JP2017178789A - Oil-in-water type emulsified composition - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide an oil-in-water type emulsified composition which comprises nicotinic acid amide, improves tension and elasticity of the skin and has an excellent feeling of use without irritating feeling and stickiness.SOLUTION: There is provided an oil-in-water type emulsified composition which comprises the following components (A) to (D): (A) 3 to 10 mass% of nicotinic acid amide, (B) 0.1 to 5 mass% of phospholipid, (C) a glycerol mono-fatty acid ester, (D) oil which is liquid at 25°C and has an IOB value of 0.10 to 0.39 and (E) water, wherein more preferably, the content ratio (A)/(B+C) between the component (A) and (B) in the composition is 0.1 to 20, the content ratio (A)/((C)+(D)) between the component (A) and the components (C) and (D) in the composition is 0.1 to 20 and the content ratio (C)/(D) between the component (C) and the component (D) in the composition is 0.01 to 5.SELECTED DRAWING: None

Description

  The present invention relates to an oil-in-water emulsified composition that improves the firmness and elasticity of the skin and is excellent in use feeling without irritation and stickiness.

Skin causes spots, wrinkles, sagging, pigmentation and the like due to internal factors such as aging and stress and external factors such as ultraviolet rays and air drying. Among them, morphological changes such as wrinkles and sagging greatly affect the appearance impression, and many people want to improve it. Many drugs have been proposed to prevent and improve these wrinkles and sagging. Among these, nicotinic acid amides are vitamins and are known to have high safety and have an effect of preventing skin aging. However, there has been a problem that irritation may be given to particularly sensitive skin such as atopic dermatitis. Although some reports have been made regarding attempts to reduce irritation after compounding nicotinamide, the effect has been insufficient. (Patent Document 2, Patent Document 3). Furthermore, it has been known that when a large amount of nicotinamide is contained, there is an undesirable feeling of use such as stickiness, and this improvement has been made. (Patent Document 4)

JP-A-10-130135 Japanese Patent Laid-Open No. 2006-22051 JP 2003-104867 A Special table 2003-502435 gazette

However, since the technique of Patent Document 2 which attempts to reduce the feeling of irritation contains both a sugar and a water-soluble film-forming polymer, it is more sticky and has a poor feeling in use. Further, Patent Document 3 which tried to reduce the irritation is limited only when the content of nicotinamide is low, and the effect is insufficient when the content is high. On the other hand, although patent document 4 which tried to suppress stickiness is a technique which contains both N-acetylglucosamine and acidic mucopolysaccharide, the effect was inadequate.

That is, cosmetics that contain nicotinamide at a high concentration, improve the firmness and elasticity of the skin, and do not have irritation or stickiness are known.

In view of this situation, the present inventors have conducted extensive research to solve the above problems, and as a result, even when nicotinamide is contained at a high concentration of 3 to 10% by mass, phospholipids and monoglycerin fatty acids are obtained. When it contains an ester and an oil that is liquid at 25 ° C. and has an IOB value of 0.10 to 0.39, stickiness during use with nicotinamide and skin irritation are reduced. I found it.

Surprisingly, by combining these, it was found that the firmness and elasticity of the skin was improved compared to the case of containing nicotinamide alone, and that morphological changes of aging such as wrinkles and sagging were prevented and improved. As a result, the present invention has been completed.

The oil-in-water emulsion composition of the present invention improves the firmness and elasticity of the skin, prevents and improves aging morphological changes such as wrinkles and sagging, and has an excellent effect on use feeling without irritation and stickiness Is.

Hereinafter, the present invention will be described in detail. In the present specification, “to” means a range including numerical values before and after. Moreover, the numerical value described in% is a value based on mass, unless otherwise specified.

Component (A): Nicotinamide The component (A) nicotinamide in the present invention is an amide of nicotinic acid (vitamin B3 / niacin). Nicotinamide is a water-soluble vitamin and is a known substance that is one of the vitamin B groups, and can be extracted from a natural product (rice bran or the like) or synthesized by a known method. Specifically, those listed in the 15th revision Japanese Pharmacopoeia 2008 can be used.

In the present invention, the amount of the component (A) is preferably 3 to 10%, particularly preferably 4 to 8%, in order to improve rough skin, firmness and elasticity of the skin, and to suppress stickiness. If it is less than 3%, the effect of improving the elasticity and elasticity of the skin is insufficient. Even if it exceeds 10%, the effect does not increase.

Component (B): Phospholipid The phospholipid of the component (B) used in the present invention refers to a lipid having a phosphate ester site in the structure. There are roughly two types of phospholipids, glycerophospholipids having glycerin as a skeleton and sphingophospholipids having sphingosine as a skeleton, and any of them can be preferably used.
The phospholipid of component (B) used in the present invention specifically includes soybean lecithin extracted from soybean and egg yolk, egg yolk lecithin and / or hydrogenated soybean lecithin hydrogenated with these, hydrogenated egg yolk lecithin, synthetic phospholipid, etc. Those generally known as phospholipids, acylated phospholipids, phospholipid derivatives modified with sugar or polyethylene glycol, and the like can be used.
A lysophospholipid having a single fatty acid binding to glycerin can also be used.
As the phospholipid, for example, phosphatidylcholine, phosphatidylethanolamine, phosphatidylglycerol, phosphatidylserine, phosphatidic acid, phosphatidylinositol and the like are preferable, and these can be used alone or in combination. Examples of the fatty acid constituting the phospholipid include saturated or unsaturated carboxylic acids having 7 to 22 carbon atoms.

0.1-5 mass% is preferable and, as for content of the component (B) of the oil-in-water emulsion composition which concerns on this invention, 0.5-3% is especially preferable. If it is less than 0.1%, the stimulus reducing effect is insufficient. Even if it exceeds 5%, the irritation reduction effect is not enhanced and stickiness increases. If it is this range, it will not become sticky, and it has a stimulus reduction effect and is excellent in the stability of the oil-in-water emulsion composition.

Component (C): Glycerin monofatty acid ester The glycerin monofatty acid ester used in the present invention is a monoester of glycerin and a fatty acid. Glycerin monofatty acid ester is obtained by esterification reaction of fatty acid and glycerin, or transesterification reaction of fats and oils, fatty acid ester and glycerin.

Examples of the fatty acid used as a raw material for the glycerin monofatty acid ester used in the present invention include linear or branched saturated or unsaturated fatty acids having 6 to 22 carbon atoms. Specific examples include glyceryl monocaproate, glyceryl monocaprylate, glyceryl monooctanoate, glyceryl monononanoate, glyceryl monocaprate, glyceryl monoundecylate, glyceryl monolaurate, glyceryl monomyristate, glyceryl monopalmitate, glyceryl monostearate Glyceryl monoisostearate, glyceryl monooleate, glyceryl monohydroxystearate, glyceryl monomonobehenate, and the like, but are not limited thereto.

Among the components (C), the number of carbon atoms is preferably 12 to 22 for excellent stimulus reduction effect. Among them, glyceryl monostearate is particularly preferable because it is excellent in the effect of reducing the stickiness as well as the stimulus reducing effect. On the other hand, a glycerin monofatty acid ester having 6 to 12 carbon atoms has an effect of reducing irritation and is excellent in storage stability of an oil-in-water emulsion composition. This effect is particularly preferably glyceryl monocaprate and glyceryl monocaprylate. These can be used alone or in combination of two or more.

The content of the component (C) in the oil-in-water emulsion composition is not particularly limited, but is preferably 0.1 to 5% by mass, more preferably 0.15 to 3% by mass, and still more preferably 0. .2 to 2% by mass. If it is in the said range, since it is excellent in the storage stability of an oil-in-water type emulsion composition while having the irritation | stimulation reduction effect without stickiness, it is preferable.

Component (D): An oil “liquid” which is liquid at 25 ° C. and has an IOB value of 0.10 to 0.39 refers to a state having fluidity at 1 atmosphere, that is, a melting point The state under the above temperature condition (in the case of an amorphous substance having no melting point, the state under the temperature condition above the melting point). The IOB value refers to the ratio of the inorganic value (IV) to the organic value (OV) in the organic conceptual diagram, that is, “inorganic value (IV) / organic value (OV)”.
Oil with an IOB value of less than 0.10 has no irritation reduction effect and increases stickiness. On the other hand, when it exceeds 0.39, the storage stability of the oil-in-water emulsion composition is inferior, and the stimulus reduction effect is insufficient.

Specific examples of oils that are liquid at 25 ° C. and have an IOB value of 0.10 to 0.39 include cetyl 2-ethylhexanoate (IOB = 0.13), isotridecyl isononanoate (IOB = 0.0.3). 15), neopentyl glycol dicaprate (IOB = 0.25), propylene glycol dicaprate (IOB = 0.26), diisostearyl malate (IOB = 0.28), trimethylolpropane triisostearate (IOB = 0.16), glyceryl tri-2-ethylhexanoate (IOB = 0.35), isopropyl myristate (IOB = 0.18), isodecyl isononanoate (IOB = 0.19), octyldodecyl neopentanoate (IOB = 0.13), isostearyl neopentanoate (IOB = 0.14), isopropyl palmitate (IOB = 0.16), hexyl laurate (IOB = 0.17), hexyldecyl ethylhexanoate (IOB = 0.13), isopropyl isostearate (IOB = 0.15), neopentyl glycol diethylhexanoate ( IOB = 0.32), trimethylolpropane triethylhexanoate (IOB = 0.33), pentaerythrityl tetraethylhexanoate (IOB = 0.35), isodecylbenzoate (IOB = 0.23), propylene glycol dicaprylate (IOB = 0.32), isononyl isononanoate (IOB = 0.20), ethylhexyl isononanoate (IOB = 0.20), isodecyl neopentanoate (IOB = 0.22), ethylhexyl ethylhexanoate (IOB = 0.0). 20), glyceryl triethylhexanoate Examples include, but are not limited to, ril (IOB = 0.36), diethylhexyl succinate (IOB = 0.32), 2-methoxyhexyl paramethoxycinnamate (IOB value = 0.28), and the like. .
These may be used alone or in combination of two or more as required.

Although content in particular of the component (D) in the cosmetics of this invention is not restrict | limited, 0.1-20% is preferable, More preferably, it is 0.5-10 mass%, More preferably, it is 1-5 mass%. is there. Within this range, excellent usability and storage stability can be obtained, and skin firmness and elasticity are excellent.

The component (E) water used in the invention is contained in order to obtain an oil-in-water emulsion composition, and is not particularly limited as long as it is generally used in cosmetics. In addition to water, purified water, hot spring water, deep water, or steam distilled water from plants may be used, and one or two or more kinds may be appropriately selected and used as necessary. Moreover, content is not specifically limited, Although it can contain suitably according to the amount of other components, it can be used in 30 to 90% of range in general.

The oil-in-water emulsion composition of the present invention contains the components (A) to (E), thereby improving the elasticity and elasticity of the skin and preventing and improving morphological changes in aging such as wrinkles and sagging. It becomes possible to make an oil-in-water emulsified composition excellent in use feeling without irritation and stickiness.

Here, the content ratio (A) / ((B) + (C)) of the component (A), the component (B), and the component (C) in the oil-in-water emulsion composition is 0.1 to 20. And the irritation | stimulation of a component (A) is reduced and it is preferable. Moreover, if the mass ratio (A) / ((C) + (D)) of the component (A) and the components (C) and (D) is 0.1 to 20, the oil-in-water emulsion composition is not sticky. Reduced and preferred. Furthermore, when (C) / (D) is in the range of 0.01 to 5, the stability of the preparation over time is particularly excellent.

The method for producing the oil-in-water emulsion composition of the present invention is not particularly limited as long as it is a known emulsion method. Specifically, a dispersion emulsification method, a transfer emulsification method, a gel emulsification method, a phase inversion temperature emulsification method, and the like. If a preferable thing is illustrated, the dispersion emulsification method obtained by preparing the aqueous component containing component (A) and (E) previously, and adding and mixing the oil-based component of component (B)-(D) to this By using this, it is possible to obtain an oil-in-water emulsion composition having excellent stability over time.

In the oil-in-water emulsion composition of the present invention, in addition to the above-mentioned components, optional components contained in ordinary cosmetics within the range that does not interfere with the effects of the present invention, that is, lower alcohols and polyhydric alcohols, and other than these Aqueous components, oils, powders, water-soluble polymers, film forming agents, surfactants other than component (B), oil-soluble gelling agents, organically modified clay minerals, resins, colorants, UV absorbers, preservatives , Antibacterial agents, perfumes, antioxidants, pH adjusters, chelating agents, cosmetic ingredients, and the like.

The oil-in-water emulsion composition of the present invention can be made into various dosage forms by using in combination with other components. Specifically, it can be carried out in various dosage forms such as liquid, gel, paste, cream, and solid.

The oil-in-water emulsion composition of the present invention can be used as a cosmetic for various applications. For example, skin lotion, milky lotion, cream, beauty essence, massage, pack, hand cream, body lotion, body cream, sunscreen and other skin care cosmetics, foundation, eye shadow, eyeliner, mascara, eyebrow, concealer, lipstick Examples thereof include cosmetics for finishing hair such as lip balm, cosmetics for hair such as hair mist, treatment, hair cream and the like. The usage method includes a method of using hands, fingers and cotton, a method of impregnating a nonwoven fabric and the like, and the like.

The oil-in-water emulsion composition of the present invention can also be used as a skin external preparation. For example, an external solution, an external gel, a cream, an ointment, a liniment, a lotion, a haptic, a plaster, a spray, an aerosol, and the like can be given. Moreover, the usage method can be mentioned similarly to the above-mentioned cosmetics.

The present invention will be described in more detail with reference to the following examples, but the present invention is not limited thereto. Unless otherwise specified, the content is expressed in mass% with respect to the system containing the component.

Preliminary experiment An oil-in-water emulsified emulsion having the formulation shown in Table 1 below was prepared.

If the amount of nicotinamide was small as in Formula 1, sufficient skin firmness and elasticity could not be obtained. When the amount of nicotinamide was increased so as to obtain a sufficient effect (Formulation 2), some people felt irritation even with phospholipids. When the amount of phospholipid was increased until no irritation was felt (Formulation 3), stickiness occurred and the feel became unacceptable.

Example 1 Products 1 to 7 of the present invention and Comparative products 1 to 4: Oil-in-water emulsified emulsions Oil-in-water emulsified emulsions having the formulations shown in Table 2 below are prepared, and the following are given regarding skin firmness / elasticity, stickiness and irritation. The method was evaluated. The results are also shown in Table 2.

(Production method)
A: Components 1 to 6 are uniformly dissolved and mixed at 70 ° C.
B: Components 7 to 8 are uniformly dissolved and mixed at 70 ° C.
C: A is added to B and emulsified at 70 ° C.
D: Components 9 to 14 were added to C and mixed, and then cooled to 40 ° C. to obtain an oil-in-water emulsion.

(Evaluation item)
A. Skin firmness and elasticity. Sticky c. Irritation

(Evaluation method)
[About Lee and Roh (Sensory evaluation)]
Women in their 20s and 40s received sensory evaluation training and selected 10 professional panels that could be evaluated according to certain standards. For each sample, the skin's firmness, elasticity, and stickiness felt when applied to the skin by each panel are rated in the following 5 grades and given a score. For each sample, the average value is calculated from the total score of all the panels. Calculated and judged according to the following four-step criteria.

(I. Evaluation of skin elasticity and elasticity)
Absolute Evaluation Criteria (Score): (Evaluation)
5 points: feels skin firmness / elasticity 4 points: feels skin elasticity / elasticity 3 points: feels somewhat skin elasticity / elasticity 2 points: feels skin firmness / elasticity 1 point: I do not feel that the skin is firm or elastic. 4 step criteria (Judgment): (Average score)
◎: More than 4 points: Very good ○: More than 3 points, 4 points or less: Good △: More than 2 points, 3 points or less: Slightly poor ×: 2 points or less: Bad

(B. Evaluation of stickiness)
Absolute Evaluation Criteria (Score): (Evaluation)
5 points: no stickiness 4 points: almost no stickiness 3 points: slightly sticky 2 points: feels sticky 1 point: very sticky 4 criteria

(Judgment): (Average score)
◎: More than 4 points: Very good ○: More than 3 points, 4 points or less: Good △: More than 2 points, 3 points or less: Slightly poor ×: 2 points or less: Bad

(Evaluation method)
[About Ha (sensory evaluation)]
The “stimulation” in the present invention is a crispness and tingling sensation (stinging) immediately after application, and usually has a reaction that disappears transiently without inflammatory symptoms such as erythema or edema. It is what you point to. An in-house sting test was conducted in advance, and 10 men in their 20s to 50s who were highly sensitive to stimuli and capable of stable evaluation were selected as specialized panels. For each sample, the irritation sensation felt when applied to the skin by the specialized panel was rated in the following 5 absolute ratings, given a score, and the average value was calculated from the total score of all panel members for each sample. Judgment was made based on the stage judgment criteria.

(Evaluation of irritation)
Absolute Evaluation Criteria (Score): (Evaluation)
5 points: No stimulation 4 points: Almost no stimulation 3 points: Slight stimulation 2 points: I feel stimulation 1 point: I feel a clear stimulus 4-step criteria (Judgment): (Average score)
◎: More than 4 points: No irritation ○: More than 3 points, 4 points or less: Almost no irritation △: More than 2 points, 3 points or less: General people hardly feel irritation ×: 2 points or less: Even ordinary people may feel irritation

As is clear from the results in Table 2, the oil-in-water emulsions of the inventive products 1 to 7 are all of the firmness / elasticity, irritation, and stickiness of the skin compared to the oil-in-water emulsions of the comparative products 1 to 4. It was excellent.
On the other hand, the comparative product 1 in which the component (C) was not blended could not reduce irritation. Moreover, in the comparative product containing other fatty acid ester instead of the component (C), the irritation sensation cannot be reduced and the stickiness tends to increase.

Example 2
Invention products 8 to 15 and comparative products 5 to 8 oil-in-water emulsion emulsions Oil-in-water emulsion emulsions having the formulations shown in Table 3 below were prepared and evaluated for the firmness, elasticity, stickiness, and irritation of the skin by the above-described methods. . The results are also shown in Table 3.
The numbers after the components are IOB values.

(Production method)
A: Components 1 to 11 are uniformly dissolved and mixed at 70 ° C.
B: Components 12 to 14 are uniformly dissolved and mixed at 70 ° C.
C: A is added to B and emulsified at 70 ° C.
D: Components 15 to 20 were added to C and mixed, and then cooled to 40 ° C. to obtain an oil-in-water emulsion.

As is apparent from the results in Table 3, the oil-in-water emulsion of the product of the present invention was superior in all of the firmness / elasticity, irritation, and stickiness of the skin compared to the oil-in-water emulsion of the comparative product. It was.
On the other hand, irritation | stimulation was not reduced even if it mix | blended the oil agent whose IOB value was out of the range instead of a component (D). Further, even when the IOB value was within the range, the solid cholesterol did not improve the stickiness.

Example 4: Oil-in-water emulsified cream (component) (mass%)
1.1,3-Butylene glycol 12.0
2. Glycerin 5.0
3. Purified water remaining amount 4. Nicotinamide 5.0
5). Phospholipid 0.5
6). Lysophospholipid 0.5
7). Trimethylolpropane triisostearate (IOB = 0.16)
1.0
8). Isononyl isononanoate (IOB = 0.20) 1.0
9. N-stearoyl dihydrosphingosine 0.1
10. Astaxanthin 0.001
11. Tocopherol 0.01
12 Cetostearyl alcohol 2.0
13. Behenyl alcohol 1.0
14 Glycerin monoisostearate 1.0
15. Methyl paraoxybenzoate appropriate amount 16. Acrylic acid / alkyl methacrylate copolymer (Note 1) 0.15
17. Xanthan gum 0.1
18. Sodium hydroxide 2% solution 0.2
19. Perfume appropriate amount Note 1: CARBOPOL 1382 (manufactured by LUBRIZOL ADVANCED MATERIALS)

(Production method)
A: Components 1 to 4 are uniformly dissolved and mixed at 70 ° C.
B: Components 5 to 15 are uniformly dissolved and mixed at 80 ° C.
C: B is added to A and emulsified at 70 ° C.
D: Components 16 to 19 were added to C and mixed, and then cooled to 40 ° C. to obtain an oil-in-water emulsified cream.

The oil-in-water emulsified cream of Example 4 was excellent in all of skin firmness / elasticity, irritation, and non-stickiness.

Example 5: Oil-in-water makeup base
(Ingredient) (mass%)
1.1,3-Butylene glycol 7.0
2. Dipropylene glycol 5.0
3. Triethanolamine 0.4
4). 4. Purified water remaining amount Nicotinamide 4.0
6). Phospholipid 0.4
7). Stearic acid 1.0
8). Polyoxyethylene hydrogenated castor oil (Note 2) 0.2
9. Polysorbate 80 0.1
10. Isopropyl isostearate (IOB = 0.15) 1.0
11. Glyceryl triethylhexanoate (IOB = 0.36) 1.0
12 Cetostearyl alcohol 0.3
13. Behenyl alcohol 0.5
14 Glycerin monocaprylate 0.3
15. Acrylic acid / alkyl methacrylate copolymer 0.3
16. Xanthan gum 0.1
17. Talc 0.4
18. Hydrous silica 0.1
19. Mica 1.3
20. Titanium oxide 6.0
21. Iron oxide 0.1
Note 2: HCO-20 (Nippon Surfactant Kogyo Co., Ltd.)

(Production method)
A: Components 15 to 21 are uniformly dispersed.
B: Components 1 to 5 are uniformly dissolved at 70 ° C., and A is added and mixed uniformly.
C: Components 6 to 14 are uniformly dissolved and mixed at 80 ° C.
D: C is added to B and emulsified at 70 ° C.
E: D was cooled to 40 ° C. to obtain an oil-in-water makeup base.

The oil-in-water type makeup base of Example 5 was excellent in all of skin firmness / elasticity, irritation, and non-stickiness.

Example 6: Oil-in-water emulsified serum
(Ingredient) (%)
1.1,3-Butylene glycol 5.0
2. Propylene glycol 5.0
3. Purified water remaining amount 4. Nicotinamide 8.0
5). Pentaerythrityl tetraethylhexanoate (IOB = 0.35) 0.25
6). Isostearyl neopentanoate (IOB = 0.14) 0.15
7). N-stearoyl phytosphingosine 0.1
8). Tocopherol acetate 0.01
9. Cetostearyl alcohol 0.5
10. Behenyl alcohol 0.6
11. Glycerin monooleate 0.4
12 Glycerin monocapric acid ester 0.1
13. Carbomer (Note 3) 0.15
14 (Na-acrylate / acryloyldimethyltaurine Na) copolymer
(Note 4) 0.1
15. Sodium hydroxide 2% solution 0.2
16. Ethanol 5.0
17. Sodium hyaluronate 0.01
18. Hydrolyzed hyaluronic acid 0.01
19. Hydrolyzed collagen 0.01
20. Perfume appropriate amount Note 3: CARBOPOL 980 (manufactured by LUBRIZOL ADVANCED MATERIALS)
Note 4: SIMULGEL EG (manufactured by SEPIC)

(Production method)
A: Components 1 to 4 are uniformly dissolved and mixed at 70 ° C.
B: Components 5 to 12 are uniformly dissolved and mixed at 80 ° C.
C: B is added to A and emulsified at 70 ° C.
D: Components 13 to 20 were added to C and mixed, and then cooled to 40 ° C. to obtain an oil-in-water emulsified cosmetic liquid.

The oil-in-water emulsified beauty liquid of Example 6 was excellent in all of skin firmness / elasticity, irritation, and stickiness.

  The present invention can be applied to cosmetics, quasi drugs, external preparations for skin, and the like.

Claims (6)

The following components (A) to (D):
(A) Nicotinamide 3 to 10% by mass
(B) Phospholipid 0.1-5 mass%
(C) Glycerin monofatty acid ester (D) An oil-in-water emulsion composition containing oil (E) water that is liquid at 25 ° C. and has an IOB value of 0.10 to 0.39.
The oil-in-water emulsion composition according to claim 1, wherein the content of the component (C) is 0.1 to 5% by mass.
The ratio (A) / ((B) + (C)) of the content mass of the component (A) and the components (B) and (C) in the composition is 0.1-20. An oil-in-water emulsion composition.
The ratio (A) / ((C) + (D)) of the content mass of the component (A) and the components (C) and (D) in the composition is 0.1-20. The oil-in-water emulsion composition described.
The oil-in-water emulsion composition according to claims 1 to 4, wherein the content ratio (C) / (D) of the components (C) and (D) in the composition is 0.01 to 5.
The oil-in-water emulsion composition according to claim 1, which is a cosmetic or a skin external preparation.