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UA106611C2 - Інгібітори зовнішнього медулярного калієвого каналу нирок - Google Patents

Інгібітори зовнішнього медулярного калієвого каналу нирок

Info

Publication number
UA106611C2
UA106611C2 UAA201114416A UAA201114416A UA106611C2 UA 106611 C2 UA106611 C2 UA 106611C2 UA A201114416 A UAA201114416 A UA A201114416A UA A201114416 A UAA201114416 A UA A201114416A UA 106611 C2 UA106611 C2 UA 106611C2
Authority
UA
Ukraine
Prior art keywords
inhibitors
potassium channels
compounds
useful
channels external
Prior art date
Application number
UAA201114416A
Other languages
English (en)
Russian (ru)
Inventor
Алєксандер Пастернак
Аураш Шахріпур
Хайфин Тан
Нардос Х. Тумелсан
Ліху Ян
Юйпін Чжу
Шон П. Уолш
Original Assignee
Мерк Шарп Енд Доме Корп.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Мерк Шарп Енд Доме Корп. filed Critical Мерк Шарп Енд Доме Корп.
Publication of UA106611C2 publication Critical patent/UA106611C2/uk

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • C07D307/88—Benzo [c] furans; Hydrogenated benzo [c] furans with one oxygen atom directly attached in position 1 or 3
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
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    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
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    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
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    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
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Abstract

Даний винахід стосується сполук структурної формули I і їх фармацевтично прийнятних солей, які інгібують зовнішній медулярний калієвий канал нирок (ROMK) (Kir 1.1). Сполуки формули І можуть застосовуватися як діуретичні і натрійуретичні лікарські засоби і, отже, можуть застосовуватися для терапії і профілактики розладів, які є результатом надмірного вмісту солі і утримання води, включаючи серцево-судинні захворювання, такі як гіпертензія і хронічна і гостра серцева недостатність. EMBED ISISServer I
UAA201114416A 2009-05-06 2010-04-29 Інгібітори зовнішнього медулярного калієвого каналу нирок UA106611C2 (uk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17584709P 2009-05-06 2009-05-06
PCT/US2010/032872 WO2010129379A1 (en) 2009-05-06 2010-04-29 Inhibitors of the renal outer medullary potassium channel

Publications (1)

Publication Number Publication Date
UA106611C2 true UA106611C2 (uk) 2014-09-25

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Country Status (31)

Country Link
US (2) US8673920B2 (uk)
EP (1) EP2427444B1 (uk)
JP (2) JP5092068B2 (uk)
KR (1) KR101373902B1 (uk)
CN (1) CN102459216B (uk)
AR (1) AR076836A1 (uk)
AU (1) AU2010246269C1 (uk)
BR (1) BRPI1014050A2 (uk)
CA (1) CA2759399C (uk)
CL (1) CL2011002761A1 (uk)
CO (1) CO6460758A2 (uk)
CR (1) CR20110578A (uk)
EA (1) EA021008B1 (uk)
EC (1) ECSP11011444A (uk)
ES (1) ES2561654T3 (uk)
GE (1) GEP20146055B (uk)
GT (1) GT201100278A (uk)
HN (1) HN2011002933A (uk)
IL (1) IL215836A0 (uk)
MA (1) MA33342B1 (uk)
MX (1) MX337570B (uk)
MY (1) MY157525A (uk)
NI (1) NI201100193A (uk)
NZ (1) NZ596229A (uk)
PE (1) PE20120346A1 (uk)
SG (1) SG175841A1 (uk)
TN (1) TN2011000540A1 (uk)
TW (1) TWI408135B (uk)
UA (1) UA106611C2 (uk)
WO (1) WO2010129379A1 (uk)
ZA (1) ZA201108070B (uk)

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WO2016127358A1 (en) 2015-02-12 2016-08-18 Merck Sharp & Dohme Corp. Inhibitors of renal outer medullary potassium channel
EA037300B1 (ru) 2016-04-20 2021-03-05 Бристол-Маерс Сквибб Компани Замещенные бициклические гетероциклические соединения
CN108290874B (zh) * 2016-06-07 2021-07-27 江苏恒瑞医药股份有限公司 一种肾外髓质分泌钾通道抑制剂的可药用盐
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US8673920B2 (en) 2014-03-18
IL215836A0 (en) 2012-01-31
KR20120011069A (ko) 2012-02-06
MA33342B1 (fr) 2012-06-01
MX337570B (es) 2016-03-10
CN102459216B (zh) 2015-01-28
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