UA99131C2 - N'-(phenyl)-n-(morpholin-4-yl-pyridin-2-yl)-pyrimidine-2,4-diamine derivatives as ephb4 kinase inhibitors for the treatment of proliferative conditions - Google Patents
N'-(phenyl)-n-(morpholin-4-yl-pyridin-2-yl)-pyrimidine-2,4-diamine derivatives as ephb4 kinase inhibitors for the treatment of proliferative conditionsInfo
- Publication number
- UA99131C2 UA99131C2 UAA200912123A UAA200912123A UA99131C2 UA 99131 C2 UA99131 C2 UA 99131C2 UA A200912123 A UAA200912123 A UA A200912123A UA A200912123 A UAA200912123 A UA A200912123A UA 99131 C2 UA99131 C2 UA 99131C2
- Authority
- UA
- Ukraine
- Prior art keywords
- treatment
- pyrimidine
- morpholin
- pyridin
- phenyl
- Prior art date
Links
- 230000002062 proliferating effect Effects 0.000 title abstract 2
- 229940043355 kinase inhibitor Drugs 0.000 title 1
- 239000003757 phosphotransferase inhibitor Substances 0.000 title 1
- 102100031983 Ephrin type-B receptor 4 Human genes 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 abstract 1
- 230000001028 anti-proliverative effect Effects 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Изобретение касается пиримидиновых соединений формулы I или их фармацевтически приемлемых солей:, Iгде A, AA, R, n, R, Rи Rимеют значения, указанные в описании.Данное изобретение также касается способа получения таких соединений, фармацевтических композиций, которые их содержат, и их применения для приготовления лекарственного средства для применения в качестве антипролиферативного средства для предотвращения или лечения опухолей или других пролиферативных состояний, чувствительных к ингибированию EphB4-киназ.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07301001 | 2007-04-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA99131C2 true UA99131C2 (en) | 2012-07-25 |
Family
ID=43038345
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UAA200912123A UA99131C2 (en) | 2007-04-27 | 2008-04-25 | N'-(phenyl)-n-(morpholin-4-yl-pyridin-2-yl)-pyrimidine-2,4-diamine derivatives as ephb4 kinase inhibitors for the treatment of proliferative conditions |
Country Status (2)
| Country | Link |
|---|---|
| UA (1) | UA99131C2 (ru) |
| ZA (1) | ZA200908402B (ru) |
-
2008
- 2008-04-25 UA UAA200912123A patent/UA99131C2/ru unknown
-
2009
- 2009-11-26 ZA ZA200908402A patent/ZA200908402B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ZA200908402B (en) | 2010-08-25 |
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