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US7727195B2 - Syringe device having venting system - Google Patents

Syringe device having venting system Download PDF

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Publication number
US7727195B2
US7727195B2 US11/169,345 US16934505A US7727195B2 US 7727195 B2 US7727195 B2 US 7727195B2 US 16934505 A US16934505 A US 16934505A US 7727195 B2 US7727195 B2 US 7727195B2
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US
United States
Prior art keywords
plunger rod
syringe
syringe tube
cavity
plunger
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime, expires
Application number
US11/169,345
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English (en)
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US20060116644A1 (en
Inventor
Paul H. Norton
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
West Pharmaceutical Services Inc
Original Assignee
West Pharmaceutical Services Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by West Pharmaceutical Services Inc filed Critical West Pharmaceutical Services Inc
Priority to US11/169,345 priority Critical patent/US7727195B2/en
Assigned to WEST PHARMACEUTICAL SERVICES, INC. reassignment WEST PHARMACEUTICAL SERVICES, INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: NORTON, PAUL H.
Publication of US20060116644A1 publication Critical patent/US20060116644A1/en
Application granted granted Critical
Publication of US7727195B2 publication Critical patent/US7727195B2/en
Adjusted expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31511—Piston or piston-rod constructions, e.g. connection of piston with piston-rod
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M2005/3117—Means preventing contamination of the medicament compartment of a syringe
    • A61M2005/3121—Means preventing contamination of the medicament compartment of a syringe via the proximal end of a syringe, i.e. syringe end opposite to needle cannula mounting end
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M2005/3123—Details having air entrapping or venting means, e.g. purging channels in pistons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M3/00—Medical syringes, e.g. enemata; Irrigators
    • A61M3/005—Medical syringes, e.g. enemata; Irrigators comprising means for injection of two or more media, e.g. by mixing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/3145—Filters incorporated in syringes

Definitions

  • This invention generally relates to syringe devices and, more particularly, to a venting system for use with a syringe device that operates to lessen the likelihood of contamination of contents of the syringe device.
  • a solvent from a syringe device is injected into a container containing the concentrated drug.
  • the reconstituted drug is drawn from the container into the syringe device and then subsequently administered to a patient using the syringe device.
  • the syringe devices of the prior art typically have no seal between a plunger rod and an end of the syringe tube in which the plunger rod is inserted. It is because of this lack of a seal in conventional syringe devices that potentially contaminated air is able to access an upper area of the syringe tube during the reconstitution process, thereby potentially contaminating an interior wall of the syringe tube.
  • the mixture is drawn back into the syringe tube, the mixture comes into contact with the interior wall of the syringe tube, thereby potentially becoming contaminated.
  • Some drugs take longer to dissolve than others, resulting in increased reconstitution process durations and an increased possibility of contamination.
  • the present invention is a syringe device for administering a medicament.
  • the syringe device comprises a syringe tube having a side wall, a distal end, and a proximal end defining a cavity within the syringe tube for containing the medicament.
  • the distal end has a passageway in fluid communication with the cavity.
  • a plunger rod sealingly engages with the syringe tube.
  • the plunger rod is slidingly disposed at least partially within the cavity of the syringe tube.
  • the plunger rod has a distal end, a generally hollow interior, and a generally open proximal end.
  • the plunger rod includes at least one aperture in fluid communication with the hollow interior of the plunger rod.
  • a plunger tip is engaged with the distal end of the plunger rod and is slidable therewith within the cavity.
  • the plunger tip sealingly interacts with an inner surface of the side wall of the syringe tube to separate the cavity into first and second areas.
  • the first area is disposed between the plunger tip and the proximal end of the syringe tube.
  • the second area is disposed between the plunger tip and the distal end of the syringe tube.
  • the at least one aperture fluidly connects the hollow interior of the plunger rod and the first area of the cavity of the syringe tube, such that the generally hollow interior of the plunger rod allows air to move between an outside of the syringe device and the first area of the cavity during sliding movement of the plunger rod within the syringe tube.
  • the present invention is in a plunger for use with a syringe tube having a side wall, a distal end, and a proximal end defining a cavity within the syringe tube for containing a medicament.
  • the distal end has a passageway in fluid communication with the cavity.
  • the plunger comprises a plunger rod sealingly engaged with the syringe tube.
  • the plunger rod is slidingly disposed at least partially within the cavity of the syringe tube.
  • the plunger rod has a distal end, a generally hollow interior, and a generally open proximal end.
  • the plunger rod includes at least one aperture in fluid communication with the hollow interior of the plunger rod.
  • a plunger tip is engaged with the distal end of the plunger rod and is slidable therewith within the cavity.
  • the plunger tip sealingly interacts with an inner surface of the side wall of the syringe tube to separate the cavity into first and second areas.
  • the first area is disposed between the plunger tip and the proximal end of the syringe tube.
  • the second area is disposed between the plunger tip and the distal end of the syringe tube.
  • the at least one aperture fluidly connects the hollow interior of the plunger rod and the first area of the cavity of the syringe tube, such that the generally hollow interior of the plunger rod allows air to move between an outside of the syringe tube and the first area of the cavity during sliding movement of the plunger rod within the syringe tube.
  • FIG. 1 is a side rear perspective view of a syringe device having a vented plunger rod in accordance with a preferred embodiment of the present invention
  • FIG. 2 is an exploded perspective view of the syringe device of FIG. 1 ;
  • FIG. 3 is a side elevational view of the syringe device of FIG. 1 ;
  • FIG. 4 is a rear elevational view of the syringe device of FIG. 1 ;
  • FIG. 5 is a cross-sectional view of the syringe device of FIG. 4 taken along line 5 — 5 .
  • FIGS. 1-5 a preferred embodiment of a syringe device, indicated generally at 10 , for administering a medicament (not shown), the syringe device 10 having a venting system in accordance with the present invention.
  • the venting system of the syringe device 10 is a plunger 17 including a vented plunger rod 20 .
  • the syringe device 10 comprises the generally hollow plunger rod 20 slidingly disposed at least partially within a cavity 40 g of the syringe tube 40 .
  • the syringe tube 40 has a side wall 40 d , a distal end 40 e , and a proximal end 40 f having an opening 40 i defining the cavity 40 g within the syringe tube 40 for containing the medicament.
  • the distal end 40 e preferably has a nozzle 42 extending generally axially therefrom with a passageway 44 therethrough in fluid communication with the cavity 40 g of the syringe tube 40 .
  • a collar 46 is affixed to the nozzle 42 to enable a needle (not shown) or other such device to be removably engaged to the nozzle 42 during use of the syringe device 10 .
  • the collar 46 is a luer lock or other such retaining device, although this is not intended to be limiting, as it is within the spirit and scope of the present invention that the collar 46 be any retaining device capable of retaining the needle or other similar device on the nozzle 42 .
  • the plunger rod 20 is sealingly engaged with the syringe tube 40 .
  • the plunger rod 20 preferably is generally cylindrical and has a generally hollow interior 20 a , a distal end 20 c , and a generally open proximal end 20 b .
  • the plunger rod 20 includes at least one aperture 28 in fluid communication with the hollow interior 20 a of the plunger rod 20 .
  • the at least one aperture 28 be disposed proximate the distal end 20 c of the plunger rod 20 , although it is within the spirit and scope of the present invention that the at least one aperture 28 be located at any location along the plunger rod 20 , provided the at least one aperture 28 remains within the cavity 40 g of the syringe tube 40 during a desired range of motion of the plunger rod 20 . Additionally, it is preferable that there be two apertures 28 , preferably diametrically opposed and disposed proximate the distal end 20 c of the plunger rod 20 .
  • the proximal end 20 b of the plunger rod 20 preferably has an opening 20 e therein.
  • a filter 26 is disposed within the proximal end 20 b of the plunger rod 20 through which air passes during sliding movement of the plunger rod 20 within the syringe tube 40 . It is preferred that the filter 26 extends completely across the opening 20 e in the proximal end 20 b of the plunger rod 20 .
  • the filter 26 is a microbial filter 26 for removing at least some contaminants from the air.
  • a generally annular flange 20 d extending radially outwardly from the proximal end 20 b of the plunger rod 20 is a generally annular flange 20 d .
  • the flange 20 d preferably includes a face or raised portion 22 extending axially outwardly from the flange 20 d .
  • the raised portion 22 includes at least one radial groove 24 therein.
  • the raised portion 22 includes four evenly spaced grooves 24 extending radially therethrough. Although it is preferred that there be four evenly spaced grooves 24 , it is within the spirit and scope of the present invention that there be more or less than four grooves 24 and that they be unevenly spaced.
  • a generally rigid piece of material (not shown) be attached to the proximal end 20 b of the plunger rod 20 , preferably bonded to the raised portion 22 using adhesive, thermal welding, or sonic welding, to name a few, in order to at least partially cover the filter 26 while leaving the at least one groove 24 generally unobstructed.
  • the piece of material acts to at least partially protect the filter 26 from damage, such as, but not limited to, tearing or puncturing during use or storage of the syringe device 10 .
  • a plunger tip 18 is engaged with the distal end 20 c of the plunger rod 20 and is slidable therewith within the cavity 40 g throughout a desired range of motion.
  • the plunger tip 18 is preferably made from an elastomeric material such as rubber.
  • the plunger tip 18 is generally cylindrical in shape, having a generally conical distal end 18 b , and sized so as to fit snugly within the syringe tube 40 .
  • the plunger tip 18 is in constant direct sealing engagement and sealingly interacts with an inner surface 40 a of the side wall 40 d of the syringe tube 40 to separate the cavity 40 g into first and second areas 40 b , 40 c as the plunger tip 18 slides throughout the desired range of motion, as will be described in more detail below.
  • the plunger tip 18 preferably has a circular cavity 18 a centrally disposed in a proximal end 18 c and extending a distance into the plunger tip 18 .
  • the cavity 18 a is preferably shaped to frictionally engage the distal end 20 c of the plunger rod 20 so that the plunger tip 18 moves with the plunger rod 20 , thereby forming the plunger 17 .
  • the distal end 20 c of the plunger rod 20 have a radially extending nib 20 f which engages within an annular recess 18 d within the cavity 18 a of the plunger tip 18 .
  • the plunger tip 18 be retained on the distal end 20 c of the plunger rod 18 in a different manner, such as, but not limited to, threadably engaging the plunger tip 18 onto the distal end 20 c of the plunger rod 18 .
  • the at least one aperture 28 is disposed through the plunger rod 20 proximate the distal end 20 c , preferably close to the proximal end 18 c of the plunger tip 18 . Although this location is preferred, it is within the spirit and scope of the present invention that the at least one aperture 28 be disposed in any portion of the plunger rod 20 that does not come into direct contact with outside air during a reconstitution process. b 2
  • the plunger rod 20 and the plunger tip 18 are slidable within the syringe tube 40 such that the plunger tip 18 creates a moveable seal with the inner surface 40 a of the syringe tube 40 to divide the syringe tube 40 into the first and second areas 40 b , 40 c .
  • the first area 40 b of the cavity 40 of the syringe tube 40 is disposed between the plunger tip 18 and the proximal end 40 f of the syringe tube 40
  • the second area 40 c is disposed between the plunger tip 18 and the distal end 40 e of the syringe tube 40 .
  • the first area 40 b (or a first cavity 40 b ) is defined between the seal 16 and the plunger tip 18 and between the syringe tube 40 and the plunger rod 20 .
  • the plunger tip 18 allows for the pushing of liquid (not shown) out of or the drawing of a mixture (not shown) into the second area 40 c between the plunger tip 18 and the distal end 40 e of the syringe tube 40 while not allowing any of the liquid or mixture into the first area 40 b between the plunger tip 18 and the proximal end 40 f of the syringe tube 40 .
  • the at least one aperture 28 fluidly connects the hollow interior 20 a of the plunger rod 20 and the first area 40 b of the cavity 40 g of the syringe tube 40 , such that the generally hollow interior 20 a of the plunger rod 20 allows air to move between outside of the syringe device 10 and the first area 40 b of the cavity 40 g during sliding movement of the plunger rod 20 within the syringe tube 40 .
  • the first cavity 40 b is vented to an exterior of the syringe device 10 through a flowpath including the at least one aperture 28 , the hollow interior of the plunger rod 20 and the filter 26 .
  • a radially extending generally ovular flange 40 h is preferably positioned at or near the proximal end 40 f of the syringe tube 40 to provide a surface for a user to grip the syringe tube 40 during use of the syringe device 10 .
  • a connection member 12 is preferably engaged with the proximal end 40 f of the syringe tube 40 to essentially cap the proximal end 40 f of the syringe tube 40 .
  • connection member 12 is portrayed in the figures as clipping onto the proximal end 40 f of the syringe tube 40 , it is within the spirit and scope of the present invention that the connection member 12 be attached to the proximal end 40 f of the syringe tube 40 in other ways, provided the connection member 12 still functions in the manner described below. For instance, attachment can be accomplished by bonding the connection member 12 to the proximal end 40 f of the syringe tube 40 using adhesive, thermal welding, or sonic welding, to name a few. b 3
  • connection member 12 preferably has a hole through a top surface through which the plunger rod 20 passes.
  • the connection member 12 functions to retain a seal 16 disposed between the syringe tube 40 and the plunger rod 20 at or near the proximal end 40 f of the syringe tube 40 for sealingly engaging the plunger rod 20 and the syringe tube 40 to inhibit air from passing into the first area 40 b of the cavity 40 g of the syringe tube 40 between the plunger rod 20 and the proximal end 40 f of the syringe tube 40 .
  • the seal 16 is supported by the syringe tube 40 proximate the opening 40 i at the proximal end of the syringe tube 40 in slidable sealing engagement with the plunger rod 20 and inhibits outside air from directly entering and exiting the first area 40 b of the syringe tube 40 .
  • the seal 16 is preferably an elastomeric O-ring seal 16 .
  • a separate sleeve (not shown) be used to wrap around the proximal end 40 f of the syringe tube 40 and the connection member 12 , thereby helping to retain the seal 16 within the proximal end 40 f of the syringe tube 40 .
  • a separate sleeve (not shown) be used to wrap around the proximal end 40 f of the syringe tube 40 and the connection member 12 , thereby helping to retain the seal 16 within the proximal end 40 f of the syringe tube 40 .
  • the plunger rod 20 , the syringe tube 40 , and the connection member 12 are made of a polymeric material, although it is within the spirit and scope of the present invention that these components be made of different materials, such as glass or metal, for instance.
  • the syringe device 10 contains a liquid (not shown), such as a saline solution, in the second area 40 c of the syringe tube 40 between the plunger tip 18 and the distal end 40 e of the syringe tube 40 .
  • the distal end 40 e of the syringe tube 40 is then engaged with a container (not shown) containing a powdered medicinal product (not shown).
  • a needle (not shown) is engaged to the nozzle 42 using the collar 46 to retain the needle thereon. The needle can then be used to engage the syringe device 10 with the container and provide a fluid connection therebetween.
  • the air is able to flow around the user's thumb (or around the piece of material at least partially covering the filter 26 ), which is necessarily placed across the raised portion 22 of the flange 20 d of the plunger rod 20 and likely covering at least the majority of the opening 20 e at the proximal end 20 b of the plunger rod 20 , and access the interior 20 a of the plunger rod 20 by passing through the grooves 24 in the raised portion 22 of the flange 20 d of the plunger rod 20 .
  • the microbial filter 26 By passing through the microbial filter 26 , at least some of the contaminants are removed from the air to lessen the likelihood of contamination of the interior surface 40 a of the syringe tube 40 .
  • the mixture is drawn from the container and into the second area 40 c of the syringe tube 40 by pulling the plunger rod 20 proximally (axially outwardly from the proximal end 40 f of the syringe tube 40 ).
  • the air contained in the first area 40 b is allowed to escape the syringe device 10 by passing through the at least one aperture 28 and out of the opening 20 e , through the microbial filter 26 , at the proximal end 20 b of the plunger rod 20 .
  • the mixture within the syringe device 10 can now be injected using the syringe device 10 .
  • the user may optionally remove the needle used for engaging the syringe device 10 with the container and replace it with another needle (not shown) to use for the injection.
  • the syringe device 10 of the present invention seals the first area 40 b of the syringe tube 40 and only allows controlled access thereto of ambient air. That is, the air must pass through microbial filter 26 before entering the first area 40 b . In this way, the syringe device 10 lessens the likelihood that a mixture drawn back into the syringe tube 40 will become contaminated.
  • venting system could take the form of a vent in the syringe tube 40 , preferably proximate the connection member 12 at the proximal end 40 f of the syringe tube 40 (not shown).
  • a vent could be disposed between the syringe tube 40 and the plunger rod 20 (not shown).
  • the syringe device 10 for reconstitution is described above, it is not intended to be limiting. Therefore, it is within the spirit and scope of the present invention that the syringe device 10 be used in other applications in which it would be desirable to lessen the likelihood of contaminating the inside of a syringe tube and the contents therein, such as disposable single-use syringes, pre-filled syringes used to mix two liquids together, and the like.

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  • Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
US11/169,345 2004-07-01 2005-06-29 Syringe device having venting system Expired - Lifetime US7727195B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US11/169,345 US7727195B2 (en) 2004-07-01 2005-06-29 Syringe device having venting system

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US58489304P 2004-07-01 2004-07-01
US11/169,345 US7727195B2 (en) 2004-07-01 2005-06-29 Syringe device having venting system

Publications (2)

Publication Number Publication Date
US20060116644A1 US20060116644A1 (en) 2006-06-01
US7727195B2 true US7727195B2 (en) 2010-06-01

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Family Applications (1)

Application Number Title Priority Date Filing Date
US11/169,345 Expired - Lifetime US7727195B2 (en) 2004-07-01 2005-06-29 Syringe device having venting system

Country Status (10)

Country Link
US (1) US7727195B2 (fr)
EP (1) EP1773428A4 (fr)
JP (1) JP4762236B2 (fr)
CN (1) CN100548395C (fr)
AU (1) AU2005262306A1 (fr)
BR (1) BRPI0512961A (fr)
CA (1) CA2572475A1 (fr)
IL (1) IL180456A0 (fr)
MX (1) MX2007000295A (fr)
WO (1) WO2006007592A2 (fr)

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US11433186B2 (en) 2017-12-13 2022-09-06 Regeneron Pharmaceuticals, Inc. Devices and methods for precision dose delivery
US11439758B2 (en) 2019-06-05 2022-09-13 Regeneron Pharmaceuticals, Inc. Devices and methods for precision dose delivery

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US7727195B2 (en) 2004-07-01 2010-06-01 West Pharmaceutical Services, Inc. Syringe device having venting system
EP1743700B1 (fr) * 2005-07-15 2008-10-01 Dentaco Dentalindustrie und -marketing GmbH Dispositif de pipetage
US7503905B2 (en) * 2005-10-03 2009-03-17 Ultradent Products, Inc. Venting syringe plunger
ES2425579T3 (es) 2006-05-25 2013-10-16 Bayer Healthcare, Llc Dispositivo de reconstitución
JP2009119171A (ja) * 2007-11-19 2009-06-04 Daikyo Seiko Ltd プランジャロッドおよび注射器
EP2224982B1 (fr) * 2007-12-19 2013-07-03 Sanofi-Aventis Deutschland GmbH Système de seringue à deux chambres comportant une membrane perméable aux gaz
WO2009140502A1 (fr) 2008-05-14 2009-11-19 Biolyph, Llc Préparation et dispositif de distribution de réactif et procédés associés
US8535275B2 (en) * 2008-06-26 2013-09-17 Bellanovus Development Company Llc Syringe-attached topical anesthetic dispenser
EP2364123B1 (fr) * 2008-10-24 2016-12-28 DENTSPLY International Inc. Récipient pour stocker et distribuer une matière liquide
ES2669185T3 (es) 2010-06-29 2018-05-24 Biolyph, Llc Conjunto de preparación de reactivo
US8523814B2 (en) 2010-09-28 2013-09-03 Covidien Lp Self-venting cannula assembly
US8919390B2 (en) 2010-11-18 2014-12-30 Biolyph, L.L.C. Reagent preparation and dispensing device
IL239366B (en) * 2015-06-11 2018-07-31 Kriheli Marino Components of a fluid transfer apparatus
US11234899B2 (en) 2017-05-11 2022-02-01 Scalpal Llc Grasping facilitators and uses thereof and kits involving the same
US11969864B2 (en) 2017-05-11 2024-04-30 Scalpal Llc Multi-tier torque enhancer driver and/or receiver and method of using same
EP3790524B1 (fr) * 2018-05-11 2024-02-28 Bristol-Myers Squibb Company Dispositifs et systèmes pour l'administration de polythérapies
CN118512685A (zh) * 2018-05-18 2024-08-20 巴德外周血管股份有限公司 用于两种或更多种流体的独立输送的双级注射器
CN112827018B (zh) * 2019-01-15 2022-07-26 温州医科大学附属第二医院（温州医科大学附属育英儿童医院） 一种使用过程防气流污染的医用注射器
KR102205149B1 (ko) * 2019-03-14 2021-01-19 장건주 주사기형 충진용기
US11229468B2 (en) * 2019-06-11 2022-01-25 Vivex Biologics Group, Inc. Mixing syringe and method of use
WO2021003164A1 (fr) * 2019-07-01 2021-01-07 West Pharmaceutical Services, Inc. Système et procédé pour mesure d'un écoulement de fluide hors d'une seringue

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IL180456A0 (en) 2007-06-03
EP1773428A4 (fr) 2014-04-30
BRPI0512961A (pt) 2008-04-22
MX2007000295A (es) 2007-08-02
CN100548395C (zh) 2009-10-14
WO2006007592A2 (fr) 2006-01-19
AU2005262306A1 (en) 2006-01-19
JP4762236B2 (ja) 2011-08-31
US20060116644A1 (en) 2006-06-01
HK1105600A1 (zh) 2008-02-22
CA2572475A1 (fr) 2006-01-19
WO2006007592A3 (fr) 2006-12-21
EP1773428A2 (fr) 2007-04-18
CN101018576A (zh) 2007-08-15
JP2008504937A (ja) 2008-02-21

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