (en) * | 2017-01-30 | 2018-08-02 | National Research Council Of Canada | Blood-brain barrier transmigrating compounds and uses thereof |
| AR111341A1 (es) | 2017-03-23 | 2019-07-03 | Hanmi Pharm Ind Co Ltd | Un conjugado del análogo de insulina con afinidad reducida para el receptor de insulina y uso del mismo |
| CN110241128B (zh) * | 2018-03-07 | 2020-10-02 | 上海大学 | 一种含有cbd的融合基因、细胞系、液态ecm与应用 |
| CA3107349A1 (en) | 2018-07-23 | 2020-01-30 | Enclear Therapies, Inc. | Methods of treating neurological disorders |
| CA3107352A1 (en) | 2018-07-23 | 2020-01-30 | Enclear Therapies, Inc. | Methods of treating neurological disorders |
| CN114007665B (zh) | 2019-04-11 | 2024-11-12 | 因柯利尔疗法公司 | 改善脑脊液的方法及其装置和系统 |
| US12337140B2 (en) | 2020-09-29 | 2025-06-24 | Enclear Therapies, Inc. | Subarachnoid fluid management method and system with varying rates |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5541087A (en) * | 1994-09-14 | 1996-07-30 | Fuji Immunopharmaceuticals Corporation | Expression and export technology of proteins as immunofusins |
| CA2320403A1 (en) * | 1998-02-25 | 1999-09-02 | Lexigen Pharmaceuticals Corporation | Enhancing the circulating half-life of antibody-based fusion proteins |
| US20020086405A1 (en) * | 2000-09-25 | 2002-07-04 | Inmaculada Silos-Santiago | 56638, a novel human neprilysin protease and uses thereof |
| CA2260376A1 (en) * | 1999-02-11 | 2000-08-11 | Universite De Montreal | New metalloproteases of the neprilysin family |
| US20030083277A1 (en) * | 2000-02-24 | 2003-05-01 | Hersh Louis B. | Use of insulin degrading enzyme (IDE) for the treatment of alzheimer's disease in patients |
| EP1390069A1 (en) * | 2001-05-30 | 2004-02-25 | Cornell Research Foundation, Inc. | Endopeptidase/anti-psma antibody fusion proteins for treatment of cancer |
| US20050118632A1 (en) * | 2003-11-06 | 2005-06-02 | Jian Chen | Polynucleotides and polypeptides encoding a novel metalloprotease, Protease-40b |
| CN101321863A (zh) * | 2005-10-03 | 2008-12-10 | 阿斯利康(瑞典)有限公司 | 具有受调控的血浆半衰期的融合蛋白 |
-
2008
- 2008-03-26 TW TW097110852A patent/TW200907056A/zh unknown
- 2008-03-27 PE PE2008000557A patent/PE20090225A1/es not_active Application Discontinuation
- 2008-03-27 UY UY30984A patent/UY30984A1/es not_active Application Discontinuation
- 2008-03-27 EP EP08741880A patent/EP2139525A4/en not_active Withdrawn
- 2008-03-27 AR ARP080101265A patent/AR066199A1/es not_active Application Discontinuation
- 2008-03-27 WO PCT/SE2008/050346 patent/WO2008118093A1/en not_active Ceased
- 2008-03-27 CN CN200880010294A patent/CN101668545A/zh active Pending
- 2008-03-27 JP JP2010500877A patent/JP2010522559A/ja not_active Withdrawn
- 2008-03-27 AU AU2008230177A patent/AU2008230177B2/en not_active Ceased
- 2008-03-27 CA CA002681404A patent/CA2681404A1/en not_active Abandoned
- 2008-03-28 CL CL2008000910A patent/CL2008000910A1/es unknown
- 2008-03-28 US US12/057,464 patent/US20080242590A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CA2681404A1 (en) | 2008-10-02 |
| US20080242590A1 (en) | 2008-10-02 |
| JP2010522559A (ja) | 2010-07-08 |
| WO2008118093A1 (en) | 2008-10-02 |
| AR066199A1 (es) | 2009-08-05 |
| EP2139525A1 (en) | 2010-01-06 |
| AU2008230177A1 (en) | 2008-10-02 |
| CL2008000910A1 (es) | 2008-11-21 |
| UY30984A1 (es) | 2008-10-31 |
| CN101668545A (zh) | 2010-03-10 |
| AU2008230177B2 (en) | 2012-05-10 |
| TW200907056A (en) | 2009-02-16 |
| EP2139525A4 (en) | 2010-08-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD | Application declared void or lapsed |