TWI890701B - Skin topical agents - Google Patents

Abstract

This invention aims to produce a composition containing niacinamide that is non-sticky, has excellent penetrating properties, and leaves skin feeling firm and firm after application. The topical skin preparation that addresses this problem contains the following ingredients (A) to (D): (A) niacinamide (1-10% by weight), (B) a cationic surfactant, (C) an anionic polymer, (D) water.

Description

Skin topical products

The present invention relates to a topical skin preparation containing niacinamide. More specifically, it relates to a topical skin preparation containing a cationic surfactant and an anionic polymer and having excellent stability.

Skin can develop spots, wrinkles, sagging, and hyperpigmentation due to internal factors like aging and stress, as well as external factors like UV rays and dry air. These changes significantly impact skin's appearance, leading to widespread desire for improvement. To prevent and improve these wrinkles and sagging, various active ingredients have been proposed. Among them, niacinamide is known to be highly safe and exhibits anti-aging effects (e.g., see Patents 1 and 2). However, high levels of niacinamide are known to cause undesirable tactile sensations, such as a sticky feel, which some researchers have attempted to improve (e.g., see Patent 3).

Furthermore, efforts are underway to improve the penetration of active ingredients into tissues in cosmetics or topical preparations for topical application to the skin and hair. One approach involves utilizing the charge within the composition. While the skin surface is known to have a negative charge, positively charged cationic substances are known to have higher adsorption and permeability into the skin. Therefore, to enhance the adsorption and permeability of active ingredients into biological tissues, cosmetics containing cationic polymers have been proposed (e.g., see Patents 4 and 5). However, the combined use of anionic substances can lead to the formation of complexes within the composition, resulting in problems such as a cloudy appearance, aggregates, and clumping. Another approach for enhancing the permeability of active ingredients is the use of vesicle particles. Vesicle compositions containing cationic surfactants are also known, combining these two approaches (see, for example, Patent Document 6). [Prior Art Document] [Patent Document]

[Patent Document 1] Japanese Patent Application Laid-Open No. 10-130135 [Patent Document 2] Japanese Patent Application Laid-Open No. 10-001414 [Patent Document 3] Japanese Patent Application Laid-Open No. 2003-502435 [Patent Document 4] Japanese Patent Application Laid-Open No. 2016-108344 [Patent Document 5] International Publication No. 2019/111415 [Patent Document 6] International Publication No. 2014/069631

[The problem that the invention aims to solve]

Therefore, the present invention aims to develop a technology that, while containing a cationic surfactant with excellent skin penetration, can inhibit and mitigate the formation of aggregates resulting from electrical interactions, resulting in excellent stability and compatibility with various anionic substances. Furthermore, the present invention aims to provide a topical skin preparation that incorporates a large amount of niacinamide as an active ingredient, exhibits a non-sticky feel during use, has excellent skin penetration, and delivers a truly effective finish, such as a firming effect, upon application. [Means for Solving the Problem]

Therefore, the inventors of this case have devoted themselves to solving the above-mentioned problems and have accumulated many studies. As a result, they discovered that by using niacinamide in a composition containing a cationic surfactant and anionic polymer, the aggregation caused by the electrical interaction between the cationic surfactant and the anionic polymer can be alleviated, thus completing the present invention.

Specifically, the present invention provides a skin preparation containing the following ingredients (A) to (D): (A) 1-10% by weight of niacinamide, (B) a cationic surfactant, (C) an anionic polymer, and (D) water. [Effects of the Invention]

According to the present invention, the co-use of niacinamide inhibits the formation of deposits caused by the electrical interaction between cationic surfactants and anionic polymers. Furthermore, the skin topical preparation of the present invention is non-sticky upon application, penetrates the skin well, and provides a superior finish, such as a firming effect, after application. Furthermore, due to its excellent stability, the skin topical preparation can be used for extended periods of time, making it useful as an anti-aging cosmetic that can enhance skin elasticity and prevent or improve aging-related changes such as wrinkles and sagging.

[Form of implementing the invention]

The present invention is described below in detail. In this specification, "~" refers to a range inclusive of the numerical values before and after it. Ingredient (A) niacinamide used in the present invention is an amide compound of niacin (vitamin B3/niacin). Niacinamide is a water-soluble vitamin and a known substance belonging to the vitamin B complex. It can be extracted from natural sources (such as rice bran) or synthesized using known methods. Specifically, those listed in the 17th Revision of the Japanese Pharmacopoeia can be used.

The content of component (A) in the present invention is 1-10% by mass (hereinafter referred to as "%"). It is preferably 3-10%, and particularly preferably 4-9%. If the content of component (A) is less than 1%, a firming effect, etc., cannot be achieved. If it exceeds 10%, the product will feel sticky during application, resulting in a poor feel during use.

The cationic surfactant (Component (B) used in this invention is used to enhance skin adsorption, penetration, and skin compatibility of topical skin preparations. Any surfactant commonly used in cosmetics or topical skin preparations is not particularly limited and can be used. Component (B) is an alkylamine salt, an amine salt such as a polyamine or amino alcohol fatty acid derivative, an alkyl quaternary ammonium salt, an aromatic quaternary ammonium salt, a pyridinium salt, or an imidazolium salt. Examples include hexadecyltrimethylammonium chloride, hexadecyltrimethylammonium bromide, octadecyltrimethylammonium chloride, octadecyltrimethylammonium bromide, behenyltrimethylammonium chloride, behenyltrimethylammonium bromide, and behenyltrimethylammonium methylsulfate. , dioctadecyldimethylammonium chloride, dioleyldimethylammonium bromide, hexadecyldimethylammonium methylsulfate, octadecyldimethylbenzylammonium chloride, disalamidoethyl hydroxyethyl methylammonium methylsulfate, dicocoylethyl hydroxyethyl methylammonium methylsulfate, distearylethyl hydroxyethyl methylammonium methylsulfate, and the like; one or more kinds thereof may be selected.

Furthermore, component (B) of the present invention can also serve as the backbone of an amphoteric surfactant, as long as it is cationic in the composition. Such surfactants are preferably those having amino acid residues, and preferably, the amino acid residues are basic amino acid residues. Specific examples include mono-N-long-chain acyl basic amino acid lower alkyl ester salts such as butyl stearyl lysine hydrochloride, N-cocoyl-L-arginine ethyl ester pyrrolidone carboxylate, and lauryl-guanidine propyl ester anhydride; and guanidine derivatives such as decylguanidine anhydride, 2-guanidinoethyl laurylamide hydrochloride, and 2-guanidinobutylstearylamide DL-pyrrolidone carboxylate. One or more of these can be selected. Examples of these salts include halogens, methylsulfates, ethylsulfates, and methylphosphates.

Among these, quaternary ammonium salts and mono-N-long-chain acyl basic amino acid lower alkyl ester salts are preferred from the perspective of stability; among quaternary ammonium salts, alkyltrimethylammonium chloride and di-long-chain acylalkylhydroxyalkylammonium are preferred; among mono-N-long-chain acyl basic amino acid lower alkyl ester salts, N-cocoyl-L-arginine ethyl ester pyrrolidone carboxylic acid salt is preferred. More specifically, a mixture with other aqueous components can be used. Examples of such commercially available products include GENAMIN KDMP (manufactured by Clariant Japan; pure content 81.5%), a mixture of behenyltrimethylammonium chloride; DEHYQUART L80 T (manufactured by BASF; pure content 80%), a mixture of dicocoylethyl hydroxyethyl methylammonium methylsulfate; DEHYQUART AU56/G and DEHYQUART C4046 (both manufactured by BASF), a mixture of disalcoholylethyl hydroxyethyl methylammonium methylsulfate; and CAE (manufactured by Ajinomoto Co., Ltd.), which is N-cocoyl-L-arginine ethyl ester pyrrolidone carboxylate. Among them, double-chain surfactants such as di-long-chain acylalkylhydroxyalkylammonium can form vesicle particles on their own, further enhancing skin permeability and providing excellent long-term stability.

The content of ingredient (B) in the present invention is preferably about 0.001-0.1%, more preferably 0.002-0.05%, and particularly preferably 0.02-0.05%, based on the viewpoint of skin permeability and safety.

In the present invention, the mass ratio (A)/(B) of component (A) to component (B) is not particularly limited, but from the perspective of usability as a skin external preparation, it is 10-500, preferably 25-300, and more preferably 25-200. Within this range, the product does not feel sticky during use, and a good penetration and firming feeling after application can be felt.

The anionic polymer used in component (C) of the present invention is an anionic polymer and is not particularly limited as long as it is commonly used in cosmetics. Specifically, examples include water-soluble polymers such as alginic acid, hyaluronic acid, gum arabic, carrageenan, chondroitin sulfate, gelatin, carboxymethyl cellulose, carboxyvinyl polymer, polyacrylic acid, and their derivatives. One or more of these polymers may be used. Furthermore, these polymers may vary depending on their source, whether natural or synthetic, and are not particularly limited.

Among them, in the present invention, carboxyvinyl polymers and/or alkyl-modified carboxyvinyl polymers are preferred from the viewpoint of having no sticky feeling during use and excellent skin tightening feeling after application. The "carboxyvinyl polymer" referred to herein is a general term for polymers containing polymerizable monomers having at least a polymerizable vinyl group and a carboxyl group or an alkyl-modified carboxyl group as constituent units. The "alkyl-modified" referred to herein refers to those in which a part or all of the carboxyl groups are esterified with an alkyl group. For example, a polymer containing at least one acrylic acid ester or methacrylic acid ester as a constituent monomer is included in the example of an alkyl-modified carboxyvinyl polymer. The number of carbon atoms in the alkyl-modified alkyl group is not limited, but is preferably 10 or more and 30 or less, and more preferably 18 or more and 24 or less. Commercially available products of alkyl-modified carboxyvinyl polymers include CARBOPOL 1342, CARBOPOL 1382 (all manufactured by LUBRIZOL Advanced Materials), Pemulen TR-1, and Pemulen TR-2 (all manufactured by NOVEON). Commercially available products of carboxyvinyl polymers include CARBOPOL 940, CARBOPOL 941, CARBOPOL 980, and CARBOPOL 934 (all manufactured by LUBRIZOL Advanced Materials), and AQUPEC HV-501 (manufactured by Sumitomo Seika Chemicals).

The blending amount of ingredient (C) in the present invention is not particularly limited as long as it is a commonly used blending amount in cosmetics. However, from the perspective of interaction with ingredient (B), it is preferably in the range of 0.001-10%, more preferably 0.01-5%, more preferably 0.05-1%, and particularly preferably 0.05-0.2%. Within this range, a skin topical preparation with excellent stability, a non-sticky feel during use, and an excellent firming feel after application can be provided.

In the present invention, the mass ratio (A)/(C) of component (A) to component (C) is not particularly limited, but is 5.0-150, preferably 5.0-125, and more preferably 10-100. Within this range, a non-sticky feel is avoided, and the skin feels more firm after application. Furthermore, the mass ratio (B)/(C) of component (B) to component (C) is not particularly limited, but is preferably 0.01-10, more preferably 0.05-5, even more preferably 0.1-1, and particularly preferably 0.2-0.6. Within this range, the aggregation-inhibiting effect is even more enhanced.

The water component (D) used in this invention is not particularly limited, as long as it is commonly used in cosmetics. Besides pure water, deep water or plant-derived waters such as rose water and lavender water can also be used, as long as the effects of this invention are not compromised. One or more of these components can be selected as needed. The blending amount of component (D) in this invention is not particularly limited, as long as it is commonly used in cosmetics, but is preferably 30-95%.

Furthermore, in the present invention, using a hydrophilic nonionic surfactant as component (E) can inhibit aggregation of components (B) and (C). Component (E) is preferably a nonionic surfactant with an HLB of 10-18, more preferably 11-16. The HLB (Hydrophile-Lypophile Balance) value used in the present invention is the value obtained by the Griffin method. Specifically, polyglycerol fatty acid esters, sucrose fatty acid esters, polyoxyethylene sorbitan fatty acid esters, polyoxyethylene sorbitol fatty acid esters, polyoxyethylene glycol fatty acid esters, polyoxyethylene glycol fatty acid esters, polyoxyethylene alkyl ethers, polyoxyethylene polyoxypropylene alkyl ethers, polyoxyethylene hydrogenated castor oil, polyoxyethylene fatty acid ethanolamides, polyoxyethylene cholesterol ethers, polyoxyethylene dihydrocholesterol ethers, polyoxyethylene phytosterol ethers, polyoxyethylene phytostanol ethers, polyoxyethylene alkyl ethers, propylene glycol fatty acid esters, polyoxyalkylene-modified polysilicone, polyoxyalkylene-alkyl co-modified polysilicone, and the like can be used alone or in combination. Among them, non-ionic surfactants having polyoxyethylene groups are preferred, and non-ionic surfactants having an average addition molar number of ethylene oxide of 5 to 100 are more preferred, and more preferably 10 to 80.

As component (E), commercially available products can be used, for example, RHEODOL TW-O120V (manufactured by Kao Corporation), Nonion OT-221 (manufactured by NOF Corporation) containing polyoxyethylene sorbitan monooleate (20 E.O.), RHEODOL TW-S120V (manufactured by Kao Corporation), Nonion ST-221 (manufactured by NOF Corporation) containing polyoxyethylene sorbitan monostearate (20 E.O.), NIKKOL PEN-4620 (manufactured by Nikko Chemicals) containing polyoxyethylene polyoxypropylene decyl tetradecyl ether (20 E.O.), EMALEX PS-30 (manufactured by NIHON EMULSION), NIKKOL BPS-30 (manufactured by Nikko Chemicals), EMALEX HC-60 (manufactured by NIHON EMULSION), NIKKOL HCO-60 (manufactured by Nikko Chemicals) containing polyoxyethylene hydrogenated castor oil (60 E.O.). Chemicals Co., Ltd.), polyoxyalkylene-modified organopolysiloxanes, such as KF-6011, KF-6011P, KF-6018, and KF-6043 (all manufactured by Shin-Etsu Chemical Co., Ltd.), and NUC Silicone SS-2802 (manufactured by Dow Corning Toray Co., Ltd.).

The content of component (E) in the present invention is not particularly limited, but is preferably 0.01-10%, more preferably 0.05-8%, even more preferably 0.1-6%, and particularly preferably 0.5-6%. Within this range, the aggregation of components (B) and (C) can be further suppressed, resulting in a long-lasting, stable topical skin preparation.

In the present invention, the mass ratio of component (E) to the total mass of component (B) and component (C), (E)/[(B) + (C)], is not particularly limited. However, based on the aggregation-inhibiting effect of components (B) and (C) and the absence of a sticky feel or a good penetrating feel during use, it is preferably 0.1 to 150, preferably 0.5 to 100, and more preferably 1.0 to 80.

Furthermore, in the present invention, by forming vesicle particles with component (B), the adsorption capacity generated by the charge and the permeability of the topical skin preparation can be enhanced, further synergistically promoting the effects of component (A) and other active ingredients. As mentioned above, if the surfactant component (B) is a bichain, it can form vesicles alone, or it can be combined with other vesicle membrane components such as phospholipids or sodium di(laurylaminoglutamic acid) lysine to form vesicle particles containing a cationic surfactant. Among these, phospholipids are preferred for safety reasons. The method for forming vesicle particles is not particularly limited and can be produced according to known methods. Vesicle particles can be confirmed using a polarizing microscope by observing the presence of a Maltese cross image under crossed polarized light. When phospholipids are used, the phospholipid content is not particularly limited, but is preferably 0.01-5%, more preferably 0.05-1%, and particularly preferably 0.1-0.5%.

The pH of the external skin preparation of the present invention is not particularly limited, but is preferably in the range of 4.0 to 7.5 at 25°C.

In addition to the aforementioned ingredients (A) to (E), the skin preparation of the present invention may also contain ingredients commonly used in skin preparations, as long as the effects of the present invention are not impaired. For example, it may contain oils such as higher alcohols, hydrocarbon oils, ester oils, waxes, silicone oils, surfactants, water-soluble polymers, polyols, aqueous components such as lower alcohols, UV absorbers, antioxidants, antibacterial agents, preservatives, moisturizers, pH adjusters, cooling agents, powders, vitamins, cosmetic ingredients, fragrances, etc. A preferred composition of the topical skin preparation of the present invention is as follows: Ingredients Preferred More Preferred Even More Preferred Particularly Preferred (A) 1-10% 3-10% 4-9% 4-9% (B) 0.001-0.1% 0.002-0.05% 0.02-0.05% 0.02-0.05% (C) 0.001-10% 0.01-5% 0.05-1% 0.05-0.2% (D) 30-95% 30-95% 30-95% 30-95% (E) 0.01~10%   0.05~8%       0.1~6%        0.5~6%

The method for producing the skin external preparation of the present invention is not particularly limited and can be prepared by conventional methods. For example, component (B) and other components as needed are heated and dissolved, and then added and mixed to the uniformly dissolved and mixed components (A), (C) to (E), and then optionally any of the above components are added and mixed.

The topical skin preparation of the present invention can be administered in various forms, including liquid, gel, and cream. The dosage forms include, but are not limited to, dissolving, oil-in-water, water-in-oil, oil-based, water-in-oil-in-water, oil-in-water, and multi-layer formulations. From a stability perspective, a low-viscosity or translucent formulation is preferred, as the effects of the present invention can be more readily felt.

Furthermore, the skin topical preparation of the present invention can be used as a skin cosmetic. Examples include toners, emulsions, creams, serums, massage preparations, facial masks, hand creams, body lotions, body creams, sunscreens, foundations, eye shadows, eyeliners, concealers, and scalp treatments. Skin cosmetics are preferred because they offer a more tangible effect. Application methods include using hands, fingers, or cotton pads, impregnating nonwoven fabrics, and applying directly by spraying. Preferred forms of the skin topical preparation of the present invention exclude hair cosmetics specifically for hair, such as shampoos, conditioners, conditioners, and hair waxes. [Example]

In order to specifically illustrate the present invention, examples are given below, but the present invention is not limited to these examples, etc. In addition, unless otherwise specified, the content is expressed as a mass % relative to the composition containing the component.

Examples 1-11 and Comparative Examples 1-4: Beauty Essences The beauty essences with the compositions shown in Table 1 were prepared according to the following production method. The serums were evaluated using the following methods for: A: Aggregation-Inhibiting Effect; B: Penetration; C: Presence of Stickiness; and D: Skin Tightening Effect after Application. The results are summarized in Table 1.

(Manufacturing method) A: Heat and dissolve ingredients (1), (2), (5) to (11), and (16) uniformly at 75°C. B: Heat and dissolve ingredients (3), (4), (12) to (15) uniformly at 75°C. C: Add A to B at 75°C and stir to obtain a beauty serum.

(Evaluation Method 1) (A. Aggregation Inhibition Effect) The aggregation inhibition effect was evaluated based on the transparency of the serums from Examples 1-11 and Comparative Examples 1-4 when diluted 10-fold with water. This transparency was confirmed to ensure long-term stability. 1.0 g of each composition was weighed into a glass beaker, diluted 10-fold with pure water, and stirred until a uniform solution was obtained. The solution was stirred manually using a metal spatula. The resulting sample was placed in a glass sample cell with an optical diameter of 10 mm long and an optical diameter of 5 mm wide. The transmittance at a wavelength of 700 nm was measured using a spectrophotometer (UV-2500PC, manufactured by Shimadzu Corporation). <Evaluation Criteria> (Evaluation): (Evaluation) ◎: Transmission 55% or higher (no aggregation or sedimentation after one month at room temperature) △: Transmission 45-55% (slight aggregation, sedimentation, and turbidity changes are visible after one month at room temperature) ×: Transmission less than 45% (aggregation, sedimentation, and turbidity changes are visible after one month at room temperature)

(Evaluation Method 2) Ten professional sensory examiners, trained in sensory assessment and capable of performing evaluations based on established criteria, were selected from women in their 20s to 40s. Each tester applied each sample to their forearm and rated the sensation of penetration, stickiness, and post-application firmness on a 5-point scale using the absolute rating system described below. For each sample, the average score from all sensory examiners was calculated and evaluated using the 4-point rating system described below.

(B: Penetration) <Absolute Rating Criteria> (Rating): (Rating) 5 points: The toner penetrates the skin 4 points: The toner slightly penetrates the skin 3 points: Average 2 points: The toner barely penetrates the skin 1 point: The toner does not penetrate the skin <4-Level Rating Criteria> (The same applies to the following rating items) (Rating): (Average of ratings) ◎: 4.5 points or higher: Very good ○: 3.5 points or higher but less than 4.5 points: Good △: 1.5 points or higher but less than 3.5 points: Slightly poor ×: Less than 1.5 points: Poor

(C: Stickiness) <Absolute Rating Criteria> (Rating): (Rating) 5 points: No stickiness 4 points: Almost no stickiness 3 points: Slightly sticky 2 points: Some stickiness 1 point: Extremely sticky

(D: Skin tightening sensation after application) <Absolute Rating Criteria> (Rating): (Rating) 5 points: Skin tightening sensation 4 points: Slightly tightening sensation 3 points: Average 2 points: Almost no tightening sensation 1 point: No tightening sensation

As shown in Table 1, the serums of Examples 1-11 exhibited superior aggregation-inhibiting effects, penetration, a non-sticky feel, and a firming feel after application compared to the serums of Comparative Examples 1-4. On the other hand, Comparative Example 1, which did not contain ingredient (A), exhibited a poorer firming feel after application. Comparative Example 2, which replaced ingredient (A) with another skin-friendly agent (dipotassium glycyrrhizate), exhibited poor aggregation-inhibiting effects, a non-sticky feel, and a less firming feel after application. Comparative Example 3, with a 0.5% concentration of Ingredient (A), also failed to provide a firming sensation after application. In Comparative Example 4, with a 15% concentration of Ingredient (A), due to the excessive amount of niacinamide, the product did not penetrate the skin and had a sticky feel.

Example 12: Toner (Ingredients) (%) (1) Alkyl trimethylammonium chloride (Note 2) 0.1 (2) Hydrogenated soybean lecithin (Note 7) 0.5 (3) 1,3-Butanediol 5.0 (4) Monooleate polyoxyethylene sorbitan (20 E.O.) 1.0 (5) Fragrance q. q. (6) Ethanol 10.0 (7) Preservative q. q. (8) Niacinamide 5.0 (9) Tranexamic acid 2.0 (10) Polyoxyethylene glycerol (26E.O.) 2.0 (11) Polyoxyethylene methyl glucoside (Note 8) 2.0 (12) (Acrylates/alkyl acrylate (C10-C30)) crosslinked copolymer (Note 3) 0.1 (13) Carboxyethylene polymer 0.1 (14) Sodium hydroxide 0.05 (15) Purified water Residue (Note 8) Macbiobride MG-10E (manufactured by NOF Corporation)

(Manufacturing method) A: Dissolve and mix components (1) to (3) uniformly at 75°C. B: While maintaining the temperature of the aforementioned A at 75°C, add a portion of the component (15) and stir with a disper mixer to obtain a vesicle dispersion. C: Dissolve and mix components (4) to (15) uniformly at room temperature. D: Add the aforementioned component B cooled to 35°C to the aforementioned component C to obtain a toner. The toner obtained above has excellent aggregation inhibition effect, penetrating feel, no stickiness, and a firming feel on the skin after application.

Example 13: Transparent toner (Ingredients) (%) (1) Polyoxyethylene Isostearate (50) Hardened Castor Oil 0.2 (2) PEG-10 Methyl Ether Dimethicone (Note 4) 0.1 (3) Dicocoyl Ethyl Hydroxyethyl Methylammonium Methyl Sulfate 0.01 (4) Alkyl Trimethylammonium Chloride 0.01 (5) Ethyl Oleate 0.05 (6) Hexadecyl 2-Ethylhexanoate 0.05 (7) Fragrance q.s. (8) Ethanol 1.0 (9) 1,3-Butanediol                                             5.0 (10) Glycerol                                                 5.0 (11) Diglycerol                                           2.0 (12) Polyoxybutylene polyoxyethylene polyoxypropylene glycerol ether (3E.O.) (Note 9)                                     3.0 (13) Niacinamide                                             5.0 (14) Carboxyvinyl polymer                                     0.1 (15) Sodium hydroxide                                             0.05 (16) Tranexamic acid                                           1.0 (17) Sodium hydroxide 0.05 (18) Preservatives As needed (19) Flavorings As needed (20) Pure water Balance (Note 9) WILBRIDE S-753D (manufactured by NOF)

(Manufacturing method) A: Dissolve and mix ingredients (1) to (10) uniformly at 70°C. B: Dissolve and mix ingredients (11) to (20) uniformly at room temperature. C: Add ingredient A to ingredient B and dissolve them at room temperature to obtain a transparent toner. The transparent toner obtained above has excellent aggregation inhibition effect, good penetrating feeling, no stickiness, and a firming feeling on the skin after application.

Example 14: Water-in-oil emulsion beauty serum (Ingredients) (%) (1) Polyglyceryl-10 (eicosanedioic acid/tetradecandioic acid) ester 1.5 (2) Tripropylene glycol 15.0 (3) Niacinamide 6.0 (4) L-theanine 0.05 (5) 1,3-Butanediol 3.5 (6) Dipropylene glycol 0.5 (7) Pure water Balance (8) Glycerin 2.0 (9) Polyethylene glycol                                               2.0 (10) Tranexamic acid                                           2.0 (11) Sodium hydrogen phosphate                                       0.3 (12) Sodium dihydrogen phosphate                                     0.6 (13) Disodium ethylenediaminetetraacetic acid                                0.02 (14) Methyl p-hydroxybenzoate                                0.1 (15) Polyoxyethylene (50) isostearate, hydrogenated castor oil         0.2 (16) Polyoxyethylene (60) hydrogenated castor oil                        0.2 (17) Dicocoylethyl hydroxyethyl methylammonium methyl sulfate 0.01 (18) Ethanol                                                   5.0 (19) L-Menthol                                           0.02 (20) Isopropyl myristate                                   0.3 (21) Dimer dilinoleic acid (phytosteryl esters/isostearyl/cetyl ester/octadecyl ester/behenyl ester (Note 10))                                     0.2 (22) Sorbitan oleate                                     0.2 (23) Tocotrienols                                         0.02 (24) Carboxyvinyl polymer                                       0.02 (25) (Acrylates/alkyl acrylate (C10-30)) crosslinked copolymer (Note 3) 0.02 (26) Xanthan gum 0.01 (27) Sodium hydroxide 0.01 (28) Hydrolyzed hyaluronic acid 0.01 (Note 10) PLANDOOL-S (made by Seika Co., Ltd.)

(Manufacturing method) A: Mix ingredients (1) to (14) uniformly at room temperature. B: Dissolve and mix ingredients (15) to (23) uniformly at 70°C. C: Add ingredient B to ingredient A and emulsify at 70°C. D: Cool ingredient C to 40°C, then add ingredients (24) to (28) and mix uniformly to obtain a beauty serum. The oil-in-water emulsion beauty serum obtained above has excellent aggregation inhibition effect, penetrating feeling, non-sticky feeling, and a firming feeling on the skin after application.

Example 15: Sunscreen (Oil-in-Water Type) (Ingredients) (%) (1) 1,3-Butanediol 5.0 (2) Dipropylene glycol 5.0 (3) Behenyltrimethylammonium chloride 0.1 (4) Hydrogenated lecithin (Note 11) 0.5 (5) Cholesterol (Note 12) 0.6 (6) Phytosterols 0.1 (7) Purified water Remainder (8) Niacinamide 3.0 (9) Tranexamic acid                                                     2.0 (10) (Acrylic acid/alkyl acrylate (C10-30)) copolymer (Note 13) 0.4 (11) Triethanolamine                                               0.4 (12) Polysilicone-15                                     1.2 (13) 4-tert-butyl-4'-methoxy-diphenylmethane   2.0 (14) 2-Ethylhexyl p-methoxycinnamate                     7.0 (15) Diethylaminohydroxybenzoyl hexyl benzoate        2.5 (16) Stearic acid, hydrogenated castor oil (Note 14)                     1.0 (17) Propylene glycol dicaprate 5.0 (18) Ethyl Oleate                                         0.3 (19) Natural Vitamin E                                         0.1 (20) Rosemary Oil                                         0.01 (21) 1,2-Pentanediol                                       0.1 (22) Zinc Oxide                                             2.0 (23) Water-soluble Collagen                                   0.01 (24) German Chamomile Flower Extract                             0.05 (25) Calendula Flower Extract                                     0.05 (26) Glycerin                                           1.0 (27) Ethanol 7.0 (28) Fragrance 0.1 (Note 11) NIKKOL RETINOL S-10 (Nikko Chemicals) (Note 12) Haili Marine Cholesterol (Nihon Suisan Co., Ltd.) (Note 13) Pemulen TR-2 (Noveon) (Note 14) Castride MS (National Mimatsu)

(Manufacturing method) A: Dissolve and mix components (1) to (6) uniformly at 75°C. B: Dissolve and mix components (7) to (11) uniformly at 70°C. C: Dissolve and mix components (12) to (19) uniformly at 80°C. D: Add components B and C to the above-mentioned A and emulsify at 70°C. E: Add and mix components (20) to (28) to the above-mentioned D, and cool to 40°C to obtain a sunscreen (oil-in-water type). The sunscreen (oil-in-water type) obtained as described above has excellent aggregation inhibition effect, penetrating feeling, non-sticky feeling, and a firming feeling on the skin after application.

Example 16: Oil-in-water emulsion (Ingredients) (%) (1) 1,3-Butanediol 5.0 (2) Dipropylene glycol 5.0 (3) Alkyltrimethylammonium chloride (Note 2) 0.03 (4) Hydrogenated soybean lecithin (Note 7) 0.2 (5) Cholesterol (Note 12) 0.7 (6) Pure water Residue (7) Niacinamide 8.0 (8) Sodium hydroxide 2% aqueous solution 0.2 (9) N-Myristyl-L-glutamine                       0.2 (10) Polyoxyethylene (10) hydrogenated castor oil                       0.2 (11) Macadamia nut oil fatty acid sterol esters (Note 15)   1.0 (12) Tri(caprylic/octanoic) glyceride                                 0.2 (13) Tocopheryl nicotinate                               0.01 (14) Natural vitamin E                                       0.1 (15) Rice germ oil                                           0.01 (16) Tocopheryl acetate                                     0.01 (17) Polyoxyethylene sorbitan monooleate (20E.O.) 1.5 (18) Octadecanol                                               0.5 (19) Docosanol                                           1.0 (20) 1,2-Pentanediol                                          0.1 (21) Octadecanol                                           0.5 (22) Carboxyvinyl polymer                                   0.2 (23) (Sodium acrylate/sodium acryloyldimethyltaurate) copolymer (Note 16)                                               0.5 (24) Tranexamic acid                                               1.0 (25) Diglycerol                                             0.5 (26) Herba Lycopersicifoliae extract 0.05 (27) Coriander extract                                   0.05 (28) Black soybean extract                                 0.05 (29) Sesame sprout extract                            0.05 (30) Glycerin                                            1.0 (31) Ethanol                                             5.0 (32) Fragrance                                                0.1 (Note 15) PLANDOOL-MAS (made by Nippon Seika Co., Ltd.) (Note 16) SIMULGEL EG QD (made by SEPPIC Co., Ltd.)

(Manufacturing method) A: Dissolve and mix components (1) to (5) uniformly at 75°C. B: While maintaining the temperature of the aforementioned A at 75°C, add a portion of the component (6) and stir with a disper mixer to obtain a vesicle dispersion. C: Dissolve and mix the remaining components (6) to (8) uniformly at room temperature. D: Dissolve and mix components (9) to (19) uniformly at 80°C. E: While maintaining the temperature of the aforementioned D at 75°C, add the heated aforementioned C and emulsify. F: Add the mixed components (20) to (32) to the aforementioned E, and cool to 40°C to obtain an oil-in-water emulsion. The oil-in-water emulsion obtained above has excellent aggregation inhibition effect, penetrating feeling, non-sticky feeling, and a firming feeling on the skin after application.

Claims (6)

A skin topical preparation comprising the following ingredients (A) to (D): (A) 1-10 mass% of niacinamide, (B) 0.001-0.1 mass% of a cationic surfactant, (C) 0.001-10 mass% of an anionic polymer, and (D) water. Component (B) comprises one or more species selected from alkyltrimethylammonium chloride and/or dilong-chain acylalkylhydroxyalkylammonium salts, and component (C) comprises one or more species selected from carboxyvinyl polymers and/or alkyl-modified carboxyvinyl polymers. The skin preparation for external use as claimed in claim 1 further contains a non-ionic surfactant having an HLB of 10 to 18 as ingredient (E). The skin external preparation of claim 1 or 2, wherein the aforementioned component (B) contains one or more selected from dicocoylethyl hydroxyethylmonium methosulfate and/or alkyltrimethylammonium chloride. The skin external preparation of claim 1 or 2, wherein the aforementioned component (B) forms vesicle particles. A method for inhibiting the aggregation of a cationic surfactant and an anionic polymer, characterized by adding niacinamide to a skin topical composition containing a cationic surfactant, an anionic polymer, and water in an amount of 1 to 10% by weight, wherein the cationic surfactant content in the skin topical composition is 0.001 to 0. 1% by mass, the cationic surfactant comprises one or more species selected from alkyltrimethylammonium chloride and/or dilong-chain acylalkylhydroxyalkylammonium salts, and the content of the anionic polymer is 0.001-10% by mass. The anionic polymer comprises one or more species selected from carboxyvinyl polymers and/or alkyl-modified carboxyvinyl polymers. A method for enhancing the stability of a topical skin preparation, characterized in that niacinamide is added to a topical skin preparation containing a cationic surfactant, an anionic polymer, and water in an amount of 1 to 10% by weight, wherein the cationic surfactant content in the topical skin preparation is 0.001 to 0.1% by weight. The cationic surfactant comprises one or more species selected from alkyltrimethylammonium chloride and/or dilong-chain acylalkylhydroxyalkylammonium salts, the content of the anionic polymer is 0.001-10% by mass, and the anionic polymer comprises one or more species selected from carboxyvinyl polymers and/or alkyl-modified carboxyvinyl polymers.