IL138044A0 - 6,9-disubstituted 2-[trans- 4-aminocyclohexyl) amino] purines - Google Patents

6,9-disubstituted 2-[trans- 4-aminocyclohexyl) amino] purines

Info

Publication number: IL138044A0
Authority: IL; Israel
Prior art keywords: aminocyclohexyl; purines; disubstituted; trans; amino
Prior art date: 1998-02-26

Application number

IL13804499A

Other languages

English (en)

Original Assignee

Aventis Pharma Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-02-26

Filing date

1999-02-18

Publication date

2001-10-31

1999-02-18 Application filed by Aventis Pharma Inc filed Critical Aventis Pharma Inc

2001-10-31 Publication of IL138044A0 publication Critical patent/IL138044A0/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/16—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two nitrogen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Hematology (AREA)
Oncology (AREA)
Psychiatry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

IL13804499A 1998-02-26 1999-02-18 6,9-disubstituted 2-[trans- 4-aminocyclohexyl) amino] purines IL138044A0 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US3238198A	1998-02-26	1998-02-26
PCT/US1999/003451 WO1999043676A2 (en)	1998-02-26	1999-02-18	6,9-disubstituted 2-[trans-(4- aminocyclohexyl) amino]purines

Publications (1)

Publication Number	Publication Date
IL138044A0 true IL138044A0 (en)	2001-10-31

Family

ID=21864658

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
IL13804499A IL138044A0 (en)	1998-02-26	1999-02-18	6,9-disubstituted 2-[trans- 4-aminocyclohexyl) amino] purines
IL138044A IL138044A (en)	1998-02-26	2000-08-23	Dual-converted purines in positions 6 and 9, 2– [trans- (4-aminocyclohexyl) amino] and pharmaceutical preparations containing them

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
IL138044A IL138044A (en)	1998-02-26	2000-08-23	Dual-converted purines in positions 6 and 9, 2– [trans- (4-aminocyclohexyl) amino] and pharmaceutical preparations containing them

Country Status (30)

Country	Link
EP (1)	EP1056745B1 (et)
JP (1)	JP2002504553A (et)
KR (1)	KR100568658B1 (et)
CN (1)	CN1128149C (et)
AP (1)	AP1258A (et)
AR (1)	AR019822A1 (et)
AT (1)	ATE269332T1 (et)
AU (1)	AU748178B2 (et)
BR (1)	BR9908325A (et)
CA (1)	CA2320448C (et)
CZ (1)	CZ291604B6 (et)
DE (1)	DE69918062T2 (et)
DK (1)	DK1056745T3 (et)
EE (1)	EE04315B1 (et)
ES (1)	ES2219038T3 (et)
HU (1)	HUP0100931A3 (et)
IL (2)	IL138044A0 (et)
NO (1)	NO20004281L (et)
NZ (1)	NZ506234A (et)
OA (1)	OA11480A (et)
PL (1)	PL344021A1 (et)
PT (1)	PT1056745E (et)
RU (1)	RU2191777C2 (et)
SI (1)	SI1056745T1 (et)
SK (1)	SK12912000A3 (et)
TR (1)	TR200002482T2 (et)
TW (1)	TW541308B (et)
UA (1)	UA62996C2 (et)
WO (1)	WO1999043676A2 (et)
ZA (1)	ZA991548B (et)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6969720B2 (en)	1999-03-17	2005-11-29	Amr Technology, Inc.	Biaryl substituted purine derivatives as potent antiproliferative agents
US6627633B2 (en) *	1999-03-17	2003-09-30	Albany Molecular Research, Inc.	6-substituted biaryl purine derivatives as potent cyclin/CDK inhibitors and antiproliferative agents
US20030187261A1 (en) *	2000-01-07	2003-10-02	Libor Havlicek	Purine derivatives, process for their preparation and use thereof
YU54202A (sh)	2000-01-18	2006-01-16	Agouron Pharmaceuticals Inc.	Jedinjenja indazola, farmaceutske smeše i postupci za stimulisanje i inhibiranje ćelijske proliferacije
HN2001000008A (es)	2000-01-21	2003-12-11	Inc Agouron Pharmaceuticals	Compuesto de amida y composiciones farmaceuticas para inhibir proteinquinasas, y su modo de empleo
FR2806626B1 (fr) *	2000-03-22	2003-11-28	Centre Nat Rech Scient	Utilisation de substances modulatrices de l'expression ou de la fonction d'une proteine impliquee dans le cycle cellulaire pour le traitement ou la prevention des lesions neurales aigues
CA2398446A1 (en)	2000-04-18	2001-10-25	Agouron Pharmaceuticals, Inc.	Pyrazoles for inhibiting protein kinases
JP2004505983A (ja)	2000-08-09	2004-02-26	アグーロン　ファーマシューティカルズ，インコーポレイテッド	ピラゾール−チアゾール化合物、これらを含む医薬組成物、およびサイクリン依存性キナーゼの阻害のためのこれらの使用方法
ATE295354T1 (de)	2000-08-18	2005-05-15	Agouron Pharma	Heterozyklische-hydroximino-fluorene und ihre verwendung zur inhibierung von proteinkinasen
ES2324763T3 (es) *	2000-10-31	2009-08-14	Aventis Pharmaceuticals Inc.	Derivados acilo y sulfonilo de 2-(trans-1,4-diaminociclohexil)-purinas 6,9-disustituidas y su uso como agentes antiproliferativos.
GB0117075D0 (en) *	2000-10-31	2001-09-05	Aventis Pharm Prod Inc	Acyl and sulfonyl derivatives of 6, 9-distributed 2-(trans-1, 4-diaminocyclohexyl)-purines and their use as antiproliferative agents
US6756374B2 (en)	2001-01-22	2004-06-29	Hoffmann-La Roche Inc.	Diaminothiazoles having antiproliferative activity
JP4381804B2 (ja)	2001-06-27	2009-12-09	サイクラセルリミテッド	２，６，９−置換プリン誘導体及び増殖性疾患の治療におけるその使用
US6812232B2 (en)	2001-09-11	2004-11-02	Amr Technology, Inc.	Heterocycle substituted purine derivatives as potent antiproliferative agents
US6667311B2 (en)	2001-09-11	2003-12-23	Albany Molecular Research, Inc.	Nitrogen substituted biaryl purine derivatives as potent antiproliferative agents
GB0219054D0 (en)	2002-08-15	2002-09-25	Cyclacel Ltd	New purine derivatives
GB0219052D0 (en)	2002-08-15	2002-09-25	Cyclacel Ltd	New puring derivatives
CA2515135A1 (en) *	2003-02-04	2004-08-19	Kabushiki Kaisha Yakult Honsha	Breast cancer-resistant protein inhibitor
US7211576B2 (en)	2004-04-20	2007-05-01	Hoffmann-La Roche Inc.	Diaminothiazoles
WO2007117438A2 (en) *	2006-03-30	2007-10-18	Ptc Therapeutics, Inc.	Methods for the production of functional protein from dna having a nonsense mutation and the treatment of disorders associated therewith
US8247410B2 (en) *	2007-10-05	2012-08-21	Verastem	Pyrimidine substituted purine derivatives
CN102241646B (zh) *	2010-05-14	2014-04-09	中国人民解放军军事医学科学院毒物药物研究所	己烯酮类化合物及其医药用途
US9493464B2 (en)	2012-02-29	2016-11-15	The Scripps Research Institute	Wee1 degradation inhibitors
JPWO2015005491A1 (ja) *	2013-07-12	2017-03-02	国立大学法人京都大学	疾病の発症又は進行の一因となる異常スプライシングを抑制できる物質のスクリーニング方法
TW202204345A (zh)	2015-01-16	2022-02-01	美商通用醫院公司	改善mRNA剪接之化合物
CN107903274A (zh) *	2017-12-28	2018-04-13	窦玉玲	一种胺类化合物及其在抗肿瘤药物中的应用
WO2021016263A1 (en) *	2019-07-21	2021-01-28	University Of Virginia Patent Foundation	Cysteine binding compositions and methods of use thereof
WO2024105159A1 (en) *	2022-11-16	2024-05-23	University Of Zurich	Ligands of the m6a-rna readers

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9301000D0 (en) *	1993-01-20	1993-03-10	Glaxo Group Ltd	Chemical compounds
GB9414208D0 (en) *	1994-07-14	1994-08-31	Glaxo Group Ltd	Compounds
EP0874846B1 (en) *	1995-11-01	2003-04-02	Novartis AG	Purine derivatives and processes for their preparation
FR2741881B1 (fr) *	1995-12-01	1999-07-30	Centre Nat Rech Scient	Nouveaux derives de purine possedant notamment des prorietes anti-proliferatives et leurs applications biologiques

1999
- 1999-02-18 KR KR1020007009421A patent/KR100568658B1/ko not_active Expired - Fee Related
- 1999-02-18 BR BR9908325-6A patent/BR9908325A/pt not_active IP Right Cessation
- 1999-02-18 AT AT99936074T patent/ATE269332T1/de not_active IP Right Cessation
- 1999-02-18 PT PT99936074T patent/PT1056745E/pt unknown
- 1999-02-18 CZ CZ20003106A patent/CZ291604B6/cs not_active IP Right Cessation
- 1999-02-18 EE EEP200000501A patent/EE04315B1/et not_active IP Right Cessation
- 1999-02-18 JP JP2000533431A patent/JP2002504553A/ja active Pending
- 1999-02-18 UA UA2000095500A patent/UA62996C2/uk unknown
- 1999-02-18 NZ NZ506234A patent/NZ506234A/en active IP Right Revival
- 1999-02-18 DK DK99936074T patent/DK1056745T3/da active
- 1999-02-18 TR TR2000/02482T patent/TR200002482T2/xx unknown
- 1999-02-18 HU HU0100931A patent/HUP0100931A3/hu unknown
- 1999-02-18 EP EP99936074A patent/EP1056745B1/en not_active Expired - Lifetime
- 1999-02-18 DE DE69918062T patent/DE69918062T2/de not_active Expired - Fee Related
- 1999-02-18 IL IL13804499A patent/IL138044A0/xx active IP Right Grant
- 1999-02-18 ES ES99936074T patent/ES2219038T3/es not_active Expired - Lifetime
- 1999-02-18 SI SI9930621T patent/SI1056745T1/xx unknown
- 1999-02-18 CA CA002320448A patent/CA2320448C/en not_active Expired - Fee Related
- 1999-02-18 CN CN99803395A patent/CN1128149C/zh not_active Expired - Fee Related
- 1999-02-18 AU AU32990/99A patent/AU748178B2/en not_active Ceased
- 1999-02-18 RU RU2000124409/04A patent/RU2191777C2/ru active
- 1999-02-18 PL PL99344021A patent/PL344021A1/xx unknown
- 1999-02-18 AP APAP/P/2000/001923A patent/AP1258A/en active
- 1999-02-18 WO PCT/US1999/003451 patent/WO1999043676A2/en not_active Ceased
- 1999-02-18 SK SK1291-2000A patent/SK12912000A3/sk unknown
- 1999-02-24 TW TW088102781A patent/TW541308B/zh not_active IP Right Cessation
- 1999-02-25 AR ARP990100782A patent/AR019822A1/es active IP Right Grant
- 1999-02-25 ZA ZA9901548A patent/ZA991548B/xx unknown
2000
- 2000-08-23 IL IL138044A patent/IL138044A/en not_active IP Right Cessation
- 2000-08-25 NO NO20004281A patent/NO20004281L/no not_active Application Discontinuation
- 2000-08-25 OA OA1200000234A patent/OA11480A/en unknown

Also Published As

Publication number	Publication date
HUP0100931A2 (hu)	2002-04-29
CA2320448C (en)	2005-02-01
IL138044A (en)	2006-04-10
NO20004281L (no)	2000-10-18
OA11480A (en)	2004-05-05
EE04315B1 (et)	2004-06-15
CN1128149C (zh)	2003-11-19
AP1258A (en)	2004-03-15
RU2191777C2 (ru)	2002-10-27
UA62996C2 (en)	2004-01-15
CZ20003106A3 (cs)	2000-12-13
HK1030948A1 (en)	2001-05-25
EP1056745B1 (en)	2004-06-16
JP2002504553A (ja)	2002-02-12
TR200002482T2 (tr)	2002-10-21
AU3299099A (en)	1999-09-15
WO1999043676A2 (en)	1999-09-02
BR9908325A (pt)	2000-11-07
PT1056745E (pt)	2004-09-30
AP2000001923A0 (en)	2000-09-30
WO1999043676A3 (en)	1999-10-21
EE200000501A (et)	2002-02-15
AU748178B2 (en)	2002-05-30
KR100568658B1 (ko)	2006-04-07
NO20004281D0 (no)	2000-08-25
HUP0100931A3 (en)	2002-08-28
TW541308B (en)	2003-07-11
DE69918062D1 (de)	2004-07-22
DK1056745T3 (da)	2004-10-25
SK12912000A3 (sk)	2001-08-06
ZA991548B (en)	1999-08-26
NZ506234A (en)	2003-05-30
CZ291604B6 (cs)	2003-04-16
ES2219038T3 (es)	2004-11-16
SI1056745T1 (en)	2004-12-31
CN1291983A (zh)	2001-04-18
EP1056745A2 (en)	2000-12-06
KR20010041315A (ko)	2001-05-15
ATE269332T1 (de)	2004-07-15
DE69918062T2 (de)	2005-06-02
AR019822A1 (es)	2002-03-20
PL344021A1 (en)	2001-09-24
CA2320448A1 (en)	1999-09-02

Publication	Publication Date	Title
IL138044A0 (en)	2001-10-31	6,9-disubstituted 2-[trans- 4-aminocyclohexyl) amino] purines
AP2000001922A0 (en)	2000-09-30	6,9-Disubstituted 2-[trans-(4-aminocyclohexyl)amino] purines
SI0891978T1 (en)	2002-06-30	5H-Thiazolo (3,2-a) pyrimidine derivatives
ZA9710156B (en)	1998-05-18	Antiviral peptide derivatives.
NO20006454D0 (no)	2000-12-18	Pyrrolo(2,3-d)pyrimidinforbindelser
NO20006453L (no)	2001-02-05	Pyrrolo(2,3-d)pyrimidinforbindelser
SG71077A1 (en)	2000-03-21	8-Substituted-1,3, 8-triaza-spiro (4.5)decan-4-on derivatives
GB9706625D0 (en)	1997-05-21	Hyper-redundant robot
ZA9811128B (en)	1999-06-07	1,3,8-Triaza-spiro(4,5)decan-4-on derivatives
HUP9600106A3 (en)	1998-04-28	2,9-disubstituted purin-6-one derivatives
ZA9810920B (en)	1999-06-01	Fungicidal combinations comprising theino (2,3-d) pyrimidin-4-one
HUP0003692A3 (en)	2002-10-28	Pyrimido[4,5-b]indolyl-alkanecarboxamide derivatives
ZA984561B (en)	1998-11-30	2-amino-7-(1-substituted-2-hydroxyethyl)-3,5-dihydro-pyrrolo[3,2--D]pyrimidin-4-ones
AU5515299A (en)	2000-03-14	9-dialkylamino purinone derivatives
GB9808224D0 (en)	1998-06-17	Turbomachine
HU9801264D0 (en)	1998-08-28	Herbicidal 3,5-difluoropyridines
SI1056744T1 (en)	2004-02-29	6,9-disubstituted 2- trans-(4- aminocyclohexyl) amino)purines
SI1198464T1 (en)	2004-04-30	8-PHENYL-6,9-DIHYDRO-(1,2,4)TRIAZOLO(3,4-i)PURIN-5-ONE DERIVATIVES
GB9713040D0 (en)	1997-08-27	Adjustable aerofoil
DE69912248D1 (de)	2003-11-27	6,9-disubstituierte 2-[trans-(4-aminocyclohexyl)amino] purine
AU132443S (en)	1997-12-15	Socket
GB9718577D0 (en)	1997-11-05	Zip aid

Legal Events

Date	Code	Title
2006-09-05	FF	Patent granted
2006-10-30	KB	Patent renewed
2009-08-31	KB	Patent renewed