UA95602C2 - Иммуногенная композиция цвс2 и способы приготовления такой композиции - Google Patents
Иммуногенная композиция цвс2 и способы приготовления такой композицииInfo
- Publication number
- UA95602C2 UA95602C2 UAA200708620A UAA200708620A UA95602C2 UA 95602 C2 UA95602 C2 UA 95602C2 UA A200708620 A UAA200708620 A UA A200708620A UA A200708620 A UAA200708620 A UA A200708620A UA 95602 C2 UA95602 C2 UA 95602C2
- Authority
- UA
- Ukraine
- Prior art keywords
- reading frame
- open reading
- expressed
- protein
- compositions
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56983—Viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
- A61K2039/552—Veterinary vaccine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/14011—Baculoviridae
- C12N2710/14111—Nucleopolyhedrovirus, e.g. autographa californica nucleopolyhedrovirus
- C12N2710/14141—Use of virus, viral particle or viral elements as a vector
- C12N2710/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/14011—Baculoviridae
- C12N2710/14111—Nucleopolyhedrovirus, e.g. autographa californica nucleopolyhedrovirus
- C12N2710/14161—Methods of inactivation or attenuation
- C12N2710/14163—Methods of inactivation or attenuation by chemical treatment
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/10011—Circoviridae
- C12N2750/10022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/10011—Circoviridae
- C12N2750/10034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/10011—Circoviridae
- C12N2750/10051—Methods of production or purification of viral material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/10011—Arteriviridae
- C12N2770/10034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Virology (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biophysics (AREA)
- Food Science & Technology (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Pathology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Physics & Mathematics (AREA)
- General Engineering & Computer Science (AREA)
- Tropical Medicine & Parasitology (AREA)
- Cell Biology (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- General Chemical & Material Sciences (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
Abstract
Изобретение относится к способу восстановления протеина, экспрессированного открытой рамкой считывания 2, из цирковируса свиньи 2. Способ включает этапы трансфектирования рекомбинантного бакуловируса, который содержит открытую рамку считывания 2, который кодирует последовательности в клетках, помещенных в ростовую среду, которая заставляет вирус экспрессировать открытую рамку считывания 2, и восстановление экспресированного протеина в супернатанте. Это восстановление происходит приблизительно через 5 дней после инфицирования клеток, чтобы достаточное количество рекомбинированного протеина экспрессировалось и секретировалось клеткой в питательную среду. Такие способы предохраняют от дорогих и трудоемких методик экстракции, которые нужны для выделения и восстановления рекомбинантного протеина в клетках.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US64051004P | 2004-12-30 | 2004-12-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA95602C2 true UA95602C2 (ru) | 2011-08-25 |
Family
ID=50836643
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UAA200708620A UA95602C2 (ru) | 2004-12-30 | 2005-12-29 | Иммуногенная композиция цвс2 и способы приготовления такой композиции |
| UAA201015883A UA107177C2 (uk) | 2004-12-30 | 2010-12-29 | Імуногенна композиція цвс2 та спосіб приготування такої композиції |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UAA201015883A UA107177C2 (uk) | 2004-12-30 | 2010-12-29 | Імуногенна композиція цвс2 та спосіб приготування такої композиції |
Country Status (2)
| Country | Link |
|---|---|
| US (2) | US9919041B2 (ru) |
| UA (2) | UA95602C2 (ru) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA95602C2 (ru) * | 2004-12-30 | 2011-08-25 | Берингер Ингельхейм Ветмедика, Инк. | Иммуногенная композиция цвс2 и способы приготовления такой композиции |
| DK3127551T3 (da) | 2005-12-29 | 2020-10-12 | Boehringer Ingelheim Animal Health Usa Inc | Pcv2-immunogen-sammensætning til at mindske kliniske symptomer i grise |
| US20080226669A1 (en) | 2005-12-29 | 2008-09-18 | Boehringer Ingelheim Vetmedica, Inc. | Multivalent pcv2 immunogenic compositions and methods of producing such compositions |
| US20100129397A1 (en) | 2006-12-11 | 2010-05-27 | Boehringer Ingelheim Vetmedica, Inc. | Effective method of treatment of porcine circovirus and lawsonia intracellularis infections |
| EP1958644A1 (en) | 2007-02-13 | 2008-08-20 | Boehringer Ingelheim Vetmedica Gmbh | Prevention and treatment of sub-clinical pcvd |
Family Cites Families (98)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0283085B1 (en) | 1987-03-17 | 1992-11-11 | Akzo N.V. | Adjuvant mixture |
| US5069901A (en) | 1988-02-03 | 1991-12-03 | Jones Elaine V | Preparation of a recombinant subunit vaccine against pseudorabies infection |
| AU638970B2 (en) | 1989-01-23 | 1993-07-15 | Auspharm International Limited | Vaccine composition |
| US5155037A (en) | 1989-08-04 | 1992-10-13 | The Texas A&M University System | Insect signal sequences useful to improve the efficiency of processing and secretion of foreign genes in insect systems |
| US5202430A (en) | 1990-01-16 | 1993-04-13 | University Of Tennessee | Transmissible gastroenteritis virus genes |
| CA2082155C (en) | 1990-05-29 | 2008-04-15 | Krishnaswamy I. Dayalu | Swine pneumonia vaccine and method of preparation |
| US5565205A (en) | 1990-08-16 | 1996-10-15 | Solvay Animal Health, Inc. | Inactivated Mycoplasma hypopneumoniae bacterin and method of use thereof |
| GB9023111D0 (en) | 1990-10-24 | 1990-12-05 | Wellcome Found | Expression system |
| CA2094515C (en) | 1990-11-01 | 1998-09-01 | Theodore T. Kramer | Bacterial attenuation method and vaccine |
| US6042830A (en) | 1992-08-05 | 2000-03-28 | Boehringer Ingelheim Vetmedica, Inc. | Viral agent associated with mystery swine disease |
| CA2076744C (en) | 1991-08-26 | 2000-06-27 | Danny W. Chladek | Viral agent associated with mystery swine disease |
| US5580557A (en) | 1991-10-09 | 1996-12-03 | Iowa State University Research Foundation, Inc. | Live, avirulent salmonella choleraesuis vaccine used for inducing an immune response in animals |
| US5338543A (en) | 1992-02-27 | 1994-08-16 | Ambico, Inc. | Thimerosal inactivated mycoplasma hyopneumoniae vaccine |
| NZ285324A (en) | 1994-05-10 | 1998-08-26 | American Home Prod | Vaccine containing modified live bovine respiratory syncytial virus (brsv) with an adjuvant and pharmaceutically acceptable carrier |
| US5885823A (en) | 1995-06-05 | 1999-03-23 | Nobl Laboratories, Inc. | Lawsonia intracellularis cultivation, anti-Lawsonia intracellularis vaccines and diagnostic agents |
| CA2264953C (en) | 1996-08-16 | 2008-09-30 | The Texas A & M University System | Modifying insect cell gylcosylation pathways with baculovirus expression vectors |
| DE69704011T2 (de) | 1996-10-09 | 2001-06-07 | Akzo Nobel Nv | Europäische Vakzinstämme des Fortplanzungs-Atmungs-Syndromsvirus des Sweins (PRRSV) |
| UA78180C2 (ru) | 1997-10-03 | 2007-03-15 | Меріаль | Кольцевой вирус свиньи, вакцины и диагностические реагенты |
| US7192594B2 (en) | 1997-10-03 | 2007-03-20 | Merial Limited | Postweaning multisystemic wasting syndrome and porcine circovirus from pigs |
| US20060029617A1 (en) | 1997-10-03 | 2006-02-09 | Charreyre Catherine E | Porcine circovirus and Helicobacter combination vaccines and methods of use |
| FR2781159B1 (fr) | 1998-07-06 | 2000-10-06 | Merial Sas | Vaccin circovirus et parvovirus porcin |
| US7211379B2 (en) | 1997-10-03 | 2007-05-01 | Merial Sas | Prevention of myocarditis, abortion and intrauterine infection associated with porcine circovirus-2 |
| US6391314B1 (en) | 1997-10-03 | 2002-05-21 | Merial | Porcine circoviruses vaccines diagnostic reagents |
| US6517843B1 (en) | 1999-08-31 | 2003-02-11 | Merial | Reduction of porcine circovirus-2 viral load with inactivated PCV-2 |
| US20040062775A1 (en) | 1997-12-05 | 2004-04-01 | Agence Francaise De Securite Sanitaire Des Aliments | Circovirus sequences associated with piglet weight loss disease (PWD) |
| FR2772047B1 (fr) | 1997-12-05 | 2004-04-09 | Ct Nat D Etudes Veterinaires E | Sequence genomique et polypeptides de circovirus associe a la maladie de l'amaigrissement du porcelet (map), applications au diagnostic et a la prevention et/ou au traitement de l'infection |
| JP3795751B2 (ja) | 1997-12-11 | 2006-07-12 | ユニバーシティ オブ サスカッチェワン | ブタからの離乳後多全身系消耗症候群ウイルス |
| US6287856B1 (en) | 1998-03-13 | 2001-09-11 | University Of Georgia Research Foundation, Inc. | Vaccines against circovirus infections |
| US6294176B1 (en) | 1998-07-10 | 2001-09-25 | Schering-Plough Veterinary Corp. | Recombinant raccoonpox virus and uses thereof as a vaccine in mammalian and avian species |
| DE69933647T2 (de) | 1998-11-19 | 2007-08-23 | Azwell Inc. | Rekombinante lysophosphatidsäure - phosphatase. |
| FR2789695B1 (fr) | 1999-02-11 | 2003-03-07 | Merial Sas | Vecteurs et vaccins viraux a base d'adenovirus porcins recombines et replicatifs |
| US6497883B1 (en) | 1999-06-10 | 2002-12-24 | Merial | Porcine circovirus recombinant poxvirus vaccine |
| US6943152B1 (en) | 1999-06-10 | 2005-09-13 | Merial | DNA vaccine-PCV |
| WO2001017556A1 (fr) | 1999-09-07 | 2001-03-15 | Shionogi & Co., Ltd. | Préparations vaccinales administrables par les muqueuses |
| US6656478B1 (en) | 1999-11-12 | 2003-12-02 | Samuel D. Charles | Cross-protective salmonella vaccines |
| DK1248646T3 (da) | 1999-12-21 | 2008-05-19 | Merial Sas | Præparater og vacciner indeholdende antigen(er) fra cryptosporidium parvum og fra andet enterisk patogen |
| EP1290016A2 (en) | 2000-06-15 | 2003-03-12 | Purdue Research Foundation | Vaccine for congenital tremors in pigs |
| US6808900B2 (en) | 2000-06-15 | 2004-10-26 | Manitoba, University Of | Cryptosporidium parvum antigens, antibodies thereto and diagnostic and therapeutic compositions thereof |
| MY129765A (en) | 2000-12-19 | 2007-04-30 | Wyeth Corp | Improved mycoplasma hyopneumoniae bacterin vaccine |
| US7018638B2 (en) | 2000-12-19 | 2006-03-28 | Wyeth | Mycoplasma hyopneumoniae bacterin vaccine |
| JP2002247979A (ja) | 2001-02-23 | 2002-09-03 | Nippon Biologicals Inc | マレック病ワクチンおよびその製造方法 |
| CZ304525B6 (cs) | 2001-03-27 | 2014-06-18 | University Of Saskatchewan | Způsob kultivace circoviru |
| US20030096377A1 (en) | 2001-06-28 | 2003-05-22 | Virginia Tech Intellectual Properties, Inc. | Differential PCR-RFLP assay for detecting and distinguishing between nonpathogenic PCV-1 and pathogenic PCV-2 |
| HRP20031079A2 (en) | 2001-07-02 | 2005-10-31 | Pfizer Products Inc. | One dose vaccination with mycoplasma hyopneumoniae |
| US7361352B2 (en) | 2001-08-15 | 2008-04-22 | Acambis, Inc. | Influenza immunogen and vaccine |
| US7279166B2 (en) | 2001-12-12 | 2007-10-09 | Virginia Tech Intellectual Properties, Inc. | Chimeric infectious DNA clones, chimeric porcine circoviruses and uses thereof |
| US7276353B2 (en) | 2001-12-12 | 2007-10-02 | Virginia Tech Intellectual Properties, Inc. | Chimeric infectious DNA clones, chimeric porcine circoviruses and uses thereof |
| US6841364B2 (en) | 2002-01-22 | 2005-01-11 | Protatek International, Inc. | Infectious cDNA clones of porcine reproductive and respiratory syndrome virus and expression vectors thereof |
| US20040121465A1 (en) | 2002-02-14 | 2004-06-24 | Novavax, Inc. | Optimization of gene sequences of virus-like particles for expression in insect cells |
| WO2003077860A2 (en) | 2002-03-13 | 2003-09-25 | Biophysica, Inc. | BOSWELLIN COMPOSITIONS ENHANCED WITH 3-β-ACETYL-11-KETO-β-BOSWELLIC ACID (“AKBA”), INDUSTRIAL MANUFACTURE AND THEIR USES |
| US20030215455A1 (en) | 2002-05-14 | 2003-11-20 | Bailey Reynolds | Vaccine stabilizer and method of use |
| AU2002951692A0 (en) | 2002-09-23 | 2002-10-17 | Vital Biotech (Hong Kong) Limited | Improvements in or relating to vaccines |
| UA84284C2 (ru) | 2003-02-03 | 2008-10-10 | Сирибас Байолоджикалз, Инк. | Способы лечения, профилактики и диагностики инфекции helicobacter cerdo |
| US7563449B2 (en) | 2003-04-21 | 2009-07-21 | Pfizer Inc, | Methods for reducing cattle reproductive diseases |
| CN1458167A (zh) | 2003-06-02 | 2003-11-26 | 中国农业科学院哈尔滨兽医研究所 | 截短表达的猪圆环病毒ⅱ型衣壳蛋白抗原及其应用 |
| US7335361B2 (en) | 2003-06-09 | 2008-02-26 | Animal Technology Institute Taiwan | Fusion antigen used as vaccine |
| UA84024C2 (ru) | 2003-07-24 | 2008-09-10 | Мериал Лимитед | Новые вакцинные композиции, которые содержат эмульсию типа "масло в воде" |
| CN101423811A (zh) | 2003-07-25 | 2009-05-06 | 贝林格尔.英格海姆维特梅迪卡有限公司 | 源自欧洲的细胞内罗森氏菌及其疫苗,诊断剂及使用方法 |
| FR2861731B1 (fr) | 2003-10-30 | 2006-02-24 | Centre Nat Rech Scient | Nouvelle proteine de fixation du phosphate, compositions pharmaceutiques la contenant et ses utilisations |
| CN1942204A (zh) | 2004-04-26 | 2007-04-04 | 株式会社中央疫苗研究所 | 用于猪呼吸病的灭活混合疫苗及其制备方法 |
| CN1579553A (zh) | 2004-05-18 | 2005-02-16 | 浙江大学 | Ii型猪圆环病毒核酸疫苗的制备方法及其应用 |
| KR100478845B1 (ko) | 2004-06-22 | 2005-03-24 | 채찬희 | 돼지 이유자돈 전신성 소모성 증후군 예방 및 치료용 생물학적 조성물 |
| EP1778283A2 (en) | 2004-06-30 | 2007-05-02 | ID Biomedical Corporation of Quebec | Vaccine compositions for treating coronavirus infection |
| US7700285B1 (en) | 2005-12-29 | 2010-04-20 | Boehringer Ingelheim Vetmedica, Inc. | PCV2 immunogenic compositions and methods of producing such compositions |
| UA95602C2 (ru) * | 2004-12-30 | 2011-08-25 | Берингер Ингельхейм Ветмедика, Инк. | Иммуногенная композиция цвс2 и способы приготовления такой композиции |
| US7833707B2 (en) | 2004-12-30 | 2010-11-16 | Boehringer Ingelheim Vetmedica, Inc. | Methods of overexpression and recovery of porcine circovirus type 2 ORF2 |
| EP1838343B1 (en) | 2005-01-13 | 2010-03-31 | Boehringer Ingelheim Vetmedica Gmbh | Prrs vaccines |
| US7300785B2 (en) | 2005-02-03 | 2007-11-27 | Universiteit Ghent | Culturing circular ssDNA viruses for the production of vaccines |
| US8834891B2 (en) | 2005-03-14 | 2014-09-16 | Boehringer Ingelheim Vetmedica, Inc. | Immunogenic compositions comprising Lawsonia intracellularis |
| WO2006113435A2 (en) | 2005-04-13 | 2006-10-26 | Merial Limited | Method for porcine circovirus production and assays for monitoring production |
| US7691368B2 (en) | 2005-04-15 | 2010-04-06 | Merial Limited | Vaccine formulations |
| RU2389506C2 (ru) | 2005-09-09 | 2010-05-20 | Интервет Интернэшнл Б.В. | Вакцина против рсv-2 |
| DK3127551T3 (da) * | 2005-12-29 | 2020-10-12 | Boehringer Ingelheim Animal Health Usa Inc | Pcv2-immunogen-sammensætning til at mindske kliniske symptomer i grise |
| US20080226669A1 (en) | 2005-12-29 | 2008-09-18 | Boehringer Ingelheim Vetmedica, Inc. | Multivalent pcv2 immunogenic compositions and methods of producing such compositions |
| WO2008064299A2 (en) | 2006-11-22 | 2008-05-29 | Boehringer Ingelheim Vetmedica, Inc. | Methods of reducing porcine circovirus-associated disease outbreaks |
| US20100129397A1 (en) | 2006-12-11 | 2010-05-27 | Boehringer Ingelheim Vetmedica, Inc. | Effective method of treatment of porcine circovirus and lawsonia intracellularis infections |
| DK2094872T4 (da) * | 2006-12-15 | 2020-05-18 | Boehringer Ingelheim Animal Health Usa Inc | Behandling af anti-PCV2-antistofseropositive svin med PCV2-antigen |
| EP1941903A1 (en) | 2007-01-03 | 2008-07-09 | Boehringer Ingelheim Vetmedica Gmbh | Prophylaxis and treatment of PRDC |
| EP1958644A1 (en) | 2007-02-13 | 2008-08-20 | Boehringer Ingelheim Vetmedica Gmbh | Prevention and treatment of sub-clinical pcvd |
| GB0712160D0 (en) | 2007-06-22 | 2007-08-01 | Univ Ghent | Methods and compositions in the treatment of procine circoviral infection |
| US20090017064A1 (en) | 2007-07-10 | 2009-01-15 | Wyeth | Methods and Compositions for Immunizing Pigs Against Porcine Circovirus |
| US7829274B2 (en) | 2007-09-04 | 2010-11-09 | Boehringer Ingelheim Vetmedica, Inc. | Reduction of concomitant infections in pigs by the use of PCV2 antigen |
| JP5613061B2 (ja) | 2008-01-23 | 2014-10-22 | ベーリンガー インゲルハイム フェトメディカ インコーポレイテッド | Pcv2マイコプラズマ・ハイオニューモニエ免疫原性組成物および前記組成物の製造方法 |
| US20110033495A1 (en) | 2008-02-15 | 2011-02-10 | Boehringer Ingelheim Vetmedica, Inc. | Methods and compositions for reducing the impact of enteric diseases |
| US8444989B1 (en) | 2008-04-18 | 2013-05-21 | Boehringer Ingelheim Vetmedica Gmbh | One dose vaccination against mycoplasma infections of pigs |
| US20100150959A1 (en) | 2008-12-15 | 2010-06-17 | Vectogen Pty Ltd. | PCV 2-Based Methods and Compositions for the Treatment of Pigs |
| AR078253A1 (es) | 2009-09-02 | 2011-10-26 | Boehringer Ingelheim Vetmed | Metodos para reducir la actividad antivirica en composiciones pcv-2 y composiciones pcv-2 con mejor inmunogenicidad |
| US20110150770A1 (en) | 2009-12-18 | 2011-06-23 | Boehringer Ingelheim Vetmedica, Inc. | Multivalent vaccine against porcine teschovirus and other disease causing organisms in swine |
| PT2547770T (pt) | 2010-03-16 | 2020-03-04 | Virginia Tech Intellectual Properties Inc | Vacina contra circovirus suíno, quimérica, atenuada, viva |
| US9580474B2 (en) | 2010-09-08 | 2017-02-28 | The Johns Hopkins University | Polyionic papilloma virus-like particle (VLP) vaccines |
| CN103122352B (zh) | 2012-09-27 | 2015-02-11 | 华中农业大学 | 一种猪圆环病毒2型重组杆状病毒及制备方法和应用 |
| CN105026419B (zh) | 2013-03-01 | 2021-08-24 | 勃林格殷格翰动物保健美国有限公司 | 疫苗组合物定量 |
| EP2991676A1 (en) | 2013-04-30 | 2016-03-09 | Boehringer Ingelheim Vetmedica, Inc. | Orf2 protein of pcv2 subtype a (pcv2a) for use in cross-protection |
| US20140348874A1 (en) | 2013-05-22 | 2014-11-27 | Boehringer Ingelheim Espana, S.A. | Method for the reduction of pcv-2 in a herd of swine |
| WO2015026912A1 (en) | 2013-08-23 | 2015-02-26 | Boehringer Ingelheim Vetmedica, Inc. | Porcine circovirus type 2 (pcv2) subunit vaccine |
| JP6778104B2 (ja) | 2013-10-02 | 2020-10-28 | ベーリンガー・インゲルハイム・アニマル・ヘルス・ユーエスエー・インコーポレイテッドBoehringer Ingelheim Animal Health Usa Inc. | Pcv2 orf2タンパク質変種および前記を含むウイルス様粒子 |
| PL3139979T3 (pl) | 2014-05-07 | 2023-12-27 | Boehringer Ingelheim International Gmbh | Jednostka, nebulizator i sposób |
| EP3277315A2 (en) | 2015-03-30 | 2018-02-07 | Boehringer Ingelheim Vetmedica, Inc. | Pcv2 orf2 carrier platform |
-
2005
- 2005-12-29 UA UAA200708620A patent/UA95602C2/ru unknown
-
2010
- 2010-12-29 UA UAA201015883A patent/UA107177C2/ru unknown
-
2015
- 2015-03-18 US US14/661,689 patent/US9919041B2/en not_active Expired - Lifetime
-
2018
- 2018-02-01 US US15/886,531 patent/US10576142B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| US20180169214A1 (en) | 2018-06-21 |
| US20150190497A1 (en) | 2015-07-09 |
| UA107177C2 (uk) | 2014-12-10 |
| US10576142B2 (en) | 2020-03-03 |
| US9919041B2 (en) | 2018-03-20 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| MY147801A (en) | Pcv2 immunogenic compositions and methods of producing such compositions | |
| PH12014500696A1 (en) | Pcv2 immunogenic compositions and methods of producing such compositions | |
| RU2007110808A (ru) | Способы культивирования цирковирусов | |
| US20220325247A1 (en) | METHOD FOR PROMOTING GROWTH OF PARIETAL DECIDUAL BASALIS-MESENCHYMAL STEM CELLS (PDB-MSCs) | |
| EP1333846A4 (en) | PREPARATION AND XENOGRAPHY OF SWINE ISLANDS | |
| CN113215094A (zh) | 逆转2型糖尿病胰岛β细胞去分化的间充质干细胞外泌体及其制备方法和应用 | |
| EP1683857A4 (en) | METHOD FOR PRODUCING A CELL CONCENTRATE AND A CELL COMPOSITION | |
| WO2008088757A3 (en) | Apparatus and methods for osmotically shocking cells | |
| CN105670986A (zh) | 一种诱导人脐带间充质干细胞分化为胰岛样细胞的培养基及其诱导方法 | |
| UA95602C2 (ru) | Иммуногенная композиция цвс2 и способы приготовления такой композиции | |
| CN104027797B (zh) | 一种白喉疫苗的制备方法 | |
| CA2488414A1 (en) | Primary cultured adipocytes for gene therapy | |
| CN109022285A (zh) | 一种提高集胞藻pcc6803铵盐耐受能力的方法与应用 | |
| DE60025016D1 (de) | Fusionsprotein aus HPV-L1 und einem Peptid, das ein VLP bilden kann und als Vehikel zum EInschleusen eines Peptids in eine Zelle dienen kann, sowie dessen medizinische Verwendungen | |
| CN107119008B (zh) | 一种青年猪胰岛分离方法及分离用消化液 | |
| CY1116252T1 (el) | Ανοσογονες συνθεσεις pcv2 για χρηση σε μεθοδο προληψης της λοιμωξης pcv2 | |
| ATE309344T1 (de) | Verfahren zur aufbereitung von biomasse zur herstellung von plasmid dna haltigem zelllysat | |
| AR130495A1 (es) | Un método para recoger productos a partir de cultivos en perfusión | |
| CN105132500A (zh) | 一种svf的制备方法 | |
| JP2729883B2 (ja) | 藍藻を用いる有機分泌物の製造方法 | |
| CN106939296A (zh) | 一种真皮间充质干细胞的分离培养方法 | |
| NZ515762A (en) | Method of producing a heparin-binding protein by expressing it in a mammalian cell that can be cultured in anaerobic conditions | |
| CN120400053A (zh) | 一种用于分离提取口腔黏膜恶性黑色素瘤肿瘤浸润细胞(TILs)的培养基及其体外提取方法 | |
| CN105724550A (zh) | 一种利用微生物发酵进行鱼类下脚料骨肉分离的方法 | |
| CN118028217A (zh) | 一种肾小管上皮细胞完全培养基及其应用 |