TWI365741B - Novel 1,3-dihydro-5-isobenzofurancarbonitrile derivatives and pharmaceutical composition thereof for the treatment of premature ejaculation - Google Patents
Novel 1,3-dihydro-5-isobenzofurancarbonitrile derivatives and pharmaceutical composition thereof for the treatment of premature ejaculationInfo
- Publication number
- TWI365741B TWI365741B TW097142052A TW97142052A TWI365741B TW I365741 B TWI365741 B TW I365741B TW 097142052 A TW097142052 A TW 097142052A TW 97142052 A TW97142052 A TW 97142052A TW I365741 B TWI365741 B TW I365741B
- Authority
- TW
- Taiwan
- Prior art keywords
- dihydro
- novel
- treatment
- pharmaceutical composition
- premature ejaculation
- Prior art date
Links
- ZLXJXAMSNFFEFG-UHFFFAOYSA-N 1,3-dihydro-2-benzofuran-5-carbonitrile Chemical class N#CC1=CC=C2COCC2=C1 ZLXJXAMSNFFEFG-UHFFFAOYSA-N 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 206010036596 premature ejaculation Diseases 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Gynecology & Obstetrics (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR20070111783 | 2007-11-02 | ||
| KR1020080105439A KR101103118B1 (ko) | 2007-11-02 | 2008-10-27 | 신규한 1,3-디히드로-5-이소벤조퓨란카르보니트릴 유도체 화합물 및 이를 함유하는 조루증 치료용 약학조성물 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TW200934481A TW200934481A (en) | 2009-08-16 |
| TWI365741B true TWI365741B (en) | 2012-06-11 |
Family
ID=40855892
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW097142052A TWI365741B (en) | 2007-11-02 | 2008-10-31 | Novel 1,3-dihydro-5-isobenzofurancarbonitrile derivatives and pharmaceutical composition thereof for the treatment of premature ejaculation |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US8242159B2 (zh) |
| EP (1) | EP2215070A4 (zh) |
| JP (1) | JP5281649B2 (zh) |
| KR (1) | KR101103118B1 (zh) |
| CN (1) | CN101910146A (zh) |
| AR (1) | AR069166A1 (zh) |
| AU (1) | AU2008319628B2 (zh) |
| BR (1) | BRPI0818267A2 (zh) |
| CA (1) | CA2703783C (zh) |
| CL (1) | CL2008003231A1 (zh) |
| CO (1) | CO6280531A2 (zh) |
| IL (1) | IL205350A0 (zh) |
| MX (1) | MX2010004727A (zh) |
| NZ (1) | NZ585091A (zh) |
| PE (1) | PE20091018A1 (zh) |
| RU (1) | RU2448963C2 (zh) |
| TW (1) | TWI365741B (zh) |
| UA (1) | UA99492C2 (zh) |
| WO (1) | WO2009057974A2 (zh) |
| ZA (1) | ZA201003794B (zh) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013026455A1 (en) * | 2011-08-24 | 2013-02-28 | Aarhus Universitet | Permanently positively charged antidepressants |
| US9169237B1 (en) * | 2014-10-24 | 2015-10-27 | Medi Synergics, LLC | Antiprotozoal amidine compounds |
| KR101637177B1 (ko) * | 2014-03-14 | 2016-07-07 | 건일제약 주식회사 | 8-히드록시클로미프라민 또는 이의 약학적으로 허용가능한 염의 제조방법 |
| HUE058698T2 (hu) | 2015-02-11 | 2022-09-28 | Sunovion Pharmaceuticals Inc | 1-heterociklusos izokromanil vegyületek és analógok a CNS rendellenességek kezelésére |
| CN116283877A (zh) | 2016-07-29 | 2023-06-23 | 赛诺维信制药公司 | 化合物、组合物及其用途 |
| AU2017301767A1 (en) | 2016-07-29 | 2019-02-14 | Pgi Drug Discovery Llc | Compounds and compositions and uses thereof |
| KR20200036008A (ko) | 2017-08-02 | 2020-04-06 | 선오비온 파마슈티컬스 인코포레이티드 | 이소크로만 화합물 및 이의 용도 |
| CN109111415B (zh) * | 2018-10-25 | 2022-08-23 | 安徽中医药大学 | 一类石斛生物碱衍生物、制备方法和医药用途 |
| MX2021010880A (es) | 2019-03-14 | 2022-01-18 | Sunovion Pharmaceuticals Inc | Sales de un compuesto de isocromanilo y formas cristalinas, procesos de preparacion, usos terapeuticos y composiciones farmaceuticas de las mismas. |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1526331A (en) * | 1976-01-14 | 1978-09-27 | Kefalas As | Phthalanes |
| GB0105627D0 (en) * | 2001-03-07 | 2001-04-25 | Cipla Ltd | Preparation of phthalanes |
| US6974839B2 (en) * | 2001-03-16 | 2005-12-13 | Dmi Biosciences, Inc. | Method of delaying ejaculation |
| BR0213949A (pt) * | 2001-11-08 | 2004-08-31 | Sepracor Inc | Métodos para o tratamento de depressão e outros distúrbios do snc utilizando metabólitos desmetila e didesmetila de citalopram enanciomericamente enriquecidos |
| IN192863B (zh) | 2001-11-13 | 2004-05-22 | Ranbaxy Lab Ltd | |
| US6764200B1 (en) * | 2003-01-15 | 2004-07-20 | Hsiang Lan Wu Liu | Decorative lantern |
| BRPI0408454A (pt) * | 2003-03-21 | 2006-04-04 | Nexmed Holdings Inc | composição tópica, método de tratar a ejaculação precoce, e, uso da composição |
| GB0409744D0 (en) * | 2004-04-30 | 2004-06-09 | Pfizer Ltd | Novel compounds |
-
2008
- 2008-10-27 KR KR1020080105439A patent/KR101103118B1/ko not_active Expired - Fee Related
- 2008-10-29 CL CL2008003231A patent/CL2008003231A1/es unknown
- 2008-10-31 PE PE2008001868A patent/PE20091018A1/es not_active Application Discontinuation
- 2008-10-31 AU AU2008319628A patent/AU2008319628B2/en not_active Ceased
- 2008-10-31 CA CA2703783A patent/CA2703783C/en not_active Expired - Fee Related
- 2008-10-31 CN CN2008801224430A patent/CN101910146A/zh active Pending
- 2008-10-31 JP JP2010531967A patent/JP5281649B2/ja not_active Expired - Fee Related
- 2008-10-31 RU RU2010122320/04A patent/RU2448963C2/ru not_active IP Right Cessation
- 2008-10-31 MX MX2010004727A patent/MX2010004727A/es active IP Right Grant
- 2008-10-31 BR BRPI0818267-1A patent/BRPI0818267A2/pt not_active IP Right Cessation
- 2008-10-31 UA UAA201006496A patent/UA99492C2/ru unknown
- 2008-10-31 TW TW097142052A patent/TWI365741B/zh not_active IP Right Cessation
- 2008-10-31 WO PCT/KR2008/006445 patent/WO2009057974A2/en not_active Ceased
- 2008-10-31 US US12/739,870 patent/US8242159B2/en not_active Expired - Fee Related
- 2008-10-31 NZ NZ585091A patent/NZ585091A/en not_active IP Right Cessation
- 2008-10-31 EP EP08846179A patent/EP2215070A4/en not_active Withdrawn
- 2008-11-03 AR ARP080104804A patent/AR069166A1/es not_active Application Discontinuation
-
2010
- 2010-04-26 IL IL205350A patent/IL205350A0/en unknown
- 2010-05-27 ZA ZA2010/03794A patent/ZA201003794B/en unknown
- 2010-06-02 CO CO10066630A patent/CO6280531A2/es active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| BRPI0818267A2 (pt) | 2015-04-14 |
| US8242159B2 (en) | 2012-08-14 |
| US20100240725A1 (en) | 2010-09-23 |
| MX2010004727A (es) | 2010-05-20 |
| EP2215070A4 (en) | 2011-11-02 |
| WO2009057974A3 (en) | 2009-07-16 |
| IL205350A0 (en) | 2010-12-30 |
| CA2703783C (en) | 2012-12-04 |
| WO2009057974A2 (en) | 2009-05-07 |
| PE20091018A1 (es) | 2009-08-17 |
| RU2448963C2 (ru) | 2012-04-27 |
| NZ585091A (en) | 2012-04-27 |
| CL2008003231A1 (es) | 2009-11-27 |
| EP2215070A2 (en) | 2010-08-11 |
| JP5281649B2 (ja) | 2013-09-04 |
| JP2011502981A (ja) | 2011-01-27 |
| RU2010122320A (ru) | 2011-12-10 |
| CN101910146A (zh) | 2010-12-08 |
| KR101103118B1 (ko) | 2012-01-04 |
| AU2008319628A1 (en) | 2009-05-07 |
| ZA201003794B (en) | 2011-02-23 |
| AR069166A1 (es) | 2010-01-06 |
| AU2008319628B2 (en) | 2012-03-29 |
| KR20090045855A (ko) | 2009-05-08 |
| CA2703783A1 (en) | 2009-05-07 |
| UA99492C2 (ru) | 2012-08-27 |
| TW200934481A (en) | 2009-08-16 |
| CO6280531A2 (es) | 2011-05-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | Annulment or lapse of patent due to non-payment of fees |