[go: up one dir, main page]

UA95922C2 - Glucuronate salt of a piperazine compound - Google Patents

Glucuronate salt of a piperazine compound

Info

Publication number
UA95922C2
UA95922C2 UAA200804630A UAA200804630A UA95922C2 UA 95922 C2 UA95922 C2 UA 95922C2 UA A200804630 A UAA200804630 A UA A200804630A UA A200804630 A UAA200804630 A UA A200804630A UA 95922 C2 UA95922 C2 UA 95922C2
Authority
UA
Ukraine
Prior art keywords
piperazine compound
glucuronate salt
salt form
present
salt
Prior art date
Application number
UAA200804630A
Other languages
English (en)
Ukrainian (uk)
Inventor
Субодх С. Дешмук
Кадум Али
Кристофер Р. Диорио
Эрик С. Эрншпергер
Махди Б. Фавзи
Суэд Музафар Шах
Махмуд Мирмехраби
Original Assignee
Эббот Хелскеа Продактс Б.В.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37603202&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UA95922(C2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Эббот Хелскеа Продактс Б.В. filed Critical Эббот Хелскеа Продактс Б.В.
Publication of UA95922C2 publication Critical patent/UA95922C2/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/538—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Addiction (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

В этом изобретении предлагается солевая форма и композиции на ее основе, которая может использоваться как модулятор одного или нескольких GPCR и имеет необходимые для этого свойства.Изобретение также предлагает способ получения указанной солевой формы, которая происходит от 8-{4-[3-(5-фтор-1Н-индол-3-ил)-пропил]-пиперазин-1-ил}-2-метил-4Н-бенз[1,4]оксазин-3-она и глюкуроновой кислоты.
UAA200804630A 2005-09-12 2006-12-09 Glucuronate salt of a piperazine compound UA95922C2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US71616705P 2005-09-12 2005-09-12

Publications (1)

Publication Number Publication Date
UA95922C2 true UA95922C2 (en) 2011-09-26

Family

ID=37603202

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA200804630A UA95922C2 (en) 2005-09-12 2006-12-09 Glucuronate salt of a piperazine compound

Country Status (20)

Country Link
US (1) US7595310B2 (ru)
EP (1) EP1940830A1 (ru)
JP (1) JP2009507921A (ru)
KR (1) KR20080045285A (ru)
CN (1) CN101287730B (ru)
AR (1) AR056506A1 (ru)
AU (1) AU2006291058B2 (ru)
BR (1) BRPI0615853A2 (ru)
CA (1) CA2620755A1 (ru)
EA (1) EA014942B1 (ru)
GT (1) GT200600414A (ru)
IL (1) IL189809A0 (ru)
MY (1) MY144782A (ru)
NO (1) NO20081809L (ru)
PE (1) PE20070433A1 (ru)
SA (1) SA06270329B1 (ru)
TW (1) TW200800974A (ru)
UA (1) UA95922C2 (ru)
WO (1) WO2007033191A1 (ru)
ZA (1) ZA200802310B (ru)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200800306A (en) 2005-09-12 2008-01-01 Wyeth Corp Sustained-release formulation and uses thereof
GT200600414A (es) 2005-09-12 2007-09-20 Sal de glucuranato de compuesto de piperazine
GT200600416A (es) 2005-09-12 2007-09-20 Sales salicilato y gentisato de un compuesto de piperazina
ES2617671T3 (es) 2007-05-11 2017-06-19 Richter Gedeon Nyrt. Forma cristalina de un derivado de carbamoil ciclohexano
HUP0700353A2 (en) 2007-05-18 2008-12-29 Richter Gedeon Nyrt Metabolites of (thio)carbamoyl-cyclohexane derivatives
US7875610B2 (en) 2007-12-03 2011-01-25 Richter Gedeon Nyrt. Pyrimidinyl-piperazines useful as D3/D2 receptor ligands
MY156288A (en) 2008-07-16 2016-01-29 Richter Gedeon Nyrt Pharmaceutical formulations containing dopamine receptor ligands.
HU230067B1 (hu) 2008-12-17 2015-06-29 Richter Gedeon Nyrt Új piperazin só és eljárás előállítására
HUP0800766A2 (en) 2008-12-18 2010-11-29 Richter Gedeon Vegyeszet Process for the preparation of piperazine derivatives
HUP0800765A2 (en) 2008-12-18 2010-11-29 Richter Gedeon Nyrt A new process for the preparation of piperazine derivatives and their hydrochloric salts
WO2014031162A1 (en) 2012-08-20 2014-02-27 Forest Laboratories Holdings Limited Crystalline form of carbamoyl-cyclohexane derivatives
US11274087B2 (en) 2016-07-08 2022-03-15 Richter Gedeon Nyrt. Industrial process for the preparation of cariprazine
US11547707B2 (en) 2019-04-10 2023-01-10 Richter Gedeon Nyrt. Carbamoyl cyclohexane derivatives for treating autism spectrum disorder

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4438119A (en) 1982-12-23 1984-03-20 Mead Johnson & Company Method for alleviation of extrapyramidal motor disorders
US4687772A (en) 1986-10-07 1987-08-18 Bristol-Myers Company Method for improvement of short term memory
US4771053A (en) 1987-03-02 1988-09-13 Bristol-Myers Company Method for alleviation of primary depressive disorders
US5162375A (en) 1988-05-06 1992-11-10 Beecham Group P.L.C. Treatment of neuronal degeneration with 5HT1A agonists
DE4135551A1 (de) 1991-08-31 1993-03-04 Schering Ag Verwendung von antagonisten oder partiellen agonisten am 5-ht1a-rezeptor zur behandlung und praevention von kognitiven stoerungen
US5824680A (en) 1991-08-31 1998-10-20 Bayer Aktiengesellschaft Ipsapirone for the treatment of alzheimer's disease by improving memory
US5716960A (en) * 1995-01-13 1998-02-10 U.S. Bioscience Inc. And Individuals Crystalline trimetrexate salts and the process for making the same
SE9900190D0 (sv) 1999-01-22 1999-01-22 Astra Ab New compounds
DE19730989A1 (de) * 1997-07-18 1999-01-21 Merck Patent Gmbh Piperazin-Derivate
AU736596B2 (en) * 1997-07-25 2001-08-02 H. Lundbeck A/S Indole and 2,3-dihydroindole derivatives, their preparation and use
HN1999000146A (es) 1998-09-21 2000-11-11 Pfizer Prod Inc Agentes farmaceuticos para el tratamiento de la enfermedad de parkinson, adhd y microadenomas.
CZ298533B6 (cs) * 1999-08-23 2007-10-31 Solvay Pharmaceuticals B. V. Deriváty fenylpiperazinu, zpusob jejich prípravy a farmaceutické prostredky s jejich obsahem
PL356605A1 (en) 2000-01-19 2004-06-28 Akzo Nobel N.V. Drug combination for the treatment of depression and related disorders comprising mirtazapine and gepirone
AR032712A1 (es) * 2001-02-21 2003-11-19 Solvay Pharm Bv Un mesilato de derivados de fenilpiperazina y composiciones farmaceuticas que lo contienen
US7514438B2 (en) 2003-08-13 2009-04-07 Amgen, Inc. Melanin concentrating hormone receptor antagonist
EP1592688A2 (en) 2003-12-18 2005-11-09 Teva Pharmaceutical Industries Ltd. Polymorphic form b2 of ziprasidone base
GT200600414A (es) 2005-09-12 2007-09-20 Sal de glucuranato de compuesto de piperazine
GT200600416A (es) * 2005-09-12 2007-09-20 Sales salicilato y gentisato de un compuesto de piperazina
TW200800306A (en) 2005-09-12 2008-01-01 Wyeth Corp Sustained-release formulation and uses thereof

Also Published As

Publication number Publication date
AR056506A1 (es) 2007-10-10
SA06270329B1 (ar) 2010-06-15
AU2006291058A1 (en) 2007-03-22
CA2620755A1 (en) 2007-03-22
MY144782A (en) 2011-11-15
BRPI0615853A2 (pt) 2011-05-31
ZA200802310B (en) 2008-12-31
EA014942B1 (ru) 2011-04-29
EP1940830A1 (en) 2008-07-09
US20070254876A1 (en) 2007-11-01
IL189809A0 (en) 2008-08-07
GT200600414A (es) 2007-09-20
TW200800974A (en) 2008-01-01
US7595310B2 (en) 2009-09-29
PE20070433A1 (es) 2007-04-24
AU2006291058B2 (en) 2011-09-08
JP2009507921A (ja) 2009-02-26
CN101287730B (zh) 2012-03-07
KR20080045285A (ko) 2008-05-22
WO2007033191A1 (en) 2007-03-22
NO20081809L (no) 2008-04-14
EA200800810A1 (ru) 2008-10-30
CN101287730A (zh) 2008-10-15

Similar Documents

Publication Publication Date Title
TW200420641A (en) Resin compositions
WO2007120980A3 (en) 2,4-pyrimidinediamine compounds for treating or preventing autoimmune diseases
WO2004082822A3 (en) Methods for isolating crystalline form i of 5-azacytidine
WO2008070462A3 (en) N-oxides of 4,5-epoxy-morphinanium analogs
NO20044882L (no) Acyl-4-karboksylfenylurinstoffderivater, deres fremstilling og anvendelse
MY152283A (en) Polo-like kinase inhibitirs
AU2002319814A1 (en) Substituted 1h-dihydropyrazoles, their preparation and use
WO2004074244A3 (en) Pyrimidine compounds
MX2009002229A (es) Benzotriazoles como moduladores de cinasas.
MX2009005462A (es) Analogos de 7,8-saturados-4,5-epoxi-morfinano.
WO2001090106A3 (en) Tryasolyl tropane derivatives as ccr5 modulators
WO2006034039A3 (en) Substituted morphinans and methods of their use
MX2010001576A (es) Compuestos 3´sustituidos que tienen afinidad con el receptor 5-hidroxitriptamina 6 (5-ht6).
AU2003228770A1 (en) Substituted pyrazolopyrimidines
UA95922C2 (en) Glucuronate salt of a piperazine compound
AU2003228674A1 (en) Muscarinic antagonists
MXPA02011370A (es) Iminoazinas substituidas.
WO2005070884A3 (en) Heterocyclic compounds useful as growth hormone secretagogues
TW200420541A (en) Crystalline forms
PT2049480E (pt) Derivados de 2-arilindole como inibidores da mpges-i
WO2006100081A3 (de) Substituierte oxindol-derivate, diese enthaltende arzneimittel und deren verwendung
MX2009008324A (es) Compuestos 6´-sustituidos que tienen afinidad con el receptor de 5-hidroxitriptamina-6.
WO2004112704A3 (en) Substituted piperidine compounds and methods of their use
WO2007134149A3 (en) 3,4-dihydro-2h-benzo[1,4]oxazine and thiazine derivatives as cetp inhibitors
WO2008116185A3 (en) Substituted pyrimidines as adenosine receptor antagonists