TWI349551B - Thiophenepyrimidinone derivatives and their use in therapy - Google Patents

Thiophenepyrimidinone derivatives and their use in therapy

Info

Publication number: TWI349551B
Authority: TW; Taiwan
Prior art keywords: therapy; thiophenepyrimidinone; derivatives; thiophenepyrimidinone derivatives
Prior art date: 2003-06-10

Application number

TW093116411A

Other languages

English (en)

Other versions

TW200509937A (en

Inventor

Leena Hirvela

Nina Johansson

Pasi Koskimies

Olli Pentikainen

Tommi Nyronen

Tiina Salminen

Mark Johnson

Pekka Lehtovuori

Original Assignee

Solvay Pharm Bv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-06-10

Filing date

2004-06-08

Publication date

2011-10-01

2004-06-08 Application filed by Solvay Pharm Bv filed Critical Solvay Pharm Bv

2005-03-16 Publication of TW200509937A publication Critical patent/TW200509937A/zh

2011-10-01 Application granted granted Critical

2011-10-01 Publication of TWI349551B publication Critical patent/TWI349551B/zh

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/08—Antiseborrheics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/12—Ophthalmic agents for cataracts
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Physical Education & Sports Medicine (AREA)
Dermatology (AREA)
Endocrinology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Rheumatology (AREA)
Orthopedic Medicine & Surgery (AREA)
Biomedical Technology (AREA)
Reproductive Health (AREA)
Diabetes (AREA)
Epidemiology (AREA)
Psychiatry (AREA)
Urology & Nephrology (AREA)
Ophthalmology & Optometry (AREA)
Hospice & Palliative Care (AREA)
Gynecology & Obstetrics (AREA)
Pregnancy & Childbirth (AREA)
Addiction (AREA)
Immunology (AREA)
Pain & Pain Management (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Plural Heterocyclic Compounds (AREA)
Joining Of Glass To Other Materials (AREA)

TW093116411A 2003-06-10 2004-06-08 Thiophenepyrimidinone derivatives and their use in therapy TWI349551B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US47704703P	2003-06-10	2003-06-10

Publications (2)

Publication Number	Publication Date
TW200509937A TW200509937A (en)	2005-03-16
TWI349551B true TWI349551B (en)	2011-10-01

Family

ID=34421462

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
TW093116411A TWI349551B (en)	2003-06-10	2004-06-08	Thiophenepyrimidinone derivatives and their use in therapy

Country Status (24)

Country	Link
US (1)	US7465739B2 (zh)
EP (1)	EP1635839B1 (zh)
JP (1)	JP4605800B2 (zh)
KR (1)	KR20060054189A (zh)
CN (1)	CN1791412A (zh)
AR (1)	AR044650A1 (zh)
AT (1)	ATE479437T1 (zh)
AU (1)	AU2004277311B8 (zh)
BR (1)	BRPI0411295A (zh)
CA (1)	CA2527617A1 (zh)
DE (1)	DE602004028934D1 (zh)
DK (1)	DK1635839T3 (zh)
ES (2)	ES2352552T3 (zh)
IL (1)	IL172316A0 (zh)
MX (1)	MXPA05012745A (zh)
NO (1)	NO20060123L (zh)
PL (1)	PL1635839T3 (zh)
PT (1)	PT1635839E (zh)
RU (1)	RU2412190C2 (zh)
SA (1)	SA04250159B1 (zh)
SI (1)	SI1635839T1 (zh)
TW (1)	TWI349551B (zh)
WO (1)	WO2005032527A2 (zh)
ZA (1)	ZA200508296B (zh)

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US7524853B2 (en)	2003-06-10	2009-04-28	Solvay Pharmaceuticals B.V.	Compounds and their use in therapy
WO2005108376A1 (en) *	2004-05-06	2005-11-17	Smithkline Beecham Corporation	Calcilytic compounds
JP2008517061A (ja) *	2004-10-20	2008-05-22	コンパスファーマシューティカルズリミティドライアビリティカンパニー	抗腫瘍剤としての化合物及びそれらの使用
EP1828197B1 (en) *	2004-12-13	2009-05-13	Solvay Pharmaceuticals GmbH	NOVEL SUBSTITUTED THIOPHENEPYRIMIDINONE DERIVATIVES AS INHIBITORS OF 17ß-HYDROXYSTEROID DEHYDROGENASE
FR2904000A1 (fr) *	2006-07-19	2008-01-25	Galderma Res & Dev S N C Snc	Modulateurs de hsd17b7 dans le traitement de l'acne ou de l'hyperseborrhee
FR2904318B1 (fr) *	2006-07-27	2011-02-25	Scras	Derives de pyrimidinone et leur utilisation comme medicament
US8080540B2 (en)	2006-09-19	2011-12-20	Abbott Products Gmbh	Therapeutically active triazoles and their use
US8288367B2 (en)	2006-11-30	2012-10-16	Solvay Pharmaceuticals Gmbh	Substituted estratriene derivatives as 17BETA HSD inhibitors
DE102007015169A1 (de)	2007-03-27	2008-10-02	Universität des Saarlandes Campus Saarbrücken	17Beta-Hydroxysteroid-Dehydrogenase-Typ1-Inhibitoren zur Behandlung hormonabhängiger Erkrankungen
WO2009001214A2 (en) *	2007-06-28	2008-12-31	Pfizer Products Inc.	Thieno[2,3-d]pyrimidin-4(3h)-one, isoxazolo[5,4-d]pyrimidin-4(5h)-one and isothiazolo[5,4-d]pyrimidin-4(5h)-one derivatives as calcium receptor antagonists
DE102007040243A1 (de)	2007-08-25	2009-02-26	Universität des Saarlandes	17Beta-Hydroxysteriod-Dehydrogenase Typ1 Inhibitoren zur Behandlung hormonabhängiger Erkrankungen
AU2009329879A1 (en)	2008-12-23	2011-08-11	President And Fellows Of Harvard College	Small molecule inhibitors of necroptosis
WO2012025638A1 (en)	2010-08-27	2012-03-01	Universität des Saarlandes	Selective 17beta-hydroxysteroid dehydrogenase type 1 inhibitors
WO2012119605A1 (en) *	2011-03-10	2012-09-13	Akar Yahya Ahmed Abdellhafeez Salem	New disperse dye with potent anticancer activity
TW201520219A (zh) *	2013-03-12	2015-06-01	Lilly Co Eli	咪唑並吡啶化合物
US20160024098A1 (en)	2013-03-15	2016-01-28	President And Fellows Of Harvard College	Hybrid necroptosis inhibitors
AR096727A1 (es)	2013-06-25	2016-01-27	Forendo Pharma Ltd	Derivados terapéuticamente activos de estratrien-tiazol
TW201512215A (zh)	2013-06-25	2015-04-01	Forendo Pharma Ltd	治療活性雌三烯噻唑衍生物
MX2015017879A (es)	2013-06-25	2017-03-01	Forendo Pharma Ltd	Derivados de estratrientiazol 17-nitrogeno substitutidos terapeuticamente activos como inhibidores de 17.beta-hidroxiestero ide deshidrogenasa.
EP3089969A2 (en)	2014-01-03	2016-11-09	Elexopharm GmbH	Inhibitors of 17beta-hydroxysteroid dehydrogenases type 1 and type 2
WO2015114663A1 (en)	2014-01-30	2015-08-06	Council Of Scientific & Industrial Research	Novel thieno [2,3-d]pyrimidin-4(3h)-one compounds with antimycobacterial properties
GB201419102D0 (en) *	2014-10-27	2014-12-10	Imp Innovations Ltd	Novel compounds
JP6545266B2 (ja)	2014-12-23	2019-07-17	フォレンドファーマリミテッド	１７β‐ＨＳＤ１抑制剤のプロドラッグ
EP3237431B1 (en)	2014-12-23	2019-03-20	Forendo Pharma Ltd	Prodrugs of 17.beta.-hsd1 -inhibitors
WO2017075694A1 (en) *	2015-11-04	2017-05-11	Simon Fraser University	Antibiotic compounds, pharmaceutical formulations thereof and methods and uses therefor
DK3634975T3 (da)	2017-06-08	2024-05-27	Organon R&D Finland Ltd	17-oximer af 15.beta.-[3-propanamido]-substituerede estra-1,3,5(10)-trien-17-oner til anvendelse i inhibition af 17.beta.-hydroxysteroid-dehydrogenaser
CN109503572B (zh) *	2017-09-15	2021-10-08	上海交通大学	一种合成吲哚喹啉类化合物的方法
EP3891167B1 (en)	2018-12-05	2024-11-13	Organon R&D Finland Oy	Estra-1,3,5(10)-triene compounds condensed in position 16(17) with a pyrazole ring as inhibitors of 17-hsd1
JP2025516002A (ja) *	2022-04-28	2025-05-23	エナンタファーマシューティカルズインコーポレイテッド	ピリミジノン含有１７－ベータ－ヒドロキシステロイドデヒドロゲナーゼ１３型阻害剤
US20250154163A1 (en) *	2023-10-26	2025-05-15	Enanta Pharmaceuticals, Inc.	Pyrimidinone-Containing 17-Beta-Hydroxysteroid Dehydrogenase Type 13 Inhibitors

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AR036492A1 (es)	2001-09-06	2004-09-15	Schering Corp	Inhibidores de la 17beta-hidroxiesteroide deshidrogenasa tipo 3, composiciones farmaceuticas y el uso de dichos inhibidores para la elaboracion de un medicamento para el tratamiento de enfermedades androgeno dependientes
US6750248B2 (en) *	2001-11-09	2004-06-15	National University Of Singapore	Methods for preparing an estrogenic preparation and isolated estrogenic compounds from a plant and uses thereof

2004
- 2004-06-07 US US10/861,907 patent/US7465739B2/en not_active Expired - Fee Related
- 2004-06-08 TW TW093116411A patent/TWI349551B/zh not_active IP Right Cessation
- 2004-06-08 AR ARP040101983A patent/AR044650A1/es not_active Application Discontinuation
- 2004-06-09 CA CA002527617A patent/CA2527617A1/en not_active Abandoned
- 2004-06-09 CN CNA200480013515XA patent/CN1791412A/zh active Pending
- 2004-06-09 ES ES04803089T patent/ES2352552T3/es not_active Expired - Lifetime
- 2004-06-09 ZA ZA200508296A patent/ZA200508296B/xx unknown
- 2004-06-09 EP EP04803089A patent/EP1635839B1/en not_active Expired - Lifetime
- 2004-06-09 PL PL04803089T patent/PL1635839T3/pl unknown
- 2004-06-09 PT PT04803089T patent/PT1635839E/pt unknown
- 2004-06-09 SI SI200431535T patent/SI1635839T1/sl unknown
- 2004-06-09 KR KR1020057022958A patent/KR20060054189A/ko not_active Abandoned
- 2004-06-09 MX MXPA05012745A patent/MXPA05012745A/es active IP Right Grant
- 2004-06-09 WO PCT/EP2004/006230 patent/WO2005032527A2/en not_active Ceased
- 2004-06-09 DK DK04803089.4T patent/DK1635839T3/da active
- 2004-06-09 RU RU2006100033/04A patent/RU2412190C2/ru not_active IP Right Cessation
- 2004-06-09 AT AT04803089T patent/ATE479437T1/de active
- 2004-06-09 AU AU2004277311A patent/AU2004277311B8/en not_active Ceased
- 2004-06-09 BR BRPI0411295-4A patent/BRPI0411295A/pt not_active IP Right Cessation
- 2004-06-09 DE DE602004028934T patent/DE602004028934D1/de not_active Expired - Lifetime
- 2004-06-09 JP JP2006515869A patent/JP4605800B2/ja not_active Expired - Fee Related
- 2004-06-12 SA SA4250159A patent/SA04250159B1/ar unknown
- 2004-11-03 ES ES04805369T patent/ES2352554T3/es not_active Expired - Lifetime
2005
- 2005-12-01 IL IL172316A patent/IL172316A0/en unknown
2006
- 2006-01-09 NO NO20060123A patent/NO20060123L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
TW200509937A (en)	2005-03-16
ES2352552T3 (es)	2011-02-21
RU2412190C2 (ru)	2011-02-20
EP1635839A2 (en)	2006-03-22
AR044650A1 (es)	2005-09-21
WO2005032527A2 (en)	2005-04-14
IL172316A0 (en)	2011-08-01
ZA200508296B (en)	2007-01-31
EP1635839B1 (en)	2010-09-01
WO2005032527A3 (en)	2005-08-04
PT1635839E (pt)	2010-10-12
NO20060123L (no)	2006-03-09
WO2005032527B1 (en)	2005-09-22
ATE479437T1 (de)	2010-09-15
AU2004277311B8 (en)	2010-05-27
CA2527617A1 (en)	2005-04-14
MXPA05012745A (es)	2006-05-17
US20050038053A1 (en)	2005-02-17
SI1635839T1 (sl)	2010-12-31
ES2352554T3 (es)	2011-02-21
DE602004028934D1 (de)	2010-10-14
CN1791412A (zh)	2006-06-21
RU2006100033A (ru)	2007-07-20
AU2004277311A1 (en)	2005-04-14
SA04250159B1 (ar)	2008-06-21
PL1635839T3 (pl)	2011-02-28
DK1635839T3 (da)	2011-01-03
BRPI0411295A (pt)	2006-08-01
JP4605800B2 (ja)	2011-01-05
AU2004277311B2 (en)	2010-04-29
US7465739B2 (en)	2008-12-16
KR20060054189A (ko)	2006-05-22
JP2006527226A (ja)	2006-11-30

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