UA85734C2 - Method for the inactivation of viruses in the immunoglobulin production - Google Patents
Method for the inactivation of viruses in the immunoglobulin productionInfo
- Publication number
- UA85734C2 UA85734C2 UAA200701571A UAA200701571A UA85734C2 UA 85734 C2 UA85734 C2 UA 85734C2 UA A200701571 A UAA200701571 A UA A200701571A UA A200701571 A UAA200701571 A UA A200701571A UA 85734 C2 UA85734 C2 UA 85734C2
- Authority
- UA
- Ukraine
- Prior art keywords
- inactivation
- viruses
- stage
- immunoglobulin
- acetate buffer
- Prior art date
Links
- 241000700605 Viruses Species 0.000 title abstract 3
- 230000002779 inactivation Effects 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 3
- 230000016784 immunoglobulin production Effects 0.000 title 1
- 108060003951 Immunoglobulin Proteins 0.000 abstract 4
- 102000018358 immunoglobulin Human genes 0.000 abstract 4
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 abstract 3
- 239000000243 solution Substances 0.000 abstract 3
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 abstract 2
- 239000008351 acetate buffer Substances 0.000 abstract 2
- 238000005406 washing Methods 0.000 abstract 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- 238000004440 column chromatography Methods 0.000 abstract 1
- 239000003599 detergent Substances 0.000 abstract 1
- 230000008030 elimination Effects 0.000 abstract 1
- 238000003379 elimination reaction Methods 0.000 abstract 1
- 238000010828 elution Methods 0.000 abstract 1
- 238000005194 fractionation Methods 0.000 abstract 1
- 229940072221 immunoglobulins Drugs 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 239000011780 sodium chloride Substances 0.000 abstract 1
- BYKRNSHANADUFY-UHFFFAOYSA-M sodium octanoate Chemical compound [Na+].CCCCCCCC([O-])=O BYKRNSHANADUFY-UHFFFAOYSA-M 0.000 abstract 1
- 239000002594 sorbent Substances 0.000 abstract 1
- 230000003612 virological effect Effects 0.000 abstract 1
Landscapes
- Peptides Or Proteins (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
The invention relates to the inactivation of viruses in the production of immunoglobulins, in particular, of G fraction. A method includes treatment of the immunoglobulin solution, isolated by alcohol fractionation and treatment with the solvent-detergent mixture. The treated immunoglobulin is immobilized on the sulfopropyl-cationite sorbent, and two-stage washing is performed by means of the column chromatography followed by elution. At the first stage of washing the acetate buffer solution is used, which contains the sodium octanoate, sodium chloride and propylene glycol, and at the second stage the acetate buffer solution is used. The method provides high efficiency in the elimination and inactivation of viruses, which increases viral safety of the immunoglobulin preparations.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| UAA200701571A UA85734C2 (en) | 2007-02-14 | 2007-02-14 | Method for the inactivation of viruses in the immunoglobulin production |
| RU2007146418/15A RU2372940C2 (en) | 2007-02-14 | 2007-12-17 | Method of virus inactivation for immunoglobulin production |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| UAA200701571A UA85734C2 (en) | 2007-02-14 | 2007-02-14 | Method for the inactivation of viruses in the immunoglobulin production |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA85734C2 true UA85734C2 (en) | 2009-02-25 |
Family
ID=41026440
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UAA200701571A UA85734C2 (en) | 2007-02-14 | 2007-02-14 | Method for the inactivation of viruses in the immunoglobulin production |
Country Status (2)
| Country | Link |
|---|---|
| RU (1) | RU2372940C2 (en) |
| UA (1) | UA85734C2 (en) |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6281336B1 (en) * | 1998-06-09 | 2001-08-28 | Statens Serum Institut | Process for producing immunoglobulins for intravenous administration and other immunoglobulin products |
| AU753468B2 (en) * | 1998-06-09 | 2002-10-17 | Csl Behring Ag | Process for producing immunoglobulins for intravenous administration and other immunoglobulin products |
| SE0001128D0 (en) * | 2000-03-30 | 2000-03-30 | Amersham Pharm Biotech Ab | A method of producing IgG |
-
2007
- 2007-02-14 UA UAA200701571A patent/UA85734C2/en unknown
- 2007-12-17 RU RU2007146418/15A patent/RU2372940C2/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| RU2372940C2 (en) | 2009-11-20 |
| RU2007146418A (en) | 2009-06-27 |
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