UY27864A1 - Producción de péptidos y proteinas por acumulación de cuerpos proteicos derivados de retículo endoplásmico en plantas - Google Patents
Producción de péptidos y proteinas por acumulación de cuerpos proteicos derivados de retículo endoplásmico en plantasInfo
- Publication number
- UY27864A1 UY27864A1 UY27864A UY27864A UY27864A1 UY 27864 A1 UY27864 A1 UY 27864A1 UY 27864 A UY27864 A UY 27864A UY 27864 A UY27864 A UY 27864A UY 27864 A1 UY27864 A1 UY 27864A1
- Authority
- UY
- Uruguay
- Prior art keywords
- nucleic acid
- protein
- endoplasm
- peptides
- proteins
- Prior art date
Links
- 108090000623 proteins and genes Proteins 0.000 title abstract 5
- 102000004169 proteins and genes Human genes 0.000 title abstract 5
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 3
- 238000009825 accumulation Methods 0.000 title 1
- 102000004196 processed proteins & peptides Human genes 0.000 title 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 5
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 3
- 239000002773 nucleotide Substances 0.000 abstract 3
- 125000003729 nucleotide group Chemical group 0.000 abstract 3
- 108020004707 nucleic acids Proteins 0.000 abstract 2
- 102000039446 nucleic acids Human genes 0.000 abstract 2
- 108010055615 Zein Proteins 0.000 abstract 1
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 1
- 230000002255 enzymatic effect Effects 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 210000003660 reticulum Anatomy 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
- C07K14/425—Zeins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/585—Calcitonins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8216—Methods for controlling, regulating or enhancing expression of transgenes in plant cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8216—Methods for controlling, regulating or enhancing expression of transgenes in plant cells
- C12N15/8221—Transit peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
- C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
Landscapes
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cell Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Botany (AREA)
- Pharmacology & Pharmacy (AREA)
- Toxicology (AREA)
- Endocrinology (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
Abstract
Se describe una molécula de ácido nucleico como que contiene una primera secuencia de ácido nucleico que comprende una secuencia de nucleótidos que codifica la proteína zeína y, o un fragmento de la misma capaz de dirigir y retener una proteína en retículo en doplásmico (ER) de una célula vegetal; una segunda secuencia de ácido nucleico que contiene una secuencia de nucleótidos que codifica una secuencia de aminoácidos que se puede escindir enzimáticamente por medios enzimáticos o químicos; y una tercera secuencia de ácidos nucleicos que contiene la secuencia de nucleóticos que codifica un péptido o una proteína de interés. También se describen los procedimientos de uso de esta molécula de ácido nucleico para transformar las células huéspedes vegetales y producir el péptido o la proteína de interés.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES200201508A ES2224792B1 (es) | 2002-06-28 | 2002-06-28 | Produccion de peptidos y proteinas por acumulacion de cuerpos proteicos derivados de reticulos endoplasmico en plantas. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UY27864A1 true UY27864A1 (es) | 2003-09-30 |
Family
ID=29797406
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UY27864A UY27864A1 (es) | 2002-06-28 | 2003-06-25 | Producción de péptidos y proteinas por acumulación de cuerpos proteicos derivados de retículo endoplásmico en plantas |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US7575898B2 (es) |
| EP (1) | EP1523558B1 (es) |
| JP (2) | JP4610334B2 (es) |
| KR (2) | KR100987946B1 (es) |
| CN (1) | CN100460510C (es) |
| AR (1) | AR040293A1 (es) |
| AT (1) | ATE366317T1 (es) |
| AU (1) | AU2002333330B2 (es) |
| CA (1) | CA2490348A1 (es) |
| DE (1) | DE60221051T2 (es) |
| DK (1) | DK1523558T3 (es) |
| ES (2) | ES2224792B1 (es) |
| MX (1) | MXPA05000290A (es) |
| RU (1) | RU2381275C2 (es) |
| UY (1) | UY27864A1 (es) |
| WO (1) | WO2004003207A1 (es) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050032211A1 (en) * | 1996-09-26 | 2005-02-10 | Metabogal Ltd. | Cell/tissue culturing device, system and method |
| IL155588A0 (en) * | 2003-04-27 | 2003-11-23 | Metabogal Ltd | Methods for expression of enzymatically active recombinant lysosomal enzymes in transgenic plant root cells and vectors used thereby |
| ES2224792B1 (es) * | 2002-06-28 | 2007-02-16 | Era Plantech, S.L. | Produccion de peptidos y proteinas por acumulacion de cuerpos proteicos derivados de reticulos endoplasmico en plantas. |
| US7951557B2 (en) | 2003-04-27 | 2011-05-31 | Protalix Ltd. | Human lysosomal proteins from plant cell culture |
| GB0426160D0 (en) * | 2004-11-29 | 2004-12-29 | Era Plantech S L | Production of proteins |
| GB0426161D0 (en) * | 2004-11-29 | 2004-12-29 | Era Plantech S L | Protein isolation and purification |
| DE112006000559T5 (de) * | 2005-03-07 | 2008-04-30 | National University Corporation Nagoya University, Nagoya | Verfahren zur Expression und Anreicherung eines Peptids in einer Pflanze |
| US8163880B2 (en) * | 2006-02-23 | 2012-04-24 | Era Biotech S.A. | Production of biologically active proteins |
| US9555097B2 (en) | 2006-02-23 | 2017-01-31 | Era Biotech, S.A. | Recombinant protein bodies as immunogen-specific adjuvants |
| US7732569B2 (en) * | 2006-10-19 | 2010-06-08 | E.I. Du Pont De Nemours And Company | Zein-based peptide tags for the expression and purification of bioactive peptides |
| JP2010525833A (ja) | 2007-05-07 | 2010-07-29 | プロタリクス リミテッド | 大規模な使い捨て型バイオリアクター |
| AU2009202819B2 (en) | 2007-07-13 | 2014-08-28 | Aramis Biotechnologies Inc. | Recombinant influenza virus-like particles (VLPs) produced in transgenic plants expressing hemagglutinin |
| CA2615372A1 (en) | 2007-07-13 | 2009-01-13 | Marc-Andre D'aoust | Influenza virus-like particles (vlps) comprising hemagglutinin |
| JP5809054B2 (ja) * | 2008-07-08 | 2015-11-10 | メディカゴ インコーポレイテッド | 可溶性組換えインフルエンザ抗原 |
| MX392585B (es) | 2009-06-24 | 2025-03-19 | Medicago Inc | Particulas similares al virus de la influenza quimericas que comprenden hemaglutinina. |
| RU2415936C1 (ru) * | 2010-01-11 | 2011-04-10 | Учреждение Российской академии наук Институт химической биологии и фундаментальной медицины Сибирского отделения РАН (ИХБФМ СО РАН) | Способ секреции зеленого флуоресцентного белка (gfp) из растительных клеток |
| EP2418284A1 (en) * | 2010-08-13 | 2012-02-15 | ERA Biotech, S.A. | Protein body-inducing polypeptide sequences |
| EP2468870A1 (en) * | 2010-12-23 | 2012-06-27 | Philip Morris Products S.A. | Method for expressing desxoyribonuclease in plants |
| EP2468871A1 (en) * | 2010-12-23 | 2012-06-27 | Philip Morris Products S.A. | Method for producing apolipoprotein in plants |
| EP2468872A1 (en) | 2010-12-23 | 2012-06-27 | Philip Morris Products S.A. | Method for producing mullerian inhibitor substance in plants |
| WO2012098119A2 (en) | 2011-01-17 | 2012-07-26 | Philip Morris Products S.A. | Protein expression in plants |
| FI20115704L (fi) | 2011-07-01 | 2013-01-02 | Teknologian Tutkimuskeskus Vtt Oy | Vierasproteiinien tuoton parantaminen |
| US9603906B2 (en) | 2012-02-01 | 2017-03-28 | Protalix Ltd. | Inhalable liquid formulations of DNase I |
| CA2969891A1 (en) * | 2014-12-05 | 2016-06-09 | Planet Biotechnology Inc. | Dpp4 immunoadhesin compositions and methods |
| DE102015107846A1 (de) | 2015-05-19 | 2016-11-24 | Johann Wolfgang Goethe-Universität Frankfurt | Synthetische Organellen in Hefe |
| KR101848082B1 (ko) * | 2017-05-11 | 2018-04-12 | 주식회사 바이오앱 | 셀룰로오즈 결합 도메인을 포함하는 재조합 벡터 및 상기 벡터를 사용하여 단백질을 분리정제하는 방법 |
| MX2019014203A (es) | 2017-05-30 | 2020-01-23 | Agrivida Inc | Plantas transgenicas inmunomoduladoras y metodos relacionados. |
| AU2021353004A1 (en) | 2020-09-30 | 2023-04-13 | Nobell Foods, Inc. | Recombinant milk proteins and food compositions comprising the same |
| US10894812B1 (en) | 2020-09-30 | 2021-01-19 | Alpine Roads, Inc. | Recombinant milk proteins |
| US10947552B1 (en) | 2020-09-30 | 2021-03-16 | Alpine Roads, Inc. | Recombinant fusion proteins for producing milk proteins in plants |
| CN113683669B (zh) * | 2021-03-25 | 2023-05-16 | 中国农业大学 | 基于与醇溶蛋白的互作在植物中积累目标蛋白的方法 |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4215040A (en) | 1978-12-22 | 1980-07-29 | The Procter & Gamble Company | Density separation process |
| DE3856589D1 (de) * | 1987-10-20 | 2006-04-06 | Bayer Bioscience Nv | 5'-flankierende Region eines Genes von Arabidopsis, das für einen 2S Albumin-Prekursor kodiert |
| AU2811889A (en) | 1987-10-20 | 1989-05-23 | Plant Genetic Systems N.V. | A process for the production of biologically active peptide via the expression of modified storage seed protein genes in transgenic plants |
| US5589615A (en) | 1988-10-14 | 1996-12-31 | Plant Genetic Systems N.V. | Process for the production of transgenic plants with increased nutritional value via the expression of modified 2S storage albumins |
| US5571697A (en) * | 1989-05-05 | 1996-11-05 | Baylor College Of Medicine Texas Medical Center | Expression of processed recombinant lactoferrin and lactoferrin polypeptide fragments from a fusion product in Aspergillus |
| US5650554A (en) | 1991-02-22 | 1997-07-22 | Sembiosys Genetics Inc. | Oil-body proteins as carriers of high-value peptides in plants |
| US5948682A (en) * | 1991-02-22 | 1999-09-07 | Sembiosys Genetics Inc. | Preparation of heterologous proteins on oil bodies |
| ES2235176T3 (es) | 1994-10-24 | 2005-07-01 | THE TEXAS A & M UNIVERSITY SYSTEM | Inmunizacion oral con plantas transgenicas. |
| US5935822A (en) | 1995-03-21 | 1999-08-10 | The Regents Of The University Of Colorado | Product and process for membrane and soluble polypeptide segregation |
| FR2744134B1 (fr) | 1996-01-29 | 1998-04-03 | Biocem | Proteines de reserve de plantes enrichies en acides amines, notamment alpha-zeine de mais enrichie en lysine plantes exprimant ces proteines |
| US5990384A (en) | 1996-05-31 | 1999-11-23 | New Mexico State University | Co-expression of proteins |
| DE69836552T3 (de) | 1997-09-30 | 2014-10-09 | The Regents Of The University Of California | Herstellung von proteinen in pflanzensamen |
| AR020090A1 (es) | 1998-06-15 | 2002-04-10 | John Innes Ct | Celula vegetal monocotiledonea o semilla de ella,planta o parte de una planta, metodo para hacer una celula vegetal monocotiledonea, metodo para hacer unaplanta, uso de una construccion de expresion para producir una celula de planta o semilla monocotiledonea, y uso de una construccion de expresion |
| CA2358548A1 (en) * | 1998-12-31 | 2000-07-13 | New Mexico State University Technology Transfer Corporation | Co-expression of proteins |
| US20020061309A1 (en) * | 2000-03-08 | 2002-05-23 | Garger Stephen J. | Production of peptides in plants as N-terminal viral coat protein fusions |
| US7417178B2 (en) | 2000-05-02 | 2008-08-26 | Ventria Bioscience | Expression of human milk proteins in transgenic plants |
| AU2002256310A1 (en) | 2001-04-18 | 2002-11-05 | New Mexico State University Technology Transfer Corporation | Co-expression of zein proteins |
| JP3940793B2 (ja) | 2002-05-15 | 2007-07-04 | 独立行政法人農業生物資源研究所 | 任意のペプチドを植物のタンパク顆粒で蓄積させる方法 |
| DK1521767T3 (da) | 2002-05-24 | 2010-04-12 | Medtronic Inc | Fremgangsmåder og konstrukter til ekspression af clostripain med højt udbytte |
| ES2224792B1 (es) | 2002-06-28 | 2007-02-16 | Era Plantech, S.L. | Produccion de peptidos y proteinas por acumulacion de cuerpos proteicos derivados de reticulos endoplasmico en plantas. |
| JP2007517504A (ja) | 2003-12-09 | 2007-07-05 | ベントリア バイオサイエンス | 融合担体として種子貯蔵蛋白を利用する植物種子中の融合ポリペプチドの高水準発現 |
| CA2558621C (en) | 2004-03-08 | 2013-04-30 | Syngenta Participations Ag | Promoter from maize prolamin seed storage protein and uses thereof |
| US20080034455A1 (en) | 2004-05-21 | 2008-02-07 | Simon Fraser University | Production Of A Protein Localized To The Endoplasmic Reticulum Protein Bodies In A Transgenic Plant And Seed |
| GB0426160D0 (en) | 2004-11-29 | 2004-12-29 | Era Plantech S L | Production of proteins |
| GB0426161D0 (en) | 2004-11-29 | 2004-12-29 | Era Plantech S L | Protein isolation and purification |
| CN101668544B (zh) * | 2006-12-26 | 2013-04-24 | 株式会社新日本科学 | 经鼻投用制剂 |
-
2002
- 2002-06-28 ES ES200201508A patent/ES2224792B1/es not_active Expired - Fee Related
- 2002-08-05 MX MXPA05000290A patent/MXPA05000290A/es active IP Right Grant
- 2002-08-05 EP EP02807566A patent/EP1523558B1/en not_active Expired - Lifetime
- 2002-08-05 RU RU2005101738/13A patent/RU2381275C2/ru not_active IP Right Cessation
- 2002-08-05 AT AT02807566T patent/ATE366317T1/de not_active IP Right Cessation
- 2002-08-05 ES ES02807566T patent/ES2289185T3/es not_active Expired - Lifetime
- 2002-08-05 KR KR1020047021412A patent/KR100987946B1/ko not_active Expired - Fee Related
- 2002-08-05 CN CNB028293754A patent/CN100460510C/zh not_active Expired - Fee Related
- 2002-08-05 KR KR1020097024928A patent/KR20100017491A/ko not_active Ceased
- 2002-08-05 WO PCT/EP2002/008716 patent/WO2004003207A1/en not_active Ceased
- 2002-08-05 CA CA002490348A patent/CA2490348A1/en not_active Abandoned
- 2002-08-05 AU AU2002333330A patent/AU2002333330B2/en not_active Ceased
- 2002-08-05 DE DE60221051T patent/DE60221051T2/de not_active Expired - Lifetime
- 2002-08-05 JP JP2004516544A patent/JP4610334B2/ja not_active Expired - Fee Related
- 2002-08-05 DK DK02807566T patent/DK1523558T3/da active
- 2002-08-06 US US10/213,462 patent/US7575898B2/en not_active Expired - Fee Related
-
2003
- 2003-06-25 UY UY27864A patent/UY27864A1/es not_active Application Discontinuation
- 2003-06-27 AR ARP030102330A patent/AR040293A1/es active IP Right Grant
-
2009
- 2009-08-17 US US12/542,514 patent/US8802825B2/en not_active Expired - Fee Related
-
2010
- 2010-05-12 JP JP2010110481A patent/JP2010213713A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| ES2224792B1 (es) | 2007-02-16 |
| EP1523558A1 (en) | 2005-04-20 |
| US20040005660A1 (en) | 2004-01-08 |
| RU2005101738A (ru) | 2006-07-20 |
| RU2381275C2 (ru) | 2010-02-10 |
| CN1639342A (zh) | 2005-07-13 |
| MXPA05000290A (es) | 2005-03-31 |
| US20100083403A1 (en) | 2010-04-01 |
| ES2289185T3 (es) | 2008-02-01 |
| AU2002333330B2 (en) | 2007-07-12 |
| US8802825B2 (en) | 2014-08-12 |
| ATE366317T1 (de) | 2007-07-15 |
| WO2004003207A1 (en) | 2004-01-08 |
| KR100987946B1 (ko) | 2010-10-18 |
| AR040293A1 (es) | 2005-03-23 |
| EP1523558B1 (en) | 2007-07-04 |
| KR20050024419A (ko) | 2005-03-10 |
| CA2490348A1 (en) | 2004-01-08 |
| DE60221051T2 (de) | 2008-03-13 |
| JP2005531309A (ja) | 2005-10-20 |
| CN100460510C (zh) | 2009-02-11 |
| AU2002333330A1 (en) | 2004-01-19 |
| DE60221051D1 (de) | 2007-08-16 |
| KR20100017491A (ko) | 2010-02-16 |
| WO2004003207A9 (en) | 2005-02-10 |
| DK1523558T3 (da) | 2007-11-05 |
| US7575898B2 (en) | 2009-08-18 |
| JP2010213713A (ja) | 2010-09-30 |
| ES2224792A1 (es) | 2005-03-01 |
| JP4610334B2 (ja) | 2011-01-12 |
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