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TWI367761B - Pharmaceutical composition containing hardly water soluble pharmaceutical substance - Google Patents

Pharmaceutical composition containing hardly water soluble pharmaceutical substance

Info

Publication number
TWI367761B
TWI367761B TW095108368A TW95108368A TWI367761B TW I367761 B TWI367761 B TW I367761B TW 095108368 A TW095108368 A TW 095108368A TW 95108368 A TW95108368 A TW 95108368A TW I367761 B TWI367761 B TW I367761B
Authority
TW
Taiwan
Prior art keywords
composition containing
water soluble
hardly water
pharmaceutical composition
containing hardly
Prior art date
Application number
TW095108368A
Other languages
English (en)
Other versions
TW200714293A (en
Inventor
Koichi Takeda
Kenji Matsuda
Toshimitsu Terao
Tadaaki Inoue
Takashi Imagawa
Original Assignee
Otsuka Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharma Co Ltd filed Critical Otsuka Pharma Co Ltd
Publication of TW200714293A publication Critical patent/TW200714293A/zh
Application granted granted Critical
Publication of TWI367761B publication Critical patent/TWI367761B/zh

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
TW095108368A 2005-03-14 2006-03-13 Pharmaceutical composition containing hardly water soluble pharmaceutical substance TWI367761B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2005071640 2005-03-14

Publications (2)

Publication Number Publication Date
TW200714293A TW200714293A (en) 2007-04-16
TWI367761B true TWI367761B (en) 2012-07-11

Family

ID=36991586

Family Applications (1)

Application Number Title Priority Date Filing Date
TW095108368A TWI367761B (en) 2005-03-14 2006-03-13 Pharmaceutical composition containing hardly water soluble pharmaceutical substance

Country Status (8)

Country Link
US (1) US20080128314A1 (zh)
EP (1) EP1862183B1 (zh)
JP (1) JP4929158B2 (zh)
KR (1) KR101391020B1 (zh)
CN (1) CN101137395B (zh)
DE (1) DE602006017979D1 (zh)
TW (1) TWI367761B (zh)
WO (1) WO2006098241A1 (zh)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8034765B2 (en) 2005-08-31 2011-10-11 Abraxis Bioscience, Llc Compositions and methods for preparation of poorly water soluble drugs with increased stability
ES2784794T3 (es) * 2005-08-31 2020-10-01 Abraxis Bioscience Llc Composiciones que comprenden agentes farmacéuticos poco solubles en agua y agentes antimicrobianos
KR100917809B1 (ko) * 2006-05-22 2009-09-18 에스케이케미칼주식회사 우수한 저장안정성을 갖는 도세탁셀 함유 주사제 조성물
EP2025333A1 (en) * 2007-08-14 2009-02-18 Pharmatex Italia Srl Injectable pharmaceutical formulation of taxoids
US20090286832A1 (en) * 2008-05-15 2009-11-19 Kiichiro Nabeta Narcotic emulsion formulations for treatment of surgical pain
CN101612120B (zh) * 2008-12-16 2011-02-02 海南美大制药有限公司 氟罗沙星冻干乳剂及其生产方法
WO2010098897A1 (en) * 2009-02-26 2010-09-02 Teikoku Pharma Usa, Inc. Narcotic emulsion formulations for treatment of cancer pain
CN102038635A (zh) * 2009-10-23 2011-05-04 天津天士力集团有限公司 一种含有pH值调节剂的紫杉烷类药物溶液及其制备方法
WO2012094020A1 (en) * 2010-01-07 2012-07-12 Innopharma, Inc. Methods and compositions for delivery of taxanes in stable oil-in-water emulsions
CN101926757B (zh) * 2010-09-01 2013-01-02 北京大学 一种难溶性药物的液体组合物及其制备方法
TWI511725B (zh) * 2010-11-10 2015-12-11 Tasly Holding Group Co Ltd A taxane-containing drug solution containing chelating agent and a preparation method thereof
CN102579338B (zh) * 2012-03-02 2013-06-19 首都医科大学 一种紫杉醇静脉注射脂肪乳的制备及应用
CN104886357B (zh) * 2014-09-15 2018-09-07 浙江万方生物科技有限公司 一种用于畜禽的水溶性肉桂醛添加剂的制备方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0331755B2 (en) * 1987-09-07 2003-02-05 Teijin Limited Medicine-containing fat emulsion of the type prepared immediately before use and process for preparing medicine-containing fat emulsion
US5616330A (en) * 1994-07-19 1997-04-01 Hemagen/Pfc Stable oil-in-water emulsions incorporating a taxine (taxol) and method of making same
KR19990075621A (ko) * 1998-03-23 1999-10-15 임성주 경사 평판형 배양조
RU2001127313A (ru) * 1999-03-09 2003-09-20 Протарга, Инк. (Us) Конъюгаты жирная кислота-противораковый агент и их применение
AU5273200A (en) * 1999-05-24 2000-12-12 Sonus Pharmaceuticals, Inc. Emulsion vehicle for poorly soluble drugs
ATE290372T1 (de) * 2000-07-24 2005-03-15 Upjohn Co Selbstemulgierendes system zur abgabe von sehr wasserunlöslichen und lipophilen arzneimitteln
KR20020013174A (ko) * 2000-08-11 2002-02-20 민경윤 경구 흡수율이 낮은 약물의 흡수율을 증가시키기 위한경구용 조성물
EP1389089B1 (en) * 2001-03-27 2009-08-26 Phares Pharmaceutical Research N.V. Method and composition for solubilising a biologically active compound with low water solubility
EP1435908A4 (en) * 2001-09-13 2006-03-15 Korea Inst Sci & Tech Oily paclitaxel composition and formulation for chemoembolization and preparation method thereof

Also Published As

Publication number Publication date
KR101391020B1 (ko) 2014-04-30
TW200714293A (en) 2007-04-16
EP1862183A4 (en) 2009-12-30
JP4929158B2 (ja) 2012-05-09
EP1862183A1 (en) 2007-12-05
US20080128314A1 (en) 2008-06-05
CN101137395B (zh) 2012-10-31
KR20080002752A (ko) 2008-01-04
JPWO2006098241A1 (ja) 2008-08-21
CN101137395A (zh) 2008-03-05
DE602006017979D1 (de) 2010-12-16
WO2006098241A1 (ja) 2006-09-21
EP1862183B1 (en) 2010-11-03

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Legal Events

Date Code Title Description
MM4A Annulment or lapse of patent due to non-payment of fees