TWI368510B - Tricyclic δ-opioid modulators - Google Patents

Tricyclic δ-opioid modulators

Info

Publication number: TWI368510B
Authority: TW; Taiwan
Prior art keywords: tricyclic; opioid modulators; opioid; modulators
Prior art date: 2003-06-27

Application number

TW093118831A

Other languages

English (en)

Other versions

TW200528105A (en

Inventor

John R Carson

Ellen Codd

Christine M Razler

Andrea Works

Original Assignee

Janssen Pharmaceutica Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-06-27

Filing date

2004-06-28

Publication date

2012-07-21

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=33563931&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=TWI368510(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2004-06-28 Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv

2005-09-01 Publication of TW200528105A publication Critical patent/TW200528105A/zh

2012-07-21 Application granted granted Critical

2012-07-21 Publication of TWI368510B publication Critical patent/TWI368510B/zh

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Psychiatry (AREA)
Immunology (AREA)
Pain & Pain Management (AREA)
Addiction (AREA)
Rheumatology (AREA)
Reproductive Health (AREA)
Physical Education & Sports Medicine (AREA)
Orthopedic Medicine & Surgery (AREA)
Heart & Thoracic Surgery (AREA)
Pulmonology (AREA)
Transplantation (AREA)
Cardiology (AREA)
Gynecology & Obstetrics (AREA)
Pregnancy & Childbirth (AREA)
Psychology (AREA)
Endocrinology (AREA)
Urology & Nephrology (AREA)
Dermatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

TW093118831A 2003-06-27 2004-06-28 Tricyclic δ-opioid modulators TWI368510B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US48338903P	2003-06-27	2003-06-27

Publications (2)

Publication Number	Publication Date
TW200528105A TW200528105A (en)	2005-09-01
TWI368510B true TWI368510B (en)	2012-07-21

Family

ID=33563931

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
TW093118831A TWI368510B (en)	2003-06-27	2004-06-28	Tricyclic δ-opioid modulators

Country Status (19)

Country	Link
US (4)	US7589103B2 (zh)
EP (1)	EP1644373A1 (zh)
JP (1)	JP4810423B2 (zh)
KR (1)	KR101132208B1 (zh)
CN (1)	CN100513407C (zh)
AR (1)	AR044940A1 (zh)
AU (1)	AU2004253898A1 (zh)
BR (1)	BRPI0411998A (zh)
CA (1)	CA2530444C (zh)
CR (1)	CR8166A (zh)
EA (1)	EA015491B1 (zh)
EC (1)	ECSP056256A (zh)
IL (1)	IL172713A0 (zh)
NO (1)	NO333611B1 (zh)
NZ (1)	NZ572901A (zh)
TW (1)	TWI368510B (zh)
UA (1)	UA86024C2 (zh)
WO (1)	WO2005003131A1 (zh)
ZA (1)	ZA200600770B (zh)

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US7781478B2 (en)	2004-07-14	2010-08-24	Ptc Therapeutics, Inc.	Methods for treating hepatitis C
AU2005275181A1 (en)	2004-07-14	2006-02-23	Ptc Therapeutics, Inc.	Methods for treating hepatitis C
US7772271B2 (en)	2004-07-14	2010-08-10	Ptc Therapeutics, Inc.	Methods for treating hepatitis C
US7868037B2 (en)	2004-07-14	2011-01-11	Ptc Therapeutics, Inc.	Methods for treating hepatitis C
NZ553329A (en)	2004-07-22	2010-09-30	Ptc Therapeutics Inc	Thienopyridines for treating hepatitis C
CA2574768A1 (en) *	2004-08-05	2006-02-05	Janssen Pharmaceutica N.V.	Tricyclic delta-opioid modulators
AU2005319060A1 (en) *	2004-12-22	2006-06-29	Janssen Pharmaceutica N.V.	Tricyclic delta-opioid modulators
BRPI0519198A2 (pt) *	2004-12-22	2008-12-30	Janssen Pharmaceutica Nv	moduladores de delta-opiàide tricÍclicos
CA2592464A1 (en) *	2004-12-22	2006-06-29	Janssen Pharmaceutica N.V.	Tricyclic .delta.-opioid modulators
CA2594347A1 (en) *	2005-01-06	2006-07-13	Janssen Pharmaceutica N.V.	Tricyclic d-opioid modulators
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CN110139852A (zh)	2016-11-04	2019-08-16	奥克兰联合服务有限公司	三环杂环衍生物及其用途
KR20190097245A (ko) *	2016-12-28	2019-08-20	헨켈 아게 운트 코. 카게아아	티오크산톤 유도체 광개시제
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WO2005003131A1 (en)	2003-06-27	2005-01-13	Janssen Pharmaceutica N.V.	Tricyclic delta opioid modulators
CA2574768A1 (en) *	2004-08-05	2006-02-05	Janssen Pharmaceutica N.V.	Tricyclic delta-opioid modulators
CA2592464A1 (en) *	2004-12-22	2006-06-29	Janssen Pharmaceutica N.V.	Tricyclic .delta.-opioid modulators
BRPI0519198A2 (pt) *	2004-12-22	2008-12-30	Janssen Pharmaceutica Nv	moduladores de delta-opiàide tricÍclicos
AU2005319060A1 (en) *	2004-12-22	2006-06-29	Janssen Pharmaceutica N.V.	Tricyclic delta-opioid modulators
CA2594347A1 (en)	2005-01-06	2006-07-13	Janssen Pharmaceutica N.V.	Tricyclic d-opioid modulators
CN101243079A (zh) *	2005-06-16	2008-08-13	詹森药业有限公司	三环阿片调节剂

2004
- 2004-06-22 WO PCT/US2004/019911 patent/WO2005003131A1/en not_active Ceased
- 2004-06-22 UA UAA200512736A patent/UA86024C2/ru unknown
- 2004-06-22 NZ NZ572901A patent/NZ572901A/en not_active IP Right Cessation
- 2004-06-22 AU AU2004253898A patent/AU2004253898A1/en not_active Abandoned
- 2004-06-22 BR BRPI0411998-3A patent/BRPI0411998A/pt not_active IP Right Cessation
- 2004-06-22 US US10/873,527 patent/US7589103B2/en active Active
- 2004-06-22 CN CNB2004800237098A patent/CN100513407C/zh not_active Expired - Fee Related
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2005
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Also Published As

Publication number	Publication date
US20090298867A1 (en)	2009-12-03
EA015491B1 (ru)	2011-08-30
EA200501868A1 (ru)	2006-06-30
JP2007516175A (ja)	2007-06-21
ZA200600770B (en)	2007-05-30
US8350041B2 (en)	2013-01-08
AU2004253898A1 (en)	2005-01-13
US8106207B2 (en)	2012-01-31
IL172713A0 (en)	2006-04-10
NO20060446L (no)	2006-03-27
CN1839135A (zh)	2006-09-27
EP1644373A1 (en)	2006-04-12
BRPI0411998A (pt)	2006-09-05
US20110245291A1 (en)	2011-10-06
UA86024C2 (ru)	2009-03-25
KR20060035645A (ko)	2006-04-26
KR101132208B1 (ko)	2012-04-12
CN100513407C (zh)	2009-07-15
US20050009860A1 (en)	2005-01-13
JP4810423B2 (ja)	2011-11-09
CA2530444A1 (en)	2005-01-13
US20120095010A1 (en)	2012-04-19
US7982042B2 (en)	2011-07-19
CA2530444C (en)	2012-03-13
ECSP056256A (es)	2006-04-19
CR8166A (es)	2009-01-16
NZ572901A (en)	2010-06-25
AR044940A1 (es)	2005-10-12
TW200528105A (en)	2005-09-01
HK1097532A1 (zh)	2007-06-29
US7589103B2 (en)	2009-09-15
NO333611B1 (no)	2013-07-22
WO2005003131A1 (en)	2005-01-13

Publication	Publication Date	Title
TWI368510B (en)	2012-07-21	Tricyclic δ-opioid modulators
PT1521757E (pt)	2008-04-03	Espiropiperidinas ou espiropirrolidinas tricíclicas
AU153883S (en)	2003-11-28	Ring
EP1632492A4 (en)	2010-08-25	TRICYCLIC CONNECTION
IL181120A0 (en)	2008-03-20	Tricyclic ?? -opioid modulators
GB0329314D0 (en)	2004-01-21	Substituted arylpyrazoles
EP1666954A4 (en)	2007-03-07	OPTICAL MODULATOR
EP1646434A4 (en)	2009-03-11	PROGRESSIVE CAGNOTTES COMMUNICATION TECHNIQUES
GB2422544B (en)	2008-05-14	Immune modulator
GB2407131B (en)	2007-04-11	Modulator
GB0306575D0 (en)	2003-04-30	Modulators
IL182307A0 (en)	2007-09-20	Heteroatoms -containing tricyclic compounds
AU2003303520A8 (en)	2004-07-29	Irs modulators
GB2408811B (en)	2005-11-23	Optical Modulator
GB0427954D0 (en)	2005-01-26	Modulator
IL165695A0 (en)	2006-01-15	Novel tricyclic spiropiperidines or spiropyrrolidines
HK1108430A (zh)	2008-05-09	三环δ-阿片样物质调节剂
GB2397449B (en)	2007-02-28	Modulator
GB0406934D0 (en)	2004-04-28	Magnet light
SI1521757T1 (sl)	2008-06-30	Triciklični spiropiperidini ali spiropirolidini
GB0317144D0 (en)	2003-08-27	Immune modulator
GB0326620D0 (en)	2003-12-17	Immune modulator
GB0401130D0 (en)	2004-02-18	Modulators
IL179559A0 (en)	2007-05-15	Theramutein modulators
GB0401131D0 (en)	2004-02-18	Modulators

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2016-04-21	MM4A	Annulment or lapse of patent due to non-payment of fees