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UA95952C2 - Заміщені біфенілкарбонові кислоти та їх похідні - Google Patents

Заміщені біфенілкарбонові кислоти та їх похідні

Info

Publication number
UA95952C2
UA95952C2 UAA200813476A UAA200813476A UA95952C2 UA 95952 C2 UA95952 C2 UA 95952C2 UA A200813476 A UAA200813476 A UA A200813476A UA A200813476 A UAA200813476 A UA A200813476A UA 95952 C2 UA95952 C2 UA 95952C2
Authority
UA
Ukraine
Prior art keywords
derivatives
carboxylic acids
substituted biphenyl
biphenyl carboxylic
group
Prior art date
Application number
UAA200813476A
Other languages
English (en)
Russian (ru)
Inventor
Френсис Вильсон
Элисон Род
Валери Ридер
Ричард Джон Херрисон
Михиро Сунозе
Ремедиос Эрнадес-Перни
Джереми Мейджор
Сирилл Буссар
Катрин Смелт
Джесс Тейлор
Аделин Леформал
Эндрю Кенсфилд
Свеня Бурккхардт
Чих Юнг Хо
Ян Жанг
Original Assignee
Орто-Макнил-Дженссен Фармасьютикалз, Инк.
Целльзом Лтд.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Орто-Макнил-Дженссен Фармасьютикалз, Инк., Целльзом Лтд. filed Critical Орто-Макнил-Дженссен Фармасьютикалз, Инк.
Publication of UA95952C2 publication Critical patent/UA95952C2/uk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
    • C07C59/66—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings
    • C07C59/68—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings the oxygen atom of the ether group being bound to a non-condensed six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/40—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/42—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton with carboxyl groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by saturated carbon chains
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Представлений винахід стосується сполук, що мають загальну формулу (І) з визначеннями X, Y, R,R, R, RRта R, поданими нижче, та їх солей або естерів.Крім того винахід стосується застосування зазначених сполук для лікування хвороби Альцгеймера та їх застосування для модулювання активності γ-секретази.
UAA200813476A 2006-04-21 2007-04-20 Заміщені біфенілкарбонові кислоти та їх похідні UA95952C2 (uk)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP06112938A EP1849762B1 (en) 2006-04-21 2006-04-21 Substituted biphenyl carboxylic acids and derivatives thereof

Publications (1)

Publication Number Publication Date
UA95952C2 true UA95952C2 (uk) 2011-09-26

Family

ID=36688012

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA200813476A UA95952C2 (uk) 2006-04-21 2007-04-20 Заміщені біфенілкарбонові кислоти та їх похідні

Country Status (35)

Country Link
US (1) US7557244B2 (uk)
EP (2) EP1849762B1 (uk)
JP (1) JP5479088B2 (uk)
KR (1) KR101542255B1 (uk)
CN (1) CN101687758B (uk)
AP (1) AP2008004656A0 (uk)
AR (1) AR060568A1 (uk)
AU (1) AU2007240335B2 (uk)
BR (1) BRPI0710656A2 (uk)
CA (1) CA2650006C (uk)
CR (2) CR10375A (uk)
CY (1) CY1109399T1 (uk)
DE (1) DE602006007810D1 (uk)
DK (1) DK1849762T3 (uk)
EA (1) EA016129B9 (uk)
ES (2) ES2328616T3 (uk)
GE (1) GEP20115269B (uk)
GT (1) GT200900120A (uk)
IL (2) IL194852A0 (uk)
MA (1) MA30475B1 (uk)
MX (1) MX2008013445A (uk)
MY (1) MY148953A (uk)
NO (1) NO20084517L (uk)
NZ (1) NZ573000A (uk)
PE (1) PE20080364A1 (uk)
PL (1) PL1849762T3 (uk)
PT (1) PT1849762E (uk)
SI (1) SI1849762T1 (uk)
SM (1) SMP200800061B (uk)
TN (1) TNSN08413A1 (uk)
TW (1) TWI399362B (uk)
UA (1) UA95952C2 (uk)
UY (1) UY30301A1 (uk)
WO (1) WO2007124394A1 (uk)
ZA (1) ZA200809856B (uk)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2010004311A (es) * 2007-10-19 2010-05-03 Janssen Pharmaceutica Nv Productos intermedios de moduladores de gamma-secretasa.
EP2212277B1 (en) * 2007-10-19 2016-08-31 Janssen Pharmaceutica, N.V. Amine linked modulators of y-secretase
NZ584716A (en) 2007-10-19 2011-12-22 Janssen Pharmaceutica Nv PIPERIDINYL AND PIPERAZINYL MODULATORS OF gamma-SECRETASE
CA2702959C (en) 2007-10-19 2016-07-26 Janssen Pharmaceutica Nv Carbon linked modulators of .gamma.-secretase
US20110092554A1 (en) * 2007-11-19 2011-04-21 Richard Chesworth 1,3,5 tri-subtituted benzenes for treatment of alzheimer's disease and other disorders
RU2527177C2 (ru) 2007-12-20 2014-08-27 Энвиво Фармасьютикалз, Инк. Четырехзамещенные бензолы
WO2011046774A1 (en) * 2009-10-16 2011-04-21 Merck Sharp & Dohme Corp. Diaryl ether derivatives as notch sparing gamma secretase inhibitors
US8785481B2 (en) 2010-09-29 2014-07-22 Merck Sharp & Dohme Corp. Ether benzotriazole derivatives
CA2828764A1 (en) * 2011-03-03 2012-09-07 Treventis Corporation Anti-amyloid compounds and methods
WO2015109109A1 (en) 2014-01-15 2015-07-23 Forum Pharmaceuticals Inc. Fused morpholinopyrimidines and methods of use thereof
US9802927B2 (en) 2015-06-10 2017-10-31 Denali Therapeutics, Inc. Oxadiazine compounds and methods of use thereof

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5877399A (en) 1994-01-27 1999-03-02 Johns Hopkins University Transgenic mice expressing APP-Swedish mutation develop progressive neurologic disease
JP3802581B2 (ja) * 1995-03-01 2006-07-26 富山化学工業株式会社 新規なビフェニル誘導体またはその塩およびそれらを含有する抗炎症剤
AU5702201A (en) 2000-04-13 2001-10-30 Mayo Foundation Abeta<sub>42</sub> lowering agents
DE10131899A1 (de) 2001-07-04 2003-02-27 Boehringer Ingelheim Pharma In vitro-Screening-Assay für gamma-Secretase
RU2319698C2 (ru) * 2002-06-27 2008-03-20 Астеллас Фарма Инк. АЛЬФА-ФЕНИЛ ИЛИ ПИРИДИЛ-ЭТАНОЛАМИНЫ И ИХ ПРИМЕНЕНИЕ В КАЧЕСТВЕ АГОНИСТОВ β3 АДРЕНЕРГИЧЕСКИХ РЕЦЕПТОРОВ
GB0305918D0 (en) * 2003-03-14 2003-04-23 Glaxo Group Ltd Novel compounds
WO2005110963A1 (en) * 2004-05-19 2005-11-24 Cellzome Ag (biphenyl-3-yl)-carboxylic acids and derivatives thereof and their use in therapy
GB0416508D0 (en) * 2004-07-23 2004-08-25 Merck Sharp & Dohme Therapeutic agents
TW200621227A (en) * 2004-08-24 2006-07-01 Kissei Pharmaceutical Medicament for preventing or treating fatty liver
US8148572B2 (en) * 2005-10-06 2012-04-03 Astrazeneca Ab Compounds

Also Published As

Publication number Publication date
CA2650006A1 (en) 2007-11-01
AU2007240335A1 (en) 2007-11-01
MY148953A (en) 2013-06-14
AP2008004656A0 (en) 2008-10-31
EP1849762B1 (en) 2009-07-15
IL194852A0 (en) 2009-08-03
EA200802172A1 (ru) 2009-06-30
JP5479088B2 (ja) 2014-04-23
EP2021314A1 (en) 2009-02-11
PT1849762E (pt) 2009-09-16
ES2328616T3 (es) 2009-11-16
TWI399362B (zh) 2013-06-21
AU2007240335B2 (en) 2013-05-02
NZ573000A (en) 2011-11-25
IL194790A0 (en) 2009-08-03
SI1849762T1 (sl) 2009-12-31
EP2021314B1 (en) 2013-01-23
CN101687758B (zh) 2014-05-14
KR20090024679A (ko) 2009-03-09
UY30301A1 (es) 2007-08-31
US20070293567A1 (en) 2007-12-20
TNSN08413A1 (en) 2010-04-14
ES2400530T3 (es) 2013-04-10
EP1849762A1 (en) 2007-10-31
JP2009544573A (ja) 2009-12-17
MX2008013445A (es) 2009-03-10
CR10451A (es) 2009-03-31
EA016129B9 (ru) 2012-06-29
BRPI0710656A2 (pt) 2011-08-16
PL1849762T3 (pl) 2009-12-31
CY1109399T1 (el) 2014-07-02
CR10375A (es) 2009-02-26
GEP20115269B (en) 2011-08-25
KR101542255B1 (ko) 2015-08-06
NO20084517L (no) 2009-01-13
US7557244B2 (en) 2009-07-07
IL194790A (en) 2012-12-31
MA30475B1 (fr) 2009-06-01
TW200815320A (en) 2008-04-01
WO2007124394A1 (en) 2007-11-01
DE602006007810D1 (de) 2009-08-27
SMP200800061B (it) 2009-07-14
CN101687758A (zh) 2010-03-31
PE20080364A1 (es) 2008-05-16
SMAP200800061A (it) 2008-11-19
ZA200809856B (en) 2009-06-24
AR060568A1 (es) 2008-06-25
CA2650006C (en) 2016-08-23
GT200900120A (es) 2009-11-16
DK1849762T3 (da) 2009-10-12
EA016129B1 (ru) 2012-02-28

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