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UA87835C2 - 8-[3-amino-piperidin-1-yl]-xanthines, the production thereof and the use in the form of a dpp inhibitor - Google Patents

8-[3-amino-piperidin-1-yl]-xanthines, the production thereof and the use in the form of a dpp inhibitor

Info

Publication number
UA87835C2
UA87835C2 UAA200609881A UAA200609881A UA87835C2 UA 87835 C2 UA87835 C2 UA 87835C2 UA A200609881 A UAA200609881 A UA A200609881A UA A200609881 A UAA200609881 A UA A200609881A UA 87835 C2 UA87835 C2 UA 87835C2
Authority
UA
Ukraine
Prior art keywords
xanthines
piperidin
amino
production
dpp
Prior art date
Application number
UAA200609881A
Other languages
Russian (ru)
Inventor
Франк Химмельсбах
Эльке Лангкопф
Маттиас Экхардт
Мохаммед Тадайон
Лео Томас
Original Assignee
Бёрингер Ингельхайм Интернациональ Гмбх
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Бёрингер Ингельхайм Интернациональ Гмбх filed Critical Бёрингер Ингельхайм Интернациональ Гмбх
Publication of UA87835C2 publication Critical patent/UA87835C2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention relates to substituted xanthines of general formula (I), wherein R is such as defined in claim 1, and to the tautomers, stereoisomers, mixtures and the salts thereof, said products exhibiting precious pharmacological properties, in particular an inhibiting effect on a dipeptidylpeptidasa-IV (DPP-IV) enzyme activity.(І)
UAA200609881A 2004-02-18 2005-02-12 8-[3-amino-piperidin-1-yl]-xanthines, the production thereof and the use in the form of a dpp inhibitor UA87835C2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE102004008112A DE102004008112A1 (en) 2004-02-18 2004-02-18 New 8-aminopiperidinyl-xanthine derivatives, useful for treating e.g. diabetes, arthritis and osteoporosis, are inhibitors of dipeptidylpeptidase-IV

Publications (1)

Publication Number Publication Date
UA87835C2 true UA87835C2 (en) 2009-08-25

Family

ID=34813493

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA200609881A UA87835C2 (en) 2004-02-18 2005-02-12 8-[3-amino-piperidin-1-yl]-xanthines, the production thereof and the use in the form of a dpp inhibitor

Country Status (5)

Country Link
CN (1) CN1980930B (en)
AR (1) AR115411A2 (en)
DE (1) DE102004008112A1 (en)
UA (1) UA87835C2 (en)
ZA (1) ZA200604281B (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CL2008002427A1 (en) * 2007-08-16 2009-09-11 Boehringer Ingelheim Int Pharmaceutical composition comprising 1-chloro-4- (bd-glucopyranos-1-yl) -2- [4 - ((s) -tetrahydrofuran-3-yloxy) benzyl] -benzene combined with 1 - [(4-methylquinazolin- 2-yl) methyl] -3-methyl-7- (2-butyn-1-yl) -8- (3- (r) -aminopiperidin-1-yl) xanthine; and its use to treat type 2 diabetes mellitus.
DE102008010661A1 (en) * 2008-02-22 2009-09-03 Dr. Felix Jäger und Dr. Stefan Drinkuth Laborgemeinschaft OHG Preparing pyridin-2-boronic acid compounds, useful e.g. to treat multiple myeloma, comprises preparing a pyridin-2-borate compound, purifying the pyridin-2-borate compound; and hydrolyzing the purified pyridin-2-borate compound
CN102311448B (en) * 2010-07-07 2014-02-19 中国科学院广州生物医药与健康研究院 Thienopyrimidinone DPP-IV Inhibitors
ES2934843T3 (en) * 2011-07-15 2023-02-27 Boehringer Ingelheim Int Substituted dimeric quinazoline derivative, its preparation and its use in pharmaceutical compositions for the treatment of type I and II diabetes
CN103450201B (en) * 2012-05-30 2017-04-12 博瑞生物医药（苏州）股份有限公司 Preparation method of chiral 8-(3-aminopiperidine-1-yl)-xanthine
CN103709163B (en) * 2012-09-29 2016-12-21 齐鲁制药有限公司 Xanthine derivative, Preparation Method And The Use
CN103319483B (en) * 2012-10-19 2016-08-03 药源药物化学（上海）有限公司 A kind of preparation method of important intermediate of linagliptin
CN103936740B (en) * 2013-01-23 2016-06-29 成都苑东生物制药股份有限公司 Xanthine derivatives
TWI682931B (en) * 2015-05-29 2020-01-21 大陸商江蘇天士力帝益藥業有限公司 Xanthine derivatives, their pharmaceutical compositions, their preparations and their uses

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SK286975B6 (en) * 2001-02-24 2009-08-06 Boehringer Ingelheim Pharma Gmbh & Co. Kg Xanthine derivatives, processes for their preparation, pharmaceutical compositions containing them and their use

Also Published As

Publication number Publication date
ZA200604281B (en) 2007-10-31
DE102004008112A1 (en) 2005-09-01
CN1980930B (en) 2012-11-21
AR115411A2 (en) 2021-01-13
CN1980930A (en) 2007-06-13

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