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UA91496C2 - PROCESS FOR THE PREPARATION OF 4,5,6,7-TETRAHYDROISOXAZOLO[5,4-c9]PYRIDIN-3-OL (THIP) - Google Patents

PROCESS FOR THE PREPARATION OF 4,5,6,7-TETRAHYDROISOXAZOLO[5,4-c9]PYRIDIN-3-OL (THIP)

Info

Publication number
UA91496C2
UA91496C2 UAA200603678A UAA200603678A UA91496C2 UA 91496 C2 UA91496 C2 UA 91496C2 UA A200603678 A UAA200603678 A UA A200603678A UA A200603678 A UAA200603678 A UA A200603678A UA 91496 C2 UA91496 C2 UA 91496C2
Authority
UA
Ukraine
Prior art keywords
thip
tetrahydroisoxazolo
pyridin
preparation
acid
Prior art date
Application number
UAA200603678A
Other languages
English (en)
Ukrainian (uk)
Inventor
Ханс Петерсен
Соммер Майкл Бек
Роберт Дансер
Original Assignee
Х. Луннбек А/С
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=58707236&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UA91496(C2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Х. Луннбек А/С filed Critical Х. Луннбек А/С
Publication of UA91496C2 publication Critical patent/UA91496C2/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

Это изобретение касается нового способа получения габоксадола (ТНИР), который пригоден для лечения расстройств сна.В частности, способ получения ТНИР включает взаимодействие соединения формулы (8b) или его соли с кислотой, как правило, минеральной кислотой, с получением ТНИР в виде кислотно-аддитивной соли.Данное изобретение касается также нескольких промежуточных соединений.
UAA200603678A 2003-09-05 2004-09-01 PROCESS FOR THE PREPARATION OF 4,5,6,7-TETRAHYDROISOXAZOLO[5,4-c9]PYRIDIN-3-OL (THIP) UA91496C2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DKPA200301277 2003-09-05

Publications (1)

Publication Number Publication Date
UA91496C2 true UA91496C2 (en) 2010-08-10

Family

ID=58707236

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA200603678A UA91496C2 (en) 2003-09-05 2004-09-01 PROCESS FOR THE PREPARATION OF 4,5,6,7-TETRAHYDROISOXAZOLO[5,4-c9]PYRIDIN-3-OL (THIP)

Country Status (20)

Country Link
US (1) US7371863B2 (ru)
EP (1) EP1664060A1 (ru)
JP (1) JP4745233B2 (ru)
KR (1) KR20060069482A (ru)
CN (2) CN100482668C (ru)
AR (1) AR045540A1 (ru)
AU (1) AU2004270323B2 (ru)
BR (1) BRPI0413741A (ru)
CA (1) CA2537840C (ru)
EA (1) EA200600542A1 (ru)
IL (1) IL174070A (ru)
IS (1) IS8333A (ru)
ME (1) MEP1708A (ru)
MX (1) MXPA06002434A (ru)
NO (1) NO20061424L (ru)
NZ (1) NZ545178A (ru)
RS (1) RS20060157A (ru)
UA (1) UA91496C2 (ru)
WO (1) WO2005023820A1 (ru)
ZA (1) ZA200602178B (ru)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11123332B2 (en) 2018-11-21 2021-09-21 Certego Therapeutics Inc. Gaboxadol for reducing risk of suicide and rapid relief of depression
US11597726B2 (en) 2020-05-20 2023-03-07 Certego Therapeutics Inc. Ring deuterated gaboxadol and its use for the treatment of psychiatric disorders

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0402118D0 (en) 2004-01-30 2004-03-03 Merck Sharp & Dohme Polymorphic forms of a GABAA agonist
JP2007530604A (ja) * 2004-04-02 2007-11-01 ハー・ルンドベック・アクチエゼルスカベット 呼吸機能障害の治療
CN104974175A (zh) * 2014-04-11 2015-10-14 天津药物研究院 一种氨甲基羟异恶唑类似物的制备方法
AU2016236239B2 (en) 2015-03-24 2020-06-25 H. Lundbeck A/S Manufacture of 4,5,6,7-tetrahydroisozaxolo[5,4-c]pyridin-3-ol
CN111320577B (zh) * 2018-12-13 2023-06-23 广东东阳光药业有限公司 一种吡啶酰胺的制备方法及其应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK270278A (da) * 1977-06-20 1978-12-21 Krogsgaard Larsen P Cycliske aminosyrer
GB2088370B (en) * 1980-11-27 1984-08-01 Kefalas As Tetrahydroisoxazolopyridine compounds
DE3145473A1 (de) * 1980-11-27 1982-08-26 Kefalas A/S, Koebenhavn-Valby 2-substituierte 4,5,6,7-tetrahydroisoxazolo (5,4-c) pyridin-3-on-verbindungen, verfahren zu ihrer herstellung und diese enthaltende arzneimittel
US4353910A (en) * 1981-11-27 1982-10-12 Kefalas A/S Derivatives of 4,5,6,7-tetrahydroisoxazolo [5,4-c] pyridine-3-one, pharmaceutical compositions and methods of treatment
DE19525598C2 (de) 1995-07-13 1997-09-25 Max Planck Gesellschaft Schlafmittel

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11123332B2 (en) 2018-11-21 2021-09-21 Certego Therapeutics Inc. Gaboxadol for reducing risk of suicide and rapid relief of depression
US11597726B2 (en) 2020-05-20 2023-03-07 Certego Therapeutics Inc. Ring deuterated gaboxadol and its use for the treatment of psychiatric disorders

Also Published As

Publication number Publication date
US7371863B2 (en) 2008-05-13
IL174070A0 (en) 2006-08-01
MXPA06002434A (es) 2006-06-20
US20070112198A1 (en) 2007-05-17
EA200600542A1 (ru) 2006-08-25
NZ545178A (en) 2009-11-27
CN100482668C (zh) 2009-04-29
IS8333A (is) 2006-02-28
AU2004270323B2 (en) 2010-01-07
WO2005023820A1 (en) 2005-03-17
AR045540A1 (es) 2005-11-02
RS20060157A (sr) 2008-06-05
JP4745233B2 (ja) 2011-08-10
NO20061424L (no) 2006-03-29
AU2004270323A1 (en) 2005-03-17
JP2007504179A (ja) 2007-03-01
HK1096398A1 (en) 2007-06-01
KR20060069482A (ko) 2006-06-21
IL174070A (en) 2011-03-31
ZA200602178B (en) 2007-07-25
CN101497619A (zh) 2009-08-05
EP1664060A1 (en) 2006-06-07
MEP1708A (xx) 2010-02-10
CA2537840C (en) 2011-10-25
BRPI0413741A (pt) 2006-10-24
CN1845928A (zh) 2006-10-11
CA2537840A1 (en) 2005-03-17

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