UA62996C2 - 6,9-disubstituted 2-[trans-(4-aminocyclohexyl)amino]purines - Google Patents

6,9-disubstituted 2-[trans-(4-aminocyclohexyl)amino]purines Download PDF

Info

Publication number: UA62996C2
Authority: UA; Ukraine
Prior art keywords: amino; aminocyclohexyl; dihydrochloride; cyclopentylpurine; trans
Prior art date: 1998-02-26

Application number

UA2000095500A

Other languages

English (en)

Ukrainian (uk)

Original Assignee

Aventic Pharmaceuticals Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-02-26

Filing date

1999-02-18

Publication date

2004-01-15

1999-02-18 Application filed by Aventic Pharmaceuticals Inc filed Critical Aventic Pharmaceuticals Inc

2004-01-15 Publication of UA62996C2 publication Critical patent/UA62996C2/uk

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YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
125000003718 tetrahydrofuranyl group Chemical group 0.000 description 1
125000001412 tetrahydropyranyl group Chemical group 0.000 description 1
125000003507 tetrahydrothiofenyl group Chemical group 0.000 description 1
238000010257 thawing Methods 0.000 description 1
125000000335 thiazolyl group Chemical group 0.000 description 1
125000001544 thienyl group Chemical group 0.000 description 1
FKKJJPMGAWGYPN-UHFFFAOYSA-N thiophen-2-ylmethanamine Chemical compound NCC1=CC=CS1 FKKJJPMGAWGYPN-UHFFFAOYSA-N 0.000 description 1
125000000341 threoninyl group Chemical group [H]OC([H])(C([H])([H])[H])C([H])(N([H])[H])C(*)=O 0.000 description 1
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235000019505 tobacco product Nutrition 0.000 description 1
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125000004306 triazinyl group Chemical group 0.000 description 1
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ITMCEJHCFYSIIV-UHFFFAOYSA-N triflic acid Chemical compound OS(=O)(=O)C(F)(F)F ITMCEJHCFYSIIV-UHFFFAOYSA-N 0.000 description 1
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208000009540 villous adenoma Diseases 0.000 description 1
210000005048 vimentin Anatomy 0.000 description 1
HOFQVRTUGATRFI-XQKSVPLYSA-N vinblastine Chemical compound C([C@@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1N=C1[C]2C=CC=C1 HOFQVRTUGATRFI-XQKSVPLYSA-N 0.000 description 1
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OGWKCGZFUXNPDA-XQKSVPLYSA-N vincristine Chemical compound C([N@]1C[C@@H](C[C@]2(C(=O)OC)C=3C(=CC4=C([C@]56[C@H]([C@@]([C@H](OC(C)=O)[C@]7(CC)C=CCN([C@H]67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)C[C@@](C1)(O)CC)CC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-XQKSVPLYSA-N 0.000 description 1
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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/16—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two nitrogen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Hematology (AREA)
Oncology (AREA)
Psychiatry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

UA2000095500A 1998-02-26 1999-02-18 6,9-disubstituted 2-[trans-(4-aminocyclohexyl)amino]purines UA62996C2 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US3238198A	1998-02-26	1998-02-26
PCT/US1999/003451 WO1999043676A2 (en)	1998-02-26	1999-02-18	6,9-disubstituted 2-[trans-(4- aminocyclohexyl) amino]purines

Publications (1)

Publication Number	Publication Date
UA62996C2 true UA62996C2 (en)	2004-01-15

Family

ID=21864658

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
UA2000095500A UA62996C2 (en)	1998-02-26	1999-02-18	6,9-disubstituted 2-[trans-(4-aminocyclohexyl)amino]purines

Country Status (30)

Country	Link
EP (1)	EP1056745B1 (et)
JP (1)	JP2002504553A (et)
KR (1)	KR100568658B1 (et)
CN (1)	CN1128149C (et)
AP (1)	AP1258A (et)
AR (1)	AR019822A1 (et)
AT (1)	ATE269332T1 (et)
AU (1)	AU748178B2 (et)
BR (1)	BR9908325A (et)
CA (1)	CA2320448C (et)
CZ (1)	CZ291604B6 (et)
DE (1)	DE69918062T2 (et)
DK (1)	DK1056745T3 (et)
EE (1)	EE04315B1 (et)
ES (1)	ES2219038T3 (et)
HU (1)	HUP0100931A3 (et)
IL (2)	IL138044A0 (et)
NO (1)	NO20004281L (et)
NZ (1)	NZ506234A (et)
OA (1)	OA11480A (et)
PL (1)	PL344021A1 (et)
PT (1)	PT1056745E (et)
RU (1)	RU2191777C2 (et)
SI (1)	SI1056745T1 (et)
SK (1)	SK12912000A3 (et)
TR (1)	TR200002482T2 (et)
TW (1)	TW541308B (et)
UA (1)	UA62996C2 (et)
WO (1)	WO1999043676A2 (et)
ZA (1)	ZA991548B (et)

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HN2001000008A (es)	2000-01-21	2003-12-11	Inc Agouron Pharmaceuticals	Compuesto de amida y composiciones farmaceuticas para inhibir proteinquinasas, y su modo de empleo
FR2806626B1 (fr) *	2000-03-22	2003-11-28	Centre Nat Rech Scient	Utilisation de substances modulatrices de l'expression ou de la fonction d'une proteine impliquee dans le cycle cellulaire pour le traitement ou la prevention des lesions neurales aigues
CA2398446A1 (en)	2000-04-18	2001-10-25	Agouron Pharmaceuticals, Inc.	Pyrazoles for inhibiting protein kinases
JP2004505983A (ja)	2000-08-09	2004-02-26	アグーロン　ファーマシューティカルズ，インコーポレイテッド	ピラゾール−チアゾール化合物、これらを含む医薬組成物、およびサイクリン依存性キナーゼの阻害のためのこれらの使用方法
ATE295354T1 (de)	2000-08-18	2005-05-15	Agouron Pharma	Heterozyklische-hydroximino-fluorene und ihre verwendung zur inhibierung von proteinkinasen
ES2324763T3 (es) *	2000-10-31	2009-08-14	Aventis Pharmaceuticals Inc.	Derivados acilo y sulfonilo de 2-(trans-1,4-diaminociclohexil)-purinas 6,9-disustituidas y su uso como agentes antiproliferativos.
GB0117075D0 (en) *	2000-10-31	2001-09-05	Aventis Pharm Prod Inc	Acyl and sulfonyl derivatives of 6, 9-distributed 2-(trans-1, 4-diaminocyclohexyl)-purines and their use as antiproliferative agents
US6756374B2 (en)	2001-01-22	2004-06-29	Hoffmann-La Roche Inc.	Diaminothiazoles having antiproliferative activity
JP4381804B2 (ja)	2001-06-27	2009-12-09	サイクラセルリミテッド	２，６，９−置換プリン誘導体及び増殖性疾患の治療におけるその使用
US6812232B2 (en)	2001-09-11	2004-11-02	Amr Technology, Inc.	Heterocycle substituted purine derivatives as potent antiproliferative agents
US6667311B2 (en)	2001-09-11	2003-12-23	Albany Molecular Research, Inc.	Nitrogen substituted biaryl purine derivatives as potent antiproliferative agents
GB0219054D0 (en)	2002-08-15	2002-09-25	Cyclacel Ltd	New purine derivatives
GB0219052D0 (en)	2002-08-15	2002-09-25	Cyclacel Ltd	New puring derivatives
CA2515135A1 (en) *	2003-02-04	2004-08-19	Kabushiki Kaisha Yakult Honsha	Breast cancer-resistant protein inhibitor
US7211576B2 (en)	2004-04-20	2007-05-01	Hoffmann-La Roche Inc.	Diaminothiazoles
WO2007117438A2 (en) *	2006-03-30	2007-10-18	Ptc Therapeutics, Inc.	Methods for the production of functional protein from dna having a nonsense mutation and the treatment of disorders associated therewith
CN102241646B (zh) *	2010-05-14	2014-04-09	中国人民解放军军事医学科学院毒物药物研究所	己烯酮类化合物及其医药用途
US9493464B2 (en)	2012-02-29	2016-11-15	The Scripps Research Institute	Wee1 degradation inhibitors
JPWO2015005491A1 (ja) *	2013-07-12	2017-03-02	国立大学法人京都大学	疾病の発症又は進行の一因となる異常スプライシングを抑制できる物質のスクリーニング方法
TW202204345A (zh)	2015-01-16	2022-02-01	美商通用醫院公司	改善mRNA剪接之化合物
CN107903274A (zh) *	2017-12-28	2018-04-13	窦玉玲	一种胺类化合物及其在抗肿瘤药物中的应用
WO2021016263A1 (en) *	2019-07-21	2021-01-28	University Of Virginia Patent Foundation	Cysteine binding compositions and methods of use thereof
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1999
- 1999-02-18 KR KR1020007009421A patent/KR100568658B1/ko not_active Expired - Fee Related
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- 1999-02-18 PT PT99936074T patent/PT1056745E/pt unknown
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- 1999-02-18 JP JP2000533431A patent/JP2002504553A/ja active Pending
- 1999-02-18 UA UA2000095500A patent/UA62996C2/uk unknown
- 1999-02-18 NZ NZ506234A patent/NZ506234A/en active IP Right Revival
- 1999-02-18 DK DK99936074T patent/DK1056745T3/da active
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- 1999-02-18 EP EP99936074A patent/EP1056745B1/en not_active Expired - Lifetime
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- 1999-02-18 IL IL13804499A patent/IL138044A0/xx active IP Right Grant
- 1999-02-18 ES ES99936074T patent/ES2219038T3/es not_active Expired - Lifetime
- 1999-02-18 SI SI9930621T patent/SI1056745T1/xx unknown
- 1999-02-18 CA CA002320448A patent/CA2320448C/en not_active Expired - Fee Related
- 1999-02-18 CN CN99803395A patent/CN1128149C/zh not_active Expired - Fee Related
- 1999-02-18 AU AU32990/99A patent/AU748178B2/en not_active Ceased
- 1999-02-18 RU RU2000124409/04A patent/RU2191777C2/ru active
- 1999-02-18 PL PL99344021A patent/PL344021A1/xx unknown
- 1999-02-18 AP APAP/P/2000/001923A patent/AP1258A/en active
- 1999-02-18 WO PCT/US1999/003451 patent/WO1999043676A2/en not_active Ceased
- 1999-02-18 SK SK1291-2000A patent/SK12912000A3/sk unknown
- 1999-02-24 TW TW088102781A patent/TW541308B/zh not_active IP Right Cessation
- 1999-02-25 AR ARP990100782A patent/AR019822A1/es active IP Right Grant
- 1999-02-25 ZA ZA9901548A patent/ZA991548B/xx unknown
2000
- 2000-08-23 IL IL138044A patent/IL138044A/en not_active IP Right Cessation
- 2000-08-25 NO NO20004281A patent/NO20004281L/no not_active Application Discontinuation
- 2000-08-25 OA OA1200000234A patent/OA11480A/en unknown

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* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
RU2681081C2 (ru) *	2007-10-05	2019-03-04	Верастэм, Инк.	Пиримидинзамещенные производные пурина, фармацевтическая композиция на их основе, способ ингибирования протеинкиназ, способ лечения или профилактики заболеваний, чувствительных к ингибированию протеинкиназ, и способ лечения пролиферативных заболеваний

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HUP0100931A2 (hu)	2002-04-29
CA2320448C (en)	2005-02-01
IL138044A (en)	2006-04-10
NO20004281L (no)	2000-10-18
OA11480A (en)	2004-05-05
EE04315B1 (et)	2004-06-15
CN1128149C (zh)	2003-11-19
AP1258A (en)	2004-03-15
RU2191777C2 (ru)	2002-10-27
CZ20003106A3 (cs)	2000-12-13
HK1030948A1 (en)	2001-05-25
EP1056745B1 (en)	2004-06-16
JP2002504553A (ja)	2002-02-12
TR200002482T2 (tr)	2002-10-21
AU3299099A (en)	1999-09-15
WO1999043676A2 (en)	1999-09-02
BR9908325A (pt)	2000-11-07
PT1056745E (pt)	2004-09-30
AP2000001923A0 (en)	2000-09-30
IL138044A0 (en)	2001-10-31
WO1999043676A3 (en)	1999-10-21
EE200000501A (et)	2002-02-15
AU748178B2 (en)	2002-05-30
KR100568658B1 (ko)	2006-04-07
NO20004281D0 (no)	2000-08-25
HUP0100931A3 (en)	2002-08-28
TW541308B (en)	2003-07-11
DE69918062D1 (de)	2004-07-22
DK1056745T3 (da)	2004-10-25
SK12912000A3 (sk)	2001-08-06
ZA991548B (en)	1999-08-26
NZ506234A (en)	2003-05-30
CZ291604B6 (cs)	2003-04-16
ES2219038T3 (es)	2004-11-16
SI1056745T1 (en)	2004-12-31
CN1291983A (zh)	2001-04-18
EP1056745A2 (en)	2000-12-06
KR20010041315A (ko)	2001-05-15
ATE269332T1 (de)	2004-07-15
DE69918062T2 (de)	2005-06-02
AR019822A1 (es)	2002-03-20
PL344021A1 (en)	2001-09-24
CA2320448A1 (en)	1999-09-02

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UA62996C2 - 6,9-disubstituted 2-[trans-(4-aminocyclohexyl)amino]purines - Google Patents

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