TWI372620B - Treatment of autoimmune diseases - Google Patents

Treatment of autoimmune diseases

Info

Publication number: TWI372620B
Authority: TW; Taiwan
Prior art keywords: autoimmune diseases; treatment; neuritis; uveitis; invention describes
Prior art date: 2005-09-09

Application number

TW099117063A

Other languages

English (en)

Other versions

TW201034659A (en

Inventor

Rainer Albert

Nigel Graham Cooke

Barbara Nuesslein-Hildesheim

Sven Weiler

Original Assignee

Novartis Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-09-09

Filing date

2006-09-08

Publication date

2012-09-21

2006-09-08 Application filed by Novartis Ag filed Critical Novartis Ag

2010-10-01 Publication of TW201034659A publication Critical patent/TW201034659A/zh

2012-09-21 Application granted granted Critical

2012-09-21 Publication of TWI372620B publication Critical patent/TWI372620B/zh

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Epidemiology (AREA)
Immunology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Emergency Medicine (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Ophthalmology & Optometry (AREA)
Transplantation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

TW099117063A 2005-09-09 2006-09-08 Treatment of autoimmune diseases TWI372620B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US71599005P	2005-09-09	2005-09-09

Publications (2)

Publication Number	Publication Date
TW201034659A TW201034659A (en)	2010-10-01
TWI372620B true TWI372620B (en)	2012-09-21

Family

ID=37056992

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
TW099117063A TWI372620B (en)	2005-09-09	2006-09-08	Treatment of autoimmune diseases
TW095133326A TWI376223B (en)	2005-09-09	2006-09-08	Treatment of autoimmune diseases

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
TW095133326A TWI376223B (en)	2005-09-09	2006-09-08	Treatment of autoimmune diseases

Country Status (28)

Country	Link
US (1)	US20080200438A1 (zh)
EP (2)	EP2295049B1 (zh)
JP (4)	JP5244598B2 (zh)
KR (3)	KR20140117704A (zh)
CN (1)	CN101257899B (zh)
AT (1)	ATE489948T1 (zh)
AU (2)	AU2006289100B2 (zh)
BR (1)	BRPI0615906A2 (zh)
CA (2)	CA2820510A1 (zh)
CY (1)	CY1111285T1 (zh)
DE (1)	DE602006018629D1 (zh)
DK (2)	DK2295049T3 (zh)
ES (2)	ES2529724T3 (zh)
IL (2)	IL189665A (zh)
JO (1)	JO2655B1 (zh)
MA (1)	MA29787B1 (zh)
MX (1)	MX2008003170A (zh)
NO (1)	NO20081727L (zh)
NZ (2)	NZ566137A (zh)
PL (2)	PL2295049T3 (zh)
PT (2)	PT2295049E (zh)
RU (2)	RU2424795C2 (zh)
SG (1)	SG165364A1 (zh)
SI (2)	SI1926483T1 (zh)
TN (1)	TNSN08103A1 (zh)
TW (2)	TWI372620B (zh)
WO (1)	WO2007028821A2 (zh)
ZA (1)	ZA200801694B (zh)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
RU2396982C2 (ru) *	2004-07-16	2010-08-20	Киорин Фармасьютикал Ко., Лтд.	Эффективный способ использования лекарственных средств и способ предотвращения выраженности побочных эффектов
ES2563034T3 (es)	2004-10-12	2016-03-10	Kyorin Pharmaceutical Co., Ltd.	Procedimiento para producir hidrocloruro de 2-amino-2-[2-[4-(3-benciloxifeniltio)-2-clorofenil]etil]-1,3-propanodiol e hidratos del mismo, e intermedios para la producción de los mismos
EP1932522B1 (en) *	2005-10-07	2012-05-23	Kyorin Pharmaceutical Co., Ltd.	Therapeutic agent for liver disease containing 2-amino-1,3-propanediol derivative as active ingredient
TWI389683B (zh) *	2006-02-06	2013-03-21	Kyorin Seiyaku Kk	A therapeutic agent for an inflammatory bowel disease or an inflammatory bowel disease treatment using a 2-amino-1,3-propanediol derivative as an active ingredient
JP5140593B2 (ja) *	2006-08-08	2013-02-06	杏林製薬株式会社	アミノアルコール誘導体及びそれらを有効成分とする免疫抑制剤
HRP20131172T1 (hr) *	2006-08-08	2014-01-17	Kyorin Pharmaceutical Co., Ltd.	Esterski derivat aminofosforne kiseline i modulator receptora s1p koji sadrži isti kao aktivni sastojak
US20100093745A1 (en) *	2007-02-13	2010-04-15	Kazuhiko Kuriyama	Therapeutic agent or prophylactic agent for demyelinating disease comprising amino alcohol derivative as active ingredient
US8476305B2 (en)	2008-02-07	2013-07-02	Kyorin Pharmaceutical Co., Ltd.	Therapeutic agent or prophylactic agent for inflammatory bowel disease comprising amino alcohol derivative as active ingredient
MY154685A (en) *	2008-05-20	2015-07-15	Kyorin Seiyaku Kk	Agent for maintanance of induced remission
CN102119028A (zh) *	2008-08-18	2011-07-06	诺瓦提斯公司	用于治疗脱髓鞘性周围神经病的氨基醇衍生物
MX2012012926A (es) *	2010-05-06	2012-12-17	Novartis Ag	Tratamiento de enfermedades autoinmunes.
EA201201515A1 (ru) *	2010-05-06	2013-08-30	Новартис Аг	Схема приема производных диарилсульфидов

Family Cites Families (15)

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Publication number	Priority date	Publication date	Assignee	Title
US5141421A (en) *	1991-12-17	1992-08-25	Carrier Corporation	Nested coupling mechanism for scroll machines
DE4428835A1 (de) *	1994-08-01	1996-02-08	Schering Ag	Neue 3-substituierte 3H-2,3-Benzodiazepinderivate, deren Herstellung und Verwendung als Arzneimittel
DE69840169D1 (de) *	1997-02-27	2008-12-11	Novartis Ag	Arzneimittel zubereitung enthaltend 2-amino-2-ä2-(4-octylphenyl)ethylüpropane-1,3-diol, ein lecithin und ein saccharid
BRPI0212894B8 (pt) *	2001-09-27	2021-05-25	Kyorin Seiyaku Kk	composto ou sal do mesmo farmaceuticamente aceitável e composição farmacêutica
US6963012B2 (en) *	2001-09-27	2005-11-08	Kyorin Pharmaceutical Co., Ltd.	Diaryl ether derivative, addition salt thereof, and immunosuppressant
KR101003877B1 (ko)	2002-09-19	2010-12-30	교린 세이야꾸 가부시키 가이샤	아미노알코올 유도체와 그 부가염 및 면역 억제제
KR101095807B1 (ko) *	2002-09-24	2011-12-21	노파르티스 아게	탈수초성 장애의 치료에 있어서의 스핑고신-1-포스페이트 수용체 아고니스트
WO2004028512A1 (en) *	2002-09-28	2004-04-08	Mcneil-Ppc, Inc.	Modified release dosage form with two cores
SI1602660T1 (sl) *	2003-02-18	2011-06-30	Kyorin Seiyaku Kk	Derivati aminofosfonske kisline, njihove adicijske soli in modulatorji receptorja za S1P
DE602004017847D1 (de) *	2003-04-08	2009-01-02	Novartis Ag	Feste pharmazeutische darreichungsformen mit einem s1p rezeptoragonisten und einem zuckeralkohol
WO2005014525A2 (en) *	2003-08-12	2005-02-17	Mitsubishi Pharma Corporation	Bi-aryl compound having immunosuppressive activity
AU2004268052B2 (en) *	2003-08-28	2009-11-19	Novartis Ag	Aminopropanol derivatives
RU2396982C2 (ru) *	2004-07-16	2010-08-20	Киорин Фармасьютикал Ко., Лтд.	Эффективный способ использования лекарственных средств и способ предотвращения выраженности побочных эффектов
ES2495690T3 (es) *	2004-11-29	2014-09-17	Novartis Ag	Régimen de dosificación de un agonista del receptor S1P
GB0504544D0 (en) *	2005-03-04	2005-04-13	Novartis Ag	Organic compounds

2006
- 2006-09-07 SG SG201006580-3A patent/SG165364A1/en unknown
- 2006-09-07 CN CN2006800328984A patent/CN101257899B/zh not_active Expired - Fee Related
- 2006-09-07 WO PCT/EP2006/066150 patent/WO2007028821A2/en not_active Ceased
- 2006-09-07 JP JP2008529636A patent/JP5244598B2/ja active Active
- 2006-09-07 CA CA2820510A patent/CA2820510A1/en not_active Abandoned
- 2006-09-07 NZ NZ566137A patent/NZ566137A/en not_active IP Right Cessation
- 2006-09-07 BR BRPI0615906-0A patent/BRPI0615906A2/pt not_active IP Right Cessation
- 2006-09-07 MX MX2008003170A patent/MX2008003170A/es active IP Right Grant
- 2006-09-07 KR KR1020147026128A patent/KR20140117704A/ko not_active Ceased
- 2006-09-07 JO JO2006298A patent/JO2655B1/en active
- 2006-09-07 SI SI200630937T patent/SI1926483T1/sl unknown
- 2006-09-07 AU AU2006289100A patent/AU2006289100B2/en not_active Ceased
- 2006-09-07 NZ NZ588372A patent/NZ588372A/en not_active IP Right Cessation
- 2006-09-07 AT AT06793341T patent/ATE489948T1/de active
- 2006-09-07 CA CA2620554A patent/CA2620554C/en not_active Expired - Fee Related
- 2006-09-07 EP EP10174280.7A patent/EP2295049B1/en not_active Not-in-force
- 2006-09-07 RU RU2008113187/15A patent/RU2424795C2/ru not_active IP Right Cessation
- 2006-09-07 US US12/065,096 patent/US20080200438A1/en not_active Abandoned
- 2006-09-07 DK DK10174280.7T patent/DK2295049T3/en active
- 2006-09-07 KR KR1020147001496A patent/KR101476591B1/ko not_active Expired - Fee Related
- 2006-09-07 DE DE602006018629T patent/DE602006018629D1/de active Active
- 2006-09-07 ES ES10174280.7T patent/ES2529724T3/es active Active
- 2006-09-07 DK DK06793341.6T patent/DK1926483T3/da active
- 2006-09-07 PL PL10174280T patent/PL2295049T3/pl unknown
- 2006-09-07 PT PT10174280T patent/PT2295049E/pt unknown
- 2006-09-07 PL PL06793341T patent/PL1926483T3/pl unknown
- 2006-09-07 SI SI200631889T patent/SI2295049T1/sl unknown
- 2006-09-07 ES ES06793341T patent/ES2357426T3/es active Active
- 2006-09-07 EP EP06793341A patent/EP1926483B1/en active Active
- 2006-09-07 RU RU2011111117/15A patent/RU2493840C2/ru not_active IP Right Cessation
- 2006-09-07 PT PT06793341T patent/PT1926483E/pt unknown
- 2006-09-08 TW TW099117063A patent/TWI372620B/zh not_active IP Right Cessation
- 2006-09-08 TW TW095133326A patent/TWI376223B/zh active
2008
- 2008-02-21 ZA ZA200801694A patent/ZA200801694B/xx unknown
- 2008-02-21 IL IL189665A patent/IL189665A/en not_active IP Right Cessation
- 2008-03-06 TN TNP2008000103A patent/TNSN08103A1/en unknown
- 2008-03-17 MA MA30758A patent/MA29787B1/fr unknown
- 2008-04-07 NO NO20081727A patent/NO20081727L/no not_active Application Discontinuation
- 2008-04-08 KR KR1020087008413A patent/KR101476451B1/ko not_active Expired - Fee Related
2010
- 2010-09-21 AU AU2010224355A patent/AU2010224355B2/en not_active Ceased
2011
- 2011-03-01 CY CY20111100242T patent/CY1111285T1/el unknown
2012
- 2012-10-17 JP JP2012230044A patent/JP6077265B2/ja not_active Expired - Fee Related
2014
- 2014-06-23 IL IL233328A patent/IL233328A0/en unknown
- 2014-09-29 JP JP2014199069A patent/JP2015025002A/ja not_active Withdrawn
2016
- 2016-09-30 JP JP2016193400A patent/JP2017019854A/ja not_active Withdrawn

Also Published As

Publication number	Publication date
PL2295049T3 (pl)	2015-04-30
JP2013010802A (ja)	2013-01-17
JP2009507810A (ja)	2009-02-26
DK2295049T3 (en)	2015-02-23
EP1926483B1 (en)	2010-12-01
KR20080046231A (ko)	2008-05-26
JO2655B1 (en)	2012-06-17
IL189665A (en)	2014-07-31
PT1926483E (pt)	2011-03-03
IL233328A0 (en)	2014-08-31
SG165364A1 (en)	2010-10-28
CN101257899A (zh)	2008-09-03
MX2008003170A (es)	2008-03-18
AU2006289100B2 (en)	2010-07-22
MA29787B1 (fr)	2008-09-01
CY1111285T1 (el)	2015-08-05
JP2017019854A (ja)	2017-01-26
SI1926483T1 (sl)	2011-04-29
KR101476591B1 (ko)	2014-12-24
US20080200438A1 (en)	2008-08-21
TNSN08103A1 (en)	2009-07-14
WO2007028821A2 (en)	2007-03-15
RU2011111117A (ru)	2012-09-27
AU2010224355A1 (en)	2010-10-14
KR20140117704A (ko)	2014-10-07
EP1926483A2 (en)	2008-06-04
ES2529724T3 (es)	2015-02-25
IL189665A0 (en)	2008-06-05
AU2006289100A1 (en)	2007-03-15
DK1926483T3 (da)	2011-03-14
KR20140019033A (ko)	2014-02-13
PL1926483T3 (pl)	2011-05-31
RU2493840C2 (ru)	2013-09-27
TW200803829A (en)	2008-01-16
TW201034659A (en)	2010-10-01
PT2295049E (pt)	2015-03-02
BRPI0615906A2 (pt)	2011-05-31
CA2820510A1 (en)	2007-03-15
ATE489948T1 (de)	2010-12-15
RU2424795C2 (ru)	2011-07-27
CA2620554A1 (en)	2007-03-15
HK1149906A1 (zh)	2011-10-21
DE602006018629D1 (de)	2011-01-13
ES2357426T3 (es)	2011-04-26
SI2295049T1 (sl)	2015-03-31
KR101476451B1 (ko)	2014-12-24
NO20081727L (no)	2008-06-06
JP2015025002A (ja)	2015-02-05
EP2295049A1 (en)	2011-03-16
ZA200801694B (en)	2009-09-30
NZ588372A (en)	2012-03-30
JP6077265B2 (ja)	2017-02-08
NZ566137A (en)	2011-05-27
CN101257899B (zh)	2012-10-03
RU2008113187A (ru)	2009-10-20
CA2620554C (en)	2013-12-17
AU2010224355B2 (en)	2012-03-29
EP2295049B1 (en)	2014-11-26
JP5244598B2 (ja)	2013-07-24
WO2007028821A3 (en)	2007-05-03
TWI376223B (en)	2012-11-11

Publication	Publication Date	Title
IL233328A0 (en)	2014-08-31	Treatment of autoimmune diseases
TW200509892A (en)	2005-03-16	Novel aminobenzophenone compounds
WO2005032471A3 (en)	2005-07-07	Benzylether and benzylamino beta-secretase inhibitors for the treatment of alzheimer's disease
WO2007022470A3 (en)	2007-06-14	Methods and compositions for treating neurological disease
WO2006058868A8 (de)	2007-01-18	Substituierte pteridine zur behandlung von entzündlichen erkrankungen
SG163517A1 (en)	2010-08-30	Antiviral compounds and methods
TW200806325A (en)	2008-02-01	Therapeutic uses of inhibitors of RTP801
WO2005051914A8 (en)	2005-08-11	Benzylether and benzylamino beta-secretase inhibitors for the treatment of alzheimer's disease
MX2011012015A (es)	2012-04-30	Tratamiento de deterioro cognitivo leve y enfermedad de alzheimer.
DE602006016449D1 (zh)	2010-10-07
WO2006058867A3 (de)	2006-10-26	Substituierte pteridine zur behandlung von entzündlichen erkrankungen
UA90698C2 (en)	2010-05-25	Triazole substituted aminobenzophenone compounds
WO2009136997A3 (en)	2009-12-30	Inhibitors of human cathepsin l, cathepsin b, and cathepsin s
TW200635597A (en)	2006-10-16	Substituted pteridines for the treatment of inflammatory diseases
WO2006078576A3 (en)	2006-10-05	Aminomethyl beta-secretase inhibitors for the treatment of alzheimer's disease
MX2008002166A (es)	2008-04-22	Compuestos y composiciones como mimeticos de trombopoietina (tpo).
WO2007058862A3 (en)	2007-10-11	Imidazolidinone compounds useful as beta-secretase inhibitors for the treatment of alzheimer's disease
TW200633711A (en)	2006-10-01	Substituted pteridines for the treatment of inflammatory diseases
TW200639155A (en)	2006-11-16	Thiazolidinones, their production and use as pharmaceutical agents
IL181713A0 (en)	2008-03-20	Use of il-17f for the treatment and/or prevention of neurological diseases
WO2007019080A3 (en)	2008-01-17	Tricyclic beta-secretase inhibitors for the treatment of alzheimer's disease
TW200603791A (en)	2006-02-01	Compounds and compositions as cathepsin S inhibitors
CY1116051T1 (el)	2017-02-08	Θεραπεια αυτοανοσων ασθενειων
BRPI0402756A (pt)	2006-02-21	método para o tratamento de distúrbios cognitivos
MX2007003281A (es)	2007-05-18	N-etilhidroxietilamina util en el tratamiento de afecciones del sistema nervioso central.

Legal Events

Date	Code	Title	Description
2016-06-21	MM4A	Annulment or lapse of patent due to non-payment of fees