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UA42747C2 - Похідні пептиду,фармацевтична композиція та спосіб стимулювання секреції гормону росту - Google Patents

Похідні пептиду,фармацевтична композиція та спосіб стимулювання секреції гормону росту

Info

Publication number
UA42747C2
UA42747C2 UA96062486A UA96062486A UA42747C2 UA 42747 C2 UA42747 C2 UA 42747C2 UA 96062486 A UA96062486 A UA 96062486A UA 96062486 A UA96062486 A UA 96062486A UA 42747 C2 UA42747 C2 UA 42747C2
Authority
UA
Ukraine
Prior art keywords
growth hormone
pharmaceutical composition
peptide derivatives
hormone secretion
stimulating growth
Prior art date
Application number
UA96062486A
Other languages
English (en)
Russian (ru)
Inventor
Нільс Лангеланд ЙОХАНСЕН
Нильс Лангеланд ЙОХАНСЕН
Йеспер ЛАУ
Келль Мадсен
Бехренд Фрідріх ЛУНДТ
Бехренд Фридрих Лундт
Хеннінг Тхьогерсен
Хеннинг Тхьогерсен
Біргіт Сехестед ХАНСЕН
Биргит Сехестед Хансен
Бернд Пешке
Original Assignee
Ново Нордіск А/С
Ново Нордиск А/С
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DK143993A external-priority patent/DK143993D0/da
Application filed by Ново Нордіск А/С, Ново Нордиск А/С filed Critical Ново Нордіск А/С
Publication of UA42747C2 publication Critical patent/UA42747C2/uk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1024—Tetrapeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/60—Growth hormone-releasing factor [GH-RF], i.e. somatoliberin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Hospice & Palliative Care (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Psychiatry (AREA)
  • Obesity (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Винахід належить до нових пептидних похідних, композицій, що містять ці похідні, та їхнього застосування для лікування медичних порушень, що є результатом дефіциту гормону росту.
UA96062486A 1993-12-23 1994-12-22 Похідні пептиду,фармацевтична композиція та спосіб стимулювання секреції гормону росту UA42747C2 (uk)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DK143993A DK143993D0 (uk) 1993-12-23 1993-12-23
DK12194 1994-01-28
DK119194 1994-10-14
PCT/DK1994/000485 WO1995017423A1 (en) 1993-12-23 1994-12-22 Compounds with growth hormone releasing properties

Publications (1)

Publication Number Publication Date
UA42747C2 true UA42747C2 (uk) 2001-11-15

Family

ID=27220421

Family Applications (1)

Application Number Title Priority Date Filing Date
UA96062486A UA42747C2 (uk) 1993-12-23 1994-12-22 Похідні пептиду,фармацевтична композиція та спосіб стимулювання секреції гормону росту

Country Status (27)

Country Link
US (1) US5767085A (uk)
EP (1) EP0736039B1 (uk)
JP (1) JP3181918B2 (uk)
KR (1) KR100354897B1 (uk)
CN (1) CN1052731C (uk)
AT (1) ATE197158T1 (uk)
AU (1) AU689181B2 (uk)
BR (1) BR9408377A (uk)
CA (1) CA2179597A1 (uk)
CZ (1) CZ293113B6 (uk)
DE (1) DE69426206T2 (uk)
DK (1) DK0736039T3 (uk)
ES (1) ES2153469T3 (uk)
FI (1) FI962584A0 (uk)
GR (1) GR3035150T3 (uk)
HU (1) HU224345B1 (uk)
IL (1) IL112112A (uk)
MX (1) MX9500072A (uk)
NO (1) NO315561B1 (uk)
NZ (1) NZ277486A (uk)
PL (1) PL181280B1 (uk)
PT (1) PT736039E (uk)
RO (1) RO115635B1 (uk)
SG (1) SG55069A1 (uk)
SK (1) SK281963B6 (uk)
UA (1) UA42747C2 (uk)
WO (1) WO1995017423A1 (uk)

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CA2176140A1 (en) * 1993-11-24 1995-06-01 Meng Hsin Chen Indolyl group containing compounds and the use thereof to promote the release of growth hormone(s)
DE69427650T2 (de) * 1993-12-23 2001-11-22 Novo Nordisk A/S, Bagsvaerd Verbindungen mit wachstumshormon-freisetzenden eigenschaften
US20020111461A1 (en) 1999-05-21 2002-08-15 Todd C. Somers Low molecular weight peptidomimetic growth hormone secretagogues
US5798337A (en) * 1994-11-16 1998-08-25 Genentech, Inc. Low molecular weight peptidomimetic growth hormone secretagogues
AU705744B2 (en) 1995-01-27 1999-06-03 Sapphire Therapeutics, Inc. Compounds with growth hormone releasing properties
HUP9802821A3 (en) * 1995-06-22 2000-03-28 Novo Nordisk As Compounds with growth hormone releasing properties
US6531314B1 (en) 1996-12-10 2003-03-11 Merck & Co., Inc. Growth hormone secretagogue receptor family
JP3798024B2 (ja) 1995-12-13 2006-07-19 メルク エンド カンパニー インコーポレーテッド 成長ホルモン分泌促進物質レセプターアッセイ
GB2308362A (en) * 1995-12-19 1997-06-25 Lilly Industries Ltd Pharmaceutical indole derivatives
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US6451970B1 (en) 1996-02-21 2002-09-17 Novo Nordisk A/S Peptide derivatives
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US5919777A (en) * 1996-04-24 1999-07-06 Novo Nordisk A/S Compounds with growth hormone releasing properties
JP4425992B2 (ja) * 1996-07-22 2010-03-03 サファイア セラピューティクス，インコーポレイティド 成長ホルモン放出特性を有する化合物
AU3938797A (en) * 1996-08-29 1998-03-19 Novo Nordisk A/S Transdermal delivery of peptides
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US6127341A (en) * 1997-06-20 2000-10-03 Novo Nordisk A/S Compounds with growth hormone releasing properties
KR20010034198A (ko) 1998-01-16 2001-04-25 한센 핀 베네드 성장 호르몬 방출성을 가지는 화합물
US6919315B1 (en) * 1998-06-30 2005-07-19 Novo Nordisk A/S Compounds with growth hormone releasing properties
US6682908B1 (en) 1998-07-10 2004-01-27 Merck & Co., Inc. Mouse growth hormone secretagogue receptor
JP2002520011A (ja) 1998-07-13 2002-07-09 メルク・アンド・カンパニー・インコーポレーテッド 成長ホルモン分泌促進物質関連受容体および核酸
WO2000009538A2 (en) 1998-08-10 2000-02-24 Merck & Co., Inc. Canine growth hormone secretagogue receptor
US6696063B1 (en) 1998-12-30 2004-02-24 Applied Research Systems Ars Holding N.V. Treatment of HIV-associated dysmorphia/dysmetabolic syndrome (HADDS) with or without lipodystrophy
CA2356109C (en) 1999-01-06 2008-04-22 Genentech, Inc. Insulin-like growth factor (igf) i mutant variants
KR100699404B1 (ko) * 1999-02-18 2007-03-23 가켄 세야쿠 가부시키가이샤 성장 호르몬 분비촉진제로서의 신규 아미드 유도체
EP1200111A1 (en) * 1999-06-04 2002-05-02 Novo Nordisk A/S Compositions for the treatment of the catabolic state of prolonged critical illness
WO2001087323A2 (en) 2000-05-16 2001-11-22 Genentech, Inc. Method for treating cartilage disorders
ATE446758T1 (de) 2000-05-31 2009-11-15 Pfizer Prod Inc Verwendung von wachstumshormonsekretagoga zur förderung der beweglichkeit des verdauungstrakts
TWI331922B (en) 2002-08-09 2010-10-21 Ipsen Pharma Sas Growth hormone releasing peptides
MXPA05012505A (es) * 2003-05-19 2006-01-30 Warner Lambert Co Capsula de gelatina dura que contiene oxido de titanio con un tamano de particula controlado y procedimiento para su produccion.
US7476653B2 (en) 2003-06-18 2009-01-13 Tranzyme Pharma, Inc. Macrocyclic modulators of the ghrelin receptor
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WO2005027913A1 (en) * 2003-09-19 2005-03-31 Pfizer Products Inc. Pharmaceutical compositions and methods comprising combinations of 2-alkylidene-19-nor-vitamin d derivatives and a growth hormone secretagogue
WO2005097261A1 (en) * 2004-03-30 2005-10-20 Sapphire Therapeutics, Inc. Method of reducing c-reactive protein using growth hormone secretagogues
UA87854C2 (en) 2004-06-07 2009-08-25 Мерк Энд Ко., Инк. N-(2-benzyl)-2-phenylbutanamides as androgen receptor modulators
KR101380200B1 (ko) * 2004-08-12 2014-04-01 헬신 세라퓨틱스 (유.에스.) 인크. 성장 호르몬 분비촉진제를 이용하여 위장관계의 운동성을촉진하는 방법
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CA2176140A1 (en) * 1993-11-24 1995-06-01 Meng Hsin Chen Indolyl group containing compounds and the use thereof to promote the release of growth hormone(s)

Also Published As

Publication number Publication date
EP0736039B1 (en) 2000-10-25
NZ277486A (en) 1997-03-24
ATE197158T1 (de) 2000-11-15
HU9501947D0 (en) 1995-11-28
KR100354897B1 (ko) 2003-01-06
IL112112A0 (en) 1995-03-15
AU689181B2 (en) 1998-03-26
BR9408377A (pt) 1997-08-19
PT736039E (pt) 2001-04-30
CN1138335A (zh) 1996-12-18
PL315113A1 (en) 1996-10-14
FI962584L (fi) 1996-06-20
FI962584A7 (fi) 1996-06-20
CN1052731C (zh) 2000-05-24
DE69426206D1 (de) 2000-11-30
SK281963B6 (sk) 2001-09-11
FI962584A0 (fi) 1996-06-20
HUT73497A (en) 1996-08-28
HU224345B1 (hu) 2005-08-29
DE69426206T2 (de) 2001-05-17
DK0736039T3 (da) 2001-02-12
RO115635B1 (ro) 2000-04-28
SK82096A3 (en) 1997-01-08
MX9500072A (es) 1997-05-31
JPH09507217A (ja) 1997-07-22
EP0736039A1 (en) 1996-10-09
IL112112A (en) 2000-06-29
NO962665L (no) 1996-08-23
PL181280B1 (pl) 2001-07-31
CZ293113B6 (cs) 2004-02-18
US5767085A (en) 1998-06-16
GR3035150T3 (en) 2001-04-30
CZ183496A3 (en) 1997-02-12
SG55069A1 (en) 1998-12-21
ES2153469T3 (es) 2001-03-01
NO962665D0 (no) 1996-06-21
CA2179597A1 (en) 1995-06-29
AU1272495A (en) 1995-07-10
JP3181918B2 (ja) 2001-07-03
WO1995017423A1 (en) 1995-06-29
NO315561B1 (no) 2003-09-22

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