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US20200060338A1 - Electronic device for producing an aerosol for inhalation by a person - Google Patents

Electronic device for producing an aerosol for inhalation by a person Download PDF

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Publication number
US20200060338A1
US20200060338A1 US16/548,831 US201916548831A US2020060338A1 US 20200060338 A1 US20200060338 A1 US 20200060338A1 US 201916548831 A US201916548831 A US 201916548831A US 2020060338 A1 US2020060338 A1 US 2020060338A1
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US
United States
Prior art keywords
electronic device
liquid
mesh material
aerosol
mesh
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
US16/548,831
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English (en)
Inventor
Mario Danek
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Qnovia Inc
Original Assignee
Respira Technologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Respira Technologies Inc filed Critical Respira Technologies Inc
Priority to US16/548,831 priority Critical patent/US20200060338A1/en
Priority to US16/657,755 priority patent/US11690963B2/en
Assigned to RESPIRA TECHNOLOGIES, INC. reassignment RESPIRA TECHNOLOGIES, INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: DANEK, MARIO
Publication of US20200060338A1 publication Critical patent/US20200060338A1/en
Priority to US17/858,039 priority patent/US12156547B2/en
Assigned to QNOVIA, INC. reassignment QNOVIA, INC. CHANGE OF NAME (SEE DOCUMENT FOR DETAILS). Assignors: RESPIRA TECHNOLOGIES, INC.
Priority to US18/072,698 priority patent/US12501929B2/en
Priority to US18/964,600 priority patent/US20250098742A1/en
Priority to US19/308,028 priority patent/US20250386859A1/en
Abandoned legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B17/00—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups
    • B05B17/04—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods
    • B05B17/06—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods using ultrasonic or other kinds of vibrations
    • B05B17/0607—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods using ultrasonic or other kinds of vibrations generated by electrical means, e.g. piezoelectric transducers
    • B05B17/0653—Details
    • B05B17/0676—Feeding means
    • A24F47/002—
    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24F—SMOKERS' REQUISITES; MATCH BOXES; SIMULATED SMOKING DEVICES
    • A24F40/00—Electrically operated smoking devices; Component parts thereof; Manufacture thereof; Maintenance or testing thereof; Charging means specially adapted therefor
    • A24F40/05—Devices without heating means
    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24F—SMOKERS' REQUISITES; MATCH BOXES; SIMULATED SMOKING DEVICES
    • A24F7/00—Mouthpieces for pipes; Mouthpieces for cigar or cigarette holders
    • A24F7/02—Mouthpieces for pipes; Mouthpieces for cigar or cigarette holders with detachable connecting members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/005—Sprayers or atomisers specially adapted for therapeutic purposes using ultrasonics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0001—Details of inhalators; Constructional features thereof
    • A61M15/0021—Mouthpieces therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0085—Inhalators using ultrasonics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/06—Inhaling appliances shaped like cigars, cigarettes or pipes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B17/00—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups
    • B05B17/04—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods
    • B05B17/06—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods using ultrasonic or other kinds of vibrations
    • B05B17/0607—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods using ultrasonic or other kinds of vibrations generated by electrical means, e.g. piezoelectric transducers
    • B05B17/0638—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods using ultrasonic or other kinds of vibrations generated by electrical means, e.g. piezoelectric transducers spray being produced by discharging the liquid or other fluent material through a plate comprising a plurality of orifices
    • B05B17/0646—Vibrating plates, i.e. plates being directly subjected to the vibrations, e.g. having a piezoelectric transducer attached thereto
    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24F—SMOKERS' REQUISITES; MATCH BOXES; SIMULATED SMOKING DEVICES
    • A24F40/00—Electrically operated smoking devices; Component parts thereof; Manufacture thereof; Maintenance or testing thereof; Charging means specially adapted therefor
    • A24F40/10—Devices using liquid inhalable precursors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/02—General characteristics of the apparatus characterised by a particular materials
    • A61M2205/0272—Electro-active or magneto-active materials
    • A61M2205/0294—Piezoelectric materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/10—General characteristics of the apparatus with powered movement mechanisms
    • A61M2205/103—General characteristics of the apparatus with powered movement mechanisms rotating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/10—General characteristics of the apparatus with powered movement mechanisms
    • A61M2205/106—General characteristics of the apparatus with powered movement mechanisms reciprocating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/12—General characteristics of the apparatus with interchangeable cassettes forming partially or totally the fluid circuit
    • A61M2205/123—General characteristics of the apparatus with interchangeable cassettes forming partially or totally the fluid circuit with incorporated reservoirs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/50—General characteristics of the apparatus with microprocessors or computers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/58—Means for facilitating use, e.g. by people with impaired vision
    • A61M2205/583—Means for facilitating use, e.g. by people with impaired vision by visual feedback
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/82—Internal energy supply devices
    • A61M2205/8206—Internal energy supply devices battery-operated

Definitions

  • the invention generally relates to apparatus, systems, and methods for producing an aerosol for inhalation by a person, whether intended for personal or recreational use or for the administration of medicines.
  • Vaping has been rapidly increasing in popularity, primarily because vaping provides a convenient, discreet, and presumably benign way to self-administer nicotine, cannabis, drugs or other micronutrients. Indeed, there is a common belief that vaping is healthier than smoking cigarettes; vaping purportedly lets smokers avoid dangerous chemicals inhaled from regular cigarettes while still getting nicotine. Vaping also can be used for cannabis. Vaping is performed using a vaporizer.
  • a vaporizer includes a vape pen or a cigarette style vape, referred to by many as an e-cigarette or “eCig”.
  • a vape pen generally is an elongate, thin, and stylized tube that resembles a fancy pen. In contrast, an e-cigarette resembles an actual cigarette.
  • a common vaporizer comprises a liquid container, which may be a tank—which is typically refillable, or a cartridge—which is typically single-use and not refillable.
  • the tank or cartridge holds a liquid often referred to as an e-liquid or e-juice.
  • Tanks are made out of polycarbonate plastic, glass, or stainless steel.
  • the vaporizer also includes a mouthpiece for inhaling by a user through the mouth; an atomizer comprising a tiny heating element that converts the liquid into tiny, airborne droplets that are inhaled; and a controller for turning on the atomizer. Many vape pens turn on automatically when a user inhales.
  • Vaporizers are electrically powered using one or more batteries.
  • the batteries typically are lithium ion batteries that are rechargeable and primarily are used to heat the heating element of the atomizer.
  • a charger usually accompanies a vaporizer when purchased for charging the batteries.
  • the charger may be a USB charger, car charger, or wall charger, and such chargers are generally very similar to phone chargers.
  • the battery-powered vaporizer produces vapor from any of a variety of substances, especially liquid containing nicotine or cannabinoids, allowing the user to inhale the vapor.
  • liquid can be non-medicated (i.e., containing no nicotine or other substances—just pure vegetable glycerin and flavoring), or the liquid can contain nicotine or even in some instances if and where legal, the liquid can contain THC/CBD.
  • the liquid also may contain one or more of a variety of flavors as well as micronutrients such as, for example, vitamin B12.
  • a user can mix the liquid for use with a vape pen.
  • E-cigarettes typically are purchased with prefilled cartridges.
  • the heating element turns the contents of the liquid into an aerosol—the vapor—that is inhaled into the lungs and then exhaled by the user.
  • the vapor that is inhaled into the lungs and then exhaled by the user.
  • the “JUUL” is a small, sleek device that resembles a computer USB flash drive.
  • Propylene glycol vegetable glycerin and combinations or methylations thereof, are chemicals that are often mixed with nicotine, cannabis, or hemp oil for use in vaporizers. Propylene glycol is the primary ingredient in a majority of nicotine-infused e-cigarette solutions. Unfortunately, at high temperatures propylene glycol converts into tiny polymers that can wreak havoc on lung tissue. In particular, scientists know a great deal about propylene glycol. It is found in a plethora of common household items—cosmetics, baby wipes, pharmaceuticals, pet food, antifreeze, etc. The U.S.
  • propylene glycol safe for human ingestion and topical application. But exposure by inhalation is another matter. Many things are safe to eat but dangerous to breathe. Because of low oral toxicity, propylene glycol is classified by the FDA as “generally recognized as safe” (GRAS) for use as a food additive, but this assessment was based on toxicity studies that did not involve heating and breathing propylene glycol. Indeed, a 2010 study published in the International Journal of Environmental Research and Public Health concluded that airborne propylene glycol circulating indoors can induce or exacerbate asthma, eczema, and many allergic symptoms. Children were said to be particularly sensitive to these airborne toxins. An earlier toxicology review warned that propylene glycol, ubiquitous in hairsprays, could be harmful because aerosol particles lodge deep in the lungs and are not respirable.
  • GRAS generally recognized as safe
  • heating element gets red hot in a vaporizer
  • the liquid undergoes a process called “smoldering”, which is a technical term for what is tantamount to “burning”; while much of the liquid is vaporized and atomized, a portion of the liquid undergoes pyrolysis or combustion. In that sense, most of the vaporizers that have flooded the commercial market may not be true vaporizers.
  • the invention includes many aspects and features. Moreover, while many aspects and features relate to, and are described in, the context of vaping, the invention is not limited to use only in such context. Indeed, depending on the context of use, the electronic device of the invention may be considered a vaporizer and may be in the form of a vape pen or e-cigarette. Indeed, those who vape may come to refer to embodiments of the invention as a vape pen even though heat is not utilized to create the aerosol that is inhaled. In the delivery of pharmaceuticals, patients may come to refer to embodiments of the invention as a nebulizer even though compressed gas is not utilized and even though the aerosol that is produced in accordance with the invention may have a smaller particle size than the mist produced by common nebulizers. Other separate and distinct contexts of use of embodiments of the invention may similarly result in different nomenclature of the electronic device. Nonetheless, while the appearance and form factor of embodiments of the invention may vary depending on the context of use, the basic components and operation remain the same.
  • an electronic device for producing an aerosol for inhalation by a person comprises: a mouthpiece and an upper housing component to which the mouthpiece attaches, wherein the upper housing component contains a liquid container and a mesh assembly having a mesh material that vibrates when actuated for aerosolizing liquid from the liquid container that comes into contact with the vibrating mesh material, and wherein the aerosol so produced may be inhaled through the mouthpiece; and a lower housing component containing circuitry and a power supply for actuating vibration of the mesh material, wherein electrical pathways connect the mesh assembly of the upper housing component with the circuitry and power supply of the lower housing component.
  • the upper housing component and the lower housing component are detachable from each other, and electrical contacts connect the electrical pathways between the upper housing component and the lower housing component when the upper housing component and the lower housing component are connected.
  • the mouthpiece is detachable from the upper housing component to expose the vibrating mesh material.
  • the mouthpiece preferably snaps onto a rim surrounding a recessed area or opening of the upper housing component in which the vibrating mesh material is located, thereby defining a partially enclosed space above the vibrating mesh material.
  • the device comprises no heating element configured to heat the liquid to aerosolize the liquid.
  • the device comprises no compressed gas configured to aerosolize the liquid.
  • the electronic device produces a fine particle, low velocity aerosol for central and deep lung deposition.
  • the mesh material comprises an oscillating piezoelectric material that aerosolizes liquid that comes into contact with one side thereof, the aerosol being produced on the opposite side of the vibrating mesh material in the partially enclosed space defined by the mouthpiece when attached to the upper housing component.
  • the oscillating piezoelectric material may be a single layer oscillating piezoelectric material, or the oscillating piezoelectric material may be a multi-layer oscillating piezoelectric material.
  • the oscillating piezoelectric material preferably is in the form of a mesh disk.
  • the liquid is pressured into contact with a first side of the vibrating mesh material, and the vibrating mesh material comprises small openings through which droplets of the liquid pass to form the aerosol as the vibrating mesh material oscillates.
  • the droplets of the aerosol produced preferably are between 1 and 4 micron aerosol droplets.
  • the liquid container comprises a cartridge.
  • the power supply comprises one or more lithium-ion batteries.
  • the power supply comprises one or more rechargeable batteries.
  • the circuitry and power supply are configured to further operate a pump system that causes the liquid from the liquid container to come into contact with the first side of the vibrating mesh material.
  • the pump system preferably comprises a motor and a threaded shaft that is rotated by the motor, the rotation of the threaded shaft causing the liquid to be pushed toward the vibrating mesh material.
  • the liquid preferably is pushed toward the vibrating mesh material by a stopper that is advanced by the rotating shaft; the stopper is advanced by engagement with a plunger that is attached to the threaded shaft and that is directly driven by rotation of the threaded shaft by the motor, or alternatively, the stopper is attached to the threaded shaft and is directly driven by rotation of the threaded shaft by the motor.
  • the electronic device further comprises means for causing the liquid to be in contact with a lower side of the mesh material facing the liquid container.
  • the means may comprise any of the pump systems disclosed herein, whether actively powered or a passive system, such as a capillary pump.
  • the electronic device comprises a capillary pump, wherein the liquid is drawn into contact with the mesh material through capillary action.
  • the upper housing component and the lower housing component fit together to define a body of the electronic device, which body is of a size and shape for gripping and holding by hand during use of the electronic device.
  • an electronic device for producing an aerosol for inhalation by a person comprises: (a) a mouthpiece; and (b) an elongate housing having opposite first and second ends, with the mouthpiece being attached to the first end and with the housing comprising therein, (i) a mesh assembly comprising a mesh material that vibrates when actuated, (ii) a liquid container containing a liquid that is aerosolized by the mesh material when actuated for inhalation through the mouthpiece, and (iii) circuitry and a power supply for actuating vibration of the mesh material, wherein electrical pathways connect the mesh assembly with the circuitry and power supply; (c) wherein the mesh assembly and the liquid container are arranged in-line along a longitudinal axis of the electronic device.
  • the mesh assembly extends between and separates the mouthpiece and the liquid container.
  • the power supply of the electronic device comprises batteries that are arranged along the longitudinal axis of the device and that are located at the second end of the housing.
  • the liquid contacts the mesh material as a result of capillary action.
  • the electronic device further comprises means for causing the liquid to be in contact with a lower side of the mesh material facing the liquid container.
  • a method for producing an aerosol for inhalation by a person using an electronic device comprises the steps of causing a mesh material to vibrate while causing a liquid to contact a first side of the mesh material, whereby droplets of the liquid are formed on the opposite side of the mesh material to create an aerosol for inhalation.
  • the mesh material is a mesh disk and the liquid is caused to contact the first side of the mesh disk at a generally constant pressure so that the aerosol that is produced will have a generally consistent concentration of the liquid. Additionally, the liquid preferably is maintained in constant contact with the first side of the mesh disk, even when the vibrating mesh is not being actuated.
  • the electronic device preferably is actuated for a predetermined period of time by a button press, whereby a consistent volume of aerosol for inhalation is produced for each button press.
  • the electronic device is actuated by depressing a button by a user of the electronic device, with the aerosol being produced while the button is depressed.
  • the liquid may be pushed from a cartridge by a stopper that is advanced through a liquid container of the cartridge, and the liquid container of the cartridge may be cylindrical.
  • the stopper may be advanced through the liquid container by actuation of a motor that drives a threaded shaft.
  • the aerosol preferably is produced without smoldering of the liquid.
  • the aerosol is produced without utilizing a compressed gas.
  • a method for producing an aerosol for inhalation by a person using an electronic device having a mouthpiece comprises the steps of causing a mesh material to vibrate while causing a liquid to contact a first side of the mesh material, whereby droplets of the liquid are formed on a second, opposite side of the mesh material to create the aerosol for inhalation through the mouthpiece.
  • the device has opposite longitudinal ends and the mouthpiece is located on one of the opposite longitudinal ends of the device.
  • the mesh material has a side facing the mouthpiece and an opposite side facing a liquid container containing the liquid for aerosolized.
  • the mouthpiece, the mesh material, and the liquid container are arranged in-line along the longitudinal axis of the electronic device, with the mesh material extending between and separating the mouthpiece from the liquid container.
  • the mesh material in preferred embodiments is a mesh disk.
  • the electronic device is actuated for a predetermined period of time for producing a consistent volume of aerosol for inhalation.
  • the electronic device is actuated by depressing a button by a user of the electronic device.
  • the liquid is caused to contact the first side of the mesh material at a generally constant pressure.
  • the liquid is pushed from a cartridge by a stopper that is advanced through a liquid container of the cartridge.
  • the liquid container of the cartridge preferably is cylindrical but may have another geometric profile.
  • the stopper preferably is advanced through the liquid container by actuation of a motor that drives a shaft.
  • the stopper may be attached to the shaft and directly driven so as to advance through the liquid container when the shaft is rotated, or the electronic device may further comprise a plunger is attached to the shaft and that is directly driven so as to advance through the liquid container when the shaft is rotated, wherein the plunger engages and advances the stopper for pushing the liquid into contact with the vibrating mesh material.
  • the aerosol preferably is produced without smoldering of the liquid.
  • the aerosol preferably is produced without utilizing a compressed gas.
  • the method further comprises a step for causing the fluid to be in constant contact with the mesh material using capillary action.
  • the step may be carried out by an active pump system or a passive pump system such as a capillary pump system using capillary action.
  • Another aspect comprises using an electronic device in accordance with one or more of the aforementioned aspects and features to perform a method of producing an aerosol for inhalation by a person using such electronic device.
  • FIG. 1 is a perspective view of a preferred electronic device in accordance with one or more aspects and features of the invention.
  • FIG. 2 is an exploded view of components of the electronic device of FIG. 1 .
  • FIG. 3 is another exploded view of components of the electronic device of FIG. 1 .
  • FIG. 4 is a partial, exploded view of components of the electronic device of FIG. 1 .
  • FIG. 5 is another partial exploded view of components of the electronic device of FIG. 1 .
  • FIG. 6 is another exploded view of components of the electronic device of FIG. 1 .
  • FIG. 7 is a transparent view of components of the electronic device of FIG. 1 .
  • FIG. 8 is a partial view of components of the electronic device of FIG. 1 .
  • FIG. 9 is another partial view of components of the electronic device of FIG. 1 .
  • FIG. 10 is another transparent view of the cartridge of the electronic device of FIG. 1 .
  • FIGS. 11, 12, 13 and 14 are partial internal views of the electronic device of FIG. 1 .
  • FIG. 15 is a block diagram of a method for producing a fine particle, low velocity aerosol using a preferred electronic device in accordance with one or more aspects and features of the invention.
  • FIG. 16 is a partial internal view of another preferred electronic device in accordance with one or more aspects and features of the invention.
  • FIG. 17 is a schematic illustration of yet another preferred electronic device in accordance with one or more aspects and features of the invention.
  • FIG. 18 is a partial schematic illustration of an electromagnetic cartridge of the electronic device of FIG. 17 .
  • FIG. 19 is a transparent view of internal components of another preferred electronic device in accordance with one or more aspects and features of the invention.
  • any sequence(s) and/or temporal order of steps of various processes or methods that are described herein are illustrative and not restrictive. Accordingly, it should be understood that, although steps of various processes or methods may be shown and described as being in a sequence or temporal order, the steps of any such processes or methods are not limited to being carried out in any particular sequence or order, absent an indication otherwise. Indeed, the steps in such processes or methods generally may be carried out in various different sequences and orders while still falling within the scope of the invention. Accordingly, it is intended that the scope of patent protection afforded the invention be defined by the issued claim(s) rather than the description set forth herein.
  • a picnic basket having an apple is the same as “a picnic basket comprising an apple” and “a picnic basket including an apple”, each of which identically describes “a picnic basket having at least one apple” as well as “a picnic basket having apples”; the picnic basket further may contain one or more other items beside an apple.
  • a picnic basket having a single apple describes “a picnic basket having only one apple”; the picnic basket further may contain one or more other items beside an apple.
  • a picnic basket consisting of an apple has only a single item contained therein, i.e., one apple; the picnic basket contains no other item.
  • picnic basket having cheese or crackers When used herein to join a list of items, “or” denotes “at least one of the items” but does not exclude a plurality of items of the list.
  • reference to “a picnic basket having cheese or crackers” describes “a picnic basket having cheese without crackers”, “a picnic basket having crackers without cheese”, and “a picnic basket having both cheese and crackers”; the picnic basket further may contain one or more other items beside cheese and crackers.
  • picnic basket having cheese and crackers When used herein to join a list of items, “and” denotes “all of the items of the list”.
  • a picnic basket having cheese and crackers describes “a picnic basket having cheese, wherein the picnic basket further has crackers”, as well as describes “a picnic basket having crackers, wherein the picnic basket further has cheese”; the picnic basket further may contain one or more other items beside cheese and crackers.
  • “at least one” followed by a list of items joined by “and” denotes an item of the list but does not require every item of the list.
  • “at least one of an apple and an orange” encompasses the following mutually exclusive scenarios: there is an apple but no orange; there is an orange but no apple; and there is both an apple and an orange. In these scenarios if there is an apple, there may be more than one apple, and if there is an orange, there may be more than one orange.
  • the phrase “one or more” followed by a list of items joined by “and” is the equivalent of “at least one” followed by the list of items joined by “and”.
  • a vibrating mesh is provided for aerosolizing a liquid without smoldering.
  • such preferred devices of the invention therefore are believed to produce an aerosol that is carcinogen free.
  • vaporizers used today to aerosolize e-liquids by heating the e-liquids as a way to aerosolize the liquid carrier and desired compounds contained therein (e.g., nicotine) or supplements such as B12, THC/CBD and other drugs or stimulants.
  • these vaporizers produce toxic byproducts like formaldehyde, a recognized Group 1 carcinogen for cancer, which toxic byproducts then are unfortunately inhaled by a person using the vaporizer.
  • the liquid carriers when the liquid carriers are heated, the liquid carriers undergo a thermochemical reaction producing unwanted emissions.
  • the unwanted emissions of the toxic byproducts may cause bodily harm from extended inhalation exposure.
  • preferred electronic devices in accordance with one or more aspects and features of the invention produce an aerosol without using heat and thus advantageously avoid such toxic byproducts created by the vaporizes currently on the market.
  • the electronic devices thereby advantageously produce a carcinogen free aerosol free of harmful emission byproducts.
  • the residual aerodynamic particle size distribution (“APSD”) of the aerosolized drug product.
  • the residual APSD is characterized by the residual mass median aerodynamic diameter (“MMAD”) and the geometric standard deviation (“GSD”).
  • MMAD signifies the aerodynamic diameter at which half of the aerosolized drug mass lies below the stated diameter.
  • MMADR MMDI ⁇ m
  • CNV mass median diameter
  • pI and pR are the densities (g/cm3) of the formulation and the residual particles, respectively.
  • the vibrating mesh may include a single layer oscillating piezoelectric material to aerosolize the liquid.
  • the mesh may have a double or multi-layer structure. Multiple mesh membranes may be arranged to induce an optimum MMAD and/or APSD for the aerosolized liquid.
  • the mesh may be constructed from one or more different piezoelectric materials to optimize the MMAD and/or APSD.
  • the vibrating mesh is configured to create a fine particle low velocity aerosol which is well suited for central and deep lung deposition.
  • one or more preferred electronic devices of the invention advantageously can produce an aerosol that is adapted to target small airways in the management of asthma and COPD.
  • a pump system is utilized to pump or push the liquid to be aerosolized into contact with the vibrating mesh whereby droplets of the liquid are created on the other side of the vibrating mesh on the order of 1 to 4 microns.
  • a capillary pump may be used (wherein the liquid is drawn into contact with the mesh material through capillary action)
  • electronic devices of the invention preferably further include a pump system that is powered by an electrical power source of the device, such as batteries and, preferably, rechargeable batteries.
  • a pump system preferably comprises a piezoelectric motor, as further described in detail below.
  • FIG. 1 is a perspective view of a preferred electronic device 100 for producing an aerosol for inhalation in accordance with one or more aspects and features of the invention.
  • the electronic device 100 comprises a mouthpiece 102 having an opening 104 through which the aerosol is inhaled; an upper housing component 106 ; and a lower housing component 108 .
  • the mouthpiece 102 , upper housing component 106 , and lower housing component 108 fit together to define a body of the electronic device 100 , which body is of a size and shape for gripping and holding by hand during use of the device 100 .
  • the electronic device 100 When used as intended, the electronic device 100 would be held with the mouthpiece 102 oriented upright or at an inclination to horizontal, or any orientation therebetween. Regardless of the orientation, the device 100 works the same in producing the aerosol for inhalation.
  • the top housing 106 is attached to the lower housing component 108 via a hinge 110 including hinge pin 112 for pivoting movement of the top housing 106 relative to the bottom housing 108 between an open position and a closed position.
  • the closed position is shown, for example, in FIG. 1 .
  • the mouthpiece 102 preferably snaps in friction fit onto the top housing 106 .
  • the form factor of the electronic device 100 resembles that of a nebulizer for administering drugs including, for example, prescription medicines.
  • Electronic devices of the invention are not limited to such form factors.
  • another electronic device 300 of the invention is illustrated in FIG. 19 , discussed below; electronic device 300 has a form factor resembling that of a vape pen.
  • the device 100 further comprises a button 114 for turning on or otherwise actuating the device 100 and a window 116 for viewing a level of liquid in the device 100 .
  • the device When actuated, the device preferably produces an aerosol for inhalation.
  • a set, predetermined volume of liquid contained in the device preferably is aerosolized each time the device is turned on or actuated using button 114 .
  • the amount of liquid remaining in the device to be aerosolized preferably is viewable through the window 116 .
  • FIG. 2 is an exploded view of components of the electronic device 100 .
  • the mouthpiece 102 , upper housing component 106 , and lower housing component 108 are separable from each other.
  • the body can be disassembled by a user.
  • a glimpse of a mesh assembly 118 including a vibrating mesh in the form of a vibrating mesh material contained within the upper housing component 106 and a glimpse of a plunger 120 contained within the lower housing component 108 also are seen in FIG. 2 .
  • FIG. 3 is another exploded view of components of the electronic device 100 .
  • FIG. 3 is perhaps best notable for revealing a liquid container in the form of a cartridge 122 that is contained within the upper housing component 106 .
  • the cartridge 122 contains the liquid that is aerosolized and the cartridge 122 preferably is removable from the upper housing component 106 either when the upper housing component is disconnected and separated from the lower housing component 108 or when the upper housing component 106 is rotated from the closed position to an open position by pivoting around the hinge 110 and hinge pin 112 .
  • the cartridge 122 is replaced with a new cartridge having a full supply of liquid to be aerosolized.
  • the cartridge 122 of FIG. 3 is full of a liquid and is seen being inserted into the upper housing component 106 .
  • the liquid container may be a tank, i.e., a refillable liquid container that is intended for multiple uses.
  • the cartridge 122 comprises a cylinder or barrel 124 and a stopper 126 .
  • FIG. 3 further reveals that the upper housing component 106 comprises two windows 116 for viewing the volume of liquid contained within the cartridge during use of the device 100 .
  • FIG. 4 is a partial, exploded view of components of the electronic device 100 .
  • FIG. 4 reveals one or more batteries 128 that are contained within a bottom portion of the lower housing component 108 .
  • the batteries preferably are rechargeable lithium-ion batteries.
  • the device 100 preferably includes a charging port 140 (illustrated in FIGS. 11-14 ) for plugging in a power source for charging the batteries 128 .
  • the charging port preferably is a micro-USB charging port.
  • FIG. 4 additionally reveals wall supports 130 of the upper housing component 106 which conform to, receive and support in friction fit the cartridge 122 when inserted into the upper housing component 106 .
  • the supports 130 preferably are formed as part of the upper housing component 106 , such as during an injection molding process of the upper housing component 106 .
  • the lower housing component 108 and mouthpiece 102 also preferably are made by injection molding or other manufacturing methodology.
  • the upper housing component 106 also comprises wall supports 131 (seen for example in FIG. 5 ) that hold the mesh assembly 118 in place in the upper housing component 106 .
  • Supports 131 also preferably form part of the upper housing component 106 and are similarly formed in a molding process.
  • FIGS. 5 and 6 each is another partial, exploded view of components of the electronic device 100 and each reveals a motor 132 and threaded shaft 134 .
  • the motor 132 preferably is a piezoelectric motor.
  • the motor 132 drives rotation of the threaded shaft 134 and is actuated by the button 114 .
  • the plunger 120 is attached to an end of the shaft 134 and rotation of the shaft 134 by the motor 132 causes the plunger to move in a direction parallel to a longitudinal axis of the rotating shaft 134 .
  • FIG. 8 is a partial view of components of the electronic device 100 and additionally shows the plunger 120 attached to the end of the threaded shaft 134 and moved to a fully retracted position in which the plunger 120 is located immediate adjacent the motor 132 .
  • the piezoelectric motor 132 preferably utilizes piezoelectric actuation technology using mechanical waves.
  • the motor advantageously provides a high-power density combined with a high efficiency (e.g., greater than 20 W mechanical) for small motors.
  • the motor is a purely mechanical structure without any winding.
  • An example suitable motor is the piezoelectric motor WLG-30.
  • the motor may have a stator diameter of approximately 30 mm (1.18 inches), a length of approximately 34 mm (1.34 inches), and a height of approximately 15 mm (0.59 inches).
  • the motor may weight approximately 37 g with an electronic card weight of 23 g.
  • the motor may have a max speed of approximately 300 rpm with a rated torque of approximately 250 mN ⁇ m, a max torque of approximately 50 mN ⁇ m, a hold torque of approximately 150 mN ⁇ m, and a torque resolution of approximately 0.18 mN ⁇ m. Additionally, the motor may have an output power of approximately 150 W.
  • the motor response time may be approximately 1.3 milliseconds with a direction change time (CW/CCW) of approximately 1 millisecond and an angular accuracy of approximately 1 degree.
  • the motor 132 may have a power supply of approximately 7.5V and a max current of approximately 1.2 A.
  • FIG. 7 is a transparent view of the cartridge 122 and components thereof in the electronic device 100 .
  • the cartridge 122 is similar to a syringe in that the stopper 126 , when advanced within the cylinder 124 toward a tapered end 123 of the cartridge 122 , pushes liquid in the cylinder 124 toward the tapered end 123 .
  • the stopper 126 forms a seal with the cylinder wall 124 and the stopper 126 prevents or stops the liquid from leaking around the stopper 126 .
  • the tapered end 123 includes an opening 125 through which the liquid passes when the stopper 126 advances toward the tapered end 123 .
  • the tapered end 123 is inserted with the opening 127 when the cartridge 122 is inserted into the upper housing component 106 , as indicated by the dashed line extending between FIGS. 9 and 10 .
  • the tapered end 123 is located within an opening 127 of the mesh assembly 118 (seen in FIG. 4 ).
  • the stopper 126 is not attached to the threaded shaft 134 and, therefore, is not directly driven by rotation of the threaded shaft 134 by the motor 132 .
  • the plunger 120 attached to the end of the threaded shaft 134 is directly driven by rotation of the threaded shaft 134 by the motor 132 , which causes the plunger 120 to advance into engagement with the stopper 126 and push the stopper toward the taper end 123 .
  • This advancement of the plunger 120 and retraction back is illustrated in the sequence seen in FIGS. 11 through 14 , which are partial internal views of the electronic device 100 .
  • the components are arranged in-line.
  • the mouthpiece 102 , the mesh assembly 118 , and the cartridge 122 containing the fluid are arranged sequentially along a longitudinal axis 90 (seen in FIG. 11 ) of the device 100 in said order, with the mesh assembly 118 being located between the mouthpiece 102 and the liquid to be aerosolized.
  • the stopper 126 , plunger 120 , and shaft 134 similarly are arranged along the longitudinal axis 90 of the device 100 .
  • the motor 132 and batteries 128 also are arranged along the longitudinal axis 90 of the device 100 .
  • the mesh disk 146 When the fluid passes through the opening 125 into the opening 127 it contacts a mesh disk 146 (perhaps best seen in FIG. 15 ) of the mesh assembly.
  • the mesh disk 146 is held or retained in the mesh assembly 118 by an annular plate 144 similar to a washer.
  • the mesh disk 146 preferably is formed from a piezoelectric material (or “piezo”) having small openings or holes 148 formed therein for the passage of small droplets of the liquid of a consistent size when the piezo mesh disk is caused to vibrate. This aerosolizes the liquid producing an aerosol.
  • the droplets produced are between 1 and 4 micron aerosol droplets.
  • FIG. 15 includes a picture of an aerosol for inhalation that is actually produced by the vibrating piezo mesh disk.
  • the aerosol produced by the vibrating mesh is a fine particle, low velocity aerosol that is believed to be optimum for central and deep lung deposition.
  • the motor 132 rotates the threaded drive shaft 134 in a reverse direction to return the plunger 120 to the retracted position, as seen in FIG. 14 .
  • FIG. 16 is a partial internal view of another electronic device 170 in accordance with one or more aspects and features of the invention.
  • the cartridge includes the threaded shaft 134 ′ extending therethrough.
  • the other components illustrated and having the same reference numbers as those with respect to device 100 are the same.
  • FIG. 17 is a schematic illustration of yet another preferred electronic device 200 in accordance with one or more aspects and features of the invention
  • FIG. 18 is a partial schematic illustration of an electromagnetic cartridge of the electronic device 200
  • Electronic device 200 preferably comprises an electromagnetic propulsion system cartridge (e.g., an electromagnetic syringe pump cartridge 201 having cartridge housing 203 ) that is utilized to push the liquid into contact with the vibrating mesh when the device 200 is activated.
  • the electronic device 200 includes a liquid window 202 .
  • the electromagnetic cartridge includes a magnetic stopper 204 , an anode 206 , a cathode 208 , and a magnetic ring 210 .
  • FIG. 19 is a transparent view of internal components of another preferred electronic device 300 in accordance with one or more aspects and features of the invention.
  • the device 300 comprises a number of components that are arranged in-line along a longitudinal axis 390 of the device 300 . These components include a mouthpiece 302 from which aerosol produced by the device 300 can be inhaled; a mesh assembly 304 comprising a vibrating mesh and aperture plate; a liquid container 306 comprising a liquid cartridge or reservoir combined with a threaded shaft 308 that longitudinally extends within the liquid container 306 and a stopper 310 that moves longitudinally within the liquid container 306 along the shaft 308 to ensure liquid moves towards and stays in contact with the vibrating mesh; and a motor and battery assembly 312 that drives rotation of the shaft 308 and consequent movement of the stopper 310 within the liquid container 306 .
  • the liquid preferably is supplied to the vibrating mesh at a generally constant pressure whereby a generally uniform aerosol is produced. This is preferably done regardless of the orientation of the electronic device.
  • the electronic device also preferably comprises a reservoir for the liquid.
  • the reservoir is an anti-pyrolysis vape reservoir with no smoldering and no combustion.
  • the device also features a thermostable liquid carrier.
  • Circuitry (not shown for clarity of illustration) preferably is included in each electronic device for controlling actuation of the vibrating mesh.
  • the circuitry also preferably controls actuation of the pump mechanism for pushing the liquid into contact with the vibrating mesh at a generally constant pressure.
  • a printed circuit board may be included, and an application specific integrated circuit may be included.
  • a microcontroller also may be included (e.g., microchip 8-bit microcontroller-based piezo mesh disk driver board).
  • the microcontroller preferably is located within the lower housing component when included, but in some embodiments the microcontroller may be located within the upper housing component.
  • Electronic devices of the invention can be utilized to deliver liquids, supplements, drugs, or therapeutically effective amounts of pharmaceuticals using an aerosol having particles of a size that can easily be inhaled.
  • the aerosol can be used, for example, by a patient within the bounds of an inhalation therapy, whereby the liquid, supplement, therapeutically effective pharmaceutical, or drug reaches the patient's respiratory tract upon inhalation.
  • the aerosol also can be used to aerosolize the liquid carrier and desired compounds used in vaping such as nicotine, flavoring, and supplements like B12, without the toxic byproducts like formaldehyde, a recognized Group 1 Carcinogen for cancer, which is created when heat traditionally is used to aerosolize the liquid for inhalation.
  • Electronic devices of the invention further can be used in the marijuana industries, but only where legal, for delivery of cannabinoids and CBD oils and the like.
  • many embodiments and adaptations of the invention other than those specifically described herein, as well as many variations, modifications, and equivalent arrangements, will be apparent from or reasonably suggested by the invention and the foregoing descriptions thereof, without departing from the substance or scope of the invention.

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US16/548,831 US20200060338A1 (en) 2018-08-22 2019-08-22 Electronic device for producing an aerosol for inhalation by a person
US16/657,755 US11690963B2 (en) 2018-08-22 2019-10-18 Electronic device for producing an aerosol for inhalation by a person
US17/858,039 US12156547B2 (en) 2018-08-22 2022-07-05 Electronic device for producing an aerosol for inhalation by a person
US18/072,698 US12501929B2 (en) 2018-08-22 2022-11-30 Electronic device for producing an aerosol for inhalation by a person
US18/964,600 US20250098742A1 (en) 2018-08-22 2024-12-01 Electronic device for producing an aerosol for inhalation by a person
US19/308,028 US20250386859A1 (en) 2018-08-22 2025-08-22 Electronic device for producing an aerosol for inhalation by a person

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US20220338534A1 (en) 2022-10-27
EP3829370A1 (fr) 2021-06-09
US12156547B2 (en) 2024-12-03
WO2020041641A1 (fr) 2020-02-27
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