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UA83928C2 - Производное пропан-1,3-диона или его соль - Google Patents

Производное пропан-1,3-диона или его соль

Info

Publication number
UA83928C2
UA83928C2 UAA200612631A UAA200612631A UA83928C2 UA 83928 C2 UA83928 C2 UA 83928C2 UA A200612631 A UAA200612631 A UA A200612631A UA A200612631 A UAA200612631 A UA A200612631A UA 83928 C2 UA83928 C2 UA 83928C2
Authority
UA
Ukraine
Prior art keywords
compound
propane
gnrh receptor
drugs
useful
Prior art date
Application number
UAA200612631A
Other languages
English (en)
Ukrainian (uk)
Inventor
Казуйоси Обицу
Original Assignee
Астеллас Фарма Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Астеллас Фарма Инк. filed Critical Астеллас Фарма Инк.
Publication of UA83928C2 publication Critical patent/UA83928C2/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • A61P5/08—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH for decreasing, blocking or antagonising the activity of the anterior pituitary hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Oncology (AREA)
  • Diabetes (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Предложены соединения, которые полезны в качестве антагонистов рецептора GnRH. В изобретении дополнительно изучены производные пропан-1,3-диона и подтверждено, что пропан-1,3-дион, который содержит 2-(1,3-дигидро-2Н-бензимидазол-2-илиден), или соединение, которое содержит бензольное или тиофеновое кольцо, замещенное производной 1-гидроксиметила, проявляет хорошую доступность, в дополнение к ее хорошей антагонистической активности относительно рецептора GnRH, что приводит к осуществлению изобретения. Поскольку соединение изобретения проявляет хорошу�
UAA200612631A 2004-06-04 2005-06-02 Производное пропан-1,3-диона или его соль UA83928C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2004166486 2004-06-04
JP2005099815 2005-03-30
PCT/JP2005/010184 WO2005118556A1 (ja) 2004-06-04 2005-06-02 プロパン－１，３－ジオン誘導体又はその塩

Publications (1)

Publication Number Publication Date
UA83928C2 true UA83928C2 (ru) 2008-08-26

Family

ID=35462868

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA200612631A UA83928C2 (ru) 2004-06-04 2005-06-02 Производное пропан-1,3-диона или его соль

Country Status (16)

Country Link
US (2) US7709519B2 (ru)
EP (1) EP1752452A4 (ru)
JP (1) JP4595938B2 (ru)
CN (1) CN1964950A (ru)
AR (1) AR049436A1 (ru)
AU (1) AU2005250273B2 (ru)
BR (1) BRPI0511796A (ru)
CA (1) CA2568590C (ru)
IL (1) IL179437A (ru)
MX (1) MXPA06014131A (ru)
NO (1) NO20070074L (ru)
NZ (1) NZ552372A (ru)
RU (1) RU2347781C2 (ru)
TW (1) TWI342307B (ru)
UA (1) UA83928C2 (ru)
WO (1) WO2005118556A1 (ru)

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JP4595938B2 (ja) 2004-06-04 2010-12-08 アステラス製薬株式会社 プロパン−１，３−ジオン誘導体又はその塩
JP4715845B2 (ja) * 2005-03-31 2011-07-06 アステラス製薬株式会社 プロパン−１，３−ジオン誘導体又はその塩
EP2095818A1 (en) 2008-02-29 2009-09-02 AEterna Zentaris GmbH Use of LHRH antagonists at non-castrating doses
EP3915367A1 (en) * 2010-08-18 2021-12-01 BioSplice Therapeutics, Inc. Diketones and hydroxyketones as catenin signaling pathway activators
US9527818B2 (en) 2012-09-07 2016-12-27 Astellas Pharma Inc. Method for producing sulfonyl amidine compound
HRP20190142T1 (hr) 2013-02-22 2019-03-22 Samumed, Llc Gama-diketoni kao aktivatori signalizacijskog puta wnt/beta-katenina
US9618507B2 (en) 2014-02-24 2017-04-11 Betanien Hospital Methods of treating rheumatoid arthritis
BR112017003959B1 (pt) 2014-08-20 2022-08-02 Samumed, Llc Uso de um composto de fórmula i ou um sal dermatologicamente aceitável do mesmo
JP2017529388A (ja) 2014-08-26 2017-10-05 ベタニエン ホスピタル 炎症性病態の治療のための方法、薬剤および組成物
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Also Published As

Publication number Publication date
US8076367B2 (en) 2011-12-13
CN1964950A (zh) 2007-05-16
RU2006142689A (ru) 2008-06-10
IL179437A (en) 2011-11-30
TW200613281A (en) 2006-05-01
AU2005250273A1 (en) 2005-12-15
RU2347781C2 (ru) 2009-02-27
EP1752452A1 (en) 2007-02-14
MXPA06014131A (es) 2007-03-07
CA2568590C (en) 2011-01-18
BRPI0511796A (pt) 2008-01-15
AR049436A1 (es) 2006-08-02
NO20070074L (no) 2007-03-02
AU2005250273B2 (en) 2010-10-14
IL179437A0 (en) 2007-05-15
NZ552372A (en) 2009-11-27
US20100173946A1 (en) 2010-07-08
TWI342307B (en) 2011-05-21
US20090018177A1 (en) 2009-01-15
JPWO2005118556A1 (ja) 2008-04-03
EP1752452A9 (en) 2007-12-12
US7709519B2 (en) 2010-05-04
EP1752452A4 (en) 2010-07-14
JP4595938B2 (ja) 2010-12-08
WO2005118556A1 (ja) 2005-12-15
CA2568590A1 (en) 2005-12-15

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