[go: up one dir, main page]

UY28246A1 - Procedimiento para la preparación de telmisartan - Google Patents

Procedimiento para la preparación de telmisartan

Info

Publication number
UY28246A1
UY28246A1 UY28246A UY28246A UY28246A1 UY 28246 A1 UY28246 A1 UY 28246A1 UY 28246 A UY28246 A UY 28246A UY 28246 A UY28246 A UY 28246A UY 28246 A1 UY28246 A1 UY 28246A1
Authority
UY
Uruguay
Prior art keywords
methyl
telmisartan
preparation
procedure
benzimidazole
Prior art date
Application number
UY28246A
Other languages
English (en)
Inventor
Norbert Hauel
Rolf Dach
Helmut Heitger
Oliver Meyer
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=33016100&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UY28246(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of UY28246A1 publication Critical patent/UY28246A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/20—Two benzimidazolyl-2 radicals linked together directly or via a hydrocarbon or substituted hydrocarbon radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/18—Benzimidazoles; Hydrogenated benzimidazoles with aryl radicals directly attached in position 2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Objeto del presente invento es un nuevo procedimiento para la preparación de telmisartan por reacción de 2-n-propil-4-metil-6-(1`-metilbencimidazol-2`-il)-bencimidazol con un compuesto de la fórmula general en la cual Z representa un grupo lábil, obteniéndose el compuesto 2-ciano-4`- (2´"- n-propil - 4" - metil- 6" - (1"- metil - bencimidazol -2"`- i l) metil) bencimidazol - 1" - il - metil) bifenilo, y la subsiguiente hidrólisis de la función nitrilo a función ácido.
UY28246A 2003-03-31 2004-03-29 Procedimiento para la preparación de telmisartan UY28246A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10314702A DE10314702A1 (de) 2003-03-31 2003-03-31 Verfahren zur Herstellung von Telmisartan

Publications (1)

Publication Number Publication Date
UY28246A1 true UY28246A1 (es) 2004-11-08

Family

ID=33016100

Family Applications (1)

Application Number Title Priority Date Filing Date
UY28246A UY28246A1 (es) 2003-03-31 2004-03-29 Procedimiento para la preparación de telmisartan

Country Status (26)

Country Link
US (2) US7193089B2 (es)
EP (2) EP1611108B1 (es)
JP (1) JP5160740B2 (es)
KR (1) KR101096499B1 (es)
CN (1) CN100418953C (es)
AR (2) AR043794A1 (es)
AT (1) ATE515500T1 (es)
AU (1) AU2004226239B2 (es)
BR (1) BRPI0408861A (es)
CA (1) CA2520714C (es)
CL (1) CL2004000687A1 (es)
CY (2) CY1112020T1 (es)
DE (1) DE10314702A1 (es)
DK (2) DK2322511T3 (es)
ES (2) ES2432647T3 (es)
IL (1) IL171145A (es)
MX (1) MXPA05009529A (es)
NZ (1) NZ543244A (es)
PE (1) PE20050390A1 (es)
PL (2) PL1611108T3 (es)
PT (2) PT2322511E (es)
RU (1) RU2430092C2 (es)
SI (2) SI2322511T1 (es)
TW (1) TWI335916B (es)
UY (1) UY28246A1 (es)
WO (1) WO2004087676A1 (es)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10314702A1 (de) * 2003-03-31 2004-10-21 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verfahren zur Herstellung von Telmisartan
GB2414019A (en) 2004-05-11 2005-11-16 Cipla Ltd One-step preparation of telmisartan by condensation and hydrolysis
DE102004045796A1 (de) * 2004-09-22 2006-03-23 Merck Patent Gmbh Arzneimittel enthaltend Carbonylverbindungen sowie deren Verwendung
WO2006044648A1 (en) * 2004-10-15 2006-04-27 Teva Pharmaceutical Industries Ltd. Process for preparing telmisartan
US7943781B2 (en) 2004-10-18 2011-05-17 Dr. Reddy's Laboratories Limited Process for preparing telmisartan
US7968727B2 (en) 2005-04-01 2011-06-28 Lek Pharmaceuticals, D.D. Synthesis of 4-bromomethyl-2′-formylbiphenyl and 4-bromomethyl-2′-hydroxymethylbiphenyl and its use in preparation of angiotensin II antagonists
ITMI20050801A1 (it) * 2005-05-03 2006-11-04 Dipharma Spa Procedimento per la preparazione di telmisartan
WO2006136916A2 (en) * 2005-06-20 2006-12-28 Glenmark Pharmaceuticals Limited Substantially pure micronized particles of telmisartan and pharmaceutical compositions containing same
US20060264491A1 (en) * 2006-06-08 2006-11-23 Chemagis Ltd. Telmisartan production process
CN101172968B (zh) * 2006-11-01 2010-05-12 浙江天宇药业有限公司 2-正丙基-4甲基-6-(甲基苯并咪唑-2-基)苯并咪唑盐及其制备方法
CN101743228B (zh) * 2007-07-03 2014-01-29 新梅斯托克尔卡托瓦纳兹德拉韦尔公司 替米沙坦的制备方法
CZ302272B6 (cs) * 2007-07-09 2011-01-19 Zentiva, A. S. Zpusob výroby 4´-[[4-methyl-6-(1-methyl-1H-benzimidazol-2-yl)-2-propyl-1H-benzimidazol-1-yl]methyl]biphenyl-2-karboxylové kyseliny (telmisartanu)
WO2009116089A2 (en) * 2008-03-14 2009-09-24 Ipca Laboratories Limited Novel intermediates and method for synthesis of 4'-[(1,4'-dimethyl-2'-propyl-[2,6'- bi-1hbenzimidazol]-l-yl)methyl]-1,1-biphenyl]-2-carboxylic acid.
EP2103609A1 (en) * 2008-03-20 2009-09-23 Lek Pharmaceuticals D.D. Catalyzed carbonylation in the synthesis of angiotensin ii antagonists
EP2103588A1 (en) * 2008-03-20 2009-09-23 Lek Pharmaceuticals D.D. 2'-Halobiphenyl-4-yl intermediates in the synthesis of angiotensin II antagonists
US8410285B2 (en) 2008-03-20 2013-04-02 Lek Pharmaceuticals D.D. 2′-halobiphenyl-4-yl intermediates in the synthesis of angiotensin II antagonists
EP2123648A1 (en) 2008-05-20 2009-11-25 Chemo Ibérica, S.A. A process for the preparation of Telmisartan.
EP2149566A1 (en) 2008-07-15 2010-02-03 Chemo Ibérica, S.A. A process for the preparation of telmisartan
EP2443094B1 (en) 2009-06-19 2013-03-20 Krka Tovarna Zdravil, D.D., Novo Mesto Process for the preparation of telmisartan
EP2277866A1 (en) * 2009-06-22 2011-01-26 Inke, S.A. Process for preparing telmisartan
EP2305650A1 (en) 2009-09-21 2011-04-06 Chemo Ibérica, S.A. Novel process for the preparation of telmisartan
EA025946B1 (ru) 2010-10-27 2017-02-28 Крка, Товарна Здравил, Д. Д., Ново Место Многослойная фармацевтическая композиция, содержащая телмисартан и амлодипин
CN102267949A (zh) * 2011-06-14 2011-12-07 张长利 替米沙坦制备新工艺
WO2014027280A1 (en) 2012-08-14 2014-02-20 U Amarnath Amarnath One pot process for the preparation of telmisartan
CN103787982A (zh) * 2012-10-31 2014-05-14 上海特化医药科技有限公司 制备替米沙坦的方法及其中间体
CN104557724B (zh) * 2014-11-17 2017-01-11 江苏中邦制药有限公司 替米沙坦不定形晶型及其制备方法
CN105130905B (zh) * 2015-09-17 2017-09-08 浙江金立源药业有限公司 一种替米沙坦的合成方法
CN109912512B (zh) * 2017-12-13 2023-05-30 上海科胜药物研发有限公司 一种新的替米沙坦杂质化合物及其制备方法和用途
CN112251770B (zh) * 2020-10-14 2021-07-27 湖南大学 一种抗高血压药替米沙坦中间体电化学制备新方法
CN113307775B (zh) * 2021-04-16 2022-04-22 河北戴桥医药科技有限公司 一种替米沙坦的制备方法
WO2023204729A1 (ru) * 2022-04-19 2023-10-26 Общество с ограниченной ответственностью "Гелеспон" Фармацевтические композиции на основе новой субстанции 4-[2-(1н-имидазол-4-ил)-этилкарбамоил]-бутановой кислоты и способ получения субстанции

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4023369A1 (de) * 1990-07-23 1992-01-30 Thomae Gmbh Dr K Benzimidazole, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
RU1836357C (ru) * 1990-07-23 1993-08-23 Др.Карл Томэ ГмбХ Производные бензимидазола, их изомеры, смеси изомеров, гидраты или их физиологически переносимые соли, обладающие антагонистическими в отношении ангиотензина свойствами
DE4103492A1 (de) * 1991-02-06 1992-10-08 Thomae Gmbh Dr K Benzimidazole, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
SI9210098B (sl) * 1991-02-06 2000-06-30 Dr. Karl Thomae Benzimidazoli, zdravila, ki te spojine vsebujejo, in postopek za njihovo pripravo
US5591762A (en) * 1991-02-06 1997-01-07 Dr. Karl Thomae Gmbh Benzimidazoles useful as angiotensin-11 antagonists
US6358986B1 (en) * 1999-01-19 2002-03-19 Boehringer Ingelheim Pharma Kg Polymorphs of telmisartan
DE19901921C2 (de) * 1999-01-19 2001-01-04 Boehringer Ingelheim Pharma Polymorphe von Telmisartan, Verfahren zu deren Herstellung und deren Verwendung zur Herstellung eines Arzneimittels
US6737432B2 (en) * 2001-10-31 2004-05-18 Boehringer Ingelheim Pharma Kg Crystalline form of telmisartan sodium
DE10314702A1 (de) * 2003-03-31 2004-10-21 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verfahren zur Herstellung von Telmisartan

Also Published As

Publication number Publication date
AR043794A1 (es) 2005-08-10
ES2369081T3 (es) 2011-11-25
EP1611108B1 (de) 2011-07-06
NZ543244A (en) 2010-02-26
KR20050118699A (ko) 2005-12-19
SI1611108T1 (sl) 2011-10-28
SI2322511T1 (sl) 2013-10-30
ATE515500T1 (de) 2011-07-15
BRPI0408861A (pt) 2006-04-11
US8993778B2 (en) 2015-03-31
EP1611108A1 (de) 2006-01-04
KR101096499B1 (ko) 2011-12-20
CA2520714A1 (en) 2004-10-14
RU2430092C2 (ru) 2011-09-27
US20130137878A1 (en) 2013-05-30
MXPA05009529A (es) 2005-10-19
CN100418953C (zh) 2008-09-17
AU2004226239B2 (en) 2011-04-21
CY1112020T1 (el) 2015-11-04
CL2004000687A1 (es) 2005-02-04
EP2322511B1 (de) 2013-07-31
CN1768044A (zh) 2006-05-03
ES2432647T3 (es) 2013-12-04
DE10314702A1 (de) 2004-10-21
TW200504055A (en) 2005-02-01
EP2322511A1 (de) 2011-05-18
RU2005133479A (ru) 2006-07-27
PT1611108E (pt) 2011-09-01
JP2006521289A (ja) 2006-09-21
DK1611108T3 (da) 2011-10-10
PT2322511E (pt) 2013-08-29
AR087209A2 (es) 2014-02-26
DK2322511T3 (da) 2013-10-28
IL171145A (en) 2010-12-30
CA2520714C (en) 2012-05-15
JP5160740B2 (ja) 2013-03-13
US20040236113A1 (en) 2004-11-25
PL1611108T3 (pl) 2011-12-30
TWI335916B (en) 2011-01-11
PL2322511T3 (pl) 2014-01-31
AU2004226239A1 (en) 2004-10-14
US7193089B2 (en) 2007-03-20
CY1115156T1 (el) 2016-12-14
WO2004087676A1 (de) 2004-10-14
PE20050390A1 (es) 2005-06-23

Similar Documents

Publication Publication Date Title
UY28246A1 (es) Procedimiento para la preparación de telmisartan
AR120456A1 (es) Síntesis mejorada del compuesto inhibidor de g12c de kras
AR074845A1 (es) Procedimiento de sintesis de la ivabradina y de sus sales de adicion a un acido farmaceuticamente aceptable
AR079491A1 (es) Metodos de sintesis de inhibidores del factor xa tal como el betrixaban y composiciones farmaceuticas que contienen la base libre de betrixaban o su sal sustancialmente pura.
EA200901619A1 (ru) Способ получения телмисартана
CL2009001684A1 (es) Procedimiento de sintesis de agomelatina por reduccion de un grupo nitrilo en presencia de anhidrido acetico.
AR080921A1 (es) Proceso para la preparacion de amidas de acido pirazolcarboxilico
UY31883A (es) Nuevo procedimiento de síntesis de 7,8-dimetoxi-1, 3-dihidro-2h-3-benzazepin-2-ona, y aplicación en la síntesis de ivabradina y de sus sales de adición a un ácido farmacéuticamente aceptable
PE20090881A1 (es) Procedimiento de sintesis del (7-metoxi-1-naftil) acetonitrilo como intermediario en la sintesis de la agomelatina
AR107494A1 (es) Proceso para la preparación de osimertinib (azd9291) o una sal del mismo, y “azd9291 anilina” o una sal de la misma
AR066054A1 (es) Proceso para preparar galantamina
AR087345A1 (es) Metodos para la preparacion de compuestos de tiofeno
CL2012000739A1 (es) Procedimientos de preparacion del acido 2-[(3,5-difluoro-3'-metoxi-1,1'-bifenil-4-il)amino]nicotinico; y uno de los compuestos intermedios considerados.
AR056181A1 (es) Procedimiento para producir nonapeptido leuprolida
AR082593A1 (es) Proceso para la preparacion de pirazoles
RU2008138015A (ru) Способ получения n-(1-адамантил)ацетамида
MD4392B1 (ro) Procedeu de sinteză a (2E)-3-(3,4-dimetoxifenil)prop-2-ennitrilului şi aplicarea acestuia în sinteza ivabradinei şi a sărurilor sale de adiţie cu un acid acceptabil farmaceutic
DK1948590T3 (da) Fremgangsmåde til frembringelse af kontrastmidler
AR057778A1 (es) Proceso para la produccion de anilinas
MD4443B1 (ro) Procedeu de sinteză a 3,4-dimetoxibiciclo[4.2.0]octa-1,3,5-trien-7-carbonitrilului şi aplicarea lui în sinteza ivabradinei şi a sărurilor sale de adiţie cu un acid acceptabil farmaceutic
AR093901A1 (es) Proceso mejorado para la preparacion de determinadas sulfiliminas sustituidas
AR049478A1 (es) Un procedimiento para la preparacion de 3-amino-8-(1-piperazinil)-2h-1-benzopiran-2-ona. sales e hidratos y composiciones farmaceuticas.
AR053972A1 (es) Procedimiento para produccion de 2 - cloro-4- nitroimidazol
AR042194A1 (es) Metodo para preparar inhibidores de fosfodiesterasa - 4
AR042946A1 (es) Procedimiento para la fabricacion de alcaloides quinazolina

Legal Events

Date Code Title Description
109 Application deemed to be withdrawn

Effective date: 20150520