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UA106056C2 - Сполуки 2-метил-1-феніл-2-(піридин-2-іл)пропан-1-аміну та їх застосування для лікування депресії - Google Patents

Сполуки 2-метил-1-феніл-2-(піридин-2-іл)пропан-1-аміну та їх застосування для лікування депресії

Info

Publication number
UA106056C2
UA106056C2 UAA201107171A UAA201107171A UA106056C2 UA 106056 C2 UA106056 C2 UA 106056C2 UA A201107171 A UAA201107171 A UA A201107171A UA A201107171 A UAA201107171 A UA A201107171A UA 106056 C2 UA106056 C2 UA 106056C2
Authority
UA
Ukraine
Prior art keywords
propan
pyridine
methyl
depression
phenyl
Prior art date
Application number
UAA201107171A
Other languages
English (en)
Russian (ru)
Inventor
Майкл Балестра
Пітер Бернстайн
Глен Е Ернст
Вілліам Фрітц
Джон П. Маккаулей
Давід Нуґіель
Ліон Шен
Original Assignee
Астразенека Аб
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42288011&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UA106056(C2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Астразенека Аб filed Critical Астразенека Аб
Publication of UA106056C2 publication Critical patent/UA106056C2/uk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4402—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 2, e.g. pheniramine, bisacodyl
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/02—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
    • C07C57/13—Dicarboxylic acids
    • C07C57/15—Fumaric acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Confectionery (AREA)

Abstract

Заявлений винахід стосується сполук 2-метил-1-феніл-2-(піридин-2-іл)пропан-1-аміну, фармацевтичних композицій, які їх містять, та способів лікування депресії застосуванням сполук 2-метил-1-феніл-2-(піридин-2-іл)пропан-1-аміну.
UAA201107171A 2008-12-24 2009-12-22 Сполуки 2-метил-1-феніл-2-(піридин-2-іл)пропан-1-аміну та їх застосування для лікування депресії UA106056C2 (uk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14067308P 2008-12-24 2008-12-24
PCT/SE2009/051493 WO2010074647A1 (en) 2008-12-24 2009-12-22 Ethanamine compounds and their use for treating depression

Publications (1)

Publication Number Publication Date
UA106056C2 true UA106056C2 (uk) 2014-07-25

Family

ID=42288011

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA201107171A UA106056C2 (uk) 2008-12-24 2009-12-22 Сполуки 2-метил-1-феніл-2-(піридин-2-іл)пропан-1-аміну та їх застосування для лікування депресії

Country Status (31)

Country Link
US (4) US8013165B2 (uk)
EP (2) EP2391606A4 (uk)
JP (1) JP5491524B2 (uk)
KR (1) KR20110097996A (uk)
CN (1) CN102333762B (uk)
AR (1) AR074981A1 (uk)
AU (1) AU2009330745B2 (uk)
BR (1) BRPI0923476A2 (uk)
CA (1) CA2748235A1 (uk)
CL (1) CL2011001590A1 (uk)
CO (1) CO6450688A2 (uk)
CR (1) CR20110365A (uk)
CU (1) CU24017B1 (uk)
DO (1) DOP2011000205A (uk)
EA (1) EA201190064A1 (uk)
EC (1) ECSP11011161A (uk)
GT (1) GT201100186A (uk)
HN (1) HN2011001773A (uk)
IL (1) IL213518A0 (uk)
MX (1) MX2011006680A (uk)
NI (1) NI201100131A (uk)
NZ (1) NZ593282A (uk)
PE (1) PE20120249A1 (uk)
SA (1) SA109310013B1 (uk)
SG (2) SG192510A1 (uk)
SV (1) SV2011003962A (uk)
TW (1) TWI442922B (uk)
UA (1) UA106056C2 (uk)
UY (1) UY32360A (uk)
WO (1) WO2010074647A1 (uk)
ZA (1) ZA201105441B (uk)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20120249A1 (es) * 2008-12-24 2012-04-19 Astrazeneca Ab Compuestos etanaminicos
CN112279843B (zh) * 2020-11-24 2023-05-16 深圳市第二人民医院(深圳市转化医学研究院) 一种具有抗抑郁活性的含氮杂环化合物
CN112250676B (zh) * 2020-11-24 2023-05-16 深圳市第二人民医院(深圳市转化医学研究院) 一种具有抗抑郁活性的含氧杂环化合物

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3422191A (en) * 1965-01-21 1969-01-14 Synergistics Inc Compositions and methods for tranquilization employing salts of n-morpholine ethanol
GB1427026A (en) 1972-11-20 1976-03-03 Ici Ltd Synthetic film materials
JPS5756474B2 (uk) 1973-05-26 1982-11-30
US5455259A (en) * 1987-02-06 1995-10-03 Fisons Corporation Compounds for the treatment of neurodegenerative disorders
GB9320273D0 (en) 1993-04-01 1993-11-17 Fisons Corp Compound useful in therapy
ES2083972T3 (es) 1988-08-12 1996-05-01 Astra Ab Arilalquil-aminas y -amidas con propiedades anticonvulsivas y neuroprotectoras.
JP2514855B2 (ja) 1990-08-08 1996-07-10 キッセイ薬品工業株式会社 光学活性なアラニンアニリド誘導体の酸付加塩
US5206248A (en) * 1992-03-27 1993-04-27 Smith Richard A Method for reducing emotional lability
AU667490B2 (en) * 1991-10-30 1996-03-28 Astra Aktiebolag 2-heterocyclicethylamine derivatives
ATE163925T1 (de) * 1992-04-03 1998-03-15 Astra Ab Enantiomere 1-phenyl-2-(2-pyridinyl)ethylamin für die behandlung neurodegenerativer störungen
PL192561B1 (pl) * 1996-04-19 2006-11-30 Akzo Nobel Nv Podstawione benzyloaminy, ich zastosowanie i kompozycja farmaceutyczna
EP0869122B1 (en) 1997-03-31 2002-12-04 Korea Research Institute Of Chemical Technology Quinolinic sulfide derivatives acting as NMDA receptor antagonists and process for preparation thereof
TW544448B (en) 1997-07-11 2003-08-01 Novartis Ag Pyridine derivatives
SE9901077D0 (sv) * 1999-03-23 1999-03-23 Astra Ab Novel use
SE9901340D0 (sv) * 1999-04-15 1999-04-15 Astra Pharma Prod Novel process
DE10334188B4 (de) * 2003-07-26 2007-07-05 Schwarz Pharma Ag Verwendung von Rotigotin zur Behandlung von Depressionen
PE20120249A1 (es) 2008-12-24 2012-04-19 Astrazeneca Ab Compuestos etanaminicos

Also Published As

Publication number Publication date
CN102333762A (zh) 2012-01-25
SG171928A1 (en) 2011-07-28
MX2011006680A (es) 2011-07-12
EA201190064A1 (ru) 2012-02-28
JP5491524B2 (ja) 2014-05-14
GT201100186A (es) 2013-10-08
US20120277272A1 (en) 2012-11-01
CN102333762B (zh) 2014-06-11
SA109310013B1 (ar) 2013-07-28
KR20110097996A (ko) 2011-08-31
EP2391606A1 (en) 2011-12-07
CL2011001590A1 (es) 2012-06-22
BRPI0923476A2 (pt) 2016-01-19
CU24017B1 (es) 2014-07-30
IL213518A0 (en) 2011-07-31
AU2009330745A1 (en) 2011-08-04
US20100179199A1 (en) 2010-07-15
US20120115913A1 (en) 2012-05-10
CO6450688A2 (es) 2012-05-31
SV2011003962A (es) 2012-01-06
NI201100131A (es) 2012-03-19
ZA201105441B (en) 2012-03-28
EP2391606A4 (en) 2012-06-13
ECSP11011161A (es) 2011-07-29
TWI442922B (zh) 2014-07-01
US9035065B2 (en) 2015-05-19
AU2009330745B2 (en) 2012-04-05
TW201028149A (en) 2010-08-01
DOP2011000205A (es) 2011-07-15
PE20120249A1 (es) 2012-04-19
US8013165B2 (en) 2011-09-06
HN2011001773A (es) 2014-08-18
CA2748235A1 (en) 2010-07-01
CU20110141A7 (es) 2012-01-31
SG192510A1 (en) 2013-08-30
CR20110365A (es) 2011-08-09
NZ593282A (en) 2013-06-28
WO2010074647A1 (en) 2010-07-01
US20130137731A1 (en) 2013-05-30
JP2012513993A (ja) 2012-06-21
UY32360A (es) 2010-07-30
EP2610246A1 (en) 2013-07-03
AR074981A1 (es) 2011-03-02

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