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UY27978A1 - Nuevos compuestos de oxazol y tiazol como inhibidores del factor de crecimiento transformador (tgf) - Google Patents

Nuevos compuestos de oxazol y tiazol como inhibidores del factor de crecimiento transformador (tgf)

Info

Publication number
UY27978A1
UY27978A1 UY27978A UY27978A UY27978A1 UY 27978 A1 UY27978 A1 UY 27978A1 UY 27978 A UY27978 A UY 27978A UY 27978 A UY27978 A UY 27978A UY 27978 A1 UY27978 A1 UY 27978A1
Authority
UY
Uruguay
Prior art keywords
tgf
compounds
growth factor
transforming growth
new
Prior art date
Application number
UY27978A
Other languages
English (en)
Inventor
Laura Cook Blumberg
Michael John Munchhof
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of UY27978A1 publication Critical patent/UY27978A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Emergency Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Se describen nuevos compuestos de oxazol y tiazol, incluyendo derivados de los mismos, intermedios para prepararlos, composiciones farmacéuticas que los contienen y su uso medicinal.Los compuestos de la presente invención son potentes inhibidores de la ruta de senalización del factor de crecimiento transformador ("TGF")-B. Son útiles en el tratamiento de diversas patologías relacionadas con TGF incluyendo, por ejemplo, cáncer y enfermedades fibróticas.
UY27978A 2002-09-18 2003-09-15 Nuevos compuestos de oxazol y tiazol como inhibidores del factor de crecimiento transformador (tgf) UY27978A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US41212002P 2002-09-18 2002-09-18
US47126503P 2003-05-16 2003-05-16
US48458103P 2003-07-02 2003-07-02

Publications (1)

Publication Number Publication Date
UY27978A1 true UY27978A1 (es) 2004-04-30

Family

ID=32034216

Family Applications (1)

Application Number Title Priority Date Filing Date
UY27978A UY27978A1 (es) 2002-09-18 2003-09-15 Nuevos compuestos de oxazol y tiazol como inhibidores del factor de crecimiento transformador (tgf)

Country Status (28)

Country Link
US (1) US7273936B2 (es)
EP (1) EP1542994B1 (es)
JP (1) JP4518956B2 (es)
KR (1) KR20050057415A (es)
CN (1) CN1681810A (es)
AP (1) AP2005003261A0 (es)
AR (1) AR041273A1 (es)
AT (1) ATE430147T1 (es)
AU (1) AU2003256003A1 (es)
BR (1) BR0314383A (es)
CA (1) CA2499429C (es)
CO (1) CO5550473A2 (es)
CR (1) CR7743A (es)
DE (1) DE60327443D1 (es)
EA (1) EA200500354A1 (es)
ES (1) ES2323421T3 (es)
HR (1) HRP20050250A2 (es)
IS (1) IS7711A (es)
MA (1) MA27443A1 (es)
MX (1) MXPA05002332A (es)
NO (1) NO20051838L (es)
OA (1) OA12926A (es)
PA (1) PA8582701A1 (es)
PE (1) PE20040987A1 (es)
PL (1) PL375975A1 (es)
TW (1) TW200413362A (es)
UY (1) UY27978A1 (es)
WO (1) WO2004026863A1 (es)

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US9242969B2 (en) 2013-03-14 2016-01-26 Novartis Ag Biaryl amide compounds as kinase inhibitors
JP6474166B2 (ja) 2014-01-01 2019-02-27 メディベイション テクノロジーズ エルエルシー 化合物及び使用方法
UY36294A (es) 2014-09-12 2016-04-29 Novartis Ag Compuestos y composiciones como inhibidores de quinasa
CN105585565B (zh) * 2014-10-23 2019-10-01 中国医学科学院药物研究所 含2-苯胺基-4-噻唑基吡啶衍生物及其制法和药物组合物与用途
CN106243012A (zh) * 2016-08-02 2016-12-21 北方民族大学 新型吲哚类衍生物及其制备方法
CN109715163B (zh) 2016-09-19 2022-11-22 诺华股份有限公司 包含raf抑制剂和erk抑制剂的治疗组合
JP7309614B2 (ja) 2017-05-02 2023-07-18 ノバルティス アーゲー 組み合わせ療法
IL271149B2 (en) * 2017-06-14 2024-05-01 Trevena Inc Compounds for modulating s1p1 activity and methods of using the same
CN113795490A (zh) 2019-05-13 2021-12-14 诺华股份有限公司 N-(3-(2-(2-羟基乙氧基)-6-吗啉代吡啶-4-基)-4-甲基苯基)-2(三氟甲基)异烟酰胺的新结晶形式作为Raf抑制剂治疗癌症
CN112694477B (zh) * 2019-10-22 2024-02-06 四川科伦博泰生物医药股份有限公司 吡唑并环类化合物，包含其的药物组合物，其制备方法及其用途
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Also Published As

Publication number Publication date
IS7711A (is) 2005-02-24
CO5550473A2 (es) 2005-08-31
BR0314383A (pt) 2005-07-19
PL375975A1 (en) 2005-12-12
PA8582701A1 (es) 2004-04-23
MA27443A1 (fr) 2005-07-01
EP1542994B1 (en) 2009-04-29
AR041273A1 (es) 2005-05-11
NO20051838L (no) 2005-04-15
US7273936B2 (en) 2007-09-25
TW200413362A (en) 2004-08-01
HRP20050250A2 (en) 2005-10-31
WO2004026863A1 (en) 2004-04-01
CN1681810A (zh) 2005-10-12
CR7743A (es) 2005-06-15
AP2005003261A0 (en) 2005-03-31
JP4518956B2 (ja) 2010-08-04
ES2323421T3 (es) 2009-07-15
ATE430147T1 (de) 2009-05-15
EA200500354A1 (ru) 2005-10-27
PE20040987A1 (es) 2004-12-27
US20040110797A1 (en) 2004-06-10
OA12926A (en) 2006-10-13
AU2003256003A1 (en) 2004-04-08
CA2499429C (en) 2010-09-21
KR20050057415A (ko) 2005-06-16
WO2004026863A8 (en) 2005-04-21
EP1542994A1 (en) 2005-06-22
CA2499429A1 (en) 2004-04-01
JP2006502235A (ja) 2006-01-19
MXPA05002332A (es) 2005-06-08
DE60327443D1 (de) 2009-06-10

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Effective date: 20150504