UA80298C2 - 1h-1,2,4-triazole-3-carboxamide derivatives as cannabinoid-cb1 receptor ligands - Google Patents
1h-1,2,4-triazole-3-carboxamide derivatives as cannabinoid-cb1 receptor ligands Download PDFInfo
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- UA80298C2 UA80298C2 UAA200503704A UA2005003704A UA80298C2 UA 80298 C2 UA80298 C2 UA 80298C2 UA A200503704 A UAA200503704 A UA A200503704A UA 2005003704 A UA2005003704 A UA 2005003704A UA 80298 C2 UA80298 C2 UA 80298C2
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- heterocyclic group
- triazole
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
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| PCT/EP2003/050628 WO2004026301A1 (en) | 2002-09-19 | 2003-09-17 | 1h-1,2,4-triazole-3-carboxamide derivatives as cannabinoid-cb1 receptor ligands |
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| US6897240B2 (en) * | 2002-05-08 | 2005-05-24 | The Regents Of The University Of California | Thio semicarbazone and semicarbazone inhibitors of cysteine proteases and methods of their use |
| RU2005135927A (ru) * | 2003-04-21 | 2006-05-10 | Дайити Фармасьютикал Ко., Лтд. (JP) | Пятичленное гетероциклическое производное |
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| JP2007512359A (ja) * | 2003-11-19 | 2007-05-17 | メタバシス・セラピューティクス・インコーポレイテッド | 新規なリン含有甲状腺ホルモン様物質 |
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| CA2581945C (en) * | 2004-10-01 | 2011-01-18 | Henrietta Dehmlow | Hexafluoroisopropanol substituted ether derivatives |
| JP2008517976A (ja) | 2004-10-25 | 2008-05-29 | ゾルファイ ファーマスーティカルズ ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｃｂ１カンナビノイド受容体拮抗薬及びカリウムチャンネルオープナーから成る、真性糖尿病１型、肥満及び関連症状の治療用の医薬組成物 |
| WO2006050472A2 (en) * | 2004-11-03 | 2006-05-11 | Xenoport, Inc. | Acyloxyalkyl carbamate prodrugs of 3-aminopropylphosphonous and -phosphinic acids |
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| US7923465B2 (en) | 2005-06-02 | 2011-04-12 | Glenmark Pharmaceuticals S.A. | Cannabinoid receptor ligands, pharmaceutical compositions containing them, and process for their preparation |
| EP1902034B1 (de) | 2005-06-02 | 2011-03-30 | Glenmark Pharmaceuticals S.A. | Neue cannabinoidrezeptorliganden, pharmazeutische zusammensetzungen, die diese enthalten, und verfahren zu ihrer herstellung |
| US7572808B2 (en) | 2005-06-17 | 2009-08-11 | Bristol-Myers Squibb Company | Triazolopyridine cannabinoid receptor 1 antagonists |
| US7632837B2 (en) | 2005-06-17 | 2009-12-15 | Bristol-Myers Squibb Company | Bicyclic heterocycles as cannabinoid-1 receptor modulators |
| US20090012127A1 (en) * | 2005-06-29 | 2009-01-08 | Astrazeneca Ab | Thiophene-2-Carboxamide Derivatives as Alpha 7 Nicotinic Receptor Modulators |
| MX2007016508A (es) | 2005-06-30 | 2008-03-04 | Prosidion Ltd | Agonistas del receptor acoplado a la proteina g. |
| FR2894579B1 (fr) * | 2005-12-12 | 2008-01-18 | Sanofi Aventis Sa | Derives diaryltriazolmethylamine, leur preparation et leur application en therapeutique. |
| EP2081905B1 (de) | 2006-07-28 | 2012-09-12 | Boehringer Ingelheim International GmbH | Sulfonyl verbindungen als cb2 rezeptor modulatoren |
| US7585996B2 (en) * | 2006-09-15 | 2009-09-08 | Xenoport, Inc. | Acyloxyalkyl carbamate prodrugs, methods of synthesis and use |
| BRPI0806312A2 (pt) | 2007-01-04 | 2011-09-06 | Prosidion Ltd | agonistas cgpr piperidina |
| RS52065B (sr) | 2007-01-04 | 2012-06-30 | Prosidion Ltd | Piperidinski gpcr agonisti |
| CL2008000018A1 (es) | 2007-01-04 | 2008-08-01 | Prosidion Ltd | Compuestos derivados de heterociclos de nitrogeno y oxigeno, agonistas de gpcr; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto para el tratamiento de la obesidad, diabetes, sindrome metabolico, hiperlipidemia, toleranci |
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| CL2008000017A1 (es) | 2007-01-04 | 2008-08-01 | Prosidion Ltd | Compuestos derivados de heterociclos de nitrogeno y oxigeno, agonistas de gpcr; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto para el tratamiento de la obesidad, diabetes, sindrome metabolico, hiperlipidemia, toleranci |
| CN101302200B (zh) * | 2007-05-09 | 2011-04-20 | 上海医药工业研究院 | 制备n-哌啶子基-5-(4-氯苯基)-1-(2,4-二氯苯基)-4-甲基吡唑-3-甲酰胺的方法 |
| GB0720390D0 (en) | 2007-10-18 | 2007-11-28 | Prosidion Ltd | G-Protein coupled receptor agonists |
| GB0720389D0 (en) | 2007-10-18 | 2008-11-12 | Prosidion Ltd | G-Protein Coupled Receptor Agonists |
| CA2704684A1 (en) | 2007-11-07 | 2009-05-14 | Boehringer Ingelheim International Gmbh | Compounds which modulate the cb2 receptor |
| EP2265585B1 (de) | 2008-02-21 | 2014-09-17 | Boehringer Ingelheim International GmbH | Amin- und etherverbindungen, die den cb2-rezeptor modulieren |
| WO2010005782A1 (en) | 2008-07-10 | 2010-01-14 | Boehringer Ingelheim International Gmbh | Sulfone compounds which modulate the cb2 receptor |
| EA201100523A1 (ru) | 2008-09-25 | 2011-10-31 | Бёрингер Ингельхайм Интернациональ Гмбх | Соединения сульфонила, которые селективно модулируют рецептор св2 |
| JP5583694B2 (ja) | 2009-01-05 | 2014-09-03 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｃｂ２受容体を調節するピロリジン化合物 |
| WO2010079241A1 (es) | 2009-01-12 | 2010-07-15 | Fundacion Hospital Nacional De Paraplejicos Para La Investigacion Y La Integracion | Uso de antagonistas y/o agonistas inversos de los receptores cb1 para la preparación de medicamentos que incrementen la excitabilidad de las motoneuronas |
| JP5705748B2 (ja) | 2009-02-18 | 2015-04-22 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｃｂ２受容体を変調する複素環化合物 |
| US8299103B2 (en) | 2009-06-15 | 2012-10-30 | Boehringer Ingelheim International Gmbh | Compounds which selectively modulate the CB2 receptor |
| US8383615B2 (en) | 2009-06-16 | 2013-02-26 | Boehringer Ingelheim International Gmbh | Azetidine 2-carboxamide derivatives which modulate the CB2 receptor |
| WO2011037795A1 (en) | 2009-09-22 | 2011-03-31 | Boehringer Ingelheim International Gmbh | Compounds which selectively modulate the cb2 receptor |
| WO2011088015A1 (en) | 2010-01-15 | 2011-07-21 | Boehringer Ingelheim International Gmbh | Compounds which modulate the cb2 receptor |
| US8329735B2 (en) | 2010-03-05 | 2012-12-11 | Boehringer Ingelheim International Gmbh | Tetrazole compounds which selectively modulate the CB2 receptor |
| JP5746764B2 (ja) | 2010-07-22 | 2015-07-08 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｃｂ２受容体を調節する化合物 |
| CN102558157B (zh) * | 2010-12-20 | 2014-04-30 | 中国科学院上海药物研究所 | 羟乙基三唑类化合物或氨乙基三唑类化合物及其制备方法和用途 |
| CN102731418B (zh) * | 2012-07-15 | 2015-03-11 | 浙江大学 | 1-取代-1h-1,2,4-三氮唑-甲酰胺衍生物及其制备和用途 |
| MX361761B (es) * | 2012-09-17 | 2018-12-17 | Hoffmann La Roche | Derivados de triazol carboxamida. |
| EP2803668A1 (de) | 2013-05-17 | 2014-11-19 | Boehringer Ingelheim International Gmbh | Neuartige (Cyano-dimethyl-methyl)-isoxazole und -[1,3,4]-thiadiazole |
| BR112016028119A2 (pt) | 2014-06-06 | 2017-08-22 | Res Triangle Inst | Agonistas receptores de apelina (apj) e usos dos mesmos |
| CA2975474C (en) | 2015-01-30 | 2023-06-13 | Neurocrine Biosciences, Inc. | Substituted triazoles and methods relating thereto |
| AU2016366310C1 (en) | 2015-12-09 | 2021-09-09 | Research Triangle Institute | Improved apelin receptor (APJ) agonists and uses thereof |
| MA46540A (fr) * | 2016-10-12 | 2019-08-21 | Res Triangle Inst | Agonistes du récepteur de l'apéline (apj) hétérocyclique et leurs utilisations |
| WO2020103856A1 (en) * | 2018-11-20 | 2020-05-28 | Shanghaitech University | Mmpl3 inhibitors, compositions and uses thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3316300A1 (de) * | 1982-05-07 | 1983-11-24 | Kureha Kagaku Kogyo K.K., Tokyo | Heribizide zusammensetzung mit einem gehalt an einem derivat des 1,2,4-triazols als wirkstoff |
| JPS58194866A (ja) * | 1982-05-07 | 1983-11-12 | Kureha Chem Ind Co Ltd | トリアゾ−ル誘導体及び該誘導体を含有する除草剤 |
| DE3817192A1 (de) * | 1988-05-20 | 1989-11-30 | Hoechst Ag | 1,2,4-triazolderivate enthaltende pflanzenschuetzende mittel sowie neue derivate des 1,2,4-triazols |
| FR2692575B1 (fr) | 1992-06-23 | 1995-06-30 | Sanofi Elf | Nouveaux derives du pyrazole, procede pour leur preparation et compositions pharmaceutiques les contenant. |
| DE4225778A1 (de) * | 1992-08-04 | 1994-02-17 | Hoechst Ag | 1,2,4-Triazolyl-3-carbonsäure-4-aminopiperidide, Verfahren zu ihrer Herstellung, sie enthaltende Mittel und ihre Verwendung als Schädlingsbekämpfungsmittel, insbesondere Fungizide |
| DE4425144A1 (de) * | 1994-07-15 | 1996-01-18 | Basf Ag | Triazolverbindungen und deren Verwendung |
| FR2741621B1 (fr) * | 1995-11-23 | 1998-02-13 | Sanofi Sa | Nouveaux derives de pyrazole, procede pour leur preparation et compositions pharmaceutiques en contenant |
| FR2789079B3 (fr) * | 1999-02-01 | 2001-03-02 | Sanofi Synthelabo | Derive d'acide pyrazolecarboxylique, sa preparation, les compositions pharmaceutiques en contenant |
| FR2796945B1 (fr) * | 1999-07-30 | 2002-06-28 | Sod Conseils Rech Applic | Nouveaux derives d'hydantoines, de thiohydantoines, de pyrimidinediones et de thioxopyrimidinones, leurs procedes de preparation et leur application a titre de medicaments |
| AU780572B2 (en) | 1999-10-18 | 2005-04-07 | University Of Connecticut, The | Pyrazole derivatives as cannabinoid receptor antagonists |
| FR2802206B1 (fr) * | 1999-12-14 | 2005-04-22 | Sod Conseils Rech Applic | Derives de 4-aminopiperidine et leur utilisation en tant que medicament |
| CA2399791A1 (en) | 2000-02-11 | 2001-08-16 | Bristol-Myers Squibb Company | Cannabinoid receptor modulators, their processes of preparation, and use of cannabinoid receptor modulators in treating respiratory and non-respiratory diseases |
-
2003
- 2003-07-19 HR HR20050053A patent/HRP20050053A2/xx not_active Application Discontinuation
- 2003-09-16 US US10/662,477 patent/US7319110B2/en not_active Expired - Fee Related
- 2003-09-16 AR ARP030103347A patent/AR041268A1/es unknown
- 2003-09-17 DE DE60331444T patent/DE60331444D1/de not_active Expired - Lifetime
- 2003-09-17 KR KR1020057004584A patent/KR100996828B1/ko not_active Expired - Fee Related
- 2003-09-17 AT AT03797318T patent/ATE458479T1/de active
- 2003-09-17 WO PCT/EP2003/050628 patent/WO2004026301A1/en not_active Ceased
- 2003-09-17 RU RU2005103244/04A patent/RU2325382C2/ru not_active IP Right Cessation
- 2003-09-17 ES ES03797318T patent/ES2341540T3/es not_active Expired - Lifetime
- 2003-09-17 EP EP03797318A patent/EP1542678B1/de not_active Expired - Lifetime
- 2003-09-17 DK DK03797318.7T patent/DK1542678T3/da active
- 2003-09-17 AU AU2003299024A patent/AU2003299024B2/en not_active Ceased
- 2003-09-17 MX MXPA05002862A patent/MXPA05002862A/es active IP Right Grant
- 2003-09-17 BR BR0312020-1A patent/BR0312020A/pt not_active IP Right Cessation
- 2003-09-17 SI SI200331803T patent/SI1542678T1/sl unknown
- 2003-09-17 CA CA2491394A patent/CA2491394C/en not_active Expired - Fee Related
- 2003-09-17 PL PL03375020A patent/PL375020A1/xx not_active Application Discontinuation
- 2003-09-17 JP JP2004537155A patent/JP2006501275A/ja active Pending
- 2003-09-17 CN CNB038173522A patent/CN1319529C/zh not_active Expired - Fee Related
- 2003-09-17 PT PT03797318T patent/PT1542678E/pt unknown
- 2003-09-17 UA UAA200503704A patent/UA80298C2/uk unknown
-
2004
- 2004-12-07 IL IL165611A patent/IL165611A/en not_active IP Right Cessation
-
2005
- 2005-01-06 ZA ZA200500133A patent/ZA200500133B/en unknown
- 2005-04-18 NO NO20051870A patent/NO20051870L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| SI1542678T1 (sl) | 2010-07-30 |
| WO2004026301A1 (en) | 2004-04-01 |
| CN1319529C (zh) | 2007-06-06 |
| IL165611A0 (en) | 2006-01-15 |
| PT1542678E (pt) | 2010-05-25 |
| AU2003299024A1 (en) | 2004-04-08 |
| US20040106614A1 (en) | 2004-06-03 |
| IL165611A (en) | 2010-04-15 |
| ES2341540T3 (es) | 2010-06-22 |
| HRP20050053A2 (en) | 2005-04-30 |
| PL375020A1 (en) | 2005-11-14 |
| DE60331444D1 (de) | 2010-04-08 |
| ZA200500133B (en) | 2005-11-01 |
| JP2006501275A (ja) | 2006-01-12 |
| AU2003299024B2 (en) | 2008-03-06 |
| EP1542678A1 (de) | 2005-06-22 |
| MXPA05002862A (es) | 2005-05-27 |
| NO20051870L (no) | 2005-06-03 |
| HK1078796A1 (en) | 2006-03-24 |
| CN1671377A (zh) | 2005-09-21 |
| CA2491394C (en) | 2010-06-15 |
| AR041268A1 (es) | 2005-05-11 |
| ATE458479T1 (de) | 2010-03-15 |
| EP1542678B1 (de) | 2010-02-24 |
| DK1542678T3 (da) | 2010-06-07 |
| BR0312020A (pt) | 2005-03-22 |
| KR100996828B1 (ko) | 2010-11-29 |
| US7319110B2 (en) | 2008-01-15 |
| RU2005103244A (ru) | 2005-06-27 |
| CA2491394A1 (en) | 2004-04-01 |
| RU2325382C2 (ru) | 2008-05-27 |
| KR20050057399A (ko) | 2005-06-16 |
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