[go: up one dir, main page]

UA80676C2 - Use of il-18 inhibitors for the treatment and/or prevention of cardiomyopathy - Google Patents

Use of il-18 inhibitors for the treatment and/or prevention of cardiomyopathy Download PDF

Info

Publication number
UA80676C2
UA80676C2 UA2003088056A UA2003088056A UA80676C2 UA 80676 C2 UA80676 C2 UA 80676C2 UA 2003088056 A UA2003088056 A UA 2003088056A UA 2003088056 A UA2003088056 A UA 2003088056A UA 80676 C2 UA80676 C2 UA 80676C2
Authority
UA
Ukraine
Prior art keywords
inhibitor
application according
receptor
antibody
heart
Prior art date
Application number
UA2003088056A
Other languages
English (en)
Ukrainian (uk)
Inventor
Charles Dinarello
Yolande Chvatchko
Original Assignee
Applied Research Systems
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Applied Research Systems filed Critical Applied Research Systems
Publication of UA80676C2 publication Critical patent/UA80676C2/uk

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7155Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52Cytokines; Lymphokines; Interferons
    • C07K14/54Interleukins [IL]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/40Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41Glycosylation, sialylation, or fucosylation
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
UA2003088056A 2001-01-29 2002-01-28 Use of il-18 inhibitors for the treatment and/or prevention of cardiomyopathy UA80676C2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01101959 2001-01-29
PCT/EP2002/000844 WO2002060479A1 (en) 2001-01-29 2002-01-28 Use of il-18 inhibitors for the treatment and/or prevention of heart disease

Publications (1)

Publication Number Publication Date
UA80676C2 true UA80676C2 (en) 2007-10-25

Family

ID=8176323

Family Applications (1)

Application Number Title Priority Date Filing Date
UA2003088056A UA80676C2 (en) 2001-01-29 2002-01-28 Use of il-18 inhibitors for the treatment and/or prevention of cardiomyopathy

Country Status (31)

Country Link
US (1) US20040234523A1 (xx)
EP (1) EP1355668B1 (xx)
JP (2) JP4860897B2 (xx)
KR (1) KR100857376B1 (xx)
CN (1) CN1326562C (xx)
AR (1) AR032422A1 (xx)
AT (1) ATE380558T1 (xx)
BG (1) BG66483B1 (xx)
BR (1) BR0206819A (xx)
CA (1) CA2435466C (xx)
CY (1) CY1107203T1 (xx)
CZ (1) CZ305653B6 (xx)
DE (1) DE60224004T2 (xx)
DK (1) DK1355668T3 (xx)
EA (2) EA010180B1 (xx)
EE (1) EE05534B1 (xx)
ES (1) ES2295332T3 (xx)
HR (1) HRP20030609A2 (xx)
HU (1) HU229164B1 (xx)
IL (2) IL157024A0 (xx)
ME (1) ME00549B (xx)
MX (1) MXPA03006776A (xx)
NO (1) NO331083B1 (xx)
PL (1) PL213568B1 (xx)
PT (1) PT1355668E (xx)
RS (1) RS51125B (xx)
SI (1) SI1355668T1 (xx)
SK (1) SK287620B6 (xx)
UA (1) UA80676C2 (xx)
WO (1) WO2002060479A1 (xx)
ZA (1) ZA200305439B (xx)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102206277A (zh) 2000-02-10 2011-10-05 雅培制药有限公司 结合人白介素-18的抗体及制备和使用方法
CA2424983A1 (en) 2000-10-11 2002-04-18 Viron Therapeutics, Inc. Nucleic acid molecules and polypeptides for immune modulation
US7718368B2 (en) 2000-12-04 2010-05-18 Viron Therapeutics Inc. Immunomodulatory protein and useful embodiments thereof
US20080076708A1 (en) 2003-05-13 2008-03-27 Valter Altarocca Active Variants of the Il-18 Binding Protein and Medical Uses Thereof
US7968684B2 (en) 2003-11-12 2011-06-28 Abbott Laboratories IL-18 binding proteins
JP4961559B2 (ja) * 2004-03-11 2012-06-27 友昭 星野 インターロイキン18阻害剤を有効成分とする疾患の予防又は治療剤
PL1885753T3 (pl) 2005-06-03 2011-12-30 Ares Trading Sa Wytwarzanie rekombinowanego białka wiążącego IL-18
ATE529433T1 (de) 2005-06-10 2011-11-15 Ares Trading Sa Verfahren zur reinigung eines il-18-bindenden proteins
AU2008324814B2 (en) * 2007-11-05 2013-05-16 Solventum Intellectual Properties Company Identification of tissue for debridement
JOP20200308A1 (ar) 2012-09-07 2017-06-16 Novartis Ag جزيئات إرتباط il-18
KR102321172B1 (ko) * 2013-09-05 2021-11-05 에이비2 바이오 에스에이 염증성 질환에서 il-18 결합 단백질(il-18bp)
CA2972689A1 (en) * 2015-03-05 2016-09-09 Ab2 Bio Sa Il-18 binding protein (il-18bp) and antibodies in inflammatory diseases
WO2018013509A1 (en) * 2016-07-11 2018-01-18 Arizona Board Of Regents On Behalf Of The University Of Arizona Compositions and methods for diagnosing and treating arrhythmias

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6204261B1 (en) * 1995-12-20 2001-03-20 Vertex Pharmaceuticals Incorporated Inhibitors of interleukin-1β Converting enzyme inhibitors
US5605690A (en) * 1989-09-05 1997-02-25 Immunex Corporation Methods of lowering active TNF-α levels in mammals using tumor necrosis factor receptor
NZ322197A (en) * 1995-11-21 1999-02-25 Yamanouchi Pharma Co Ltd Pyrido[2,3-d] pyrimidine derivatives and pharmaceutical compositions thereof
CA2265853C (en) * 1996-09-12 2010-08-03 Idun Pharmaceuticals, Inc. Inhibition of apoptosis using interleukin-1.beta.-converting enzyme (ice)/ced-3 family inhibitors
JP4094066B2 (ja) * 1996-12-06 2008-06-04 バーテックス ファーマシューティカルズ インコーポレイテッド インターロイキン−1β変換酵素のインヒビター
WO1998041232A2 (en) * 1997-03-18 1998-09-24 Basf Aktiengesellschaft Compositions for modulating responsiveness to corticosteroids
IL121860A0 (en) * 1997-08-14 1998-02-22 Yeda Res & Dev Interleukin-18 binding proteins their preparation and use
DE19743687C1 (de) * 1997-10-06 1998-11-26 Henkel Kgaa Detergensgemische und deren Verwendung
WO2000000490A2 (en) * 1998-06-26 2000-01-06 Eli Lilly And Company 5-ht1f agonists
CA2340579A1 (en) * 1998-09-01 2000-03-09 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo Interleukin 18-binding protein
EP1022027A1 (en) * 1999-01-22 2000-07-26 Applied Research Systems ARS Holding N.V. Tumor necrosis factor antagonists and their use in endometriosis
ATE336480T1 (de) * 1999-03-16 2006-09-15 Cytovia Inc Substituierte 2-aminobenzamin caspase inhibitoren und ihre verwendung
JP2002541237A (ja) * 1999-04-09 2002-12-03 サイトビア インコーポレイテッド カスパーゼインヒビターおよびその使用
WO2001003719A2 (en) * 1999-07-09 2001-01-18 Amgen Inc. Combination therapy for conditions leading to bone loss
CN102206277A (zh) * 2000-02-10 2011-10-05 雅培制药有限公司 结合人白介素-18的抗体及制备和使用方法
EA007014B1 (ru) * 2000-05-05 2006-06-30 Апплайд Резеч Системз Арс Холдинг Н.В. Применение il-18 в качестве диагностического маркера
AU2002224417A1 (en) * 2000-10-18 2002-04-29 Immunex Corporation Methods for treating il-18 mediated disorders

Also Published As

Publication number Publication date
MXPA03006776A (es) 2003-10-24
KR100857376B1 (ko) 2008-09-05
PL366802A1 (en) 2005-02-07
CZ20032335A3 (en) 2004-07-14
JP2009102354A (ja) 2009-05-14
HK1062810A1 (en) 2004-11-26
IL157024A0 (en) 2004-02-08
PL213568B1 (pl) 2013-03-29
EE200300328A (et) 2003-10-15
HUP0303306A2 (hu) 2004-01-28
SK287620B6 (sk) 2011-04-05
EA200300844A1 (ru) 2003-12-25
WO2002060479A1 (en) 2002-08-08
BG66483B1 (bg) 2015-03-31
DK1355668T3 (da) 2008-05-05
CN1499982A (zh) 2004-05-26
ES2295332T3 (es) 2008-04-16
CZ305653B6 (cs) 2016-01-27
CY1107203T1 (el) 2012-11-21
DE60224004D1 (de) 2008-01-24
ME00549B (me) 2011-10-10
NO331083B1 (no) 2011-10-03
US20040234523A1 (en) 2004-11-25
EP1355668A1 (en) 2003-10-29
EP1355668B1 (en) 2007-12-12
IL157024A (en) 2014-02-27
RS51125B (sr) 2010-10-31
BR0206819A (pt) 2004-02-03
YU57803A (sh) 2006-05-25
JP2004522748A (ja) 2004-07-29
PT1355668E (pt) 2008-01-04
EA010180B1 (ru) 2008-06-30
DE60224004T2 (de) 2009-07-23
CA2435466A1 (en) 2002-08-08
NO20033228L (no) 2003-09-26
ATE380558T1 (de) 2007-12-15
CN1326562C (zh) 2007-07-18
SK10892003A3 (sk) 2004-02-03
EE05534B1 (et) 2012-04-16
HUP0303306A3 (en) 2005-12-28
HU229164B1 (en) 2013-09-30
EA200501549A1 (ru) 2006-04-28
KR20030070143A (ko) 2003-08-27
BG108128A (bg) 2004-11-30
JP4860897B2 (ja) 2012-01-25
NO20033228D0 (no) 2003-07-16
ZA200305439B (en) 2004-07-15
HRP20030609A2 (en) 2005-06-30
AR032422A1 (es) 2003-11-05
EA006767B1 (ru) 2006-04-28
SI1355668T1 (sl) 2008-06-30
CA2435466C (en) 2012-04-03

Similar Documents

Publication Publication Date Title
JP2009102354A (ja) 心疾患の治療および/または予防のためのil−18阻害剤の使用
UA85531C2 (uk) Застосування il-18 інгібіторів для лікування або попередження пов'язаної з сепсисом дисфункції серця
US20040224360A1 (en) Methods for diagnosing renal disorders
EP2216399A1 (en) Human soluble CD146, preparation and uses thereof
EA007014B1 (ru) Применение il-18 в качестве диагностического маркера
CN101374543A (zh) 预防或治疗血流量增加引发的组织损伤的方法
EP1447095B1 (en) Preventives and/or remedies for post-transplant arteriosclerosis as rejection of organ transplant
CA2474778A1 (en) A novel target to inhibit angiogenesis
JP3911416B2 (ja) 新規なポリペプチドESDN、その製造方法、ESDNをコードするcDNA、そのcDNAからなるベクター、そのベクターで形質転換された宿主細胞、ESDNの抗体、ESDNまたは抗体を含有する薬学的組成物、ESDNを用いたスクリーニング方法、および抗ESDN抗体を用いたESDNの免疫化学測定法
WO2005077397A2 (en) Methods and compositions for treating vascular diseases
AU2002249144B2 (en) Use of IL-18 inhibitors for the treatment and/or prevention of heart disease
HK1062810B (en) Use of il-18 inhibitors for the manufacture of medicaments for treatment and/or prevention of heart disease
RS57803B1 (sr) Biokompatibilni mikroemulzioni sistemi sa kontrolisanim oslobađanjem ibuprofena, njihovo dobijanje i primena
EP1636258A2 (en) Angiogenic factor and inhibitors thereof
AU2002249144A1 (en) Use of IL-18 inhibitors for the treatment and/or prevention of heart disease
JPWO1997000320A1 (ja) 改変ポリペプチド、これをコードするdna、形質転換体及び該ポリペプチドを含有する医薬組成物