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AR115411A2 - 8- [3-AMINO-PIPERIDIN-1-IL] -XANTHINES AS INHIBITORS OF DPP-IV - Google Patents

8- [3-AMINO-PIPERIDIN-1-IL] -XANTHINES AS INHIBITORS OF DPP-IV

Info

Publication number
AR115411A2
AR115411A2 ARP190101358A ARP190101358A AR115411A2 AR 115411 A2 AR115411 A2 AR 115411A2 AR P190101358 A ARP190101358 A AR P190101358A AR P190101358 A ARP190101358 A AR P190101358A AR 115411 A2 AR115411 A2 AR 115411A2
Authority
AR
Argentina
Prior art keywords
methyl
dpp
piperidin
amino
xanthines
Prior art date
Application number
ARP190101358A
Other languages
Spanish (es)
Inventor
Leo Thomas
Mohammad Tadayyon
Matthias Eckhardt
Elke Langkopf
Frank Himmelsbach
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of AR115411A2 publication Critical patent/AR115411A2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

8-[3-amino-piperidin-1-il]-xantinas sustituidas como inhibidoras de DPP-IV utilizadas en el tratamiento de la diabetes mellitus de tipo I o tipo II. Reivindicación 1: Un compuesto caracterizado por la fórmula general (1), en donde R se selecciona del grupo que consiste en (3-ciano-piridin-2-il)metilo, (3-ciano-quinolin-2-il)metilo, (4,6-dimetil-pirimidin-2-il)metilo y (4-metil-pirimidin-2-il)metilo, 2-cianobencilo.8- [3-amino-piperidin-1-yl] -xanthines substituted as DPP-IV inhibitors used in the treatment of type I or type II diabetes mellitus. Claim 1: A compound characterized by the general formula (1), wherein R is selected from the group consisting of (3-cyano-pyridin-2-yl) methyl, (3-cyano-quinolin-2-yl) methyl, (4,6-dimethyl-pyrimidin-2-yl) methyl and (4-methyl-pyrimidin-2-yl) methyl, 2-cyanobenzyl.

ARP190101358A 2004-02-18 2019-05-22 8- [3-AMINO-PIPERIDIN-1-IL] -XANTHINES AS INHIBITORS OF DPP-IV AR115411A2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE102004008112A DE102004008112A1 (en) 2004-02-18 2004-02-18 New 8-aminopiperidinyl-xanthine derivatives, useful for treating e.g. diabetes, arthritis and osteoporosis, are inhibitors of dipeptidylpeptidase-IV

Publications (1)

Publication Number Publication Date
AR115411A2 true AR115411A2 (en) 2021-01-13

Family

ID=34813493

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP190101358A AR115411A2 (en) 2004-02-18 2019-05-22 8- [3-AMINO-PIPERIDIN-1-IL] -XANTHINES AS INHIBITORS OF DPP-IV

Country Status (5)

Country Link
CN (1) CN1980930B (en)
AR (1) AR115411A2 (en)
DE (1) DE102004008112A1 (en)
UA (1) UA87835C2 (en)
ZA (1) ZA200604281B (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CL2008002427A1 (en) * 2007-08-16 2009-09-11 Boehringer Ingelheim Int Pharmaceutical composition comprising 1-chloro-4- (bd-glucopyranos-1-yl) -2- [4 - ((s) -tetrahydrofuran-3-yloxy) benzyl] -benzene combined with 1 - [(4-methylquinazolin- 2-yl) methyl] -3-methyl-7- (2-butyn-1-yl) -8- (3- (r) -aminopiperidin-1-yl) xanthine; and its use to treat type 2 diabetes mellitus.
DE102008010661A1 (en) * 2008-02-22 2009-09-03 Dr. Felix Jäger und Dr. Stefan Drinkuth Laborgemeinschaft OHG Preparing pyridin-2-boronic acid compounds, useful e.g. to treat multiple myeloma, comprises preparing a pyridin-2-borate compound, purifying the pyridin-2-borate compound; and hydrolyzing the purified pyridin-2-borate compound
CN102311448B (en) * 2010-07-07 2014-02-19 中国科学院广州生物医药与健康研究院 Thienopyrimidinone DPP-IV Inhibitors
ES2934843T3 (en) * 2011-07-15 2023-02-27 Boehringer Ingelheim Int Substituted dimeric quinazoline derivative, its preparation and its use in pharmaceutical compositions for the treatment of type I and II diabetes
CN103450201B (en) * 2012-05-30 2017-04-12 博瑞生物医药（苏州）股份有限公司 Preparation method of chiral 8-(3-aminopiperidine-1-yl)-xanthine
CN103709163B (en) * 2012-09-29 2016-12-21 齐鲁制药有限公司 Xanthine derivative, Preparation Method And The Use
CN103319483B (en) * 2012-10-19 2016-08-03 药源药物化学（上海）有限公司 A kind of preparation method of important intermediate of linagliptin
CN103936740B (en) * 2013-01-23 2016-06-29 成都苑东生物制药股份有限公司 Xanthine derivatives
TWI682931B (en) * 2015-05-29 2020-01-21 大陸商江蘇天士力帝益藥業有限公司 Xanthine derivatives, their pharmaceutical compositions, their preparations and their uses

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SK286975B6 (en) * 2001-02-24 2009-08-06 Boehringer Ingelheim Pharma Gmbh & Co. Kg Xanthine derivatives, processes for their preparation, pharmaceutical compositions containing them and their use

Also Published As

Publication number Publication date
ZA200604281B (en) 2007-10-31
DE102004008112A1 (en) 2005-09-01
CN1980930B (en) 2012-11-21
UA87835C2 (en) 2009-08-25
CN1980930A (en) 2007-06-13

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