TWI377027B - Microbicidal composition - Google Patents
Microbicidal composition Download PDFInfo
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- TWI377027B TWI377027B TW100149810A TW100149810A TWI377027B TW I377027 B TWI377027 B TW I377027B TW 100149810 A TW100149810 A TW 100149810A TW 100149810 A TW100149810 A TW 100149810A TW I377027 B TWI377027 B TW I377027B
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- methyl
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- 239000000203 mixture Substances 0.000 title claims description 39
- 230000003641 microbiacidal effect Effects 0.000 title 1
- 230000000844 anti-bacterial effect Effects 0.000 claims description 36
- MUCRYNWJQNHDJH-OADIDDRXSA-N Ursonic acid Chemical compound C1CC(=O)C(C)(C)[C@@H]2CC[C@@]3(C)[C@]4(C)CC[C@@]5(C(O)=O)CC[C@@H](C)[C@H](C)[C@H]5C4=CC[C@@H]3[C@]21C MUCRYNWJQNHDJH-OADIDDRXSA-N 0.000 claims description 3
- YNQNTUVMQPQFEW-UHFFFAOYSA-N methyl 2-hydroxyacetate;sodium Chemical compound [Na].COC(=O)CO YNQNTUVMQPQFEW-UHFFFAOYSA-N 0.000 claims description 2
- KUQCZABKHLILRI-UHFFFAOYSA-M sodium;2,2-dihydroxyacetate Chemical compound [Na+].OC(O)C([O-])=O KUQCZABKHLILRI-UHFFFAOYSA-M 0.000 claims description 2
- WBTIFBJEYFLFFW-UHFFFAOYSA-N 2-(hydroxymethylazaniumyl)acetate Chemical compound OCNCC(O)=O WBTIFBJEYFLFFW-UHFFFAOYSA-N 0.000 claims 1
- KOAOGWOLJJHLPN-UHFFFAOYSA-N 2-sulfanyl-3h-1,2-benzothiazole Chemical compound C1=CC=C2SN(S)CC2=C1 KOAOGWOLJJHLPN-UHFFFAOYSA-N 0.000 claims 1
- 108700019599 monomethylolglycine Proteins 0.000 claims 1
- 229940101011 sodium hydroxymethylglycinate Drugs 0.000 claims 1
- CITBNDNUEPMTFC-UHFFFAOYSA-M sodium;2-(hydroxymethylamino)acetate Chemical compound [Na+].OCNCC([O-])=O CITBNDNUEPMTFC-UHFFFAOYSA-M 0.000 claims 1
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- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000001117 sulphuric acid Substances 0.000 description 1
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- 239000012085 test solution Substances 0.000 description 1
- 238000004448 titration Methods 0.000 description 1
- 229960002622 triacetin Drugs 0.000 description 1
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- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
- A01N43/80—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,2
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Description
1377027 * t 六、發明說明： 【發明所屬之技術領域】 本發明係關於-種經選擇之殺菌劑的協同組合，其具 有之活性比在個別殺菌劑中所觀察到之活性更大。 【先前技術】 在某些情況中’即使是在高使用濃度下，由於商用殺 菌劑對抗某些類型的微生物（例如，對於某些殺菌劑且有抗 性之微生物）之活性弱’或由於侵略性環境條件，而使該等 商用殺菌劑無法提供有效的微生物控制。有時候，在特定 目的使祕境中制不同殺_核合，以提供全面的微 生物控制。例如’美國專利申請公開案第2〇〇7/〇〇78ii8 號揭示N-曱基-1，2-苯并異嗔吐琳_3_網（顧^與盆他殺 生物劑之協同組合。然而，為提供有效的微生物控制，對 於具有抗各種微生物菌株之增強活性的額外殺菌劑組合仍 有所需求。再者，為了環境及經濟效益，對於含有較低量 •個別殺菌劑之組合亦有所需求。本發明係提供此等額外的 殺菌劑組合而解決問題。 • 【發明内容】 . 本發明係有關一種殺菌組成物（下文中有稱為「抗菌組 成物」之情形）’其包含：（a) Ν-甲基-1，2-苯并異。塞唑琳-3-酮；及（b)至少一種殺菌劑，其係選自下列各者所組成之群 組：六氩-1，3,5-參（2-羥基乙基）對稱三啡（hexahydr〇 一 l，3,5-tris(2-hydroxyethyl)-s-triazine);4,4-:f*
Pf唑啶；羥基曱基甘胺酸鈉；肉豆蔻醯胺丙基丙二醇—氯化 94379D02 1377027 二甲基敍填酸酉旨（myristamidopropy 1 PG-dimonium chloride phosphate);辛酸；2-乙基己基甘油；單辛酸甘 油酯；單癸酸甘油酯；7α-乙基二氫-1H, 3H，5H-噚唑并 (3,4-〇噚唑；及2-(硫基氰基甲基硫基）苯并噻唑（2-(thiocyanomethylthio)benzothiazole) ° 【實施方式】 如本文中所使用，除非文中另有明確指示，否則下列 術語具有指定的定義。“MBIT”係N-甲基-1,2-苯并異噻 唑啉-3-酮。術語“殺菌劑”意指能夠於一位置（locus)殺 死微生物、抑制微生物生長或控制微生物生長的化合物； 殺菌劑包括殺細菌劑、殺真菌劑及殺藻劑。術語“微生物” 包括例如真菌（例如酵母菌及黴菌）、細菌及藻類。術語“位 置”意指受到微生物污染之工業系統或産品。下列縮寫係 用於說明書全文中：ppm=以重量計之每百萬份之份數（重量 /重量），mL=毫升’ ATCC=美國菌種保藏中心（American Type Culture Collection)，MBC=最低殺菌濃度，及 MIC=最低 抑制濃度。除非另外指明’否則溫度係以攝氏度（°C)計， 且百分比（％)之參考基準係以重量計。有機殺菌劑的量係由 以ppm (重量/重量）計之活性成分基質呈現。 意外地發現本發明之組成物能在組合的活性成分含 量低於個別殺邊劑的活性成分含量之情況下，提供增強的 殺菌效力^超出申請專利範圍所列殺菌劑範疇之其他殺菌 劑亦可存在於該組成物中。 於本發明的一具體例中，該抗菌組成物包含N_甲基 94379D02 4 1377027 -1，2-苯并異噻唑啉-3-酮及六氫-1，3, 5~參（2-經基乙基） 對稱二哄。六虱-1，3, 5-參（2-赵基乙基）對稱三卩并對n_甲 基-1，2-苯并異噻唑啉-3-酮之重量比較佳為1 : 〇 〇〇14至 1 : 150，更佳為 1 : 〇. 012 至 1 : 150。 於本發明的一具體例中，該抗菌組成物包含N_曱基 -1，2-苯并異噻唑琳-3-酮及4, 4-二曱基噚唑啶。4, 4_二曱 基吗峻咬對N-甲基-1，2-苯并異隹嗤淋-3-酮之重量比較 佳為 1 : 0. 0011 至 1 : 3. 5。 於本發明的一具體例中，該抗菌組成物包含N_甲基 -,1，2-苯并異噻唑琳-3-酮及經基曱基甘胺酸納。經基甲基 甘胺酸鈉對N-曱基-1，2-苯并異噻唑啉-3-酮之重量比較 佳為 1 : 0. 0005 至 1 : 2. 3，更佳為 1 : 0. 14 至 1 : 2. 3，又 更佳為1 : 0.29至1 : 2. 3。 於本發明的一具體例中，該抗菌組成物包含N_甲基 -1，2 -本并異蜜嗤嚇-3-酮及肉豆謹酿胺丙基丙二醇-氣化 • 二甲基銨磷酸酯。肉豆蔻醯胺丙基丙二醇-氯化二曱基銨磷 酸醋對N-甲基-1，2-苯并異噻唑啉-3-酮之重量比較佳為 • 1 : 〇· 〇〇11 至 1 : 150。 •於本發明的一具體例中，該抗菌組成物包含N-曱基 -1，2-苯并異噻唑啉_3_酮及辛酸。辛酸對N-甲基-1，2-苯 并異嗟唾啉-3-酮之重量比較佳為1 : 〇. 〇〇46至1 : 〇. 68， 更佳為 1 : 0.029 至 1 : 〇. 68。 於本發明的一具體例中，該抗菌組成物包含N-甲基 -1,2-苯并異噻唑啉—3_酮及2_乙基己基甘油。2-乙基己基 5 94379D02 1377027 對N甲基_ι’2_苯并異嗟唑琳_3_酮之重量比較佳 1 : 〇·〇17至 1 : 2 3。 一 於本發明的一具體例+，該抗菌組成物包含N_甲基 -1,2-苯并異噻唑啉_3_酮及單辛酸甘油酯。單辛酸甘油酯 對N甲基-ι，2_苯并異噻唑啉_3—酮之重量比較佳為工： 〇· 0004 至 1 : 75，更隹為 1 : 0. 012 至 1 : 75。 於本發明的一具體例中，該抗菌組成物包含N-甲基 1’2苯并異噻唑啉_3_酮及單癸酸甘油酯。單癸酸甘油酯 對N甲基-ι，2—笨并異噻唑啉_3_酮之重量比較佳為^ : 0.0031 至 1 : 8 8，更佳為 n 〇 〇17 至 i : 8 8。 於本發明的一具體例中，該抗菌組成物包含N-曱基 1，2-苯并異噻唑啉_3—酮及7“_乙基二氫_1{|，3H，噚 唑并（3,4-C)卩萼唑。7α_乙基二氫^扎3H，5H_噚唑并 (3’4 C)P§«坐對N-甲基_i，2-苯并異噻唾淋_3_酮之重量比 較佳為 1 : 0. 0003 至 1 : 7. 1。 於本發明的一具體例中，該抗菌組成物包含甲基 -1’2-苯并異噻唑啉—3_酮及2_(硫基氰基甲基硫基）苯并 噻唑。硫基氰基甲基硫基）苯并噻唑對N-甲基-1，2-苯 并異噻唑啉-3-酮之重量比較佳為1 : 〇63至1 : ι43。 可使用本發明組成物中之殺菌劑“本身”或可先將 該殺菌劑與溶劑或固體載劑調製。適當的溶劑包括例如：
Jc ’ 一醇例如乙一醇、丙二醇、二乙二醇、二丙二醇、 聚乙二醇及聚丙二醇；二醇醚；醇，例如甲醇、乙醇、丙 醇、笨乙醇及苯氧基丙醇；酮，例如丙酮及甲基乙基酮； 6 94379D02 1377027 酉曰、例如醋酸乙§旨、醋酸丁自旨、擰檬酸三乙醯醋及三错酸 甘油酉曰，兔_旨，例如碳酸丙二自旨及碳酸二甲西旨；及其混 口物該’合劑較佳係選自水、二醇、二醇醚、酯及其混合 物。適當的固體載劑包括例如：環糊精、氧化石夕、石夕藻土 °、 躐、纖維質材料、鹼金屬及驗土金屬（例如，納、鎮、卸） 鹽’氣化物、硝酸鹽、溴化物、硫酸鹽）及木炭。 將殺囷劑組分調製於溶劑中時，該調配物可視需要含 有界面活性劑。t此等調配物含有界面活性劑時，其通常 化'辰縮物、乳液、微乳化遭縮物、或微乳液形式。乳 ，濃縮物^添加足量水之後，會形成乳液。微乳化濃縮物 〜添加足里水之後，會形成微乳液。此等乳化及微乳化濃 =物於本技術領域中普遍為人所熟知；此等調配物較佳不 含界面活性劑。可查閱美國專利第5, 444, 078號，以進一 ^乂取4備各種微乳液及微乳化濃縮物之—般及具體細 節。 、 亦可將殺菌劑組分調製成分散液形式。分散液之溶劑 組分可為有機溶劑或水’較佳為水。此等分散液可含有佐 劑，例如共溶劑、增稠劑、防凍劑、分散劑、填充劑、顏 料、界面活性劑、生物分散劑、續酸基琥⑽醋、㈣、 11 夫喃網、Μ陽離子、安定劑、防㈣!及防腐*添加劑。 當將兩種殺菌劑各自首先與溶劑調製時，用於第一種 鈇菌劑之溶劑可與用於調製另一種商用殺菌劑之溶劑相同 或不同，但對於大部分工業殺菌應用而言，水為較佳者。 該兩種溶劑較佳為可混溶者。 94379D02 7 1377027 熟悉此項技術者將瞭解，可相繼或同時添加本發明之 殺菌劑組分至一位置，或可在添加至該位置之前，先組合 該等殺菌劑組分。較佳為同時或相繼添加第一種殺菌劑及 第二種殺菌劑組分至一位置。當同時或相繼添加該等殺菌 劑時，個別組分可各自含有佐劑，舉例而言，例如溶劑、 增稠劑、防凍劑、著色劑、螯合劑（例如乙二胺四醋酸、乙 二胺二琥珀酸、亞胺基二琥珀酸及其鹽）、分散劑、界面活 性劑、生物分散劑、續酸基琥ίό酸醋、萜稀、吱喃酮、多 價陽離子、安定劑、防垢劑及防腐蝕添加劑。 可藉由將殺菌有效量之本發明殺菌組成物引至受微生 物侵襲的位置上、位置内或位置處，而將本發明殺菌組成 物用於抑制微生物或較高等水生生物種類（例如原生動物、 無脊椎動物、苔蘚蟲類、雙鞭毛藻類、曱殼動物、軟體動 物等）的生長。適當的位置包括例如：工業處理水；電塗沉 積系統；冷卻塔；空氣清洗器；氣體洗滌器；礦物漿料； 廢水處理；裝飾用喷泉；逆滲透過濾；超過濾；壓艙水； 蒸發冷凝器；熱交換器；紙漿及紙張加工流體與添加劑； 澱粉；塑膠；乳液；分散液；油漆；乳膠；塗料，例如清 漆；建築產品，例如膠黏劑（mastics)、填隙劑及密封劑； 建築黏著劑，例如陶兗黏著劑、地毯背襯黏著劑及層合黏 著劑；工業或消費性黏著劑；照相化學品；印刷流體；家 用產品，例如浴室及廚房清潔劑與清潔濕巾；美容用品； 化妝品；洗髮精；肥爸；去汙劑；工業清潔劑；地板光亮 劑；洗衣用洗濯水；金屬加工流體；輸送機潤滑劑；液壓 94379D02 矣體；皮革及皮革產品n織造產品；木材及木 品’例如合板、碎木片板、牆板、创花板、層合襟、定向 剖花板、硬板及粒片板；石油加I流體；燃料；油田流體， 例如嘴射水、㈣趙及鑽井m業佐難存；界面 活性劑保存；醫學裝置；診斷試解存；食物保存，例如 ^膠或紙製食品包裝；食品、飲料及卫業處理殺菌器便 现，娛樂用水；水池；以及礦表。 較佳地，本發明殺g組成物制於抑制在選自下列一 或多個位置處的微生物之生長：礦物聚料；紙聚及紙張加 =流體與添加劑；澱粉；乳液；分散液；油漆；乳膠；塗 ^ ’建築黏著劑’例如陶.著劑、地毯背襯黏著劑；昭 ^學品流體；家用產品，例如浴室及廚房清潔劑 潔濕巾；美容用品；化妝品；洗髮精；肥g;去汙劑； 工f青潔劑；地板光亮劑；洗衣用洗濯水；金屬加工流體； ^織造產品：木材及木材產品；農業佐劑保存；界面活性劑 ，存；診斷試舰存；食物保存；以及食品、飲料及工業 處理殺菌器。 、抑制或控制一位置之微生物及較高等水生生物種類 $生長所需之本發明組成物的具體量係取決於欲保護之特 疋=。典型地，在一位置控制微生物生長的本發明組成 '"月^於^亥位置提供〇· 1至1，〇〇〇卯m的該組成物之異嗜 坐啉酮成分，則其量為足夠。在該位置，該組成物之異噻 ^琳，成分較佳以至少〇.5ppm，更佳以至少4ppm，最佳 乂至〆l〇ppm的量存在。在該位置，該組成物之異噻唑啉 9 94379D02 1377027 _成分較佳以不超過1000 ppm，更佳以不超過500 ppm， 最佳以不超過200 ppm的量存在。 實施例 材料及方法 本發明之組合的協同作用係藉由測試廣泛濃度及比 率範圍的該等化合物而予以證實。 協同作用之一種量測法係Kull，F. C. ; Eisman，P. C.; Sylwestrowicz，H.D.及 Mayer, R. L.在 APPlied Microbiology 9:538-541 (1961)中所述之工業上接受的方 法，其係使用下述公式所測定之比率： Q3/Qa + Qb/QB =協同指數（“SI ) 其中：
Qa=以ppm計的單獨作用之化合物a(第/種組分）的濃度， 其產生一終點（化合物A之MIC)。
Qa=以ppm計的混合物中之化合物a的濃度，其產生一終點。 QB=以ppm計的單獨作用之化合物B(第二種組分）的濃度， 其產生一終點（化合物B之MIC)。
Qb=以ppm計的混合物中之化合物b的濃度，其產生一終點。 當Qa/QA及Qb/QB之總和大於1時，表示拮抗作用。當 該總和等於1時，表示相加性；而當該總和小於1時，則 說明為協同作用。SI值愈低，則該特定混合物所展現的協 同性愈高。殺菌劑之最低抑制濃度（MIC)為在阻止所添加微 生物之生長的一組特別條件下所測得之最低濃度。 使用標準微量滴定盤分析，以設計成使測試微生物達 10 94379D02 1377027 到最佳生長之培養基來進行協同性測試。補充有〇. 2%葡萄 糖及0. 1%酵母萃取物的基本鹽類培養基（M9GY培養基）係 用於測試細菌；馬鈴薯葡萄糖培養液（PDB培養基）係用於 測試酵母菌及黴菌。在此方法中，藉由在各種濃度的MBIT 之存在下進行高解析度MIC分析來測試廣範圍的殺菌劑組 合。藉由對微量滴定盤的其中一攔添加不同量的殺菌劑， 並使用自動液體處理系統進行十倍連續稀釋，以獲得活性 成分自2 ppm至10，0 0 0 ppm變化的一系列終點，來測定高 解析度ΜIC。 本發明之組合的協同性係以對抗如下表中所述之數種 微生物而予以測定。所使用的細菌之濃度約為每毫升5χ 106 個細菌，而酶母菌及黴菌之濃度為每毫升5χ105個真菌。 此等微生物代表許多消費性及工業性應用中的自然污染 物。經過於25°C (酶母菌及黴菌）或30°C (細菌）培養不同時 間後，對滴定盤進行微生物生長（混濁度）之視覺評估，以 • 測定MIC。 用於證實本發明之MBIT組合之協同性的測試結果係 ' 顯示於下表1至10中。於各測試中，第二組分（B)為MBIT， • 而第一組分（A)為其他商用殺菌劑。各表係顯示：MBIT與 其他組分之特定組合；以各培養時間測試之對抗微生物的 結果；藉由單獨的MBIT (Qb)、單獨的其他組分（Qa)、混合 物中的MBIT (Qb)及混合物中的其他組分（Qa)之MIC所量測 的以ppm計之終點活性；所計算之SI值；以及所測試之各 組合（其他組分/MBIT或A/B)的協同比率範圍。 11 94379D02 1377027 表1
Ca : BIOBAN GK(六氫-1，3, 5-參（2-羥基乙基）對稱三哄）之 ppm(活性成分）
Cb:MBIT(N-曱基-1，2-苯并異噻唑啉-3-酮）之ppm(活性成分） 比率：Ca : Cb 測試生物 接觸時間 Ca Cb S.I. Ca：Cb 黑麴菌（A. niger) 3天 425 - • - ATCC # 16404 - 37.5 - ~ 110 18.8 0.76 1:0.1709 200 18.8 0.97 1:0.0940 300 18.8 1.21 1:0.0627 300 9.4 0.96 1:0.0313 425 9.4 1.25 1:0.0221 300 4.7 0.83 1:0.0157 425 4.7 1.13 1:0.0111 300 2.4 0.77 1:0.0080 425 2.4 1.06 1:0.0056 300 1.2 0.74 1:0.0040 425 1.2 1.03 1:0.0028 7天 650 - - - - 150 - - 42.5 75 0.57 1:1.76头7 65 75 0.60 1:1.1538 110 75 0.67 1:0.6818 200 75 0.81 1:0.3750 300 75 0.96 1:0.2500 400 75 1.12 1:0.1875 425 18.8 0.78 1:0.0442 525 18.8 0.93 1:0.0358 650 9.4 1.06 1:0.0145 525 4.7 0.84 1:0.0090 650 4.7 1.03 1:0.0072 525 2.4 0.82 1:0.0046 650 2.4 1.02 1:0.0037 650 1.2 1.01 1:0.0018 白色念珠菌 48小時 875 - - - (C.albicans) - 30 ATCC# 10231 87.5 15 0.60 1Ό.1714 110 15 0.63 1:0.1364 200 15 0.73 1:0.0750 300 15 0.84 1:0.0500 425 15 0.99 1:0.0353 110 7.5 0.38 1:0.0682 200 7.5 0.48 1:0.0375 300 7.5 0.59 1:0.0250 425 7.5 0.74 1Ό.0176 525 7.5 0.85 1:0.0143 650 7.5 0.99 1:0.0115 425 3.75 0.61 1:0.0088 525 3.75 0.73 1:0.0071 650 3.75 0.87 1:0.0058
12 94379D02
S 1377027 » *
875 3.75 1.13 1:0·0043 650 1.86 0.80 1:0.0029 875 1.86 1.06 1:0·0021 650 0.94 0.77 1:0.0014 875 0.94 1.03 1:0.0011 72小時 875 * - - - 30 • - 87.5 15 0.60 1:0.1714 110 15 0.63 1:0.1364 200 15 0.73 1：0.0750 300 15 0.84 1:0.0500 425 15 0.99 1 0.0353 425 7.5 0.74 1:0.0176 525 7.5 0.85 1:0.0143 650 7.5 0.99 1:0.0115 875 1.86 1.06 1:0.0021 875 0.94 1.03 1Ό.0011 綠膿桿菌 24小時 55 - * - (Ps.aeruginosa) 75 • ATCC#9027 32.5 37.5 1.09 1:1.1538 43.75 18.75 1.05 1:0.4286 43.75 9.4 0.92 1:0.2149 43.75 4.6 0.86 1ΌΛ051 48小時 55 - - •- - 125 • * 26.25 75 1.08 1:2.8571 32.5 37.5 0.89 1:1.1538 43.75 37.5 1.10 1:0.8571 55 4.6 1.04 1:0.0836 金黃色葡萄球菌 24小時 55 - - - (S. aureus) - 15 • - ATCC#6538 15 7.5 0.77 1:0.5000 32.5 3.8 0.84 1:0.1169 43.75 3.8 1.05 1:0.0869 32.5 1.8 0.71 1:0.0554 43.75 1.8 0.92 1:0_0411 55 1.8 1.12 1:0.0327 55 0-94 1.06 1:0.0171 48小時 55 - * - - 30 - 0.1 15 0.50 1： 150.0000 1.5 15 0.53 1:10.0000 2.625 15 0.55 1:5.7143 4.375 15 0.58 1:3.4286 5.5 15 0.60 1:2.7273 10 15 0.68 1:1·5000 15 15 0.77 1:1.0000 21.25 15 0.89 1:0.7059 26.25 15 0.98 1:0.5714 32.5 15 1.09 1:0.4615 21.25 7.5 0.64 1:0.3529 26.25 7.5 0.73 1:0.2857 32.5 7.5 0.84 1:0.2308 43.75 7.5 1.05 1:0.1714 32.5 3.8 0.72 1:0.1169 43.75 3:8 0.92 1:0.0869 55 3.8 1.13 1:0.0691 32.5 1.8 0.65 1Ό.0554 55 1.8 1.06 1:0.0327 43.75 0.94 0.83 1:0.0215 55 0.94 1,03 1:0.0171 13 94379D02 1377027 表2
Ca : BIOBAN 1135(4, 4-二甲基噚唑啶）之ppm(活性成分） Cb:MBIT(N-曱基-1, 2-苯并異噻唑啉-3-酮）之ppm(活性成分） 比率：Ca : Cb 測試生物 接觸時間 Ca Cb S.I. Ca:Cb 黑麴菌（A. niger) 3天 525 - - * ATCC# 16404 - 37.5 • 200 18.8 0.88 1:0.0940 300 18.8 1.07 1:0·0627 300 9.4 0.82 1:0.0313 425 9.4 1.06 1:0.0221 425 4.7 0.93 1:0.0111 525 4.7 1.13 1:0.0090 425 2.4 0.87 1:0.0056 525 2.4 1.06 1:0.0046 425 1.2 0.84 1:0.0028 525 1.2 1.03 1:0.0023 7夭 875 - • - - 150 - - 525 75 1.1 1:0.1429 650 37.5 0.99 1:0.0577 875 9.4 1.06 1:0.0107 650 4.7 0.77 1:0.0072 875 4.7 1.03 1:0.0054 650 2.4 0.76 1:0.0037 875 2.4 1.02 1:0.0027 875 1.2 1.01 1:0.0014 白色念珠菌 48小時 1100 - - - (C, albicans) - 30 - - ATCC# 10231 425 15 0.89 1:0.0353 525 15 0.98 1:0.0286 650 15 1.09 1:0.0231 650 7.5 0.84 1:0.0115 875 7.5 1.05 1Ό.0086 875 3.75 0.92 1:0.0043 1100 3.75 1.13 1:0.0034 875 1.86 0.86 1:0.0021 1100 1.86 1.06 1:0.0017 875 0.94 0.83 1:0.0011 14 94379D02 1377027 , t
1100 .0.94 1.03 1:0.0009 72小時 1100 - - - 30 - - 425 15 0.89 1:0.0353 525 15 0.98 1:0.0286 650 15 1.09 1:0.0231 875 7.5 1.05 1:0.0086 875 3.75 0.92 1:0.0043 1100 3.75 1.13 1:0.0034 875 1.86 0.86 1:0.0021 1100 1.86 1.06 1:0.0017 875 0.94 0.83 1:0.0011 1100 0.94 1.03 1:0.0009 綠膿桿菌 24小時 100 - - * (Ps. aeruginosa) - 75 - ATCC#9027 55 37.5 1.05 1:0.6818 55 9.4 0.68 1:0.1709 100 9.4 1.13 1:0.0940 55 4.6 0.61 1:0.0836 100 4.6 1.06 1:0.0460 48小時 100 - * • - 125 • * 21.25 75 0.81 1:3.5294 26.25 75 0.86 1:2.8571 32.5 75 0.93 1:2.3077 43.75 75 1.04 1:1.7143 55 37.5 0.85 1:0.6818 100 9.4 1.08 1:0.0940 100 4-6 1.04 1:0.0460 金黃色葡萄球菌 24小時 55 - • - (S. aureus) - 30 - ATCC#6538 21.25 15 0.89 1:0.7059 26.25 15 0.98 1:0.5714 32.5 15 1.09 1:0.4615 26.25 7.5 0.73 1:0.2857 32.5 7.5 0.84 1:0.2308 43.75 7.5 1.05 1:0.1714 43.75 3.8 0.92 1:0.0869 55 3.8 1.13 1-0.0691 55 1.8 1.06 1:0.0327 55 0.94 1.03 1:0.0171 48小時 55 - - - - 30 - * 21.25 15 0.89 1:0.7059 26.25 15 0.98 1:0.5714 32.5 15 1.09 1:0.4615 26.25 7.5 0.73 1:0.2857 32.5 7.5 0.84 1:0.2308 43.75 7.5 1.05 1:0.1714 43.75 3.8 0.92 1Ό.0869 55 3.8 1.13 1:0.0691 55 1.8 1.06 1:0.0327 55 0.94 1.03 1:0.0171 15 94379D02 1377027 表3
Ca : SUTTOCIDE A(羥基甲基甘胺酸鈉）之ppm(活性成分） Cb:MBIT(N-曱基-1，2-苯并異噻唑啉-3-酮）之ppm(活性成分） 比率：Ca : Cb 測試生物 接觸時間 Ca Cb S.I. Ca:Cb 黑麴菌（A. niger) 3天 875 - - ATCC # 16404 75 • • 425 18.8 0.74 1:0.0442 525 18.8 0.85 1:0.0358 650 18.8 0.99 1:0.0289 425 9.4 0.61 1:0.0221 525 9.4 0.73 1:0.0179 650 9.4 0.87 1:0.0145 875 9.4 1.13 1:0.0107 650 4.7 0.81 1:0.0072 875 4.7 1.06 1:0.0054 525 2.4 0.63 1:0.0046 650 2.4 0.77 1:0.0037 875 2.4 1.03 1:0.0027 650 1.2 0.76 1:0.0018 875 1.2 1.02 1:0.0014 7天 1100 • - - - 150 - - 110 75 0.60 1:0.6818 200 75 0.68 1:0.3750 300 75 0.77 1:0.2500 425 75 0.89 1:0.1765 525 75 0.98 1:0.1429 650 75 1.09 1:0.1154 425 37.5 0.64 1:0.0882 525 37.5 0.73 1:0.0714 650 37.5 0.84 1:0.0577 875 37.5 1.05 1:0.0429 525 18.8 0.6 1:0.0358 650 18.8 0.72 1:0.0289 875 18.8 0.92 1:0.0215 1100 18.8 1.13 1:0.0171 525 9.4 0.54 1:0.0179 650 9.4 0.65 1:0.0145 875 9.4 0.86 1:0.0107 1100 9.4 1.06 1:0.0085 650 4.7 0.62 1:0.0072 875 4.7 0.83 1:0.0054 1100 4.7 1.03 1:0.0043 650 2.4 0.61 1:0.0037 875 2.4 0.81 1:0.0027 16 94379D02 1377027 . »
1100 650 875 1100 2.4 1.2 1.2 1.2 1.02 0.60 0.80 1.01 1:0.0022 1Ό.0018 1:0.0014 1:0.0011 白色念珠菌 48小時 3000 - - - (C. albicans) - 30 - - ATCC # 10231 525 15 0.68 1:0.0286 650 15 0.72 1:0.0231 875 15 0.79 1:0.0171 1100 15 0.87 1:0.0136 2000 15 1.17 1:0.0075 525 7.5 0.43 1:0.0143 650 7.5 0.47 1:0.0115 875 7.5 0.54 1:0.0086 1100 7.5 0.62 1:0.0068 2000 7.5 0.92 1:0.0038 3000 7.5 1.25 1:0.0025 875 3.75 0.42 1:0.0043 1100 3.75 0.49 1:0.0034 2000 3.75 0.79 1:0.0019 3000 3.75 1.13 1:0.0013 2000 1.86 0.73 1:0.0009 3000 1.86 1.06 1:0.0006 2000 0.94 0.70 1O.00G5 3000 0.94 1.03 1:0.0003 72小時 3000 - - * - 30 - - 525 15 0.68 1:0.0286 650 15 0.72 1:0.0231 875 15 0.79 1:0.0171 1100 15 0.87 1:0.0136 2000 15 1.17 1:0.0075 3000 15 1.5 1:0.0050 525 7.5 0.43 1:0.0143 650 7.5 0.47 1:0.0115 875 7.5 0.54 1:0.0086 1100 7.5 0.62 1:0.0068 2000 7.5 0.92 1:0.0038 3000 7.5 1.25 1:0.0025 875 3.75 0.42 1:0.0043 1100 3.75 0.49 1:0.0034 2000 3.75 0.79 1-0.0019 3000 3.75 1.13 1:0.0013 2000 1.86 0.73 1:0.0009 3000 1.86 1.06 1:0.0006 2000 0.94 0.70 1:0.0005 3000 0.94 1.03 1:0.0003 綠膿桿菌 24小時 87.5 - - - (Ps. aeruginosa) - 75 - ' ATCC#9027 65 9.4 0.87 1:0.1446 87.5 9.4 1.13 1:0.1074 48小時 110 - - 17 94379D02 1377027 87.5 110 110 125 9.4 9.4 4.6 0.87 1.08 1.04 金黃色葡萄球菌 24小時 110 - - (S. aureus) - 15 - ATCC#6538 30 7.5 0.77 42.5 7.5 89 52.5 7.5 98 65 7.5 1.09 52.5 3.8 0.73 65 3.8 0.84 87.5 3.8 1.05 110 0.94 1.06 48小時 110 - - * 30 6.5 15 0.56 8.75 15 0.58 11 15 0.6 20 15 0.68 30 15 0.77 42.5 15 0.89 52.5 15 0.98 65 15 1.09 42.5 7.5 0.64 52.5 7.5 0.73 65 7.5 0.84 87.5 7,5 1.05 65 3.8 0.72 110 1.8 1.06 110 0.94 1.03 1:0.1074 1:0.0855 1:0.0418 1:0.2500 1:0.1765 1:0.1429 1:0.1154 1:0.0724 1:0.0585 1:0.0434 1:0.0085 1:2.3077 1:1.7143 1:1.3636 1:0-7500 1:0.5000 1:0.3529 1:0.2857 1:0.2308 1:0.1765 1:0.1429 1:0.1154 1:0.0857 1:0.0585 1:0.0164 1:0.0085 18 94379D02 1377027 表4
Ca : Phospholipid PTM(肉豆蔻酿胺丙基丙二醇-氯化二曱 基銨填酸醋）之ppm(活性成分）
Cb:MBIT(N-曱基-1，2-苯并異嗟峻淋-3-酮）之ppm(活性成分） 比率：Ca : Cb
測試生物 接觸時間 Ca Cb S.I. Ca：Cb 黑麴菌（A. niger) 3天 1100 - - • ATCC# 16404 - 37.5 • - 425 18.8 0.89 1:0.0442 525 18.8 0.98 1:0.0358 650 18.8 1.09 1:0.0289 525 9.4 0.73 1:0.0179 650 9.4 0.84 10.0145 875 9.4 1.05 1:0.0107 1100 2.4 1.06 1:0.0022 1100 1.2 1.03 1:0.0011 7天 1100 - - - 19 94379D02 1377027 2 20 200 525 650 20 52.5 87.5 200 425 650 875 650 875 1100 650 875 1100 1100 1100 1100 150 75 75 75 75 75 37.5 37.5 37.5 37.5 37.5 37.5 37.5 18.8 18.8 18.8 9.4 9.4 9.4 4.7 2.4 1.2 0.50 0.52 0.68 0.98 1.09 0.27 0.3 0.33 0.43 0.64 0.84 1.05 0.72 0.92 1.13 0.65 0.86 1.06 1.03 1.02 1.01 1:37.5000 1:3.7500 1:0.3750 1:0.1429 10.1154 1:1.8750 1:0.7143 1:0.4286 1:0.1875 1:0.0882 1:0.0577 1:0.0429 1:0.0289 1:0.0215 1:0.0171 1:0.0145 1:0.0107 1:0.0085 1:0.0043 1:0.0022 1:0.0011 白色念珠菌 48小時 1100 .· - (C. albicans) - 30 - · ATCC# 10231 525 15 0.98 1:0.0286 650 15 1.09 1:0.0231 525 7.5 0.73 1:0.0143 650 7.5 0.84 1:0.0115 875 7.5 1.05 1:0.0086 650 3.75 0.72 1:0.0058 875 3.75 0.92 1:0.0043 1100 3.75 1.13 1Ό.0034 875 1.86 0.86 1:0.0021 1100 1.86 1.06 1:0.0017 875 0.94 0.83 1:0.0011 1100 0.94 1.03 1Ό.0009 72小時 1100 • - • - 60 - 2 30 0.50 1:15.0000 20 30 0.52 1:1.5000 110 30 0.60 1:0.2727 200 30 0.68 1:0.1500 300 30 0.77 1:0.1000 425 30 0.89 1:0.0706 525 30 0.98 1:0.0571 650 30 1.09 1:0.0462 525 15 0.73 1:0.0286 650 15 0.84 1:0.0231 525 7.5 0.6 1:0.0143 650 7.5 0.72 1:0.0115 875 7.5 0.92 1:0_0086 650 3.75 0.65 1:0.0058 20 94379D02 1377027 > *»
875 1100 875 1100 875 1100 3.75 3.75 1.86 1.86 0.94 0.94 0.86 1.06 0.83 1.03 0.81 1.02 1:0.0043 1:0.0034 1:0.0021 1:0.0017 1:0.0011 1:0.0009 綠膿桿菌 24小時 425 畢 - - (Ps. aeruginosa) - 75 * ATCC#9027 425 4.6 1.06 1:0.0108 48小時 525 - - - - 125 - • 525 4.6 1.04 1:0.0088 金黃色葡萄球菌 24小時 10 - - - (S. aureus) - 15 - ATCC#6538 2.625 7.5 0.76 1:2.8571 3.25 7.5 0.83 1:2.3077 4.375 7.5 0.94 1:1.7143 5.5 7.5 1.05 1:1.3636 4.375 3.8 0.69 1:0.8686 5.5 3.8 0.80 1:0.6909 10 3.8 1.25 1:0.3800 4.375 1.8 0.56 1:0.4114 5.5 1.8 0.67 1:0.3273 10 1.8 1.12 1:0.1800 10 0.94 1.06 1:0.0940 48小時 10 - - - - 30 - • 0.1 15 0.51 1:150.0000 0.5 15 0.55 1:30.0000 1 15 0.6 1:15.0000 1.5 15 0.65 1:10.0000 2.125 15 0.71 1:7.0588 2.625 15 0.76 1:5.7143 3.25 15 0.83 1:4.6154 4.375 15 0.94 1:3.4286 5.5 15 1.05 1:2.7273 4.375 7.5 0.69 1:1.7143 5.5 7.5 0.80 1:1.3636 10 7.5 1.25 1:0.7500 4.375 3.8 0.56 1:0.8686 5.5 3.8 0.68 1:0.6909 10 3.8 1.13 1:0.3800 5.5 1.8 0.61 1:0.3273 10 1.8 1.06 1:0.1800 10 0.94 1.03 1:0.0940 21 94379D02 1377027 表5
Ca : Caprylic acid(辛酸）之 ppm(活性成分）
Cb:MBIT(N-曱基-1，2-苯并異噻唑啉-3-酮）之ppm(活性成分） 比率：Ca : Cb 劂試生物 接觸時間 Ca Cb S.L Ca：Cb 黑麴菌（A.niger) 3天 650 - - * ATCC# 16404 * 75 425 18.8 0.9 1:0.0442 525 18.8 1.06 1Ό.0358 525 9.4 0.93 1Ό.0Χ79 650 9.4 1.13 1:0.0145 525 4.7 0.87 1:0.0090 525 2.4 0.84 1:0.0046 650 2.4 1.03 1:0.0037 650 1.2 1.02 1:0.0018 7天 875 - - * - 150 - 110 75 0.63 1:0.6818 200 75 0.73 1:0.3750 300 75 0.84 1Ό.2500 425 75 0.99 1:0.1765 650 37.5 0.99 1Ό.0577 425 18.8 0,61 1:0.0442 650 18.8 0.87 1:0.0289 875 18.8 L13 1:0.0215 875 9.4 1.06 1:0.0107 875 4.7 1.03 1:0.0054 875 2.4 1.02 1:0.0027 875 1.2 1,01 1:0.0014 白色念珠菌 48小時 65 音 - - (C. albicans) - 30 • - ATCC #10231 42.5 7.5 0.9 1:0.1765 52.5 7.5 1.06 1:0.1429 65 1.86 1.06 1:0.0286 65 0.94 1.03 1:0.0145 72小時 87.5 - • - • 30 - - 42.5 15 0.99 1:0.3529 42.5 7.5 0,74 1:0,1765 52.5 7.5 0.85 1:0.1429 65 7.5 0.99 1:0.1154 65 3,75 0.87 1:0.0577 87.5 3.75 1.13 1:0.0429 87.5 1.86 1.06 1:0.0213 87.5 0.94 1.03 1:0.0107 綠腹桿菌 48小時 >11000 • * - (Ps.aeruginosa) - 125 • ATCC#9027 8750 75 1.4 1:0.0086 11000 37.5 1.3 1:0.0034 11000 18.75 1.15 1:0.0017 11000 9.4 1.08 1：0.0009 11000 4.6 1.04 1:0.0004 金黃色葡萄球面 24小時 425 • - - (S. aureus) - 15 - - ATCC#6538 425 0.94 1.06 1:0.0022 48小時 425 - • - - 30 - - 425 1.8 1.06 1:0.0042 425 0.94 1.03 1:0.0022 22 94379D02 1377027 表6
Ca: SENSIVASC 50 (3[(2-乙基己基）氧基]1，2-丙二醇）（2-乙基己基甘油）之ppm(活性成分）
Cb:MBIT(N-曱基-1，2-苯并異噻唑啉-3-酮）之ppm(活性成分） 比率：Ca : Cb
測試生物 接觸時間 Ca Cb S.I. Ca：Cb 黑麴菌（A. niger) 3天 875 - - - ATCC# 16404 • 37.5 • * 650 9.4 0.99 1:0.0145 650 4.7 0.87 1:0.0072 875 4.7 1·13 1:0.0054 875 2.4 1.06 1:0.0027 875 1.2 1.03 1:0.0014 7天 1100 - - 150 - - 87.5 75 0.58 1:0.8571 110 75 0.60 1:0.6818 200 75 0.68 1:0.3750 300 75 0.77 1:0.2500 425 75 0.89 1:0.1765 525 75 0.98 1:0.1429 650 75 1.09 1:0.1154 650 37.5 0.84 1:0.0577 1100 9.4 1.06 1:0.0085 1100 4.7 1.03 1:0.0043 1100 2.4 1.02 1:0.0022 1100 1.2 1.01 1:0.0011 白色念珠菌 48小時 2000 - - - (C. albicans) - 30 - - ATCC# 10231 6.5 15 0.50 1:2.3077 11 15 0.51 1:1.3636 110 15 0.56 1:0.1364 200 15 0.60 1:0.0750 300 15 0.65 1:0.0500 650 15 0.83 1:0.0231 875 15 0.94 1:0.0171 1100 15 1.05 1:0.0136 2000 1.86 1.06 1:0.0009 23 94379D02 1377027 2000 0.94 1.03 1:0.0005 72小時 2000 - - - 30 - - 425 15 0.71 1:0.0353 525 15 0.76 1:0.0286 650 15 0.83 1:0.0231 875 15 0.94 1:0.0171 1100 15 1.05 1:0.0136 2000 1.86 1.06 1:0.0009 2000 0.94 1.03 1:0.0005 綠腹桿菌 24小時 11000 • _ (Ps. aeruginosa) - 75 - * ATCC#9027 8750 37.5 1.3 1:0.0043 48小時 11000 - - * - 125 * 4250 75 0.99 1:0.0176 金黃色葡萄球菌 24小時 2000 - - - (S.aureus) - 30 - - ATCC#6538 8.75 15 0.5 1:1.7143 20 15 0.51 1:0.7500 42.5 15 0.52 1:0.3529 65 15 0.53 1:0.2308 110 15 0.56 1:0.1364 200 15 0.6 1:0.0750 425 15 0.71 1:0.0353 525 15 0.76 1:0.0286 650 15 0.83 1:0.0231 875 15 0.94 1:0.0171 1100 15 1.05 1:0.0136 2000 1.8 1.06 1:0.0009 2000 0.94 1.03 1:0.0005 48小時 2000 - - - - 30 - - 8.75 15 0.50 1:1.7143 20 15 0.51 10.7500 42.5 15 0.52 1:0.3529 65 15 0.53 1:0.2308 110 15 0.56 1:0.1364 200 15 0.60 1:0.0750 425 15 0.71 1:0.0353 525 15 0.76 1:0.0286 650 15 0.83 1:0.0231 875 15 0.94 1:0.0171 1100 15 1.05 1:0.0136 2000 1.8 1.06 1:0.0009 2000 0.94 1.03 1:0.0005 24 94379D02 1377027 » 表7
Ca : CAPMUL MCM C8(單辛酸甘油酯）之ppm(活性成分） Cb:MBIT(N-曱基-1，2-笨并異噻唑啉-3-酮）之ppm(活性成分） 比率：Ca : Cb
到試生物 接觸時間 Ca Cb S.I. Ca：Cb 黑鲍菌（A. niger) 3天 4250 - ATCC # 16404 - 75 釋 2000 37.5 0.97 1:0.0188 3000 37.5 1.21 1:0.0125 2000 18.8 0.72 1:0.0094 3000 18.8 0.96 1:0.0063 4250 18.8 1.25 1:0.0044 2000 9.4 0.60 1:0.0047 3000 9.4 0.83 1:0.0031 4250 9.4 1.13 1:0.0022 2000 4.7 0.53 1:0.0024 3000 4.7 0.77 1:0.0016 4250 4.7 1.06 1:0.0011 2000 2.4 0.5 1:0.0012 3000 2.4 0.74 1:0.0008 4250 2.4 1.03 1：0.0006 3000 1.2 0.72 1:0.0004 4250 1.2 1.02 1:0.0003 7天 4250 - - • - 150 1100 75 0.76 1:0.0682 2000 75 0.97 1:0.0375 3000 75 1.21 1:0.0250 2000 37.5 0.72 1:0.0188 3000 37.5 0.96 1Ό.0125 4250 37.5 1.25 1:0.0088 2000 18.8 0.60 1:0.0094 3000 18.8 0.83 1:0.0063 4250 18.8 1.13 1:0.0044 2000 9.4 0.53 1:0.0047 3000 9.4 0.77 1:0.0031 4250 9.4 1.06 1:0.0022 2000 4.7 0.50 1:0.0024 3000 4.7 0.74 1:0.0016 4250 4.7 1.03 1:0.0011 2000 2.4 0.49 1:0.0012 3000 2.4 0.72 1:0.0008 4250 2.4 1.02 1:0.0006 白色念珠菌 48小時 200 - - - (C. albicans) - 30 - - ATCC# 10231 0.2 15 0.50 1:75.0000 2 15 0.51 1:7.5000 20 15 0.60 1:0.7500 42.5 15 0.71 1:0.3529 65 15 0.83 1:0.2308 25 94379D02 1377027 87.5 15 0.94 1:(U714 110 15 1.05 1:0.1364 200 1.86 1.06 1:0.0093 200 0.94 1.03 1:0.0047 72小時 200 - - - 30 - 0.2 15 0.50 1:75.0000 2 15 0.51 1:7.5000 20 15 0.6 1:0.7500 42.5 15 0.71 1:0.3529 65 15 0.83 10.2308 87.5 15 0.94 1:0.1714 110 15 1.05 1:0.1364 200 1.86 1.06 1:0.0093 200 0.94 1.03 1:0.0047 綠膿桿菌 48小時 >11000 - - (Ps. aeruginosa) 125 - * ATCC#9027 2000 75 0.78 1:0.0375 3000 75 0.87 1:0.0250 4250 75 0.99 1:0.0176 金黃色葡萄球固 24小時 650 - - - (S. aureus) - 30 - - ATCC#6538 0.2 15 0.50 1:75.0000 2 15 0.50 1：7.50Θ0 6.5 15 0.51 1:2.3077 11 15 0.52 1:1.3636 20 15 0.53 1:0.7500 30 15 0.55 1:0.5000 42.5 15 0.57 1:0.3529 52.5 15 0.58 1:0-2857 65 15 0.60 1:0.2308 87.5 15 0.63 1:0.1714 110 15 0.67 1:0.1364 200 15 0.81 1Ό.0750 300 15 0.96 1:0.0500 425 15 1.15 1:0.0353 425 7.5 0.9 1:0.0176 525 7.5 1.06 1:0.0143 48小時 875 - - - - 30 - • 0.2 15 0.50 1:75,0000 2 15 0.50 1:7.5000 6.5 15 0.51 1:2.3077 11 15 0.51 1:1.3636 20 15 0.52 1:0.7500 30 15 0.53 1:0.5000 42.5 15 0.55 1:0.3529 52.5 15 0.56 1:0.2857 65 15 0.57 1:0.2308 87.5 15 0.60 1-0.1714 110 15 0.63 1:0.1364 200 15 0.73 1:0.0750 300 15 0.84 1:0.0500 425 15 0.99 1:0.0353 650 7.5 0.99 1:0.0115 875 1.8 1.06 1:0.0021 875 0.94 1.03 1:0.0011 26 94379D02 1377027 表8
Ca : CapmulMCM CIO (癸酸之單/二甘油自旨（單癸酸甘油酯）） 之ppm(活性成分）
Cb:MBIT(N-曱基-1，2-苯并異嗟吐淋-3-酮）之ppm(活性成分） 比率：Ca : Cb
測試生物 接觸時間 Ca Cb S.I. Ca:Cb 黑錄菌（A. niger) 3天 2000 - - - ATCC# 16404 - 75 - - 4.25 37.5 0.50 1:8.8235 6.5 37.5 0.50 1:5.7692 11 37.5 0.51 1:3.4091 30 37.5 0.52 1 1.2500 65 37.5 0.53 1:0.5769 110 37.5 0.56 1:0.3409 200 37.5 0.60 1:0.1875 300 37.5 0.65 1:0.1250 425 37.5 0.71 1:0.0882 525 37.5 0.76 1:0.0714 650 37.5 0.83 1:0.0577 875 37.5 0.94 1:0.0429 1100 37.5 1.05 1:0.0341 1100 18.8 0.8 1:0.0171 2000 4.7 1.06 1:0.0024 2000 2.4 1.03 10.0012 2000 1.2 1.02 1:0.0006 7天 2000 - - - - 150 - - 525 75 0.76 1:0.1429 650 75 0.83 1:0.1154 875 75 0.94 1:0.0857 1100 75 1.05 1:0.0682 1100 37.5 0.8 1:0.0341 1100 18.8 0.68 1:0.0171 2000 9.4 1.06 1:0.0047 2000 4.7 1.03 1:0.0024 2000 2.4 1.02 1:0.0012 2000 1.2 1.01 1:0.0006 白色念珠菌 48小時 425 - - - CC. albicans) - 30 - - ATCC# 10231 87.5 15 0.71 1:0.1714 110 15 0.76 1:0.1364 200 15 0.97 1:0.0750 300 15 1.21 1:0.0500 27 94379D02 1377027 200 7.5 0.72 1:0.0375 300 7.5 0.96 1:0.0250 425 7.5 1.25 1:0.0176 200 3.75 0.60 1:0.0188 300 3.75 0 83 1:0.0125 425 3.75 113 1:0.0088 200 1.86 0.53 1:0.0093 300 1.86 0.77 1:0.0062 425 1.86 1.06 1:0.0044 200 0.94 0.50 1:0.0047 300 0.94 0.74 1:0.0031 425 0.94 1Ό3 1:0.0022 72小時 425 - - * - 30 • * 87.5 15 0.71 1:0.1714 110 15 0.76 1:0.1364 200 15 0.97 1Ό.0750 300 15 1.21 1:0.0500 200 7.5 0.72 1:0.0375 300 7.5 0.98 1:0.0250 425 7.5 1.25 10.0176 200 3.75 0.60 1:0.0188 300 3.75 0.83 i:0.0125 425 3.75 1.13 1-0.0088 200 1.86 0.53 1:0.0093 300 1.86 0.77 1:0.0062 425 1.86 1.06 1:0.0044 200 0.94 0.50 1:0.0047 300 0.94 0.74 1:0.0031 425 0.94 1.03 1:0.0022 綠膿桿菌 24小時 11000 - (Ps. aeruginosa) - 75 ATCC#9027 - 37.5 - 18.75 - 9.4 - 4.6 48小時 11000 - - 125 - 75 - 37.5 • 18.75 - 9.4 - 4.6 金黃色葡萄 24小時 200 - (S. aureus) • 30 ATCC#6538 5.25 15 0.53 1:2.8571 11 15 0.56 1 1.3636 20 15 0.60 1:0.7500 30 15 0.65 1-0.5000 42.5 15 0.71 1:0.3529 52.5 15 0.76 1Ό.2857 65 15 0.83 1:0.2308 87.5 15 0.94 1:0.1714 110 15 1.05 Γ0.1364 48小時 200 ·. - - 30 - • 65 15 0.83 1:0.2308 87.5 15 0.94 1:0.1714 110 15 1.05 1:0.1364 28 94379D02 1377027 表9
Ca:BI0BAN1246(7 a-乙基二氫-1H，3H，5H-曙唑并（3,4-C) 曙吐）之ppm(活性成分）
Cb:MBIT(N-曱基-1, 2-苯并異噻唑啉-3-酮）之ppm(活性成分） 比率：Ca : Cb
阑試生物 接觸時間 Ca Cb Si Ca：Cb 黑魏菌（A. niger) 3天 650 - • - ATCC # 16404 37.5 * 200 18.8 0.81 1:0.0940 300 18.8 0.96 1:0.0627 425 18.8 1.16 1:0.0442 425 9.4 0.90 1:0.0221 525 9.4 1.06 1:0.0179 425 4.7 0.78 1:0.0111 525 4.7 0.93 1:0.0090 650 4.7 1.13 1:0.0072 425 2.4 0.72 1:0.0056 525 2.4 0.87 1:0.0046 650 2.4 1.06 1:0.0037 425 1.2 0.69 1:0.0028 525 1.2 0.84 1:0.0023 650 1.2 1.03 1:0.0018 7天 875 - - - 150 - - 425 75 0.99 1:0.1765 650 37.5 0.99 1:0.0577 525 18.8 0.73 1:0.0358 650 18.8 0.87 1:0.0289 875 18.8 1.13 1:0.0215 875 9.4 1.06 1:0.0107 875 4.7 1.03 1:0.0054 875 2.5 1.02 10.0029 875 1.2 1.01 1:0.0014 白色念珠菌 48小時 3000 • - (C. albicans) - 30 - - ATCC# 10231 875 15 0.79 1:0.0171 1100 15 0.87 1:0.0136 2000 15 1.17 1:0.0075 875 7.5 0.54 1:0.0086 1100 7.5 0.62 1:0.0068 2000 7.5 0.92 1:0.0038 29 94379D02 1377027 3000 7.5 1.25 1:0.0025 2000 3.75 0.79 1:0.0019 3000 3.75 1.13 1:0.0013 2000 1.86 0.73 1:0.0009 3000 1.86 1.06 1:0.0006 3000 0.94 1.03 1:0.0003 72小時 4250 - - - - 30 - - 875 15 0.71 1:0.0171 1100 15 0.76 1:0.0136 2000 15 0.97 1:0.0075 3000 15 1.21 1:0.0050 875 7.5 0.46 1:0.0086 1100 7,5 0.51 1:0.0068 2000 7.5 0.72 1:0.0038 3000 7.5 0.96 1:0.0025 4250 7.5 1.25 1:0.0018 2000 3.75 0.6 1:0.0019 3000 3.75 0.83 1:0.0013 4250 3.75 1.13 1:0.0009 2000 1.86 0.53 1:0,0009 3000 0.94 0.74 1Ό.0003 4250 0.94 1.03 1:0.0002 綠膿桿途 24小時 100 - - - - (Ps. aeruginosa) * 75 - - ATCC#9027 26.25 75 1.26 1:2.8571 43.75 37.5 0.94 1:0.8571 55 37.5 1.05 1:0.6818 55 18.75 0.80 1:0.3409 100 18.75 1.25 1:0.1875 55 9.4 0.68 1:0.1709 100 9.4 1.13 1:0.0940 100 4.6 1.06 1:0.0460 48小時 150 - - - • 125 • 26.25 75 0.78 1:2.8571 32.5 75 0.82 1:2.3077 43.75 75 0.89 1:1.7143 55 75 0.97 1:1.3636 100 75 1.27 1:0.7500 55 37.5 0.67 1:0.6818 100 37.5 0.97 1:0.3750 150 37.5 1.3 1:0.2500 100 18.75 0.82 1:0.1875 150 18.75 1.15 1:0.1250 150 9.4 1.08 1:0.0627 150 4.6 1.04 1:0.0307 金黃色葡萄球菌 24小時 55 - - - (S. aureus) - 30 - - ATCC#6538 2.125 15 0.54 1:7.0588 5.5 15 0.60 1:2.7273 10 15 0.68 1:1.5000 30 94379D02 1377027
26.25 15 0.98 1:0.5714 32.5 15 1.09 1:0.4615 21.25 7.5 0.64 1:0.3529 26.25 7.5 0.73 1:0.2857 32.5 7.5 0.84 1:0.2308 43.75 7.5 1.05 1:0.1714 32.5 3.8 0.72 1:0.1169 43.75 3.8 0.92 1:0.0869 55 3.8 1.13 1:0.0691 55 1.8 1,06 1:0.0327 55 0.94 1.03 1:0.0171 48小時 55 - - _ - 30 - • 2.125 15 0.54 1:7.0588 5.5 15 0.60 1:2.7273 10 15 0.68 1:1.5000 26.25 15 0.98 1:0.5714 32.5 15 1.09 1:0.4615 21.25 7.5 0.64 1:0.352? 26.25 7.5 0.73 1:0.2857 32.5 7.5 0.84 1:0.2308 43.75 7.5 1.05 1:0.1714 32.5 3.8 0.72 1:0.1169 43.75 3.8 0.92 1:0.0869 55 3.8 1.13 1:0.0691 55 1.8 1.06 1:0.0327 55 0.94 1,03 1:0.0171
31 94379D02 1377027 表10
Ca:TCMTB(2-(硫基氰基甲基硫基）笨并噻唑）之PPm(活性成分） Cb : MBIT (N-曱基-1，2-苯并異噻唑啉-3-酮）之ppm(活性成分） 比率：Ca : Cb 測試生物 接觸時間 Ca Cb S.I. Ca'Cb 黑麵菌（A. niger) 3天 3 - • * ATCC# 16404 • 37.5 - * 3 2.4 1.06 1:0.8000 3 1.2 1.03 1:0.4000 7天 8.75 - • • • 150 - - 0.525 75 0.56 1:142.8571 0.65 75 0.57 1:115.3846 0.875 75 0.60 1:85.7143 1.1 75 0.63 1:68.1818 2 75 0.73 1:37.5000 3 75 0.84 1:25.0000 4.25 75 0.99 1:17.6471 8.75 9.4 1.06 1:1.0743 6.5 2.4 0.76 1：0.3692 8.75 2.4 1.02 1:0.2743 8.75 1.2 1.01 1:0.1371 白色念珠菌 48小時 4.25 - - (C. albicans) - 30 - ATCC# 10231 4.25 1.86 1.06 1Ό.4376 4.25 0.94 1.03 1:0.2212 72小時 5.25 - - - -. 60 - - 1.1 30 0.71 1:27.2727 2 30 0.88 1:15.0000 3 30 1.07 1:10.0000 4.25 15 1.06 1:3.5294 4.25 7.5 0.93 1:1.7647 5.25 3.75 1.06 ΓΌ.7143 4.25 1.86 0.84 1:0.4376 5.25 1.86 1.03 1:0.3543 4.25 0.94 0.83 1:0.2212 5.25 0.94 1.02 1:0.1790 綠膿桿菌 48小時 212.5 - - - (Ps. aeruginosa) • 125 - ATCC#9027 21.25 75 0.70 1:3.5294 26.25 75 0.72 1:2.8571 43.75 75 0.81 11.7143 55 75 0.86 1:1.3636 100 75 1.07 1:0.7500 150 37.5 1.01 1*0.2500 150 18.75 0.86 1:0.1250 212.5 18.75 1.15 1:0,0882 150 9.4 0.78 1:00627 212.5 9.4 1.08 1:0.0442 212.5 4.6 1.04 1:0.0216 金黃色葡萄球菌 24小時 26.25 - - * (S. aureus) - 15 - - ATCC#6538 26.25 0.94 1:06 1:0.0358 32 94379D02 1377027 【圖式簡單說明】 無 【主要元件符號說明】 無 33 94379D02
Claims (1)
- 七、申請專利範圍： 一種殺菌組成物，包含： (a) N-甲基-1，2-笨并異嗟嗤琳一3-_ ;及 (b) 羥基曱基甘胺酸鈉。 2·如申請專利範圍第1項之殺菌組成物，其中，經基甲基 甘胺酸鈉對N-曱基-1，2-苯并異噻唑啉_3_酮之比率為^ 1 : 0. 0005 至 1 : 2.3。 3. 如申請專利範圍第2項之殺菌組成物，其中，羥基甲基 甘胺馱鈉對N-曱基-1，2-苯并異嘆唾琳—3-酮之該比率 為 1 : 〇· 14 至 1 : 2. 3。 4. 如申請專利範圍第3項之殺菌組成物，其中，羥基甲基 甘胺酸納對N一甲基_i，2_苯并異嗟哇琳—3，之該比率土 為 1 : 29 至 1 : 2. 3。 94379D02 1
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