[go: up one dir, main page]

NO962665L - Forbindelser med veksthormonfrigjörende egenskaper - Google Patents

Forbindelser med veksthormonfrigjörende egenskaper

Info

Publication number
NO962665L
NO962665L NO962665A NO962665A NO962665L NO 962665 L NO962665 L NO 962665L NO 962665 A NO962665 A NO 962665A NO 962665 A NO962665 A NO 962665A NO 962665 L NO962665 L NO 962665L
Authority
NO
Norway
Prior art keywords
growth hormone
compounds
hormone releasing
releasing properties
pct
Prior art date
Application number
NO962665A
Other languages
English (en)
Other versions
NO315561B1 (no
NO962665D0 (no
Inventor
Nils Langeland Johansen
Jesper Lau
Kjeld Madsen
Behrend Friedrich Lundt
Henning Thoegersen
Birgit Sehested Hansen
Bernd Peschke
Original Assignee
Novo Nordisk As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DK143993A external-priority patent/DK143993D0/da
Application filed by Novo Nordisk As filed Critical Novo Nordisk As
Publication of NO962665D0 publication Critical patent/NO962665D0/no
Publication of NO962665L publication Critical patent/NO962665L/no
Publication of NO315561B1 publication Critical patent/NO315561B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1024—Tetrapeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/60—Growth hormone-releasing factor [GH-RF], i.e. somatoliberin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Hospice & Palliative Care (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Psychiatry (AREA)
  • Obesity (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
NO19962665A 1993-12-23 1996-06-21 Forbindelser med veksthormonfrigjörende egenskaper, farmasöytiske preparater som omfatter dem, samt anvendelse derav til fremstilling avmedikamenter NO315561B1 (no)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DK143993A DK143993D0 (no) 1993-12-23 1993-12-23
DK12194 1994-01-28
DK119194 1994-10-14
PCT/DK1994/000485 WO1995017423A1 (en) 1993-12-23 1994-12-22 Compounds with growth hormone releasing properties

Publications (3)

Publication Number Publication Date
NO962665D0 NO962665D0 (no) 1996-06-21
NO962665L true NO962665L (no) 1996-08-23
NO315561B1 NO315561B1 (no) 2003-09-22

Family

ID=27220421

Family Applications (1)

Application Number Title Priority Date Filing Date
NO19962665A NO315561B1 (no) 1993-12-23 1996-06-21 Forbindelser med veksthormonfrigjörende egenskaper, farmasöytiske preparater som omfatter dem, samt anvendelse derav til fremstilling avmedikamenter

Country Status (27)

Country Link
US (1) US5767085A (no)
EP (1) EP0736039B1 (no)
JP (1) JP3181918B2 (no)
KR (1) KR100354897B1 (no)
CN (1) CN1052731C (no)
AT (1) ATE197158T1 (no)
AU (1) AU689181B2 (no)
BR (1) BR9408377A (no)
CA (1) CA2179597A1 (no)
CZ (1) CZ293113B6 (no)
DE (1) DE69426206T2 (no)
DK (1) DK0736039T3 (no)
ES (1) ES2153469T3 (no)
FI (1) FI962584A7 (no)
GR (1) GR3035150T3 (no)
HU (1) HU224345B1 (no)
IL (1) IL112112A (no)
MX (1) MX9500072A (no)
NO (1) NO315561B1 (no)
NZ (1) NZ277486A (no)
PL (1) PL181280B1 (no)
PT (1) PT736039E (no)
RO (1) RO115635B1 (no)
SG (1) SG55069A1 (no)
SK (1) SK281963B6 (no)
UA (1) UA42747C2 (no)
WO (1) WO1995017423A1 (no)

Families Citing this family (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995014666A1 (en) * 1993-11-24 1995-06-01 Merck & Co., Inc. Indolyl group containing compounds and the use thereof to promote the release of growth hormone(s)
CZ291382B6 (cs) * 1993-12-23 2003-02-12 Novo Nordisk A/S Peptidické deriváty ovlivňující uvolňování růstového hormonu, farmaceutický přípravek je obsahující a jejich použití
US5798337A (en) * 1994-11-16 1998-08-25 Genentech, Inc. Low molecular weight peptidomimetic growth hormone secretagogues
US20020111461A1 (en) * 1999-05-21 2002-08-15 Todd C. Somers Low molecular weight peptidomimetic growth hormone secretagogues
PL186511B1 (pl) * 1995-01-27 2004-01-30 Novo Nordisk As Nowe związki peptydowe, kompozycje farmaceutycznedo pobudzania uwalniania hormonu wzrostu i zastosowanie tych związków do wytwarzania leku do pobudzania uwalniania hormonu wzrostu
IL122371A0 (en) * 1995-06-22 1998-06-15 Novo Nordisk As Compounds with growth hormone releasing properties
US6531314B1 (en) 1996-12-10 2003-03-11 Merck & Co., Inc. Growth hormone secretagogue receptor family
ATE334394T1 (de) 1995-12-13 2006-08-15 Merck & Co Inc Testverfahren für die sekretionsrezeptoren von wachstumshormonen
GB2308362A (en) * 1995-12-19 1997-06-25 Lilly Industries Ltd Pharmaceutical indole derivatives
IL124702A0 (en) * 1995-12-22 1998-12-06 Novo Nordisk As Compounds with growth hormone releasing properties
US6451970B1 (en) 1996-02-21 2002-09-17 Novo Nordisk A/S Peptide derivatives
US5919777A (en) * 1996-04-24 1999-07-06 Novo Nordisk A/S Compounds with growth hormone releasing properties
DE69718469T2 (de) * 1996-04-24 2003-10-30 Novo Nordisk A/S, Bagsvaerd Verbindungen mit wachtumshormon freisetzenden eigenschaften
ATE218537T1 (de) * 1996-07-22 2002-06-15 Novo Nordisk As Verbindungen mit wachstumshormon freisetzenden eigenschaften
WO1998008492A1 (en) * 1996-08-29 1998-03-05 Novo Nordisk A/S Transdermal delivery of peptides
US6121416A (en) 1997-04-04 2000-09-19 Genentech, Inc. Insulin-like growth factor agonist molecules
US6420518B1 (en) 1997-04-04 2002-07-16 Genetech, Inc. Insulin-like growth factor agonist molecules
US6127341A (en) * 1997-06-20 2000-10-03 Novo Nordisk A/S Compounds with growth hormone releasing properties
EP1005484A1 (en) 1997-06-20 2000-06-07 Novo Nordisk A/S Compounds with growth hormone releasing properties
CA2318558A1 (en) 1998-01-16 1999-07-22 Novo Nordisk A/S Compounds with growth hormone releasing properties
US6919315B1 (en) 1998-06-30 2005-07-19 Novo Nordisk A/S Compounds with growth hormone releasing properties
US6682908B1 (en) 1998-07-10 2004-01-27 Merck & Co., Inc. Mouse growth hormone secretagogue receptor
JP2002520011A (ja) 1998-07-13 2002-07-09 メルク・アンド・カンパニー・インコーポレーテッド 成長ホルモン分泌促進物質関連受容体および核酸
CA2340095A1 (en) 1998-08-10 2000-02-24 Merck & Co., Inc. Canine growth hormone secretagogue receptor
US6696063B1 (en) * 1998-12-30 2004-02-24 Applied Research Systems Ars Holding N.V. Treatment of HIV-associated dysmorphia/dysmetabolic syndrome (HADDS) with or without lipodystrophy
IL143866A0 (en) 1999-01-06 2002-04-21 Genentech Inc Insulin-like growth factor (igf) i mutant variants
JP2002542151A (ja) * 1999-02-18 2002-12-10 科研製薬株式会社 成長ホルモン分泌促進物質としての新規なアミド誘導体
AU4911500A (en) * 1999-06-04 2000-12-28 Novo Nordisk A/S Compositions for the treatment of the catabolic state of prolonged critical illness
WO2001087323A2 (en) 2000-05-16 2001-11-22 Genentech, Inc. Method for treating cartilage disorders
DE60140285D1 (de) 2000-05-31 2009-12-10 Pfizer Prod Inc Verwendung von Wachstumshormonsekretagoga zur Förderung der Beweglichkeit des Verdauungstrakts
TWI331922B (en) 2002-08-09 2010-10-21 Ipsen Pharma Sas Growth hormone releasing peptides
CN1791387A (zh) * 2003-05-19 2006-06-21 沃尼尔·朗伯有限责任公司 含有控制粒径二氧化钛的硬明胶胶囊及其生产方法
US7476653B2 (en) 2003-06-18 2009-01-13 Tranzyme Pharma, Inc. Macrocyclic modulators of the ghrelin receptor
WO2005049792A2 (en) 2003-09-12 2005-06-02 Tercica, Inc. Methods for treatment of insulin-like growth factor-1 (igf-1) deficiency
WO2005027913A1 (en) * 2003-09-19 2005-03-31 Pfizer Products Inc. Pharmaceutical compositions and methods comprising combinations of 2-alkylidene-19-nor-vitamin d derivatives and a growth hormone secretagogue
EP1735055A1 (en) * 2004-03-30 2006-12-27 Sapphire Therapeutics, Inc. Method of reducing c-reactive protein using growth hormone secretagogues
UA87854C2 (en) 2004-06-07 2009-08-25 Мерк Энд Ко., Инк. N-(2-benzyl)-2-phenylbutanamides as androgen receptor modulators
EP1789067B8 (en) * 2004-08-12 2012-08-15 Helsinn Healthcare S.A. Use of growth hormone secretagogues for stimulating the motility of the gastrointestinal system
CU23558A1 (es) 2006-02-28 2010-07-20 Ct Ingenieria Genetica Biotech Compuestos análogos a los secretagogos peptidicos de la hormona de crecimiento
EP2021015A2 (en) * 2006-04-28 2009-02-11 The Administrators Of The Tulane Educational Fund Ghrelin/growth hormone releasing peptide/growth hormone secretatogue receptor antagonists and uses thereof
CN101657436A (zh) 2007-02-09 2010-02-24 特兰齐姆制药公司 大环生长素释放肽受体调节剂及其使用方法
MX2009008561A (es) * 2007-02-13 2010-01-15 Helsinn Therapeutics Us Inc Metodo para tratar trastornos proliferativos celulares utilizando secretagogos.
TWI429436B (zh) * 2007-04-10 2014-03-11 Helsinn Therapeutics Us Inc 使用生長激素促泌素治療或預防嘔吐之方法
US20100099640A1 (en) 2007-05-04 2010-04-22 Joannes Geuns Tissue degeneration protection
CA2710039C (en) 2007-12-26 2018-07-03 Critical Outcome Technologies, Inc. Semicarbazones, thiosemicarbazones and related compounds and methods for treatment of cancer
WO2010006438A1 (en) 2008-07-17 2010-01-21 Critical Outcome Technologies Inc. Thiosemicarbazone inhibitor compounds and cancer treatment methods
UA105657C2 (uk) * 2009-02-27 2014-06-10 Хелсінн Терапьютікс (Ю.Ес.), Інк. Поліпшені способи лікування мігрені на основі анамореліну
US9724381B2 (en) 2009-05-12 2017-08-08 The Administrators Of The Tulane Educational Fund Methods of inhibiting the ghrelin/growth hormone secretatogue receptor pathway and uses thereof
KR20120030530A (ko) * 2009-06-12 2012-03-28 헬신 세라퓨틱스 (유.에스.) 인크. 이파모렐린 디아세테이트 주사 및 주입 용액
US8987272B2 (en) 2010-04-01 2015-03-24 Critical Outcome Technologies Inc. Compounds and method for treatment of HIV
WO2013190520A2 (en) 2012-06-22 2013-12-27 The General Hospital Corporation Gh-releasing agents in the treatment of vascular stenosis and associated conditions
US9119832B2 (en) 2014-02-05 2015-09-01 The Regents Of The University Of California Methods of treating mild brain injury
BR112016027778A2 (pt) 2014-05-30 2017-08-15 Pfizer Usos de derivados de carbonitrila, sua combinação e sua composição farmacêutica
WO2017075535A1 (en) 2015-10-28 2017-05-04 Oxeia Biopharmaceuticals, Inc. Methods of treating neurodegenerative conditions
US12012467B2 (en) 2017-03-28 2024-06-18 Regents Of The University Of Michigan Small molecule DCN1 inhibitors and therapeutic methods using the same
WO2023275715A1 (en) 2021-06-30 2023-01-05 Pfizer Inc. Metabolites of selective androgen receptor modulators
CN119930744B (zh) * 2025-01-20 2025-12-19 昆明理工大学 一种发酵马乳源小分子肽及其应用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4223020A (en) * 1979-03-30 1980-09-16 Beckman Instruments, Inc. Synthetic peptides having pituitary growth hormone releasing activity
US4223019A (en) * 1979-03-30 1980-09-16 Beckman Instruments, Inc. Synthetic peptides having pituitary growth hormone releasing activity
US4228156A (en) * 1979-03-30 1980-10-14 Beckman Instruments, Inc. Synthetic peptides having pituitary growth hormone releasing activity
BR8208035A (pt) * 1981-12-28 1983-11-22 Beckman Instruments Inc Peptideos sinteticos tendo atividade liberadora de hormonio do crescimento da pituitaria
US4410512A (en) * 1981-12-28 1983-10-18 Beckman Instruments, Inc. Combinations having synergistic pituitary growth hormone releasing activity
US4803261A (en) * 1986-06-27 1989-02-07 The Administrators Of The Tulane Educational Fund Method for synthesizing a peptide containing a non-peptide
IL98910A0 (en) * 1990-07-24 1992-07-15 Polygen Holding Corp Polypeptide compounds having growth hormone releasing activity and pharmaceutical compositions containing them
US5663146A (en) * 1991-08-22 1997-09-02 Administrators Of The Tulane Educational Fund Polypeptide analogues having growth hormone releasing activity
WO1994007519A1 (en) * 1992-09-25 1994-04-14 Smithkline Beecham Corporation Growth hormone releasing peptides
WO1995014666A1 (en) * 1993-11-24 1995-06-01 Merck & Co., Inc. Indolyl group containing compounds and the use thereof to promote the release of growth hormone(s)

Also Published As

Publication number Publication date
US5767085A (en) 1998-06-16
EP0736039A1 (en) 1996-10-09
UA42747C2 (uk) 2001-11-15
CA2179597A1 (en) 1995-06-29
CZ293113B6 (cs) 2004-02-18
SG55069A1 (en) 1998-12-21
JPH09507217A (ja) 1997-07-22
FI962584L (fi) 1996-06-20
HUT73497A (en) 1996-08-28
SK281963B6 (sk) 2001-09-11
JP3181918B2 (ja) 2001-07-03
NO315561B1 (no) 2003-09-22
AU689181B2 (en) 1998-03-26
CZ183496A3 (en) 1997-02-12
IL112112A (en) 2000-06-29
WO1995017423A1 (en) 1995-06-29
IL112112A0 (en) 1995-03-15
ES2153469T3 (es) 2001-03-01
PL181280B1 (pl) 2001-07-31
MX9500072A (es) 1997-05-31
GR3035150T3 (en) 2001-04-30
AU1272495A (en) 1995-07-10
FI962584A0 (fi) 1996-06-20
HU9501947D0 (en) 1995-11-28
HU224345B1 (hu) 2005-08-29
PT736039E (pt) 2001-04-30
DE69426206D1 (de) 2000-11-30
NO962665D0 (no) 1996-06-21
KR100354897B1 (ko) 2003-01-06
CN1052731C (zh) 2000-05-24
ATE197158T1 (de) 2000-11-15
EP0736039B1 (en) 2000-10-25
RO115635B1 (ro) 2000-04-28
NZ277486A (en) 1997-03-24
PL315113A1 (en) 1996-10-14
DE69426206T2 (de) 2001-05-17
DK0736039T3 (da) 2001-02-12
SK82096A3 (en) 1997-01-08
BR9408377A (pt) 1997-08-19
CN1138335A (zh) 1996-12-18
FI962584A7 (fi) 1996-06-20

Similar Documents

Publication Publication Date Title
NO962665D0 (no) Forbindelser med veksthormonfrigjörende egenskaper
KR960701051A (ko) 이미다조피리딘 및 이를 위장 질환의 치료에 사용하는 방법(imidazopyridines and their use in treating castrointestinal diseases)
MX9709278A (es) Dipeptidos que promueven la liberacion de la hormona de crecimiento, composiciones que los contienen y uso de los mismos.
IL114794A0 (en) Peptidic compounds analogous to distramycin process for their preparation and their use
DK0804223T3 (da) Farmaceutiske præparater indeholdende hGH
IL126235A (en) Compounds with growth hormone releasing properties, pharmaceutical compositions comprising them and their use
MX9303605A (es) Derivados de azabicicloheptano n-substituidas, su obtencion y uso.
BR9906975A (pt) Composto, uso do mesmo, composição farmacêutica, e, processo para estimular a liberação do hormÈnio do crescimento pela pituitária de um mamìfero
BR9610175A (pt) Composto processo de preparação do composto composição farmacêutica e utilização do composto
AU6722498A (en) Disubstituted biphenyloxazolines
MX9710377A (es) Compuestos con propiedades de liberacion de la hormona de crecimiento.
PL309339A1 (en) Novel triazoquinazolines, methods of obtaining them and their application
NO306343B1 (no) Difluorstaton-analoger
NO950114L (no) Amylin-antagonister og agonister
NO974687L (no) Kondenserte <beta>-carboliner

Legal Events

Date Code Title Description
MM1K Lapsed by not paying the annual fees