TWI341330B - Streptomyces avermitilis gene directing the ratio of b2:b1 avermectins - Google Patents

Streptomyces avermitilis gene directing the ratio of b2:b1 avermectins

Info

Publication number: TWI341330B
Authority: TW; Taiwan
Prior art keywords: avermectins; ratio; streptomyces avermitilis; gene directing; avermitilis gene
Prior art date: 2002-02-12

Application number

TW092102676A

Other languages

English (en)

Other versions

TW200303918A (en

Inventor

Kim Jonelle Stutzman-Engwall

Claes Gustafsson

Anke Krebber

Sun Ai Raillard

Jeremy Stephen Minshull

Seran Kim

Yan Chen

Original Assignee

Pfizer Prod Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-02-12

Filing date

2003-02-10

Publication date

2011-05-01

2003-02-10 Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc

2003-09-16 Publication of TW200303918A publication Critical patent/TW200303918A/zh

2011-05-01 Application granted granted Critical

2011-05-01 Publication of TWI341330B publication Critical patent/TWI341330B/zh

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
- C12P17/181—Heterocyclic compounds containing oxygen atoms as the only ring heteroatoms in the condensed system, e.g. Salinomycin, Septamycin
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/44—Preparation of O-glycosides, e.g. glucosides
- C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
- C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
- C12P19/623—Avermectin; Milbemycin; Ivermectin; C-076

Landscapes

Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Wood Science & Technology (AREA)
Zoology (AREA)
Genetics & Genomics (AREA)
Bioinformatics & Cheminformatics (AREA)
Biotechnology (AREA)
General Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Microbiology (AREA)
Biochemistry (AREA)
Biomedical Technology (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Veterinary Medicine (AREA)
Tropical Medicine & Parasitology (AREA)
Plant Pathology (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Virology (AREA)
Physics & Mathematics (AREA)
Biophysics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Peptides Or Proteins (AREA)
Saccharide Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Detergent Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

TW092102676A 2002-02-12 2003-02-10 Streptomyces avermitilis gene directing the ratio of b2:b1 avermectins TWI341330B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US35622202P	2002-02-12	2002-02-12

Publications (2)

Publication Number	Publication Date
TW200303918A TW200303918A (en)	2003-09-16
TWI341330B true TWI341330B (en)	2011-05-01

Family

ID=27734621

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
TW092102676A TWI341330B (en)	2002-02-12	2003-02-10	Streptomyces avermitilis gene directing the ratio of b2:b1 avermectins

Country Status (25)

Country	Link
US (2)	US7388085B2 (zh)
EP (2)	EP1476539B1 (zh)
JP (1)	JP2005517406A (zh)
KR (1)	KR100718378B1 (zh)
CN (2)	CN1630712B (zh)
AR (1)	AR038405A1 (zh)
AT (2)	ATE530645T1 (zh)
AU (1)	AU2003245052B2 (zh)
BR (1)	BRPI0307620B8 (zh)
CA (1)	CA2475214C (zh)
CY (2)	CY1110454T1 (zh)
DE (1)	DE60326824D1 (zh)
DK (2)	DK1476539T3 (zh)
ES (2)	ES2321827T3 (zh)
IL (3)	IL162866A0 (zh)
ME (1)	ME00472B (zh)
MX (1)	MXPA04007777A (zh)
PL (1)	PL211693B1 (zh)
PT (2)	PT1476539E (zh)
RS (1)	RS50813B (zh)
RU (1)	RU2293117C2 (zh)
SI (2)	SI2050815T1 (zh)
TW (1)	TWI341330B (zh)
WO (1)	WO2003068955A2 (zh)
ZA (1)	ZA200405345B (zh)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN1630712B (zh)	2002-02-12	2011-09-28	辉瑞产品公司	指导b2:b1除虫菌素比例的除虫链霉菌基因
CN102241750B (zh) *	2010-05-14	2014-05-28	中国科学院微生物研究所	一种生产阿维菌素的基因工程方法及其专用菌株
CN102093997B (zh) *	2010-12-01	2013-03-13	中国科学院上海有机化学研究所	一种改造除虫链霉菌产生多拉菌素的方法
CN109576196B (zh) *	2019-01-25	2022-01-04	北大方正集团有限公司	一种生产多拉菌素的发酵培养基及多拉菌素的生产方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SE434277B (sv)	1976-04-19	1984-07-16	Merck & Co Inc	Sett att framstella nya antihelmintiskt verkande foreningar genom odling av streptomyces avermitilis
US4429042A (en)	1978-09-08	1984-01-31	Merck & Co., Inc.	Strain of Streptomyces for producing antiparasitic compounds
IN167980B (zh)	1987-01-23	1991-01-19	Pfizer
US5252474A (en)	1989-03-31	1993-10-12	Merck & Co., Inc.	Cloning genes from Streptomyces avermitilis for avermectin biosynthesis and the methods for their use
WO1995009863A1 (en) *	1993-10-05	1995-04-13	Pfizer Inc.	Process and antiparasitic intermediates for doramectin
US5837458A (en)	1994-02-17	1998-11-17	Maxygen, Inc.	Methods and compositions for cellular and metabolic engineering
US6117679A (en)	1994-02-17	2000-09-12	Maxygen, Inc.	Methods for generating polynucleotides having desired characteristics by iterative selection and recombination
US5605793A (en)	1994-02-17	1997-02-25	Affymax Technologies N.V.	Methods for in vitro recombination
US6248579B1 (en) *	1998-02-13	2001-06-19	Pfizer Inc	Streptomyces avermitilis gene directing the ratio of B2:B1 avermectins
JP2002503473A (ja) *	1998-02-13	2002-02-05	ファイザー・プロダクツ・インク	Ｂ２：ｂ１アベルメクチンの比に関するストレプトミセス・アベルミティリス遺伝子
RU2156301C2 (ru) *	1998-06-09	2000-09-20	Мосин Владимир Александрович	Штамм актиномицета streptomyces avermitilis ссм 4697 - продуцент авермектинов
US6197591B1 (en)	1998-09-14	2001-03-06	Pfizer Inc.	Streptomyces avermitilis regulatory genes for increased avermectin production
EA200200056A1 (ru) *	1999-08-12	2002-06-27	Пфайзер Продактс Инк.	Ген streptomyces avermitilis, направляющий соотношение авермектинов b2:b1
CA2381882C (en)	1999-08-13	2011-01-25	Vertex Pharmaceuticals Incorporated	Inhibitors of c-jun n-terminal kinases (jnk) and other protein kinases
CN1630712B (zh)	2002-02-12	2011-09-28	辉瑞产品公司	指导b2:b1除虫菌素比例的除虫链霉菌基因

2003
- 2003-01-31 CN CN038037416A patent/CN1630712B/zh not_active Expired - Lifetime
- 2003-01-31 EP EP03739390A patent/EP1476539B1/en not_active Expired - Lifetime
- 2003-01-31 AU AU2003245052A patent/AU2003245052B2/en not_active Expired
- 2003-01-31 ES ES03739390T patent/ES2321827T3/es not_active Expired - Lifetime
- 2003-01-31 PT PT03739390T patent/PT1476539E/pt unknown
- 2003-01-31 RS YUP-700/04A patent/RS50813B/sr unknown
- 2003-01-31 DE DE60326824T patent/DE60326824D1/de not_active Expired - Lifetime
- 2003-01-31 PT PT09150098T patent/PT2050815E/pt unknown
- 2003-01-31 IL IL16286603A patent/IL162866A0/xx unknown
- 2003-01-31 SI SI200332087T patent/SI2050815T1/sl unknown
- 2003-01-31 ES ES09150098T patent/ES2373629T3/es not_active Expired - Lifetime
- 2003-01-31 PL PL371320A patent/PL211693B1/pl unknown
- 2003-01-31 CN CN2011102082591A patent/CN102392028B/zh not_active Expired - Lifetime
- 2003-01-31 EP EP09150098A patent/EP2050815B1/en not_active Expired - Lifetime
- 2003-01-31 AT AT09150098T patent/ATE530645T1/de active
- 2003-01-31 CA CA2475214A patent/CA2475214C/en not_active Expired - Lifetime
- 2003-01-31 SI SI200331553T patent/SI1476539T1/sl unknown
- 2003-01-31 RU RU2004124521/13A patent/RU2293117C2/ru active
- 2003-01-31 KR KR1020047012437A patent/KR100718378B1/ko not_active Expired - Lifetime
- 2003-01-31 AT AT03739390T patent/ATE426659T1/de active
- 2003-01-31 WO PCT/IB2003/000348 patent/WO2003068955A2/en not_active Ceased
- 2003-01-31 MX MXPA04007777A patent/MXPA04007777A/es active IP Right Grant
- 2003-01-31 JP JP2003568070A patent/JP2005517406A/ja active Pending
- 2003-01-31 BR BRPI0307620A patent/BRPI0307620B8/pt not_active IP Right Cessation
- 2003-01-31 ME MEP-2008-730A patent/ME00472B/me unknown
- 2003-01-31 DK DK03739390T patent/DK1476539T3/da active
- 2003-01-31 DK DK09150098.3T patent/DK2050815T3/da active
- 2003-02-10 AR ARP030100408A patent/AR038405A1/es active IP Right Grant
- 2003-02-10 TW TW092102676A patent/TWI341330B/zh not_active IP Right Cessation
- 2003-02-10 US US10/361,376 patent/US7388085B2/en not_active Expired - Lifetime
2004
- 2004-07-05 IL IL162866A patent/IL162866A/en active IP Right Grant
- 2004-07-05 ZA ZA200405345A patent/ZA200405345B/xx unknown
2008
- 2008-04-23 US US12/107,949 patent/US8008078B2/en not_active Expired - Fee Related
- 2008-06-22 IL IL192371A patent/IL192371A/en active IP Right Grant
2009
- 2009-04-27 CY CY20091100467T patent/CY1110454T1/el unknown
2011
- 2011-12-02 CY CY20111101193T patent/CY1112491T1/el unknown

Also Published As

Publication number	Publication date
TW200303918A (en)	2003-09-16
US20030166165A1 (en)	2003-09-04
ES2321827T3 (es)	2009-06-12
SI2050815T1 (sl)	2012-01-31
PT2050815E (pt)	2012-01-02
IL162866A0 (en)	2005-11-20
CY1110454T1 (el)	2015-04-29
BR0307620A (pt)	2004-12-07
CN1630712A (zh)	2005-06-22
PT1476539E (pt)	2009-04-09
CA2475214C (en)	2012-07-31
CN102392028A (zh)	2012-03-28
WO2003068955A2 (en)	2003-08-21
US7388085B2 (en)	2008-06-17
AU2003245052A1 (en)	2003-09-04
ES2373629T3 (es)	2012-02-07
EP2050815B1 (en)	2011-10-26
JP2005517406A (ja)	2005-06-16
AU2003245052B2 (en)	2008-07-31
PL211693B1 (pl)	2012-06-29
KR100718378B1 (ko)	2007-05-14
HK1074644A1 (zh)	2005-11-18
EP1476539A2 (en)	2004-11-17
KR20040081199A (ko)	2004-09-20
BRPI0307620B8 (pt)	2016-09-13
US20090017508A1 (en)	2009-01-15
CY1112491T1 (el)	2015-12-09
PL371320A1 (en)	2005-06-13
RS50813B (sr)	2010-08-31
ATE426659T1 (de)	2009-04-15
CN102392028B (zh)	2013-08-14
BRPI0307620B1 (pt)	2015-08-11
DE60326824D1 (de)	2009-05-07
DK2050815T3 (da)	2011-12-12
RU2293117C2 (ru)	2007-02-10
AR038405A1 (es)	2005-01-12
EP2050815A1 (en)	2009-04-22
ATE530645T1 (de)	2011-11-15
ZA200405345B (en)	2005-06-14
IL162866A (en)	2009-11-18
DK1476539T3 (da)	2009-05-11
US8008078B2 (en)	2011-08-30
HK1168383A1 (zh)	2012-12-28
MXPA04007777A (es)	2004-10-15
RU2004124521A (ru)	2005-04-10
RS70004A (sr)	2006-10-27
SI1476539T1 (sl)	2009-06-30
CN1630712B (zh)	2011-09-28
WO2003068955A3 (en)	2003-11-13
IL192371A (en)	2010-11-30
CA2475214A1 (en)	2003-08-21
IL192371A0 (en)	2008-12-29
ME00472B (me)	2011-10-10
EP1476539B1 (en)	2009-03-25

Publication	Publication Date	Title
AU2002363246A1 (en)	2003-05-12	Game with multiple chambers
AU2003237249A1 (en)	2003-12-12	Oligonucleotides having modified nucleoside units
AU2003241621A1 (en)	2003-12-12	Oligonucleotides having modified nucleoside units
SI1594878T1 (sl)	2008-10-31	Monosaharidni derivati avermektina s pesticidnimilastnostmi
IL147562A0 (en)	2002-08-14	Streptomyces avermitilis gene directing the ratio of b2:b1 avermectins
TWI341330B (en)	2011-05-01	Streptomyces avermitilis gene directing the ratio of b2:b1 avermectins
IL137610A0 (en)	2001-07-24	Streptomyces avermitilis gene directing the ratio of b2:b1 avermectins
HUP0202487A3 (en)	2004-07-28	Streptomyces avermitilis gene directing the ratio of b2:b1 avermectins
AU2003279392A1 (en)	2004-01-06	Pharmaceutical compositions of azithromycin
AU2002317415A1 (en)	2003-02-17	Azalide antibiotic compositions
AU2003285599A1 (en)	2004-06-30	Novel semisynthetic macrolide antibiotics of the azalide series
AU2003304705A1 (en)	2005-08-03	11-csubsituted erythromycin derivatives
ZA200507475B (en)	2008-03-26	Derivatives of azithromycin
PL1638984T3 (pl)	2008-02-29	Monosacharydowe pochodne awermektyny B1
AU2003253701A1 (en)	2004-01-06	11-c-substituted derivatives of clarithromycin
AU2003243789A1 (en)	2004-01-06	11-c-substituted ketolides
DK1200605T3 (da)	2005-03-21	Streptomyces avermitilis gen, der dirigerer forholdet imellem B2:B1 avermectiner
AU2003267572A1 (en)	2004-04-08	Antibiotic derivatives of erythromycin
HK1071531A (zh)	2005-07-22	具有多个腔室的游戏
AU2002236982A1 (en)	2002-08-28	Laulimalide derivatives
GB0221809D0 (en)	2002-10-30	Antibiotic derivatives
AU2003217311A1 (en)	2003-09-02	Base-labeled nucleosides and nucleotides

Legal Events

Date	Code	Title	Description
2023-03-21	MK4A	Expiration of patent term of an invention patent