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UA97795C2 - Дейтеровані похідні катехоламіну і медикаменти, що містять згадані сполуки - Google Patents

Дейтеровані похідні катехоламіну і медикаменти, що містять згадані сполуки

Info

Publication number
UA97795C2
UA97795C2 UAA200811184A UAA200811184A UA97795C2 UA 97795 C2 UA97795 C2 UA 97795C2 UA A200811184 A UAA200811184 A UA A200811184A UA A200811184 A UAA200811184 A UA A200811184A UA 97795 C2 UA97795 C2 UA 97795C2
Authority
UA
Ukraine
Prior art keywords
compounds
catecholamine derivatives
deuterated catecholamine
well
medicaments
Prior art date
Application number
UAA200811184A
Other languages
English (en)
Russian (ru)
Inventor
Рудольф-Гізберт Алкен
Франк Шнайдер
Original Assignee
Бьордз Фарма Гмбх Бероліна Інновейтів Ресерч Унд Девелопмент Сервісіз
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Бьордз Фарма Гмбх Бероліна Інновейтів Ресерч Унд Девелопмент Сервісіз filed Critical Бьордз Фарма Гмбх Бероліна Інновейтів Ресерч Унд Девелопмент Сервісіз
Publication of UA97795C2 publication Critical patent/UA97795C2/uk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C229/36—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings with at least one amino group and one carboxyl group bound to the same carbon atom of the carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/001—Acyclic or carbocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/26—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one amino group bound to the carbon skeleton, e.g. lysine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychology (AREA)
  • Psychiatry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Представлений винахід стосується дейтерованих похідних катехоламіну, також як і фармацевтичних препаратів, що містять ці сполуки. Крім того, винахід стосується застосування дейтерованих похідних катехоламіну, також як і їх фізіологічно прийнятних солей, а також фармацевтичних композицій, які містять ці сполуки, а також комбінації з інгібіторами ферменту, для лікування допаміндефіцитних захворювань або захворювань, які базуються на порушенні транспорту тирозину або порушенні тирозиндекарбоксилази, також як і інших розладів.
UAA200811184A 2006-02-17 2007-02-16 Дейтеровані похідні катехоламіну і медикаменти, що містять згадані сполуки UA97795C2 (uk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102006008316 2006-02-17
PCT/EP2007/001555 WO2007093450A2 (en) 2006-02-17 2007-02-16 Deuterated catecholamine derivatives and medicaments comprising said compounds

Publications (1)

Publication Number Publication Date
UA97795C2 true UA97795C2 (uk) 2012-03-26

Family

ID=38236462

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA200811184A UA97795C2 (uk) 2006-02-17 2007-02-16 Дейтеровані похідні катехоламіну і медикаменти, що містять згадані сполуки

Country Status (24)

Country Link
US (2) USRE46555E1 (uk)
EP (2) EP1991522B1 (uk)
JP (1) JP5248331B2 (uk)
KR (1) KR101411422B1 (uk)
CN (1) CN101384545B (uk)
AU (1) AU2007214622B2 (uk)
BR (1) BRPI0708071A8 (uk)
CA (1) CA2642593C (uk)
CY (1) CY1117995T1 (uk)
DK (1) DK1991522T3 (uk)
EA (1) EA017983B1 (uk)
ES (1) ES2587368T3 (uk)
HR (1) HRP20161039T1 (uk)
HU (1) HUE028777T2 (uk)
IL (1) IL193102A (uk)
LT (1) LT1991522T (uk)
ME (1) ME02508B (uk)
PL (1) PL1991522T3 (uk)
PT (1) PT1991522T (uk)
RS (1) RS55142B1 (uk)
SI (1) SI1991522T1 (uk)
UA (1) UA97795C2 (uk)
WO (1) WO2007093450A2 (uk)
ZA (1) ZA200806568B (uk)

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US7776314B2 (en) 2002-06-17 2010-08-17 Grunenthal Gmbh Abuse-proofed dosage system
US20070048228A1 (en) 2003-08-06 2007-03-01 Elisabeth Arkenau-Maric Abuse-proofed dosage form
US8969417B2 (en) 2008-06-06 2015-03-03 Pharmatwob Ltd. Pharmaceutical compositions for treatment of Parkinsons disease
CA2730734C (en) 2008-07-15 2017-04-25 Theracos, Inc. Deuterated 2,3,4-trihydroxy-tetrahydropyranyl-benzylbenzene compounds having sodium glucose cotransporter inhibitory activity
EP2819656A1 (en) 2012-02-28 2015-01-07 Grünenthal GmbH Tamper-resistant dosage form comprising pharmacologically active compound and anionic polymer
US9550780B2 (en) 2012-09-18 2017-01-24 Auspex Pharmaceuticals, Inc. Formulations pharmacokinetics of deuterated benzoquinoline inhibitors of vesicular monoamine transporter 2
HK1212232A1 (en) 2012-09-18 2016-06-10 Auspex Pharmaceuticals, Inc. Formulations pharmacokinetics of deuterated benzoquinoline inhibitors of vesicular monoamine transporter 2
US9763904B2 (en) 2013-02-05 2017-09-19 Teva Pharmaceuticals International Gmbh Position-specific asymmetric deuterium enriched catecholamine derivatives and medicaments comprising said compounds
CN104968643B (zh) * 2013-02-05 2020-03-03 梯瓦制药国际有限责任公司 位置特异性的非对称氘富集儿茶酚胺衍生物和包含所述化合物的药物
WO2014174425A2 (en) * 2013-04-24 2014-10-30 Mahesh Kandula Compositions and methods for the treatment of orthostasis and neurological diseases
CN105473545B (zh) * 2013-07-08 2017-08-04 奥斯拜客斯制药有限公司 二羟苯基神经递质化合物、组合物以及方法
HK1224294A1 (zh) * 2013-11-22 2017-08-18 Auspex Pharmaceuticals, Inc. 治疗异常肌肉活动的方法
NZ720301A (en) 2013-12-03 2022-01-28 Auspex Pharmaceuticals Inc Deuterated tetrabenazine compounds
EA201691582A1 (ru) 2014-02-07 2017-01-30 Оспекс Фармасьютикалз, Инк. Новые фармацевтические препараты
EP2918266A1 (en) 2014-03-11 2015-09-16 CDRD Berolina AB Composition comprising a dopamine agonist and an L-DOPA derivative for treating Parkinson's disease
GB201420341D0 (en) * 2014-11-17 2014-12-31 Evolution Valves Ltd Valve arrangement
SG11201706959TA (en) 2015-03-06 2017-09-28 Auspex Pharmaceuticals Inc Methods for the treatment of abnormal involuntary movement disorders
CN106343013A (zh) * 2015-07-19 2017-01-25 中国科学院上海有机化学研究所 一种粮食储存方法
BR112018007118A2 (pt) 2015-10-09 2018-12-11 Teva Pharmaceuticals Int Gmbh método para tratar um distúrbio de deficiência de dopamina, método para melhorar o tempo motor ativo sem discinesia num paciente com doença de parkinson, método para reduzir discinesia num indivíduo com um distúrbio de deficiência de dopamina, método para reduzir o tempo motor inativo num indivíduo com um distúrbio de deficiência de dopamina, método para reduzir flutuações de nível de dopamina estriatal num indivíduo com um distúrbio de deficiência de dopamina, método para reduzir discinesia num indivíduo com um distúrbio de deficiência de dopamina após um tratamento de longo prazo, composição farmacêutica e embalagem
CN105360267B (zh) * 2015-10-09 2017-11-10 青岛振坤食品机械有限公司 一种全自动穿串机
CN105862897B (zh) * 2016-04-11 2018-01-16 江苏省华建建设股份有限公司 砂质泥岩地基浅基础原槽浇筑施工工法
SG11202101817UA (en) 2018-09-13 2021-03-30 Univ Canberra Methods of inhibition
SG11202105545QA (en) * 2018-12-06 2021-06-29 Senda Biosciences Inc Quaternary ammonium salts as inhibitors of trimethylamine production

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US3699158A (en) 1969-08-25 1972-10-17 Merck & Co Inc Selective deuteration of tyrosine, aspartic and glutamic acids
DE2049807A1 (en) 1970-10-10 1972-04-13 Hartmeyer H Conversion of closed cell plastics foam to - open cell structure
DE2049115C3 (de) 1970-10-06 1981-07-30 Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai, Tokyo Verwendung von Calcium-5-butylpicolinat und/oder Calcium-5-pentylpicolinat bei der Bekämpfung des Parkinsonismus mit 3-(3,4-Dihydroxyphenyl)-L-alanin (L-Dopa)
DE3779500T2 (de) * 1986-06-10 1993-01-21 Chiesi Farma Spa Levodopa-methyl-ester enthaltende pharmazeutische zusammensetzungen, ihre herstellung und therapeutische verwendungen.
IT1226902B (it) 1988-07-12 1991-02-21 Mini Ricerca Scient Tecnolog Processo per la sintesi del levodopa
US5354885A (en) * 1992-12-24 1994-10-11 Yissum Research Development Company Of The Hebrew University Of Jerusalem Process for preparing ethyl ester of L-DOPA
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US6440710B1 (en) * 1998-12-10 2002-08-27 The Scripps Research Institute Antibody-catalyzed deuteration, tritiation, dedeuteration or detritiation of carbonyl compounds
PT1104760E (pt) * 1999-12-03 2003-06-30 Pfizer Prod Inc Compostos de sulfamoil-heteroarilpirazole como agentes analgesicos e anti-inflamatorios
DE10261808A1 (de) * 2002-12-19 2004-07-08 Turicum Drug Development Ag Verwendung von L-DOPA, seiner Derivate und diese Verbindungen enthaltender Arzneimittel zur Prophylaxe psychotischer Erkrankungen
DE10261807A1 (de) 2002-12-19 2004-07-01 Turicum Drug Development Ag Deuterierte Catecholaminderivate sowie diese Verbindungen enthaltende Arzneimittel

Also Published As

Publication number Publication date
IL193102A (en) 2015-01-29
CN101384545A (zh) 2009-03-11
CA2642593C (en) 2014-11-04
EP3101001B1 (en) 2020-04-01
EA017983B1 (ru) 2013-04-30
BRPI0708071A2 (pt) 2011-05-17
CA2642593A1 (en) 2007-08-23
KR101411422B1 (ko) 2014-07-03
CN101384545B (zh) 2014-09-03
JP2009526799A (ja) 2009-07-23
HUE028777T2 (en) 2017-01-30
KR20080106539A (ko) 2008-12-08
US8247603B2 (en) 2012-08-21
SI1991522T1 (sl) 2016-10-28
US20090018191A1 (en) 2009-01-15
BRPI0708071A8 (pt) 2017-12-26
PT1991522T (pt) 2016-08-23
AU2007214622B2 (en) 2012-02-23
RS55142B1 (sr) 2016-12-30
WO2007093450A3 (en) 2007-09-27
DK1991522T3 (en) 2016-08-29
WO2007093450A2 (en) 2007-08-23
AU2007214622A1 (en) 2007-08-23
USRE46555E1 (en) 2017-09-19
ME02508B (me) 2017-06-20
EP1991522B1 (en) 2016-05-18
EP1991522A2 (en) 2008-11-19
IL193102A0 (en) 2009-02-11
LT1991522T (lt) 2016-09-26
ZA200806568B (en) 2009-07-29
EP3101001A1 (en) 2016-12-07
JP5248331B2 (ja) 2013-07-31
PL1991522T3 (pl) 2017-07-31
CY1117995T1 (el) 2017-05-17
ES2587368T3 (es) 2016-10-24
HRP20161039T1 (hr) 2016-11-04
EA200801826A1 (ru) 2009-02-27

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