TWI673315B - Aqueous composition with the ability to release active ingredients and reusable contact lens products - Google Patents

Abstract

An aqueous composition and a reusable contact lens product with the ability to release active ingredients are obtained by adding at least one binding agent and at least one active ingredient to a buffer solution of the aqueous composition, and the binding agent is uniformly dispersed in the buffer solution. And it can be used to absorb and store the active ingredients, so that the buffer solution can release the active ingredients. When this aqueous composition is used to save contact lenses, the active ingredients can be released from the buffer solution onto the contact lenses, and this function can be continued and Repeated use enables the contact lenses to effectively exert the beneficial effects of active ingredients.

Description

Aqueous composition capable of releasing active ingredient and reusable contact lens product

The present invention relates to an aqueous composition, in particular to an aqueous composition having the ability to release active ingredients and a reusable contact lens product. The buffer solution of the aqueous composition can be combined with a desired active ingredient and can be used for Store contact lenses to release their active ingredients onto contact lenses.

Contact lenses are a very popular option for people with vision deterioration or deterioration such as nearsightedness, and they can replace ordinary glasses to correct vision problems. In addition, contact lenses have also achieved the status of a fashion statement. Contact lenses with colored designs around the optical zone have become a must-have fashion accessory in many countries. In some styles, contact lenses have the dual function of correcting vision and presenting a special style to the wearer.

Among the various materials used to make contact lenses, contact lenses can be divided into hard and soft contact lenses according to the materials used. Some practical examples of materials used to make contact lenses include siloxane monomers, poly-2 (hydroxyethyl methacrylate) (pHEMA, Poly (2-hydroxyethyl methacrylate)), and combinations of the two. Soft contact lenses are generally cheaper and therefore widely used in various markets. However, the materials used to make soft contact lenses can deprive the cornea of oxygen. On the other hand, using silicone monomers can overcome this problem, but they face many challenges, such as hydrophobicity and adhesion of deposits on lenses. Therefore, even if the material properties of contact lenses have been improved, there are still some problems related to contact lenses.

One of the main problems associated with the use of contact lenses is the irritation to the eyes after prolonged use. Many factors include irritation of eye cells, deprivation of oxygen, and discomfort caused by the shape and surface of contact lenses, which are said to be related to eye inflammation caused by contact lens use. Another major problem affecting contact lens use is the dryness encountered with contact lenses. It is very difficult to find a contact lens to comprehensively solve all the problems caused by different factors.

One way to improve the discomfort or irritation caused by contact lens use is to deliver certain active ingredients to the eye. The selected active ingredient has various beneficial effects for various regions of the eye structure, such as reducing inflammation, ciliary muscle relaxation, and providing a cooling sensation. Traditionally, eye drops with active ingredients have been chosen to deliver the active ingredients to the eyes to produce beneficial effects. However, with eye drops, most of the active ingredients are lost through drainage in the nasolacrimal system, and the rest are lost with eye movements (for example, blinking and continuous tear turnover).

In order to overcome the above disadvantages, the present invention discloses an aqueous composition and a reusable contact lens product having the ability to release the active ingredient, adding the active ingredient and a binding agent that can help absorb and store the active ingredient in a buffer solution, and It can be used as a preservation solution for contact lenses to carry these beneficial active ingredients to the eye area through the contact lens, so that the active ingredients are not easily lost due to various actions occurring in the eye area.

In view of this, the main object of the present invention is to provide an aqueous composition capable of releasing active ingredients and a reusable contact lens product. The aqueous composition uses a binding agent in a buffer solution to help the absorption and It can be stored and used as a preservation solution for contact lenses to release active ingredients onto contact lenses, and this aqueous composition can be continuously and repeatedly used to maintain the beneficial effects of the active ingredients.

Another object of the present invention is to provide an aqueous composition capable of releasing an active ingredient and a reusable contact lens product. The contact lens is stored in a buffer solution having the active ingredient, and when the contact lens is worn on the eye It can be used to release active ingredients to the eye environment to improve various conditions that cause eye discomfort.

Still another object of the present invention is to provide an aqueous composition capable of releasing active ingredients and a reusable contact lens product. The contact lens can be worn throughout the day, and the contact lens can be used in an aqueous composition capable of releasing active ingredients. It can be stored overnight so that the contact lens can be combined with the active ingredient again and reused the next day. Therefore, as long as the water-containing composition having the ability to release the active ingredient is continuously supplemented, the active ingredient can be continuously released from the contact lens, which is very suitable for long-term use.

In order to achieve the above object, the present invention provides an aqueous composition having an ability to release an active ingredient, which includes a buffer solution, at least one binding agent, and at least one active ingredient. The binding agent is uniformly dispersed in a buffer solution; the binding agent may be selected from hyaluronic acid, hydroxypropyl methyl cellulose, and 2-methacryloxyethyl phosphate choline ( 2-methacryloyloxyethyl phosphorylcholine), cyclodextrins, chitosan, and combinations thereof. The active ingredient is absorbed by the binding agent and stored in a buffer solution; the active ingredient may be selected from vitamins, phytochemicals, growth factors, therapeutic compounds, naturally derived ingredients, biologically active ingredients, and combinations thereof. This aqueous composition can be used to preserve contact lenses, so that contact lenses have active ingredients, which can be worn on the eyes to exert the beneficial effects of active ingredients.

In the aforementioned aqueous composition having the ability to release the active ingredient, the proportion of the active ingredient in the buffer solution is 10-30 mg / ml (mg / mL).

In the aforementioned aqueous composition having the ability to release the active ingredient, the proportion of the binding agent in the buffer solution is 5-30 mg / ml (mg / mL).

In addition, the present invention also provides a contact lens product, which includes a contact lens and a packaging container. Wherein, the aforementioned packaging container has an aqueous composition capable of releasing an active ingredient as described above, and the contact lens is stored in a buffer solution of the aqueous composition, so that the buffer solution releases the active ingredient onto the contact lens. When the user removes the contact lens from the buffer solution of the packaging container and wears it on the eye, the contact lens can release the active ingredient to the eye area of the user to reduce various discomforts suffered by the eye.

The aqueous composition and the reusable contact lens product with the ability to release active ingredients disclosed in the present invention are added with a binding agent capable of absorbing and storing active ingredients in a buffer solution, and can effectively combine various active ingredients. The method for the binder to absorb and store the active ingredient may be a complexation effect, a matrix effect, an ionic attraction effect, or a combination of these effects. Using this aqueous composition as a storage solution for contact lenses can release the active ingredients to the contact lenses. Since the active ingredients have a beneficial effect on the eyes, contact lenses with these active ingredients can be used to reduce eye exposure such as dust, Discomfort caused by environmental stresses such as dirt, smoke and pollution.

Detailed descriptions will be provided below through specific embodiments to make it easier to understand the purpose, technical content, features and effects of the present invention.

The present invention discloses an aqueous composition having the ability to release active ingredients, the composition of which is to add at least one binding agent and at least one active ingredient to a buffer solution. The binding agent is uniformly dispersed in the buffer solution, and the active ingredient is absorbed by the binding agent and stored in the buffer solution.

The aqueous composition used in the present invention refers to an aqueous solution for storing contact lenses to prevent the contact lenses from drying out during storage and transportation. The buffer solution used in the aqueous composition of the present invention has a pH and osmotic pressure within a specific range to prevent human eye discomfort. In the present invention, the buffer solution is prepared by using any of the following buffer systems: phosphate, borate, trimethylolaminomethane (TRIS), propanesulfonic acid (MOPS), 4-hydroxyethyl Ethanesulfonic acid (HEPES). For example, add 8 grams (g) of sodium chloride (osmotic pressure regulator), 2.2 g of sodium phosphate dibasic dihydrate, and 0.4 g of sodium dihydrogen phosphate to 1000 ml (mL) of water. Sodium dihydrogen phosphate dihydrate salts were used to prepare a buffer solution.

The binding agent used in the present invention refers to an agent capable of absorbing and storing a desired active ingredient through various methods, and the method for absorbing and storing the active ingredient through the binding agent may be a complexation effect, a matrix effect , Ionic attraction effect, or a combination of these effects. The materials of these binding agents may include, but are not limited to, hyaluronic acid, hydroxypropyl methyl cellulose, 2-methacryloyloxyethyl phosphorylcholine, and cyclopaste Cyclodextrins, chitosan, and combinations thereof; the cyclodextrin used in the present invention may be selected from the group consisting of α-cyclodextrin, β-cyclodextrin, γ-cyclodextrin, and combinations thereof. In order for the aqueous composition to provide a stable release of the active ingredient, the binding agent must be evenly distributed in the buffer solution; and the amount of the binding agent used is determined by its solubility. For example, it can be 5-30 mg / ml (mg / mL) ratio of the binding agent to the buffer solution. For example, 25 mg / mL of γ-cyclodextrin is weighed and added to the buffer solution prepared above, and stirred until completely dissolved to obtain an intermediate aqueous composition.

The active ingredient used in the present invention refers to various substances that can have a certain degree of beneficial effects on the tissues of the eye area. Active ingredients used in the present invention may include, but are not limited to, vitamins, phytochemicals, growth factors, therapeutic compounds, naturally derived ingredients, biologically active ingredients, and combinations thereof. Specifically, the vitamin may be selected from vitamin B6, vitamin B12, vitamin C, and vitamins. E; Phytochemicals can be selected from curcumin, quercetin, lutein and angelica extract; growth factors can be selected from EGF, VEGF, PDGF, retinoic acid and butylene phthalone (butylidenephthalide); the therapeutic compound may be selected from cyclosporine A, erythromycin, ciprofloxacin, gatifloxacin, ofloxacin, Polymyxin B (polymyxin B), besifloxacin, moxifloxacin, gentamicin, tobramycin, neomycin, streptomycin (natamycin), fluconazole, voriconazole, antihistamines, dexamethasone, timolol maleate, puerarin, tetrahydrochloride Tetrahydrozoline hydrochloride and chlorpheniramine maleate; natural derived ingredients can be selected from genistein, myriocin, mangiferin, scutellaria baicalensis Baicalin, resina draconis, powder Tetrandrine, lycopene, anthocyanin, and combinations thereof; and the bioactive component may be mitochondria extracted from stem cells. The amount of the active ingredient used in the present invention depends on the type of the active ingredient; specifically, the proportion of the active ingredient in the buffer solution is 10-30 milligrams per milliliter (ml / mL). For example, 100 mg of vitamin B12 is weighed and added to the aforementioned 1000 ml intermediate aqueous composition. Then, it was stirred at room temperature until dissolved.

The active ingredients used in the present invention may provide at least one beneficial effect to the eyes, which may include, but is not limited to, providing comfort (vitamin B6); relaxing ciliary muscles (vitamin B12); providing increased sense of moisture (vitamin B6 and B12) ; Reduce inflammation (vitamin B12, curcumin); reduce free radical damage (quercetin, lutein); reduce inflammation and redness caused by hypoxia and dry eye (vitamin B12, curcumin, quercetin) Reduced chance of age-related macular degeneration (lutein); reduced intraocular pressure (timolol maleate and dexamethasone); reduced fungal / bacterial infections (erixomycin, ciprofloxacin , Gatifloxacin, ofloxacin, polymyxin B, befloxacin, moxifloxacin, gentamicin, tobramycin, neomycin, natamycin, fluconazole, and voriconazole) Reduce allergic reactions (antihistamines); increase the regenerative potential of eye cells (EGF, VEGF, PDGF, retinoic acid, butylene phthalide); and overall increase in healthy eye tissue (mitochondria extracted from stem cells).

In order to achieve the present invention, the composition of the buffer solution can be adjusted corresponding to the active ingredients to maintain the buffer solution within the required pH and osmotic pressure parameters; for example, the buffer solution can be formulated with vitamins at appropriate concentrations to ensure activity The combination of the ingredients with the binders present in contact lenses.

In practical applications, the aqueous composition of the present invention having the ability to release active ingredients can be used as a preservation solution for contact lenses. Through this preservation solution, the active ingredient can be released to the contact lens when worn on the eye. In the eyes, and bring the desired benefits to the eyes.

In addition, as shown in FIG. 1, the present invention further discloses a reusable contact lens product 10, which includes a contact lens 20 and a packaging container 30. Wherein, the packaging container 30 has the aforementioned aqueous composition 40 having the ability to release the active ingredient, and the contact lens 20 is stored in the packaging container 30 having the aqueous composition 40 having the ability to release the active ingredient. The aqueous composition 40 having the ability to release active ingredients is composed of at least one binding agent and at least one active ingredient added to a buffer solution, and the active ingredients can be released onto the contact lens 20.

In the present invention, the contact lens 20 refers to an optical device used in combination with methacrylates, siloxanes, or a combination thereof with a cross-linking agent, a polymerization initiator, or the like, which uses, for example, lathe cutting (Lathe-cutting), cast-molding, spin coating, UV curing or heat curing, etc., can be used for vision correction and dressing. If necessary, the contact lens 20 can be used for more than one use cycle.

According to the reusable contact lens product 10 provided by the present invention, the aqueous composition 40 having the ability to release the active ingredient will release the active ingredient onto the contact lens 20 to provide the desired beneficial effect to the eye. For example, when the aqueous composition 40 having the ability to release an active ingredient contains an antibiotic, the contact lens 20 can be used to provide an antibacterial effect to the eye. Such beneficial effects can be combined with other functions of contact lenses, such as vision correction and the cosmetic effect of colored contact lenses.

According to the reusable contact lens product 10 provided by the present invention, the contact lens 20 is stored in a packaging container 30 containing an aqueous composition 40 having the ability to release active ingredients, and is sterilized by packaging using moist heat or gamma radiation. At the same time, a large-scale long-term packaging container or a large number of disposable packaging containers can also be provided to the user to provide an additional aqueous composition 40 with the ability to release active ingredients. Please refer to FIG. 2 and FIG. 3 to explain how the present invention uses the aqueous composition 40 having the ability to release active ingredients to supplement the active ingredients in the contact lens 20; as shown in FIG. 2, it uses a large long-term packaging container 50 to package the aqueous composition 40 with the ability to release the active ingredient, and if necessary, add it to the original packaging container 30 of the contact lens 20 so that the contact lens 20 can obtain the active ingredient (such as vitamin B12) after soaking. Such a packaging container 50 may have a capacity of about 150 ml to provide multiple days of use; as shown in FIG. 3, a plurality of disposable packaging containers 60 are used to package the aqueous composition 40 having the ability to release active ingredients. The packaging container 60 may have a capacity of about 2-3 milliliters, for example, and may be used as a disposable or portable product for single use.

Please refer to FIG. 4A to FIG. 4C to explain how the present invention uses a reusable contact lens product for a long time. As shown in Figure 4A, in the first use cycle, the user only needs to open the packaging container and place the contact lens 20 in an appropriate position in the eye 70. The user can wear the contact lens 20 all day, at least Use about 6-8 hours. At the end of the day, after the contact lens 20 releases all the active ingredients to the eye 70, the user can decide whether to use them again. If the user does not want to use it, the contact lens 20 may be discarded. However, if the user wishes to use the contact lens 20 again, the contact lens 20 must be placed in its packaging container 30, and the packaging container 30 can be filled with the aqueous composition 40 having the ability to release the active ingredient, as shown in FIG. 4B. Show. The contact lens 20 is stored in an aqueous composition 40 having an ability to release an active ingredient overnight. On the second day, as shown in FIG. 4C, the user can simply put the contact lens 20 on the eye 70 again. This usage cycle can last for a long time, for example, a week or a month.

In addition, please refer to FIG. 5, which illustrates a reusable contact lens product 10 provided by the present invention, which is combined with a plurality of disposable packaging containers 80 having an aqueous composition 40 capable of releasing active ingredients. That is, the contact lens 20 is combined with the aqueous composition 40 having the ability to release the active ingredient required to provide the active ingredient to make it a whole, which is convenient for users to carry and use when going out, so that the contact lens 20 releases the active ingredient. Can be used for a week or a month.

Next, by presenting a specific example, the following will further detail and fully explain how the present invention effectively prepares an aqueous composition and a reusable contact lens product having the ability to release active ingredients.

First, in step S100, a contact lens is prepared. Contact lenses can be made by casting, lathe cutting, UV curing or heat curing, and can use any polymerizable material, such as methacrylate, silicone, or both Mixture and cross-linking agent, polymerization initiator, etc .; since the manufacturing technology of contact lens is not the focus of the present invention, it will not be described in detail here.

Then, in step S110, a buffer solution is first prepared. It was prepared by adding 8 g of sodium chloride (osmotic pressure regulator), 2.2 g of disodium hydrogen phosphate dihydrate, and 0.4 g of sodium dihydrogen phosphate dihydrate to 1000 ml of water.

In step S120, a binding agent required to absorb and store any desired active ingredients is used. In one embodiment, 25 mg / mL of γγ cyclodextrin is added to the above buffer solution and stirred until completely dissolved to obtain an intermediate aqueous composition. In another embodiment, 30 mg / mL hyaluronic acid is added to the above buffer solution and stirred until dissolved. In another embodiment, 5 mg / mL of hydroxypropyl methyl cellulose is added to the above buffer solution and stirred until dissolved.

Then, in step S130, an active ingredient is added. In one embodiment, 100 mg of vitamin B12 is weighed and added to the buffer solution described above.

Thereafter, in step S140, the contact lens is placed in a packaging container together with the aqueous composition, and sterilized by moist heat or gamma irradiation.

After completing this step S140, the user can wear contact lenses on his eyes. In the first use cycle, the user can simply remove the contact lens from the aqueous composition and wear it on the eye. After the required usage time, multiple-use contact lenses must be left in a similar aqueous composition overnight (about 6-8 hours). After the overnight soaking process, multiple-use contact lenses can be used on the eyes again. Such a process can last for a long time, for example, a week or even a month.

In general, at least one binding agent and at least one active ingredient are added to a buffer solution. The aqueous composition and the reusable contact lens product having the ability to release active ingredients according to the present invention can help The active ingredient is absorbed and stored in a buffer solution, and this aqueous composition can be used to preserve contact lenses so that the active ingredients can be released onto the contact lenses. As a result, when a user puts contact lenses on the eyes, the active ingredients can be released from the contact lenses to the eye area, and the beneficial effects of the active ingredients can be exerted, thereby reducing eye exposure to such things as dust, dirt, smoke and Discomfort caused by environmental pressures such as pollution.

Furthermore, according to the aqueous composition and the reusable contact lens product disclosed in the present invention, which have the ability to release the active ingredient, the contact lens can be used in the aqueous composition having the ability to release the active ingredient after the contact lens is worn all day. It can be stored overnight and reused the next day. The overnight storage can make the active ingredients bind to the contact lens, and then release it steadily when wearing the contact lens. By repeating the aforementioned storage action, the contact lens can be kept for a long time. Maintains the beneficial effects of its active ingredients.

The foregoing are merely preferred embodiments of the present invention, and are not intended to limit the scope of implementation of the present invention. Therefore, all equal changes or modifications made according to the features and spirit described in the scope of the application of the present invention shall be included in the scope of patent application of the present invention.

10 Reusable contact lens products 20 Contact lenses 30 Packaging containers 40 Aqueous compositions with the ability to release active ingredients 50 Packaging containers 60 Packaging containers 70 Eyes 80 Packaging containers

FIG. 1 is a schematic diagram of a reusable contact lens product provided by the present invention.

FIG. 2 is a schematic diagram of supplementing an active ingredient in a contact lens by using an aqueous composition having a capability of releasing an active ingredient in a large-scale long-term packaging container according to the present invention.

FIG. 3 is a schematic diagram of supplementing an active ingredient in a contact lens by using an aqueous composition having the ability to release an active ingredient in a plurality of disposable packaging containers according to the present invention.

4A to 4C are schematic diagrams of a long-term reusable contact lens product according to the present invention.

FIG. 5 is a schematic view of combining a reusable contact lens product provided by the present invention with an aqueous composition capable of releasing active ingredients into a set.

Claims (10)

An aqueous composition having the ability to release an active ingredient includes: a buffer solution; a binding agent, the binding agent being uniformly dispersed in the buffer solution, the binding agent being cyclodextrins; and at least one active ingredient, the The active ingredient is absorbed by the binding agent and stored in the buffer solution. The active ingredient is selected from the group consisting of vitamins, phytochemicals, naturally derived ingredients, biologically active ingredients, and combinations thereof. The aqueous composition having the ability to release an active ingredient according to claim 1, wherein the vitamin is selected from vitamin B6, vitamin B12, vitamin C, and vitamin E, and the phytochemical is selected from curcumin and quercetin , Lutein and angelica extract, the natural derivative is selected from the group consisting of genistein, myriocin, mangiferin, baicalin, and resina draconis ), Tetrandrine, lycopene, anthocyanin, and combinations thereof. The biologically active ingredient is mitochondria extracted from stem cells. The aqueous composition having the ability to release an active ingredient according to claim 1, wherein the buffer solution is selected from the group consisting of phosphate, borate, trimethylolaminomethane (TRIS), propanesulfonic acid (MOPS), and 4 -Isethionate (HEPES). The aqueous composition having the ability to release an active ingredient according to claim 1, wherein the cyclodextrin is selected from the group consisting of α-cyclodextrin, β-cyclodextrin, γ-cyclodextrin, and combinations thereof. The aqueous composition having the ability to release an active ingredient according to item 1 of the claim, wherein the proportion of the active ingredient in the buffer solution is 10-30 mg / ml (mg / mL). The aqueous composition having the ability to release an active ingredient according to claim 5, wherein the The ratio of the binding agent in the buffer solution is 5-30 mg / ml (mg / mL). The aqueous composition having the ability to release an active ingredient according to claim 1 is used as a preservation solution for contact lenses. A reusable contact lens product comprising: a contact lens; and a packaging container having an aqueous composition capable of releasing an active ingredient as described in claim 1, the contact lens is stored in the buffer solution To cause the buffer solution to release the active ingredient onto the contact lens. The reusable contact lens product according to item 8 of the claim, wherein the contact lens is ready for wearing and releasing the active ingredient. Capable aqueous composition is stored overnight, allowing the contact lens to bind the active ingredient again. The reusable contact lens product according to claim 8, wherein the contact lens is made using lathe-cutting, cast-molding, spin coating, UV curing ( UV curing) or heat curing (heat curing) method.