TWI462915B - 一種組織胺ｈ３受體拮抗劑的新穎富馬酸鹽 - Google Patents
一種組織胺ｈ３受體拮抗劑的新穎富馬酸鹽 Download PDFInfo
- Publication number
- TWI462915B TWI462915B TW099120734A TW99120734A TWI462915B TW I462915 B TWI462915 B TW I462915B TW 099120734 A TW099120734 A TW 099120734A TW 99120734 A TW99120734 A TW 99120734A TW I462915 B TWI462915 B TW I462915B
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- Prior art keywords
- ethyl
- cyclohexylmethyl
- sulfonamide
- methyl
- pyrrolidin
- Prior art date
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- C07—ORGANIC CHEMISTRY
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- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
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- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
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| US22068309P | 2009-06-26 | 2009-06-26 | |
| FR0959110 | 2009-12-17 |
Publications (2)
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| TW201103911A TW201103911A (en) | 2011-02-01 |
| TWI462915B true TWI462915B (zh) | 2014-12-01 |
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| Country | Link |
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| US (1) | US8664245B2 (fr) |
| EP (1) | EP2445899B1 (fr) |
| JP (1) | JP6053519B2 (fr) |
| KR (1) | KR101804749B1 (fr) |
| CN (1) | CN102803247B (fr) |
| AR (1) | AR077223A1 (fr) |
| AU (1) | AU2010264422B2 (fr) |
| BR (1) | BRPI1011258A2 (fr) |
| CA (1) | CA2766154C (fr) |
| CO (1) | CO6480943A2 (fr) |
| DO (1) | DOP2011000398A (fr) |
| ES (1) | ES2587064T3 (fr) |
| IL (1) | IL216924A0 (fr) |
| MA (1) | MA33378B1 (fr) |
| MX (1) | MX2011012824A (fr) |
| NZ (1) | NZ597219A (fr) |
| PE (1) | PE20121403A1 (fr) |
| PL (1) | PL2445899T3 (fr) |
| RU (1) | RU2537847C2 (fr) |
| SG (1) | SG176645A1 (fr) |
| TN (1) | TN2011000620A1 (fr) |
| TW (1) | TWI462915B (fr) |
| UY (1) | UY32738A (fr) |
| WO (1) | WO2010151611A1 (fr) |
| ZA (1) | ZA201108838B (fr) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR080374A1 (es) | 2010-03-05 | 2012-04-04 | Sanofi Aventis | Procedimiento para la preparcion de 2-(ciclohexilmetil)-n-(2-((2s)-1-metilpirrolidin-2-il) etil)- 1,2,3,4-tetrahidroisoquinolin-7- sulfonamida |
| WO2013151982A1 (fr) | 2012-04-03 | 2013-10-10 | Arena Pharmaceuticals, Inc. | Méthodes et composés utiles pour traiter le prurit, et procédés d'identification desdits composés |
| EP2647377A1 (fr) * | 2012-04-06 | 2013-10-09 | Sanofi | Utilisation d'un antagoniste du récepteur h3 pour le traitement de la maladie d'Alzheimer |
| JP2015524400A (ja) * | 2012-07-19 | 2015-08-24 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ９−［４−（３−クロロ−２−フルオロ−フェニルアミノ）−７−メトキシ−キナゾリン−６−イルオキシ］−１，４−ジアザ−スピロ［５．５］ウンデカン−５−オンのフマル酸塩、その薬物としての使用及び調製 |
| WO2015032966A1 (fr) * | 2013-09-09 | 2015-03-12 | Sanofi | Antagoniste des récepteurs h3 combiné à un inhibiteur de la cholinestérase et utilisé dans le cadre du traitement de la maladie d'alzheimer |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070105834A1 (en) * | 2004-05-25 | 2007-05-10 | Sanofi-Aventis | Tetrahydroisoquinoline sulfonamide derivatives, the preparation thereof, and the use of the same in therapeutics |
| US20080318952A1 (en) * | 2007-05-18 | 2008-12-25 | Keith John M | Diaryl-substituted tetrahydroisoquinolines as histamine h3 receptor and serotonin transporter modulators |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4228170A (en) | 1979-08-30 | 1980-10-14 | Smithkline Corporation | 7- and/or 8-Sulfur substituted 1,2,3,4-tetrahydroisoquinoline compounds |
| EP0306375A1 (fr) | 1987-08-07 | 1989-03-08 | Synthelabo | Dérivés de[(pipéridinyl-4)méthyl]-2 tétrahydro-1,2,3,4 isoquinoléine, leur préparation et leur application en thérapeutique |
| IL89156A (en) | 1988-07-12 | 1993-05-13 | Synthelabo | Derivatives of 2-((4-piperidinyl) methyl)- 1,2,3,4- tetrahydroisoquinoline, their preparation and their application in therapeutics |
| SK1212002A3 (en) | 1999-07-29 | 2002-11-06 | Egyt Gyogyszervegyeszeti Gyar | Isoquinoline derivatives, pharmaceutical compositions containing the same, and a process for the preparation of the active substance |
| US6825198B2 (en) * | 2001-06-21 | 2004-11-30 | Pfizer Inc | 5-HT receptor ligands and uses thereof |
| CA2469967A1 (fr) | 2001-12-26 | 2003-07-10 | Bayer Healthcare Ag | Derives d'uree |
| US7790231B2 (en) | 2003-07-10 | 2010-09-07 | Brewer Science Inc. | Automated process and apparatus for planarization of topographical surfaces |
| JP2008534542A (ja) * | 2005-03-31 | 2008-08-28 | ユセベ ファルマ ソシエテ アノニム | オキサゾール部分又はチアゾール部分を含む化合物、それらの製造方法及びそれらの使用 |
| JP2009530274A (ja) * | 2006-03-15 | 2009-08-27 | ワイス | ヒスタミン−３アンタゴニストとしてのｎ−置換−アザシクリルアミン化合物 |
| PE20081152A1 (es) * | 2006-10-06 | 2008-08-10 | Wyeth Corp | Azaciclilaminas n-sustituidas como antagonistas de histamina-3 |
| EP2170875A1 (fr) * | 2007-07-16 | 2010-04-07 | Wyeth LLC | Dérivés d'aminoalkylazole en tant qu'antagonistes d'histamine-3 |
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2010
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2011
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070105834A1 (en) * | 2004-05-25 | 2007-05-10 | Sanofi-Aventis | Tetrahydroisoquinoline sulfonamide derivatives, the preparation thereof, and the use of the same in therapeutics |
| US20080318952A1 (en) * | 2007-05-18 | 2008-12-25 | Keith John M | Diaryl-substituted tetrahydroisoquinolines as histamine h3 receptor and serotonin transporter modulators |
Also Published As
| Publication number | Publication date |
|---|---|
| IL216924A0 (en) | 2012-03-01 |
| MX2011012824A (es) | 2012-01-27 |
| RU2012102671A (ru) | 2013-08-10 |
| BRPI1011258A2 (pt) | 2016-03-22 |
| EP2445899B1 (fr) | 2016-05-11 |
| TW201103911A (en) | 2011-02-01 |
| UY32738A (es) | 2011-01-31 |
| SG176645A1 (en) | 2012-01-30 |
| AU2010264422A1 (en) | 2012-02-02 |
| NZ597219A (en) | 2013-05-31 |
| US8664245B2 (en) | 2014-03-04 |
| CN102803247A (zh) | 2012-11-28 |
| CO6480943A2 (es) | 2012-07-16 |
| PL2445899T3 (pl) | 2017-08-31 |
| PE20121403A1 (es) | 2012-11-02 |
| EP2445899A1 (fr) | 2012-05-02 |
| ZA201108838B (en) | 2012-08-29 |
| KR20120039555A (ko) | 2012-04-25 |
| CA2766154C (fr) | 2015-04-07 |
| ES2587064T3 (es) | 2016-10-20 |
| TN2011000620A1 (en) | 2013-05-24 |
| US20120149728A1 (en) | 2012-06-14 |
| MA33378B1 (fr) | 2012-06-01 |
| AU2010264422B2 (en) | 2014-12-18 |
| JP6053519B2 (ja) | 2016-12-27 |
| WO2010151611A1 (fr) | 2010-12-29 |
| JP2012531424A (ja) | 2012-12-10 |
| AR077223A1 (es) | 2011-08-10 |
| CN102803247B (zh) | 2014-11-05 |
| CA2766154A1 (fr) | 2010-12-29 |
| KR101804749B1 (ko) | 2017-12-05 |
| DOP2011000398A (es) | 2012-01-31 |
| RU2537847C2 (ru) | 2015-01-10 |
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